Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	2011
Gene name	Microtubule affinity regulating kinase 2
Gene symbol	MARK2
Synonyms (NCBI Gene)	EMK-1EMK1MRD76PAR-1Par-1bPar1b
Chromosome	11
Chromosome location	11q13.1
Summary	This gene encodes a member of the Par-1 family of serine/threonine protein kinases. The protein is an important regulator of cell polarity in epithelial and neuronal cells, and also controls the stability of microtubules through phosphorylation and inacti

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miRTarBase ID	miRNA	Experiments	Reference
MIRT048862	hsa-miR-93-5p	CLASH	23622248
MIRT048691	hsa-miR-99a-5p	CLASH	23622248
MIRT044813	hsa-miR-320a	CLASH	23622248
MIRT041517	hsa-miR-193b-3p	CLASH	23622248
MIRT437446	hsa-miR-190a-5p	ImmunofluorescenceLuciferase reporter assayqRT-PCRWestern blot	24009311
MIRT473643	hsa-miR-4436b-3p	PAR-CLIP	23592263
MIRT473642	hsa-miR-4632-5p	PAR-CLIP	23592263
MIRT473641	hsa-miR-6735-5p	PAR-CLIP	23592263
MIRT473640	hsa-miR-6879-5p	PAR-CLIP	23592263
MIRT473638	hsa-miR-7843-5p	PAR-CLIP	23592263
MIRT473639	hsa-miR-4761-3p	PAR-CLIP	23592263
MIRT473637	hsa-miR-4459	PAR-CLIP	23592263
MIRT473636	hsa-miR-7515	PAR-CLIP	23592263
MIRT473635	hsa-miR-4722-5p	PAR-CLIP	23592263
MIRT473634	hsa-miR-3202	PAR-CLIP	23592263
MIRT473633	hsa-miR-149-3p	PAR-CLIP	23592263
MIRT473632	hsa-miR-4728-5p	PAR-CLIP	23592263
MIRT473631	hsa-miR-6785-5p	PAR-CLIP	23592263
MIRT473630	hsa-miR-6883-5p	PAR-CLIP	23592263
MIRT181931	hsa-miR-4271	PAR-CLIP	23592263
MIRT181932	hsa-miR-4725-3p	PAR-CLIP	23592263
MIRT181935	hsa-miR-6780b-5p	PAR-CLIP	23592263
MIRT473629	hsa-miR-6795-5p	PAR-CLIP	23592263
MIRT473628	hsa-miR-6887-5p	PAR-CLIP	23592263
MIRT473627	hsa-miR-328-5p	PAR-CLIP	23592263
MIRT473626	hsa-miR-6774-5p	PAR-CLIP	23592263
MIRT473625	hsa-miR-519a-3p	PAR-CLIP	23592263
MIRT473624	hsa-miR-519b-3p	PAR-CLIP	23592263
MIRT473623	hsa-miR-519c-3p	PAR-CLIP	23592263
MIRT473622	hsa-miR-302a-3p	PAR-CLIP	23592263
MIRT473621	hsa-miR-302b-3p	PAR-CLIP	23592263
MIRT473620	hsa-miR-302c-3p	PAR-CLIP	23592263
MIRT473619	hsa-miR-302d-3p	PAR-CLIP	23592263
MIRT473618	hsa-miR-302e	PAR-CLIP	23592263
