Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
200933
Gene name Gene Name - the full gene name approved by the HGNC.
F-box protein 45
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
FBXO45
Synonyms (NCBI Gene) Gene synonyms aliases
Fbx45
Chromosome Chromosome number
3
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
3q29
Summary Summary of gene provided in NCBI Entrez Gene.
Members of the F-box protein family, such as FBXO45, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box pr
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT023967 hsa-miR-1-3p Microarray 18668037
MIRT049278 hsa-miR-92a-3p CLASH 23622248
MIRT039138 hsa-miR-769-5p CLASH 23622248
MIRT703623 hsa-miR-3974 HITS-CLIP 23313552
MIRT703622 hsa-miR-624-3p HITS-CLIP 23313552
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001764 Process Neuron migration IEA
GO:0005515 Function Protein binding IPI 19581926
GO:0006511 Process Ubiquitin-dependent protein catabolic process IDA 19581926
GO:0006974 Process Cellular response to DNA damage stimulus IDA 19581926
GO:0014069 Component Postsynaptic density IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
609112 29148 ENSG00000174013
Protein
UniProt ID P0C2W1
Protein name F-box/SPRY domain-containing protein 1 (F-box only protein 45) (hFbxo45)
Protein function Component of E3 ubiquitin ligase complex consisting of FBXO45, MYCBP2 and SKP1 (PubMed:29997255). Functions in substrate recognition but also plays an important role in assembly of the complex (PubMed:29997255). Required for normal neuromuscular
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF12937 F-box-like 37 85 F-box-like Domain
PF00622 SPRY 154 281 SPRY domain Family
Sequence
Sequence length 286
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Schizophrenia Schizophrenia rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346
View all (12 more)
24878430
Unknown
Disease term Disease name Evidence References Source
Vitiligo Vitiligo GWAS
Asthma Asthma GWAS
Psoriasis Psoriasis GWAS
Associations from Text Mining
Disease Name Relationship Type References
Carcinoma Non Small Cell Lung Associate 35838331
Carcinoma Pancreatic Ductal Stimulate 35046938
Influenza Human Associate 36379255
Lung Neoplasms Associate 35838331
Neoplasms Associate 24992930
Neoplasms Stimulate 35838331