Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein
Entrez ID	2016
Gene name	Empty spiracles homeobox 1
Gene symbol	EMX1
Synonyms (NCBI Gene)	-
Chromosome	2
Chromosome location	2p13.2

136

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miRTarBase ID	miRNA	Experiments	Reference
MIRT447814	hsa-miR-100-3p	PAR-CLIP	22100165
MIRT447813	hsa-miR-3125	PAR-CLIP	22100165
MIRT447812	hsa-miR-3916	PAR-CLIP	22100165
MIRT447811	hsa-miR-6859-5p	PAR-CLIP	22100165
MIRT447810	hsa-miR-3928-3p	PAR-CLIP	22100165
MIRT447809	hsa-miR-3150b-3p	PAR-CLIP	22100165
MIRT447808	hsa-miR-4784	PAR-CLIP	22100165
MIRT447806	hsa-miR-6077	PAR-CLIP	22100165
MIRT450515	hsa-miR-4271	PAR-CLIP	22100165
MIRT450514	hsa-miR-4725-3p	PAR-CLIP	22100165
MIRT450513	hsa-miR-6780b-5p	PAR-CLIP	22100165
MIRT447807	hsa-miR-3915	PAR-CLIP	22100165
MIRT447805	hsa-miR-1224-5p	PAR-CLIP	22100165
MIRT447804	hsa-miR-4689	PAR-CLIP	22100165
MIRT447803	hsa-miR-6858-5p	PAR-CLIP	22100165
MIRT450512	hsa-miR-2110	PAR-CLIP	22100165
MIRT447802	hsa-miR-4646-5p	PAR-CLIP	22100165
MIRT447814	hsa-miR-100-3p	PAR-CLIP	22100165
MIRT447813	hsa-miR-3125	PAR-CLIP	22100165
MIRT447812	hsa-miR-3916	PAR-CLIP	22100165
MIRT447811	hsa-miR-6859-5p	PAR-CLIP	22100165
MIRT447810	hsa-miR-3928-3p	PAR-CLIP	22100165
MIRT447809	hsa-miR-3150b-3p	PAR-CLIP	22100165
MIRT447808	hsa-miR-4784	PAR-CLIP	22100165
MIRT447806	hsa-miR-6077	PAR-CLIP	22100165
MIRT447807	hsa-miR-3915	PAR-CLIP	22100165
MIRT447805	hsa-miR-1224-5p	PAR-CLIP	22100165
MIRT447804	hsa-miR-4689	PAR-CLIP	22100165
MIRT447803	hsa-miR-6858-5p	PAR-CLIP	22100165
MIRT447802	hsa-miR-4646-5p	PAR-CLIP	22100165
MIRT736717	hsa-miR-497-5p	Luciferase reporter assayWestern blottingqRT-PCR	31481972
MIRT447814	hsa-miR-100-3p	PAR-CLIP	22100165
MIRT447813	hsa-miR-3125	PAR-CLIP	22100165
MIRT447812	hsa-miR-3916	PAR-CLIP	22100165
MIRT447811	hsa-miR-6859-5p	PAR-CLIP	22100165
MIRT447810	hsa-miR-3928-3p	PAR-CLIP	22100165
MIRT447809	hsa-miR-3150b-3p	PAR-CLIP	22100165
MIRT447808	hsa-miR-4784	PAR-CLIP	22100165
MIRT447806	hsa-miR-6077	PAR-CLIP	22100165
MIRT450515	hsa-miR-4271	PAR-CLIP	22100165
MIRT450514	hsa-miR-4725-3p	PAR-CLIP	22100165
MIRT450513	hsa-miR-6780b-5p	PAR-CLIP	22100165
MIRT447807	hsa-miR-3915	PAR-CLIP	22100165
MIRT447805	hsa-miR-1224-5p	PAR-CLIP	22100165
MIRT447804	hsa-miR-4689	PAR-CLIP	22100165
MIRT447803	hsa-miR-6858-5p	PAR-CLIP	22100165
MIRT450512	hsa-miR-2110	PAR-CLIP	22100165
MIRT447802	hsa-miR-4646-5p	PAR-CLIP	22100165
MIRT447814	hsa-miR-100-3p	PAR-CLIP	22100165
MIRT447813	hsa-miR-3125	PAR-CLIP	22100165
MIRT447812	hsa-miR-3916	PAR-CLIP	22100165
MIRT447811	hsa-miR-6859-5p	PAR-CLIP	22100165
MIRT447810	hsa-miR-3928-3p	PAR-CLIP	22100165
MIRT447809	hsa-miR-3150b-3p	PAR-CLIP	22100165
MIRT447808	hsa-miR-4784	PAR-CLIP	22100165
MIRT447806	hsa-miR-6077	PAR-CLIP	22100165
MIRT447807	hsa-miR-3915	PAR-CLIP	22100165
MIRT447805	hsa-miR-1224-5p	PAR-CLIP	22100165
MIRT447804	hsa-miR-4689	PAR-CLIP	22100165
MIRT447803	hsa-miR-6858-5p	PAR-CLIP	22100165
MIRT447802	hsa-miR-4646-5p	PAR-CLIP	22100165
MIRT962716	hsa-let-7a	CLIP-seq
MIRT962717	hsa-let-7b	CLIP-seq
MIRT962718	hsa-let-7c	CLIP-seq
MIRT962719	hsa-let-7d	CLIP-seq
MIRT962720	hsa-let-7e	CLIP-seq
MIRT962721	hsa-let-7f	CLIP-seq
MIRT962722	hsa-let-7g	CLIP-seq
MIRT962723	hsa-let-7i	CLIP-seq
MIRT962724	hsa-miR-1270	CLIP-seq
MIRT962725	hsa-miR-1323	CLIP-seq
MIRT962726	hsa-miR-150	CLIP-seq
MIRT962727	hsa-miR-1976	CLIP-seq
MIRT962728	hsa-miR-2861	CLIP-seq
MIRT962729	hsa-miR-296-5p	CLIP-seq
MIRT962730	hsa-miR-3135b	CLIP-seq
MIRT962731	hsa-miR-3545-3p	CLIP-seq