MIRT473617	hsa-miR-372-3p	PAR-CLIP	23592263
MIRT473616	hsa-miR-373-3p	PAR-CLIP	23592263
MIRT473615	hsa-miR-520a-3p	PAR-CLIP	23592263
MIRT473614	hsa-miR-520b	PAR-CLIP	23592263
MIRT473613	hsa-miR-520c-3p	PAR-CLIP	23592263
MIRT473612	hsa-miR-520d-3p	PAR-CLIP	23592263
MIRT473611	hsa-miR-520e	PAR-CLIP	23592263
MIRT473610	hsa-miR-6805-5p	PAR-CLIP	23592263
MIRT473609	hsa-miR-296-3p	PAR-CLIP	23592263
MIRT473607	hsa-miR-6823-5p	PAR-CLIP	23592263
MIRT473608	hsa-miR-6132	PAR-CLIP	23592263
MIRT473606	hsa-miR-6836-5p	PAR-CLIP	23592263
MIRT473605	hsa-miR-1909-3p	PAR-CLIP	23592263
MIRT473604	hsa-miR-6722-3p	PAR-CLIP	23592263
MIRT473603	hsa-miR-1343-5p	PAR-CLIP	23592263
MIRT473602	hsa-miR-939-5p	PAR-CLIP	23592263
MIRT473601	hsa-miR-6825-5p	PAR-CLIP	23592263
MIRT473600	hsa-miR-4489	PAR-CLIP	23592263
MIRT473599	hsa-miR-6846-5p	PAR-CLIP	23592263
MIRT473598	hsa-miR-6848-5p	PAR-CLIP	23592263
MIRT473597	hsa-miR-92a-1-5p	PAR-CLIP	23592263
MIRT473596	hsa-miR-2110	PAR-CLIP	23592263
MIRT473595	hsa-miR-6810-5p	PAR-CLIP	23592263
MIRT231222	hsa-miR-3150a-3p	PAR-CLIP	23592263
MIRT231226	hsa-miR-6763-5p	PAR-CLIP	23592263
MIRT473594	hsa-miR-6857-5p	PAR-CLIP	23592263
MIRT473593	hsa-miR-450a-2-3p	PAR-CLIP	23592263
MIRT473643	hsa-miR-4436b-3p	PAR-CLIP	23592263
MIRT473642	hsa-miR-4632-5p	PAR-CLIP	23592263
MIRT473641	hsa-miR-6735-5p	PAR-CLIP	23592263
MIRT473640	hsa-miR-6879-5p	PAR-CLIP	23592263
MIRT473638	hsa-miR-7843-5p	PAR-CLIP	23592263
MIRT473639	hsa-miR-4761-3p	PAR-CLIP	23592263
MIRT473637	hsa-miR-4459	PAR-CLIP	23592263
MIRT473636	hsa-miR-7515	PAR-CLIP	23592263
MIRT473635	hsa-miR-4722-5p	PAR-CLIP	23592263
MIRT473634	hsa-miR-3202	PAR-CLIP	23592263
MIRT473633	hsa-miR-149-3p	PAR-CLIP	23592263
MIRT473632	hsa-miR-4728-5p	PAR-CLIP	23592263
MIRT473631	hsa-miR-6785-5p	PAR-CLIP	23592263
MIRT473630	hsa-miR-6883-5p	PAR-CLIP	23592263
MIRT181931	hsa-miR-4271	PAR-CLIP	23592263
MIRT181932	hsa-miR-4725-3p	PAR-CLIP	23592263
MIRT181935	hsa-miR-6780b-5p	PAR-CLIP	23592263
MIRT473629	hsa-miR-6795-5p	PAR-CLIP	23592263
MIRT473628	hsa-miR-6887-5p	PAR-CLIP	23592263
MIRT473627	hsa-miR-328-5p	PAR-CLIP	23592263
MIRT473626	hsa-miR-6774-5p	PAR-CLIP	23592263
MIRT473625	hsa-miR-519a-3p	PAR-CLIP	23592263
MIRT473624	hsa-miR-519b-3p	PAR-CLIP	23592263
MIRT473623	hsa-miR-519c-3p	PAR-CLIP	23592263
MIRT473622	hsa-miR-302a-3p	PAR-CLIP	23592263
MIRT473621	hsa-miR-302b-3p	PAR-CLIP	23592263
MIRT473620	hsa-miR-302c-3p	PAR-CLIP	23592263
MIRT473619	hsa-miR-302d-3p	PAR-CLIP	23592263
MIRT473618	hsa-miR-302e	PAR-CLIP	23592263
MIRT473617	hsa-miR-372-3p	PAR-CLIP	23592263
MIRT473616	hsa-miR-373-3p	PAR-CLIP	23592263
MIRT473615	hsa-miR-520a-3p	PAR-CLIP	23592263
MIRT473614	hsa-miR-520b	PAR-CLIP	23592263
MIRT473613	hsa-miR-520c-3p	PAR-CLIP	23592263
MIRT473612	hsa-miR-520d-3p	PAR-CLIP	23592263
MIRT473611	hsa-miR-520e	PAR-CLIP	23592263
MIRT473610	hsa-miR-6805-5p	PAR-CLIP	23592263
MIRT473609	hsa-miR-296-3p	PAR-CLIP	23592263
MIRT473607	hsa-miR-6823-5p	PAR-CLIP	23592263
MIRT473608	hsa-miR-6132	PAR-CLIP	23592263
MIRT473606	hsa-miR-6836-5p	PAR-CLIP	23592263
MIRT473605	hsa-miR-1909-3p	PAR-CLIP	23592263
MIRT473604	hsa-miR-6722-3p	PAR-CLIP	23592263
MIRT473603	hsa-miR-1343-5p	PAR-CLIP	23592263
MIRT473602	hsa-miR-939-5p	PAR-CLIP	23592263
MIRT473601	hsa-miR-6825-5p	PAR-CLIP	23592263
MIRT473600	hsa-miR-4489	PAR-CLIP	23592263
MIRT473599	hsa-miR-6846-5p	PAR-CLIP	23592263
MIRT473598	hsa-miR-6848-5p	PAR-CLIP	23592263
MIRT473597	hsa-miR-92a-1-5p	PAR-CLIP	23592263
MIRT473596	hsa-miR-2110	PAR-CLIP	23592263
MIRT473595	hsa-miR-6810-5p	PAR-CLIP	23592263
MIRT231222	hsa-miR-3150a-3p	PAR-CLIP	23592263
MIRT231226	hsa-miR-6763-5p	PAR-CLIP	23592263
MIRT473594	hsa-miR-6857-5p	PAR-CLIP	23592263
MIRT473593	hsa-miR-450a-2-3p	PAR-CLIP	23592263
MIRT1132557	hsa-miR-1207-5p	CLIP-seq
MIRT1132558	hsa-miR-1224-3p	CLIP-seq
MIRT1132559	hsa-miR-1226	CLIP-seq
MIRT1132560	hsa-miR-1252	CLIP-seq
MIRT1132561	hsa-miR-1260	CLIP-seq
MIRT1132562	hsa-miR-1260b	CLIP-seq
MIRT1132563	hsa-miR-1273d	CLIP-seq
MIRT1132564	hsa-miR-1280	CLIP-seq
MIRT1132565	hsa-miR-1290	CLIP-seq
MIRT1132566	hsa-miR-1321	CLIP-seq
MIRT1132567	hsa-miR-138	CLIP-seq
MIRT1132568	hsa-miR-1538	CLIP-seq
MIRT1132569	hsa-miR-155	CLIP-seq
MIRT1132570	hsa-miR-185	CLIP-seq
MIRT1132571	hsa-miR-193a-3p	CLIP-seq
MIRT1132572	hsa-miR-193b	CLIP-seq
MIRT1132573	hsa-miR-19a	CLIP-seq
