Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
2017
Gene name Gene Name - the full gene name approved by the HGNC.
Cortactin
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
CTTN
Synonyms (NCBI Gene) Gene synonyms aliases
EMS1
Chromosome Chromosome number
11
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
11q13.3
Summary Summary of gene provided in NCBI Entrez Gene.
This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT019566 hsa-miR-340-5p Sequencing 20371350
MIRT023872 hsa-miR-1-3p Proteomics 18668040
MIRT023872 hsa-miR-1-3p Proteomics;Microarray 18668037
MIRT025473 hsa-miR-34a-5p Proteomics 21566225
MIRT025473 hsa-miR-34a-5p Proteomics 21566225
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001726 Component Ruffle ISS
GO:0002102 Component Podosome IEA
GO:0005515 Function Protein binding IPI 15169891, 15574754, 16636290, 17065230, 17255943, 17620599, 18387954, 19146815, 19419567, 21220424, 21847094, 22252131, 22282019, 24658140, 25241761, 31980649
GO:0005522 Function Profilin binding IPI 24700464
GO:0005737 Component Cytoplasm IDA 10760273, 24700464
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
164765 3338 ENSG00000085733
Protein
UniProt ID Q14247
Protein name Src substrate cortactin (Amplaxin) (Oncogene EMS1)
Protein function Contributes to the organization of the actin cytoskeleton and cell shape (PubMed:21296879). Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of ne
PDB 1X69 , 2D1X
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02218 HS1_rep 83 118 Repeat in HS1/Cortactin Repeat
PF02218 HS1_rep 120 155 Repeat in HS1/Cortactin Repeat
PF02218 HS1_rep 157 192 Repeat in HS1/Cortactin Repeat
PF02218 HS1_rep 194 229 Repeat in HS1/Cortactin Repeat
PF02218 HS1_rep 231 266 Repeat in HS1/Cortactin Repeat
PF02218 HS1_rep 268 303 Repeat in HS1/Cortactin Repeat
PF02218 HS1_rep 305 332 Repeat in HS1/Cortactin Repeat
PF14604 SH3_9 499 547 Variant SH3 domain Domain
Sequence
MWKASAGHAVSIAQDDAGADDWETDPDFVNDVSEKEQRWGAKTVQGSGHQEHINIHKLRE
NVFQEHQTLKEKELETGPKASHGYGGKFGVEQDRMDKSAVGHEYQSKLSKHCSQVDSVRG
FGGKFGVQMDRVDQSAVGFEYQGKTEKHASQKDYS
SGFGGKYGVQADRVDKSAVGFDYQG
KTEKHESQRDYS
KGFGGKYGIDKDKVDKSAVGFEYQGKTEKHESQKDYVKGFGGKFGVQT
DRQDKCALGWDHQEKLQLHESQKDYK
TGFGGKFGVQSERQDSAAVGFDYKEKLAKHESQQ
DYS
KGFGGKYGVQKDRMDKNASTFEDVTQVSSAYQKTVPVEAVTSKTSNIRANFENLAKE
KEQEDRRKAEAERAQRMAKERQEQEEARRKLEEQARAKTQTPPVSPAPQPTEERLPSSPV
YEDAASFKAELSYRGPVSGTEPEPVYSMEAADYREASSQQGLAYATEAVYESAEAPGHYP
AEDSTYDEYENDLGITAVALYDYQAAGDDEISFDPDDIITNIEMIDDGWWRGVCKGRYGL
FPANYVE
LRQ
Sequence length 550
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Tight junction
Bacterial invasion of epithelial cells
Pathogenic Escherichia coli infection
Shigellosis
Proteoglycans in cancer
  Clathrin-mediated endocytosis
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Arthritis Juvenile arthritis rs1594890601, rs1594882933, rs184370809, rs776489319, rs1594883470 19565504
Carcinoma Squamous cell carcinoma rs121912654, rs555607708, rs786202962, rs1564055259 27148699
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma Associate 18820669
Ameloblastoma Inhibit 39941035
Asthma Associate 18521921
Atherosclerosis Associate 35059464
Breast Neoplasms Associate 18403644, 19589785, 20219074, 24753582, 26166158, 26447611, 27026610, 28356423, 30562756, 36043996, 36137995, 9054437
Calcinosis Cutis Associate 19898426
Carcinoma Hepatocellular Associate 12552080, 23518204, 25958313, 31138777, 33466191
Carcinoma Non Small Cell Lung Associate 27572123, 29986736
Carcinoma Renal Cell Associate 25527159
Carcinoma Squamous Cell Associate 27877079, 30804117