SPRED2 (sprouty related EVH1 domain containing 2)

Gene

• Entrez ID: 200734
• Gene name: Sprouty related EVH1 domain containing 2
• Gene symbol: SPRED2
• Synonyms (NCBI Gene): NS14, Spred-2
• Chromosome: 2
• Chromosome location: 2p14
• Summary: SPRED2 is a member of the Sprouty (see SPRY1; MIM 602465)/SPRED family of proteins that regulate growth factor-induced activation of the MAP kinase cascade (see MAPK1; MIM 176948) (Nonami et al., 2004 [PubMed 15465815]).[supplied by OMIM, Mar 2008]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT021167	hsa-miR-186-5p	Sequencing	20371350
MIRT569487	hsa-miR-6776-3p	PAR-CLIP	20371350
MIRT569485	hsa-miR-4715-5p	PAR-CLIP	20371350
MIRT569486	hsa-miR-1914-5p	PAR-CLIP	20371350
MIRT569484	hsa-miR-192-5p	PAR-CLIP	20371350
MIRT569483	hsa-miR-215-5p	PAR-CLIP	20371350
MIRT569482	hsa-miR-647	PAR-CLIP	20371350
MIRT569481	hsa-miR-6842-3p	PAR-CLIP	20371350
MIRT569480	hsa-miR-6822-5p	PAR-CLIP	20371350
MIRT569486	hsa-miR-1914-5p	PAR-CLIP	26701625
MIRT569484	hsa-miR-192-5p	PAR-CLIP	26701625
MIRT569484	hsa-miR-192-5p	PAR-CLIP	26701625
MIRT569484	hsa-miR-192-5p	PAR-CLIP	26701625
MIRT569483	hsa-miR-215-5p	PAR-CLIP	26701625
MIRT569483	hsa-miR-215-5p	PAR-CLIP	26701625
MIRT569483	hsa-miR-215-5p	PAR-CLIP	26701625
MIRT569485	hsa-miR-4715-5p	PAR-CLIP	26701625
MIRT569485	hsa-miR-4715-5p	PAR-CLIP	26701625
MIRT569485	hsa-miR-4715-5p	PAR-CLIP	26701625
MIRT569482	hsa-miR-647	PAR-CLIP	26701625
MIRT569482	hsa-miR-647	PAR-CLIP	26701625
MIRT569482	hsa-miR-647	PAR-CLIP	26701625
MIRT569487	hsa-miR-6776-3p	PAR-CLIP	26701625
MIRT569487	hsa-miR-6776-3p	PAR-CLIP	26701625
MIRT569487	hsa-miR-6776-3p	PAR-CLIP	26701625
MIRT569480	hsa-miR-6822-5p	PAR-CLIP	26701625
MIRT569480	hsa-miR-6822-5p	PAR-CLIP	26701625
MIRT569480	hsa-miR-6822-5p	PAR-CLIP	26701625
MIRT569481	hsa-miR-6842-3p	PAR-CLIP	26701625
MIRT569481	hsa-miR-6842-3p	PAR-CLIP	26701625
MIRT569481	hsa-miR-6842-3p	PAR-CLIP	26701625
MIRT732503	hsa-miR-1246	Immunohistochemistry (IHC), Immunoprecipitaion (IP), Luciferase reporter assay, qRT-PCR, Western blotting	31492150
MIRT569487	hsa-miR-6776-3p	PAR-CLIP	20371350
MIRT569485	hsa-miR-4715-5p	PAR-CLIP	20371350
MIRT569486	hsa-miR-1914-5p	PAR-CLIP	20371350
MIRT569484	hsa-miR-192-5p	PAR-CLIP	20371350
MIRT569483	hsa-miR-215-5p	PAR-CLIP	20371350
MIRT569482	hsa-miR-647	PAR-CLIP	20371350
MIRT569481	hsa-miR-6842-3p	PAR-CLIP	20371350
MIRT569480	hsa-miR-6822-5p	PAR-CLIP	20371350
MIRT1385722	hsa-miR-1	CLIP-seq
MIRT1385723	hsa-miR-1184	CLIP-seq