MIRT1132574	hsa-miR-19b	CLIP-seq
MIRT1132575	hsa-miR-224	CLIP-seq
MIRT1132576	hsa-miR-302a	CLIP-seq
MIRT1132577	hsa-miR-302b	CLIP-seq
MIRT1132578	hsa-miR-302c	CLIP-seq
MIRT1132579	hsa-miR-302d	CLIP-seq
MIRT1132580	hsa-miR-3125	CLIP-seq
MIRT1132581	hsa-miR-3126-5p	CLIP-seq
MIRT1132582	hsa-miR-3150b-3p	CLIP-seq
MIRT1132583	hsa-miR-3179	CLIP-seq
MIRT1132584	hsa-miR-3190	CLIP-seq
MIRT1132585	hsa-miR-3613-3p	CLIP-seq
MIRT1132586	hsa-miR-365	CLIP-seq
MIRT1132587	hsa-miR-3663-3p	CLIP-seq
MIRT1132588	hsa-miR-3664-5p	CLIP-seq
MIRT1132589	hsa-miR-3675-5p	CLIP-seq
MIRT1132590	hsa-miR-3677-5p	CLIP-seq
MIRT1132591	hsa-miR-372	CLIP-seq
MIRT1132592	hsa-miR-373	CLIP-seq
MIRT1132593	hsa-miR-3916	CLIP-seq
MIRT1132594	hsa-miR-3919	CLIP-seq
MIRT1132595	hsa-miR-3943	CLIP-seq
MIRT1132596	hsa-miR-4252	CLIP-seq
MIRT1132597	hsa-miR-4270	CLIP-seq
MIRT1132598	hsa-miR-4286	CLIP-seq
MIRT1132599	hsa-miR-4290	CLIP-seq
MIRT1132600	hsa-miR-4306	CLIP-seq
MIRT1132601	hsa-miR-4313	CLIP-seq
MIRT1132602	hsa-miR-4419a	CLIP-seq
MIRT1132603	hsa-miR-4441	CLIP-seq
MIRT1132604	hsa-miR-4476	CLIP-seq
MIRT1132605	hsa-miR-4487	CLIP-seq
MIRT1132606	hsa-miR-4510	CLIP-seq
MIRT1132607	hsa-miR-4523	CLIP-seq
MIRT1132608	hsa-miR-4533	CLIP-seq
MIRT1132609	hsa-miR-4632	CLIP-seq
MIRT1132610	hsa-miR-4644	CLIP-seq
MIRT1132611	hsa-miR-4649-5p	CLIP-seq
MIRT1132612	hsa-miR-4675	CLIP-seq
MIRT1132613	hsa-miR-4687-3p	CLIP-seq
MIRT1132614	hsa-miR-4690-3p	CLIP-seq
MIRT1132615	hsa-miR-4701-5p	CLIP-seq
MIRT1132616	hsa-miR-4707-3p	CLIP-seq
MIRT1132617	hsa-miR-4710	CLIP-seq
MIRT1132618	hsa-miR-4714-5p	CLIP-seq
MIRT1132619	hsa-miR-4716-3p	CLIP-seq
MIRT1132620	hsa-miR-4719	CLIP-seq
MIRT1132621	hsa-miR-4739	CLIP-seq
MIRT1132622	hsa-miR-4741	CLIP-seq
MIRT1132623	hsa-miR-4745-3p	CLIP-seq
MIRT1132624	hsa-miR-4752	CLIP-seq
MIRT1132625	hsa-miR-4756-5p	CLIP-seq
MIRT1132626	hsa-miR-4763-3p	CLIP-seq
MIRT1132627	hsa-miR-4773	CLIP-seq
MIRT1132628	hsa-miR-4779	CLIP-seq
MIRT1132629	hsa-miR-4784	CLIP-seq
MIRT1132630	hsa-miR-4786-5p	CLIP-seq
MIRT1132631	hsa-miR-4792	CLIP-seq
MIRT1132632	hsa-miR-4802-5p	CLIP-seq
MIRT1132633	hsa-miR-486-3p	CLIP-seq
MIRT1132634	hsa-miR-513c	CLIP-seq
MIRT1132635	hsa-miR-514b-5p	CLIP-seq
MIRT1132636	hsa-miR-516b	CLIP-seq
MIRT1132637	hsa-miR-519a	CLIP-seq
MIRT1132638	hsa-miR-520a-5p	CLIP-seq
MIRT1132639	hsa-miR-525-5p	CLIP-seq
MIRT1132640	hsa-miR-539	CLIP-seq
MIRT1132641	hsa-miR-548aa	CLIP-seq
MIRT1132642	hsa-miR-548q	CLIP-seq
MIRT1132643	hsa-miR-587	CLIP-seq
MIRT1132644	hsa-miR-588	CLIP-seq
MIRT1132645	hsa-miR-640	CLIP-seq
MIRT1132646	hsa-miR-646	CLIP-seq
MIRT1132647	hsa-miR-922	CLIP-seq
MIRT1132582	hsa-miR-3150b-3p	CLIP-seq
MIRT1132629	hsa-miR-4784	CLIP-seq
MIRT2037761	hsa-miR-1202	CLIP-seq
MIRT2037762	hsa-miR-1289	CLIP-seq
MIRT2037763	hsa-miR-1291	CLIP-seq
MIRT1132566	hsa-miR-1321	CLIP-seq
MIRT2037764	hsa-miR-1324	CLIP-seq
MIRT1132568	hsa-miR-1538	CLIP-seq
MIRT2037765	hsa-miR-1909	CLIP-seq
MIRT2037766	hsa-miR-218	CLIP-seq
MIRT1132576	hsa-miR-302a	CLIP-seq
MIRT1132577	hsa-miR-302b	CLIP-seq
MIRT1132578	hsa-miR-302c	CLIP-seq
MIRT1132579	hsa-miR-302d	CLIP-seq
MIRT1132580	hsa-miR-3125	CLIP-seq
MIRT1132582	hsa-miR-3150b-3p	CLIP-seq
MIRT2037767	hsa-miR-3160-5p	CLIP-seq
MIRT2037768	hsa-miR-3173-5p	CLIP-seq
MIRT2037769	hsa-miR-3175	CLIP-seq
MIRT2037770	hsa-miR-3176	CLIP-seq
MIRT2037771	hsa-miR-3192	CLIP-seq
MIRT2037772	hsa-miR-3194-5p	CLIP-seq
MIRT2037773	hsa-miR-3198	CLIP-seq
MIRT2037774	hsa-miR-361-3p	CLIP-seq
MIRT1132590	hsa-miR-3677-5p	CLIP-seq
MIRT2037775	hsa-miR-371b-3p	CLIP-seq
MIRT1132591	hsa-miR-372	CLIP-seq
MIRT1132592	hsa-miR-373	CLIP-seq
MIRT1132593	hsa-miR-3916	CLIP-seq
MIRT2037776	hsa-miR-3922-3p	CLIP-seq
MIRT2037777	hsa-miR-3942-3p	CLIP-seq
MIRT2037778	hsa-miR-3972	CLIP-seq
MIRT1132597	hsa-miR-4270	CLIP-seq
MIRT2037779	hsa-miR-4294	CLIP-seq
MIRT2037780	hsa-miR-4300	CLIP-seq
MIRT2037781	hsa-miR-4309	CLIP-seq
MIRT1132602	hsa-miR-4419a	CLIP-seq
MIRT1132603	hsa-miR-4441	CLIP-seq
MIRT1132604	hsa-miR-4476	CLIP-seq
MIRT1132606	hsa-miR-4510	CLIP-seq
MIRT1132609	hsa-miR-4632	CLIP-seq
MIRT2037782	hsa-miR-4640-5p	CLIP-seq
MIRT1132611	hsa-miR-4649-5p	CLIP-seq
MIRT2037783	hsa-miR-4651	CLIP-seq
MIRT2037784	hsa-miR-4663	CLIP-seq
MIRT1132612	hsa-miR-4675	CLIP-seq
MIRT1132616	hsa-miR-4707-3p	CLIP-seq
MIRT2037785	hsa-miR-4708-3p	CLIP-seq
