LRRC45 (leucine rich repeat containing 45)

Gene Gene information from NCBI Gene database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID 201255
Gene name Leucine rich repeat containing 45
Gene symbol LRRC45
Synonyms (NCBI Gene)
-
Chromosome 17
Chromosome location 17q25.3
miRNA miRNA information provided by mirtarbase database.
420
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all (420)
miRTarBase ID miRNA Experiments Reference
MIRT484149 hsa-miR-4484 PAR-CLIP 20371350
MIRT484148 hsa-miR-4716-3p PAR-CLIP 20371350
MIRT484147 hsa-miR-6794-5p PAR-CLIP 20371350
MIRT484146 hsa-miR-1292-3p PAR-CLIP 20371350
MIRT484145 hsa-miR-548aj-5p PAR-CLIP 20371350
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
10
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all (10)
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 25416956, 30404835, 31515488, 32296183, 32814053
GO:0005737 Component Cytoplasm IEA
GO:0005813 Component Centrosome IBA
GO:0005813 Component Centrosome IDA 21399614, 31974111
GO:0005813 Component Centrosome IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
MIM HGNC e!Ensembl
621312 28302 ENSG00000169683
Protein Protein information from UniProt database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q96CN5
Protein name Leucine-rich repeat-containing protein 45
Protein function Component of the proteinaceous fiber-like linker between two centrioles, required for centrosome cohesion.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF13516 LRR_6 84 → 107 Leucine Rich repeat Repeat
PF13516 LRR_6 145 → 165 Leucine Rich repeat Repeat
Sequence 
MEEFRRSYSRLCRESGAEPQEAVLQQLHQLPRGRLDLATQSLTVETCRALGKLLPRETLC
TELVLSDCMLSEEGATLLLRGLCANTVLRFLDLKGNNLRAAGAEALGKLLQQNKSIQSLT
LEWNSLGTWDDAFATFCGGLAANGALQRLDLRNNQISHKGAEELALALKGNTTLQQLDLR
WNNVGLLGGRALMNCLPSNRTLWRLDLAGNNIPGDVLRAVEQAMGHSQDRLTTFQENQAR
THVLSKEVQHLREEKSKQFLDLMETIDKQREEMAKSSRASAARVGQLQEALNERHSIINA
LKAKLQMTEAALALSEQKAQDLGELLATAEQEQLSLSQRQAKELKLEQQEAAERESKLLR
DLSAANEKNLLLQNQVDELERKFRCQQEQLFQTRQEMTSMSAELKMRAIQAEERLDMEKR
RCRQSLEDSESLRIKEVEHMTRHLEESEKAMQERVQRLEAARLSLEEELSRVKAAALSER
GQAEEELIKAKSQARLEEQQRLAHLEDKLRLLAQARDEAQGACLQQKQVVAEAQTRVSQL
GLQVEGLRRRLEELQQELSLKDQERVAEVSRVRVELQEQNGRLQAELAAQEALREKAAAL
ERQLKVMASDHREALLDRESENASLREKLRLREAEIARIRDEEAQRASFLQNAVLAYVQA
SPVRTLSPPK
Sequence length 670
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
5
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Show/Hide Unknown Diseases (5)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
CILIOPATHIES — Disgenet
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CILIOPATHY — GenCC
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
LRRC45-related disorder Likely benign; Uncertain significance ClinVar
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
NEUROBLASTOMA — GWAS catalog
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Show/Hide Text Mining Associations (2)
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Ciliopathies Associate 34716235
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Neuroblastoma Associate 32599975
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations