FBXO45 (F-box protein 45)
| Gene | |
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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200933 |
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Gene name
Gene Name - the full gene name approved by the HGNC.
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F-box protein 45 |
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Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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FBXO45 |
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Synonyms (NCBI Gene)
Gene synonyms aliases
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Fbx45 |
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Chromosome
Chromosome number
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3 |
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Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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3q29 |
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Summary
Summary of gene provided in NCBI Entrez Gene.
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Members of the F-box protein family, such as FBXO45, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box pr |
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miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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| Protein | ||||||||||||||||
| UniProt ID | P0C2W1 | |||||||||||||||
| Protein name | F-box/SPRY domain-containing protein 1 (F-box only protein 45) (hFbxo45) | |||||||||||||||
| Protein function | Component of E3 ubiquitin ligase complex consisting of FBXO45, MYCBP2 and SKP1 (PubMed:29997255). Functions in substrate recognition but also plays an important role in assembly of the complex (PubMed:29997255). Required for normal neuromuscular | |||||||||||||||
| Family and domains |
Pfam
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| Sequence |
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| Sequence length | 286 | |||||||||||||||
| Interactions | View interactions | |||||||||||||||
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Associated diseases
Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
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