MIRT1385724	hsa-miR-1229	CLIP-seq
MIRT1385725	hsa-miR-1253	CLIP-seq
MIRT1385726	hsa-miR-1257	CLIP-seq
MIRT1385727	hsa-miR-1265	CLIP-seq
MIRT1385728	hsa-miR-1272	CLIP-seq
MIRT1385729	hsa-miR-1275	CLIP-seq
MIRT1385730	hsa-miR-1286	CLIP-seq
MIRT1385731	hsa-miR-1301	CLIP-seq
MIRT1385732	hsa-miR-1305	CLIP-seq
MIRT1385733	hsa-miR-140-3p	CLIP-seq
MIRT1385734	hsa-miR-141	CLIP-seq
MIRT1385735	hsa-miR-186	CLIP-seq
MIRT1385736	hsa-miR-1914	CLIP-seq
MIRT1385737	hsa-miR-200a	CLIP-seq
MIRT1385738	hsa-miR-2052	CLIP-seq
MIRT1385739	hsa-miR-2053	CLIP-seq
MIRT1385740	hsa-miR-206	CLIP-seq
MIRT1385741	hsa-miR-218	CLIP-seq
MIRT1385742	hsa-miR-2392	CLIP-seq
MIRT1385743	hsa-miR-3064-5p	CLIP-seq
MIRT1385744	hsa-miR-3123	CLIP-seq
MIRT1385745	hsa-miR-3133	CLIP-seq
MIRT1385746	hsa-miR-3153	CLIP-seq
MIRT1385747	hsa-miR-3163	CLIP-seq
MIRT1385748	hsa-miR-3182	CLIP-seq
MIRT1385749	hsa-miR-3198	CLIP-seq
MIRT1385750	hsa-miR-340	CLIP-seq
MIRT1385751	hsa-miR-342-3p	CLIP-seq
MIRT1385752	hsa-miR-3545-3p	CLIP-seq
MIRT1385753	hsa-miR-3591-5p	CLIP-seq
MIRT1385754	hsa-miR-3612	CLIP-seq
MIRT1385755	hsa-miR-3652	CLIP-seq
MIRT1385756	hsa-miR-3662	CLIP-seq
MIRT1385757	hsa-miR-3667-3p	CLIP-seq
MIRT1385758	hsa-miR-3673	CLIP-seq
MIRT1385759	hsa-miR-3674	CLIP-seq
MIRT1385760	hsa-miR-3682-3p	CLIP-seq
MIRT1385761	hsa-miR-3682-5p	CLIP-seq
MIRT1385762	hsa-miR-3925-5p	CLIP-seq
MIRT1385763	hsa-miR-3941	CLIP-seq
MIRT1385764	hsa-miR-3977	CLIP-seq
MIRT1385765	hsa-miR-409-3p	CLIP-seq
MIRT1385766	hsa-miR-421	CLIP-seq
MIRT1385767	hsa-miR-4255	CLIP-seq
MIRT1385768	hsa-miR-4257	CLIP-seq
MIRT1385769	hsa-miR-4260	CLIP-seq
MIRT1385770	hsa-miR-4264	CLIP-seq
MIRT1385771	hsa-miR-4269	CLIP-seq
MIRT1385772	hsa-miR-4276	CLIP-seq
MIRT1385773	hsa-miR-4292	CLIP-seq
MIRT1385774	hsa-miR-4307	CLIP-seq
MIRT1385775	hsa-miR-4308	CLIP-seq
MIRT1385776	hsa-miR-4309	CLIP-seq
MIRT1385777	hsa-miR-4327	CLIP-seq
MIRT1385778	hsa-miR-4418	CLIP-seq
MIRT1385779	hsa-miR-4430	CLIP-seq
MIRT1385780	hsa-miR-4443	CLIP-seq
MIRT1385781	hsa-miR-4496	CLIP-seq
MIRT1385782	hsa-miR-4505	CLIP-seq
MIRT1385783	hsa-miR-450b-5p	CLIP-seq
MIRT1385784	hsa-miR-4511	CLIP-seq
MIRT1385785	hsa-miR-4514	CLIP-seq
MIRT1385786	hsa-miR-4521	CLIP-seq
MIRT1385787	hsa-miR-4653-3p	CLIP-seq
MIRT1385788	hsa-miR-466	CLIP-seq
MIRT1385789	hsa-miR-4660	CLIP-seq
MIRT1385790	hsa-miR-4662a-3p	CLIP-seq
MIRT1385791	hsa-miR-4665-5p	CLIP-seq
MIRT1385792	hsa-miR-4666-5p	CLIP-seq
MIRT1385793	hsa-miR-4668-5p	CLIP-seq
MIRT1385794	hsa-miR-4672	CLIP-seq