MIRT2037786	hsa-miR-4709-3p	CLIP-seq
MIRT2037787	hsa-miR-4726-5p	CLIP-seq
MIRT1132621	hsa-miR-4739	CLIP-seq
MIRT1132622	hsa-miR-4741	CLIP-seq
MIRT1132623	hsa-miR-4745-3p	CLIP-seq
MIRT2037788	hsa-miR-4753-3p	CLIP-seq
MIRT1132625	hsa-miR-4756-5p	CLIP-seq
MIRT1132628	hsa-miR-4779	CLIP-seq
MIRT2037789	hsa-miR-4781-5p	CLIP-seq
MIRT1132629	hsa-miR-4784	CLIP-seq
MIRT2037790	hsa-miR-4787-5p	CLIP-seq
MIRT2037791	hsa-miR-4797-5p	CLIP-seq
MIRT1132637	hsa-miR-519a	CLIP-seq
MIRT1132638	hsa-miR-520a-5p	CLIP-seq
MIRT1132639	hsa-miR-525-5p	CLIP-seq
MIRT2037792	hsa-miR-543	CLIP-seq
MIRT2037793	hsa-miR-556-3p	CLIP-seq
MIRT2037794	hsa-miR-608	CLIP-seq
MIRT2037795	hsa-miR-636	CLIP-seq
MIRT1132645	hsa-miR-640	CLIP-seq
MIRT2037796	hsa-miR-661	CLIP-seq
MIRT2037797	hsa-miR-759	CLIP-seq
MIRT2037798	hsa-miR-765	CLIP-seq
MIRT2037799	hsa-miR-920	CLIP-seq
MIRT2037800	hsa-miR-939	CLIP-seq
MIRT2267827	hsa-miR-1253	CLIP-seq
MIRT2037765	hsa-miR-1909	CLIP-seq
MIRT2267828	hsa-miR-214	CLIP-seq
MIRT2037769	hsa-miR-3175	CLIP-seq
MIRT2267829	hsa-miR-329	CLIP-seq
MIRT2267830	hsa-miR-3619-5p	CLIP-seq
MIRT2267831	hsa-miR-4434	CLIP-seq
MIRT2267832	hsa-miR-4516	CLIP-seq
MIRT2037783	hsa-miR-4651	CLIP-seq
MIRT2267833	hsa-miR-4693-3p	CLIP-seq
MIRT1132628	hsa-miR-4779	CLIP-seq
MIRT2037794	hsa-miR-608	CLIP-seq
MIRT2267834	hsa-miR-761	CLIP-seq
MIRT2037765	hsa-miR-1909	CLIP-seq
MIRT2267835	hsa-miR-1913	CLIP-seq
MIRT2267828	hsa-miR-214	CLIP-seq
MIRT2267836	hsa-miR-3127-3p	CLIP-seq
MIRT2037768	hsa-miR-3173-5p	CLIP-seq
MIRT2037769	hsa-miR-3175	CLIP-seq
MIRT2267837	hsa-miR-324-3p	CLIP-seq
MIRT2267830	hsa-miR-3619-5p	CLIP-seq
MIRT2267838	hsa-miR-3667-3p	CLIP-seq
MIRT1132590	hsa-miR-3677-5p	CLIP-seq
MIRT1132599	hsa-miR-4290	CLIP-seq
MIRT1132601	hsa-miR-4313	CLIP-seq
MIRT1132607	hsa-miR-4523	CLIP-seq
MIRT1132628	hsa-miR-4779	CLIP-seq
MIRT1132633	hsa-miR-486-3p	CLIP-seq
MIRT2267839	hsa-miR-544b	CLIP-seq
MIRT2267834	hsa-miR-761	CLIP-seq
MIRT1132647	hsa-miR-922	CLIP-seq
MIRT2037800	hsa-miR-939	CLIP-seq
MIRT1132609	hsa-miR-4632	CLIP-seq
MIRT1132616	hsa-miR-4707-3p	CLIP-seq
MIRT1132595	hsa-miR-3943	CLIP-seq
MIRT1132599	hsa-miR-4290	CLIP-seq
MIRT1132601	hsa-miR-4313	CLIP-seq