MIRT962732	hsa-miR-3661	CLIP-seq
MIRT962733	hsa-miR-3689d	CLIP-seq
MIRT962734	hsa-miR-370	CLIP-seq
MIRT962735	hsa-miR-3909	CLIP-seq
MIRT962736	hsa-miR-3927	CLIP-seq
MIRT962737	hsa-miR-4267	CLIP-seq
MIRT962738	hsa-miR-4279	CLIP-seq
MIRT962739	hsa-miR-4287	CLIP-seq
MIRT962740	hsa-miR-4451	CLIP-seq
MIRT962741	hsa-miR-4453	CLIP-seq
MIRT962742	hsa-miR-4458	CLIP-seq
MIRT962743	hsa-miR-4469	CLIP-seq
MIRT962744	hsa-miR-4487	CLIP-seq
MIRT962745	hsa-miR-4500	CLIP-seq
MIRT962746	hsa-miR-4531	CLIP-seq
MIRT962747	hsa-miR-4538	CLIP-seq
MIRT962748	hsa-miR-4633-3p	CLIP-seq
MIRT962749	hsa-miR-4685-3p	CLIP-seq
MIRT962750	hsa-miR-4713-5p	CLIP-seq
MIRT962751	hsa-miR-4786-5p	CLIP-seq
MIRT962752	hsa-miR-532-3p	CLIP-seq
MIRT962753	hsa-miR-548o	CLIP-seq
MIRT962754	hsa-miR-619	CLIP-seq
MIRT962755	hsa-miR-620	CLIP-seq
MIRT962756	hsa-miR-631	CLIP-seq
MIRT962757	hsa-miR-635	CLIP-seq
MIRT962758	hsa-miR-642a	CLIP-seq
MIRT962759	hsa-miR-98	CLIP-seq
MIRT1985367	hsa-miR-15a	CLIP-seq
MIRT1985368	hsa-miR-15b	CLIP-seq
MIRT1985369	hsa-miR-16	CLIP-seq
MIRT1985370	hsa-miR-195	CLIP-seq
MIRT1985371	hsa-miR-424	CLIP-seq
MIRT1985372	hsa-miR-4435	CLIP-seq
MIRT1985373	hsa-miR-497	CLIP-seq
MIRT1985367	hsa-miR-15a	CLIP-seq
MIRT1985368	hsa-miR-15b	CLIP-seq
MIRT1985369	hsa-miR-16	CLIP-seq
MIRT1985370	hsa-miR-195	CLIP-seq
MIRT962728	hsa-miR-2861	CLIP-seq
MIRT962735	hsa-miR-3909	CLIP-seq
MIRT1985371	hsa-miR-424	CLIP-seq
MIRT1985372	hsa-miR-4435	CLIP-seq
MIRT962743	hsa-miR-4469	CLIP-seq
MIRT2219955	hsa-miR-4530	CLIP-seq
MIRT2219956	hsa-miR-4700-3p	CLIP-seq
MIRT1985373	hsa-miR-497	CLIP-seq
MIRT2387391	hsa-miR-3677-5p	CLIP-seq
MIRT2387392	hsa-miR-4270	CLIP-seq
MIRT1985372	hsa-miR-4435	CLIP-seq
MIRT2387393	hsa-miR-4441	CLIP-seq
MIRT2465206	hsa-miR-1273e	CLIP-seq
MIRT2465207	hsa-miR-3157-5p	CLIP-seq
MIRT2465208	hsa-miR-3194-5p	CLIP-seq
MIRT2465209	hsa-miR-4690-3p	CLIP-seq
MIRT2465210	hsa-miR-4691-3p	CLIP-seq
MIRT962725	hsa-miR-1323	CLIP-seq
MIRT2523728	hsa-miR-4711-5p	CLIP-seq
MIRT962753	hsa-miR-548o	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	ISA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IEA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0001701	Process	In utero embryonic development	IEA
GO:0003677	Function	DNA binding	IEA
GO:0005515	Function	Protein binding	IPI	20887964, 29263200
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	20887964
GO:0005634	Component	Nucleus	IEA
GO:0005694	Component	Chromosome	IDA
GO:0005730	Component	Nucleolus	IDA
GO:0005737	Component	Cytoplasm	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0007417	Process	Central nervous system development	IBA
GO:0007420	Process	Brain development	IBA
GO:0007420	Process	Brain development	IEA
GO:0009410	Process	Response to xenobiotic stimulus	IEA
GO:0009791	Process	Post-embryonic development	IEA
GO:0021537	Process	Telencephalon development	IEA
GO:0021796	Process	Cerebral cortex regionalization	IEA
GO:0021895	Process	Cerebral cortex neuron differentiation	IEA
GO:0021987	Process	Cerebral cortex development	IEA
GO:0030182	Process	Neuron differentiation	IBA
GO:0030182	Process	Neuron differentiation	IEA
GO:0048854	Process	Brain morphogenesis	IEA
GO:0048872	Process	Homeostasis of number of cells	IEA
GO:0060019	Process	Radial glial cell differentiation	IEA
GO:0060563	Process	Neuroepithelial cell differentiation	IEA
GO:0070445	Process	Regulation of oligodendrocyte progenitor proliferation	IEA
GO:1990138	Process	Neuron projection extension	IEA
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IDA	28473536

