DENND6A (DENN domain containing 6A)

Gene

• Entrez ID: 201627
• Gene name: DENN domain containing 6A
• Gene symbol: DENND6A
• Synonyms (NCBI Gene): AFI1A, FAM116A
• Chromosome: 3
• Chromosome location: 3p14.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT003166	hsa-miR-210-3p	immunoprecipitaion, Microarray, qRT-PCR	19826008
MIRT022584	hsa-miR-124-3p	Microarray	18668037
MIRT049746	hsa-miR-92a-3p	CLASH	23622248
MIRT659119	hsa-miR-483-5p	HITS-CLIP	23824327
MIRT659118	hsa-miR-4781-3p	HITS-CLIP	23824327
MIRT659117	hsa-miR-4716-5p	HITS-CLIP	23824327
MIRT659116	hsa-miR-3663-5p	HITS-CLIP	23824327
MIRT659115	hsa-miR-432-5p	HITS-CLIP	23824327
MIRT659114	hsa-miR-4755-3p	HITS-CLIP	23824327
MIRT659113	hsa-miR-6131	HITS-CLIP	23824327
MIRT659112	hsa-miR-193b-5p	HITS-CLIP	23824327
MIRT659111	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT659110	hsa-miR-1269a	HITS-CLIP	23824327
MIRT659109	hsa-miR-1269b	HITS-CLIP	23824327
MIRT659108	hsa-miR-5009-5p	HITS-CLIP	23824327
MIRT659107	hsa-miR-8058	HITS-CLIP	23824327
MIRT659106	hsa-miR-548s	HITS-CLIP	23824327
MIRT659105	hsa-miR-588	HITS-CLIP	23824327
MIRT659104	hsa-miR-4435	HITS-CLIP	23824327
MIRT659103	hsa-miR-3187-3p	HITS-CLIP	23824327
MIRT659102	hsa-miR-4529-3p	HITS-CLIP	23824327
MIRT659101	hsa-miR-5096	HITS-CLIP	23824327
MIRT659100	hsa-miR-1303	HITS-CLIP	23824327
MIRT440689	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT727721	hsa-miR-19a-3p	HITS-CLIP	22473208
MIRT727720	hsa-miR-19b-3p	HITS-CLIP	22473208
MIRT440689	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT659119	hsa-miR-483-5p	HITS-CLIP	23824327
MIRT659118	hsa-miR-4781-3p	HITS-CLIP	23824327
MIRT659117	hsa-miR-4716-5p	HITS-CLIP	23824327
MIRT659116	hsa-miR-3663-5p	HITS-CLIP	23824327
MIRT659115	hsa-miR-432-5p	HITS-CLIP	23824327
MIRT659114	hsa-miR-4755-3p	HITS-CLIP	23824327
MIRT659113	hsa-miR-6131	HITS-CLIP	23824327
MIRT659112	hsa-miR-193b-5p	HITS-CLIP	23824327
MIRT659111	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT659110	hsa-miR-1269a	HITS-CLIP	23824327
MIRT659109	hsa-miR-1269b	HITS-CLIP	23824327
MIRT659108	hsa-miR-5009-5p	HITS-CLIP	23824327
MIRT659107	hsa-miR-8058	HITS-CLIP	23824327
MIRT659106	hsa-miR-548s	HITS-CLIP	23824327
MIRT659105	hsa-miR-588	HITS-CLIP	23824327
MIRT659104	hsa-miR-4435	HITS-CLIP	23824327
MIRT659103	hsa-miR-3187-3p	HITS-CLIP	23824327
MIRT659102	hsa-miR-4529-3p	HITS-CLIP	23824327
MIRT659101	hsa-miR-5096	HITS-CLIP	23824327
MIRT659100	hsa-miR-1303	HITS-CLIP	23824327

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IDA	22595670
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IEA
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	TAS
GO:0005515	Function	Protein binding	IPI	25852190, 33961781
GO:0005737	Component	Cytoplasm	IDA	22595670
GO:0005737	Component	Cytoplasm	IEA
GO:0005768	Component	Endosome	IEA
GO:0005829	Component	Cytosol	TAS
GO:0055037	Component	Recycling endosome	IBA
GO:0055037	Component	Recycling endosome	IDA	22595670
GO:0055037	Component	Recycling endosome	IEA
GO:2000049	Process	Positive regulation of cell-cell adhesion mediated by cadherin	IDA	22595670

Other IDs

• MIM: 620561
• HGNC: 26635
• e!Ensembl: ENSG00000174839

Protein

• UniProt ID: Q8IWF6
• Protein name: Protein DENND6A (DENN domain-containing protein 6A)
• Protein function: Guanine nucleotide exchange factor (GEF) for RAB14. Component of an endocytic recycling pathway that is required for the control of ADAM10 transport, shedding of N-cadherin/CDH2 by ADAM9 or ADAM10 and regulation of cell-cell junctions. Required
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF09794	Avl9	62 → 203	Transport protein Avl9	Family
  PF08616	SPA	268 → 376		Family

• Sequence:

  MALRGPAGLGPGSRRPLDEAVAGAEGREAPALVAAGGAPEDDEEDDGRGRGLLRWDSFSA
  WLHCVCVVGFDLELGQAVEVIYPQHSKLTDREKTNICYLSFPDSNSGCLGDTQFCFRFRQ
  SSGRRVSLHCLLDQFDKDLPVYLKKDPAYFYGYVYFRQVRDKTLKRGYFQKSLVLISKLP
  YIHFFHTVLKQIAPEYFEKNEPYLEAACNDVDRWPAPVPGKTLHLPIMGVVMKVRIPTCH
  DKPGTTQIVQLTQQVDTNISVILPTVHEVDIFRCFCPVFLHSQMLWELVLLGEPLVVMAP
  SPSESSETVLALVNCISPLKYFSDFRPYFTIHDSEFKEYTTRTQAPPSVILGVTNPFFAK
  TLQHWPHIIRIGDLKPTGEIPKQVKVKKLKNLKTLDSKPGVYTSYKPYLNRDEEIIKQLQ
  KGVQQKRPSEAQSVILRRYFLELTQSFIIPLERYVASLMPLQKSISPWKSPPQLRQFLPE
  EFMKTLEKTGPQLTSRIKGDWIGLYRHFLKSPNFDGWFKTRRKEMTQKLEALHLEALCEE
  DLLLWIQKHTEVETVDLVLKLKNKLLQADREHLPVKPDTMEKLRTHIDAIILALPEDLQG
  ILLKTGMT

• Sequence length: 608

Pathways

Reactome:

RAB GEFs exchange GTP for GDP on RABs