Show/Hide all (64)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0000226	Process	Microtubule cytoskeleton organization	IBA
GO:0000287	Function	Magnesium ion binding	IDA	14976552
GO:0000422	Process	Autophagy of mitochondrion	NAS	24522549
GO:0001764	Process	Neuron migration	ISS
GO:0003723	Function	RNA binding	HDA	22658674
GO:0004672	Function	Protein kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	IDA	10542369, 14976552, 16717194, 16775013, 16980613, 20194617
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	ISS	24251416
GO:0004674	Function	Protein serine/threonine kinase activity	NAS	8274451, 28386764
GO:0004674	Function	Protein serine/threonine kinase activity	TAS	9730619, 24522549
GO:0005515	Function	Protein binding	IPI	14676191, 15161933, 15324659, 16306228, 16775013, 16959763, 16980613, 17442826, 17979178, 19553522, 19615732, 19966800, 20194617, 23902687, 24255178, 28514442, 32707033, 33961781, 35271311, 36931259
GO:0005524	Function	ATP binding	IDA	14976552
GO:0005524	Function	ATP binding	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	23666762
GO:0005737	Component	Cytoplasm	IEA
GO:0005739	Component	Mitochondrion	NAS	24522549
GO:0005856	Component	Cytoskeleton	IEA
GO:0005884	Component	Actin filament	IDA	23902687
GO:0005886	Component	Plasma membrane	IDA	23902687
GO:0005886	Component	Plasma membrane	IEA
GO:0006468	Process	Protein phosphorylation	IDA	14976552
GO:0006468	Process	Protein phosphorylation	IMP	23666762
GO:0006468	Process	Protein phosphorylation	NAS	8274451
GO:0008289	Function	Lipid binding	IEA
GO:0010976	Process	Positive regulation of neuron projection development	IDA	12429843
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	IMP	14976552
GO:0016055	Process	Wnt signaling pathway	IEA
GO:0016301	Function	Kinase activity	IEA
GO:0016328	Component	Lateral plasma membrane	IDA	23902687
GO:0016328	Component	Lateral plasma membrane	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0030010	Process	Establishment of cell polarity	IDA	12429843
GO:0030010	Process	Establishment of cell polarity	TAS	16775013
GO:0030154	Process	Cell differentiation	IEA
GO:0030295	Function	Protein kinase activator activity	TAS	24522549
GO:0030425	Component	Dendrite	IDA	23666762
GO:0030425	Component	Dendrite	IEA
GO:0035556	Process	Intracellular signal transduction	IBA
GO:0035556	Process	Intracellular signal transduction	IDA	14976552
GO:0042995	Component	Cell projection	IEA
GO:0045197	Process	Establishment or maintenance of epithelial cell apical/basal polarity	IDA	15324659
GO:0045296	Function	Cadherin binding	HDA	25468996
GO:0046777	Process	Protein autophosphorylation	ISS
GO:0046872	Function	Metal ion binding	IEA
GO:0048156	Function	Tau protein binding	ISS	24251416
GO:0048156	Function	Tau protein binding	NAS	28386764
GO:0050321	Function	Tau-protein kinase activity	IBA
GO:0050321	Function	Tau-protein kinase activity	IMP	23666762
GO:0050321	Function	Tau-protein kinase activity	ISS	24251416
GO:0050321	Function	Tau-protein kinase activity	NAS	28386764
GO:0050770	Process	Regulation of axonogenesis	IMP	20194617
GO:0051493	Process	Regulation of cytoskeleton organization	ISS
GO:0051646	Process	Mitochondrion localization	NAS	24522549
GO:0061564	Process	Axon development	ISS	16717194
GO:0070507	Process	Regulation of microtubule cytoskeleton organization	IDA	10542369
GO:0071963	Process	Establishment or maintenance of cell polarity regulating cell shape	ISS	16717194
GO:0097427	Component	Microtubule bundle	IDA	23902687
GO:0106310	Function	Protein serine kinase activity	IEA
GO:1902996	Process	Regulation of neurofibrillary tangle assembly	ISS	24251416

