Gene Gene information from NCBI Gene database.
Entrez ID 201292
Gene name Tripartite motif containing 65
Gene symbol TRIM65
Synonyms (NCBI Gene)
4732463G12Rik
Chromosome 17
Chromosome location 17q25.1
miRNA miRNA information provided by mirtarbase database.
456
miRTarBase ID miRNA Experiments Reference
MIRT022681 hsa-miR-124-3p Microarray 18668037
MIRT023281 hsa-miR-122-5p Microarray 17612493
MIRT029564 hsa-miR-26b-5p Sequencing 20371350
MIRT048856 hsa-miR-93-5p CLASH 23622248
MIRT043464 hsa-miR-331-3p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
32
GO ID Ontology Definition Evidence Reference
GO:0002376 Process Immune system process IEA
GO:0004842 Function Ubiquitin-protein transferase activity IEA
GO:0005654 Component Nucleoplasm IDA
GO:0005737 Component Cytoplasm IDA 34512673
GO:0005737 Component Cytoplasm IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
619408 27316 ENSG00000141569
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q6PJ69
Protein name E3 ubiquitin-protein ligase TRIM65 (EC 2.3.2.27) (Tripartite motif-containing protein 65)
Protein function E3 ubiquitin ligase that plays a role in several processes including innate immnity, autophagy or inflammation (PubMed:28594402, PubMed:34512673). Negatively regulates miRNAs by modulating the ubiquitination and stability of TNRC6A, a protein in
PDB 7JL0 , 7JL2 , 7JL4
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00097 zf-C3HC4 12 50 Zinc finger, C3HC4 type (RING finger) Domain
PF00643 zf-B_box 90 130 B-box zinc finger Domain
PF00622 SPRY 383 502 SPRY domain Family
Sequence
MAAQLLEEKLTCAICLGLYQDPVTLPCGHNFCGACIRDWWDRCGKACPECREPFPDGAEL
RRNVALSGVLEVVRAGPARDPGPDPGPGPDPAARCPRHGRPLELFCRTEGRCVCSVCTVR
ECRLHERALL
DAERLKREAQLRASLEVTQQQATQAEGQLLELRKQSSQIQNSACILASWV
SGKFSSLLQALEIQHTTALRSIEVAKTQALAQARDEEQRLRVHLEAVARHGCRIRELLEQ
VDEQTFLQESQLLQPPGPLGPLTPLQWDEDQQLGDLKQLLSRLCGLLLEEGSHPGAPAKP
VDLAPVEAPGPLAPVPSTVCPLRRKLWQNYRNLTFDPVSANRHFYLSRQDQQVKHCRQSR
GPGGPGSFELWQVQCAQSFQAGHHYWEVRASDHSVTLGVSYPQLPRCRLGPHTDNIGRGP
CSWGLCVQEDSLQAWHNGEAQRLPGVSGRLLGMDLDLASGCLTFYSLEPQTQPLYTFHAL
FNQPLTPVFWLLEGRTLTLCHQ
PGAVFPLGPQEEVLS
Sequence length 517
Interactions View interactions
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
1
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Melanoma Uncertain significance rs145909647 RCV005929235
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Breast Neoplasms Associate 30670769
Cardiomyopathy Dilated Associate 36056063
Cerebral Infarction Associate 33148145
Colorectal Neoplasms Associate 34498706
Leukoaraiosis Associate 27583843
Leukoencephalopathies Associate 33148145