MIM	HGNC	e!Ensembl
600034	3340	ENSG00000135638

Q04741

Protein name

Homeobox protein EMX1 (Empty spiracles homolog 1) (Empty spiracles-like protein 1)

Protein function

Transcription factor, which in cooperation with EMX2, acts to generate the boundary between the roof and archipallium in the developing brain. May function in combinations with OTX1/2 to specify cell fates in the developing central nervous syste

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00046	Homeodomain	160 → 216	Homeodomain	Domain

Tissue specificity

TISSUE SPECIFICITY: Cerebral cortex.

Sequence

MFQPAAKRGFTIESLVAKDGGTGGGTGGGGAGSHLLAAAASEEPLRPTALNYPHPSAAEA
AFVSGFPAAAAAGAGRSLYGGPELVFPEAMNHPALTVHPAHQLGASPLQPPHSFFGAQHR
DPLHFYPWVLRNRFFGHRFQASDVPQDGLLLHGPFARKPKRIRTAFSPSQLLRLERAFEK
NHYVVGAERKQLAGSLSLSETQVKVWFQNRRTKYKRQKLEEEGPESEQKKKGSHHINRWR
IATKQANGEDIDVTSND

Sequence length

257

Interactions

View interactions

EMX1 (empty spiracles homeobox 1)