SPNS3 (SPNS lysolipid transporter 3, sphingosine-1-phosphate (putative))

Gene

• Entrez ID: 201305
• Gene name: SPNS lysolipid transporter 3, sphingosine-1-phosphate (putative)
• Gene symbol: SPNS3
• Synonyms (NCBI Gene): SLC62A3, SLC63A3
• Chromosome: 17
• Chromosome location: 17p13.2

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1385056	hsa-miR-3144-5p	CLIP-seq
MIRT1385057	hsa-miR-3151	CLIP-seq
MIRT1385058	hsa-miR-3188	CLIP-seq
MIRT1385059	hsa-miR-3191	CLIP-seq
MIRT1385060	hsa-miR-4327	CLIP-seq
MIRT1385061	hsa-miR-4447	CLIP-seq
MIRT1385062	hsa-miR-4472	CLIP-seq
MIRT1385063	hsa-miR-4652-5p	CLIP-seq
MIRT1385064	hsa-miR-491-5p	CLIP-seq
MIRT1385065	hsa-miR-766	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32296183, 33961781
GO:0006869	Process	Lipid transport	IEA
GO:0016020	Component	Membrane	IBA
GO:0016020	Component	Membrane	IEA
GO:0022857	Function	Transmembrane transporter activity	IBA
GO:0022857	Function	Transmembrane transporter activity	IEA
GO:0055085	Process	Transmembrane transport	IEA

Other IDs

• MIM: 611701
• HGNC: 28433
• e!Ensembl: ENSG00000182557

Protein

• UniProt ID: Q6ZMD2
• Protein name: Protein spinster homolog 3
• Protein function: Sphingolipid transporter.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF07690	MFS_1	51 → 420	Major Facilitator Superfamily	Family

• Sequence:

  MAGGMSAECPEPGPGGLQGQSPGPGRQCPPPITPTSWSLPPWRAYVAAAVLCYINLLNYM
  NWFIIAGVLLDIQEVFQISDNHAGLLQTVFVSCLLLSAPVFGYLGDRHSRKATMSFGILL
  WSGAGLSSSFISPRYSWLFFLSRGIVGTGSASYSTIAPTVLGDLFVRDQRTRVLAVFYIF
  IPVGSGLGYVLGSAVTMLTGNWRWALRVMPCLEAVALILLILLVPDPPRGAAETQGEGAV
  GGFRSSWCEDVRYLGKNWSFVWSTLGVTAMAFVTGALGFWAPKFLLEARVVHGLQPPCFQ
  EPCSNPDSLIFGALTIMTGVIGVILGAEAARRYKKVIPGAEPLICASSLLATAPCLYLAL
  VLAPTTLLASYVFLGLGELLLSCNWAVVADILLSVVVPRCRGTAEALQITVGHILGDAGS
  PYLTGLISSVLRARRPDSYLQRFRSLQQSFLCCAFVIALGGGCFLLTALYLERDETRAWQ
  PVTGTPDSNDVDSNDLERQGLLSGAGASTEEP

• Sequence length: 512

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
CLONAL HEMATOPOIESIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CORONARY ARTERY DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PSYCHIATRIC DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SMALL CELL LUNG CARCINOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Relationship Type	References	Evidence Score
Colorectal Neoplasms	Associate	24349560	★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid Acute	Associate	34608834, 35249471	★☆☆☆☆ Found in Text Mining only