MIM	HGNC	e!Ensembl
600526	3332	ENSG00000072518

Q7KZI7

Protein name

Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (EC 2.7.11.26) (ELKL motif kinase 1) (EMK-1) (MAP/microtubule affinity-regulating kinase 2) (PAR1 homolog) (PAR1 homolog b) (Par-1b) (Par1b)

Protein function

Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4 and RAB11FIP2. Phosphorylates the microtubule-associated protein MAPT/TA

PDB

3IEC , 5EAK , 5KZ7 , 5KZ8 , 8TXY

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00069	Pkinase	53 → 304	Protein kinase domain	Domain
PF00627	UBA	324 → 360	UBA/TS-N domain	Domain
PF02149	KA1	744 → 788	Kinase associated domain 1	Domain

Tissue specificity

TISSUE SPECIFICITY: High levels of expression in heart, brain, skeletal muscle and pancreas, lower levels observed in lung, liver and kidney. {ECO:0000269|PubMed:9730619}.

Sequence

MSSARTPLPTLNERDTEQPTLGHLDSKPSSKSNMIRGRNSATSADEQPHIGNYRLLKTIG
KGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIE
TEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAEN
LLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVIL
YTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMK
DRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLL
LGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKVQRSVSANPKQRRFSDQAAGPAIPTS
NSYSKKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGLERKKTTPTPSTNSVLSTST
NRSRNSPLLERASLGQASIQNGKDSLTMPGSRASTASASAAVSAARPRQHQKSMSASVHP
NKASGLPPTESNCEVPRPSTAPQRVPVASPSAHNISSSGGAPDRTNFPRGVSSRSTFHAG
QLRQVRDQQNLPYGVTPASPSGHSQGRRGASGSIFSKFTSKFVRRNLSFRFARRNLNEPE
SKDRVETLRPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTSSMEPNEMMREIRKVLDA
NSCQSELHEKYMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNGVRFKRISGTSMAFKNIAS
KIANELKL

Sequence length

788

Interactions

View interactions

Show/Hide Causal Diseases (5)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Autism spectrum disorder	Pathogenic; Likely pathogenic	rs868032104, rs2539321295, rs2539322573, rs1940823816, rs2539326870, rs2539330444, rs2539332826, rs1941197590, rs2539306245, rs2539335503, rs2539336006, rs1252482376, rs1369701108, rs2539350226, rs2539350467 View all (8 more)	RCV004593554 RCV004593555 RCV004593557 RCV004593558 RCV004593559 RCV004593560 RCV004593561 RCV004593562 RCV004593563 RCV004593564 RCV004593566 RCV004593567 RCV004593568 RCV004593569 RCV004593570 RCV004593571 RCV004593572 RCV004593573 RCV004593574 RCV004593575 RCV004593576 RCV004593577 RCV004593578
Intellectual developmental disorder, autosomal dominant 76	Pathogenic; Likely pathogenic	rs2539321295, rs2539350226, rs2539350467, rs2539306253, rs2539313698, rs2539315343	RCV005622270 RCV005622271 RCV005622272 RCV005622273 RCV005622274 RCV006254406
Intellectual disability	Likely pathogenic	rs1252482376	RCV005410971
Malignant tumor of urinary bladder	Pathogenic	rs2539322573	RCV005933654
MARK2-associated neurodevelopmental disorder	Likely pathogenic	rs2539336006	RCV005249702

Show/Hide Unknown Diseases (6)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Acute myeloid leukemia	Benign	rs56291692	RCV005902819
Cervical cancer	Benign	rs56291692	RCV005902820
Colon adenocarcinoma	Benign	rs56291692	RCV005902818
Developmental disorder	Likely benign	rs2135335880	RCV001843802
Gastric cancer	Benign	rs56291692	RCV005902821
Ovarian serous cystadenocarcinoma	Benign	rs56291692	RCV005902822

Show/Hide Text Mining Associations (17)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Alzheimer Disease	Associate	21811019
Alzheimer Disease 15	Associate	16472737
Antiphospholipid Syndrome	Associate	37901230
Attention Deficit Disorder with Hyperactivity	Associate	32066674
Autistic Disorder	Associate	35982159
Bipolar Disorder	Associate	34953473
Carcinogenesis	Associate	35743080
Carcinoma Non Small Cell Lung	Associate	25907283, 36922348
Diabetes Mellitus	Associate	18626018
Infections	Associate	35743080
Inflammation	Associate	15158914, 30580666
Kidney Diseases	Associate	15158914
Lung Neoplasms	Associate	25907283
Neoplasm Metastasis	Associate	17695512
Neoplasms	Associate	17695512, 35743080
Renal Insufficiency Chronic	Associate	15158914
Stomach Neoplasms	Associate	35743080

MARK2 (microtubule affinity regulating kinase 2)