MIRT1385795	hsa-miR-4692	CLIP-seq
MIRT1385796	hsa-miR-4699-3p	CLIP-seq
MIRT1385797	hsa-miR-4709-5p	CLIP-seq
MIRT1385798	hsa-miR-4711-5p	CLIP-seq
MIRT1385799	hsa-miR-4722-5p	CLIP-seq
MIRT1385800	hsa-miR-4732-5p	CLIP-seq
MIRT1385801	hsa-miR-4738-3p	CLIP-seq
MIRT1385802	hsa-miR-4742-5p	CLIP-seq
MIRT1385803	hsa-miR-4744	CLIP-seq
MIRT1385804	hsa-miR-4764-5p	CLIP-seq
MIRT1385805	hsa-miR-4768-3p	CLIP-seq
MIRT1385806	hsa-miR-4775	CLIP-seq
MIRT1385807	hsa-miR-4790-3p	CLIP-seq
MIRT1385808	hsa-miR-4795-3p	CLIP-seq
MIRT1385809	hsa-miR-4796-3p	CLIP-seq
MIRT1385810	hsa-miR-4797-3p	CLIP-seq
MIRT1385811	hsa-miR-4802-3p	CLIP-seq
MIRT1385812	hsa-miR-485-3p	CLIP-seq
MIRT1385813	hsa-miR-485-5p	CLIP-seq
MIRT1385814	hsa-miR-486-3p	CLIP-seq
MIRT1385815	hsa-miR-487a	CLIP-seq
MIRT1385816	hsa-miR-493	CLIP-seq
MIRT1385817	hsa-miR-499-3p	CLIP-seq
MIRT1385818	hsa-miR-499a-3p	CLIP-seq
MIRT1385819	hsa-miR-5047	CLIP-seq
MIRT1385820	hsa-miR-507	CLIP-seq
MIRT1385821	hsa-miR-509-3-5p	CLIP-seq
MIRT1385822	hsa-miR-509-5p	CLIP-seq
MIRT1385823	hsa-miR-520g	CLIP-seq
MIRT1385824	hsa-miR-520h	CLIP-seq
MIRT1385825	hsa-miR-552	CLIP-seq
MIRT1385826	hsa-miR-557	CLIP-seq
MIRT1385827	hsa-miR-568	CLIP-seq
MIRT1385828	hsa-miR-569	CLIP-seq
MIRT1385829	hsa-miR-572	CLIP-seq
MIRT1385830	hsa-miR-602	CLIP-seq
MIRT1385831	hsa-miR-613	CLIP-seq
MIRT1385832	hsa-miR-622	CLIP-seq
MIRT1385833	hsa-miR-629	CLIP-seq
MIRT1385834	hsa-miR-636	CLIP-seq
MIRT1385835	hsa-miR-643	CLIP-seq
MIRT1385836	hsa-miR-650	CLIP-seq
MIRT1385837	hsa-miR-659	CLIP-seq
MIRT1385838	hsa-miR-718	CLIP-seq
MIRT1385839	hsa-miR-885-3p	CLIP-seq
MIRT1385840	hsa-miR-105	CLIP-seq
MIRT1385841	hsa-miR-1207-5p	CLIP-seq
MIRT1385842	hsa-miR-1224-5p	CLIP-seq
MIRT1385843	hsa-miR-1255a	CLIP-seq
MIRT1385844	hsa-miR-1255b	CLIP-seq
MIRT1385845	hsa-miR-1304	CLIP-seq
MIRT1385734	hsa-miR-141	CLIP-seq
MIRT1385846	hsa-miR-183	CLIP-seq
MIRT1385847	hsa-miR-185	CLIP-seq
MIRT1385735	hsa-miR-186	CLIP-seq
MIRT1385848	hsa-miR-1909	CLIP-seq
MIRT1385737	hsa-miR-200a	CLIP-seq
MIRT1385739	hsa-miR-2053	CLIP-seq
MIRT1385849	hsa-miR-219-5p	CLIP-seq
MIRT1385745	hsa-miR-3133	CLIP-seq
MIRT1385850	hsa-miR-3146	CLIP-seq
MIRT1385747	hsa-miR-3163	CLIP-seq
MIRT1385851	hsa-miR-320a	CLIP-seq
MIRT1385852	hsa-miR-320b	CLIP-seq
MIRT1385853	hsa-miR-320c	CLIP-seq
MIRT1385854	hsa-miR-320d	CLIP-seq
MIRT1385855	hsa-miR-331-5p	CLIP-seq
MIRT1385750	hsa-miR-340	CLIP-seq
MIRT1385856	hsa-miR-3915	CLIP-seq
MIRT1385857	hsa-miR-3920	CLIP-seq
MIRT1385858	hsa-miR-3928	CLIP-seq
MIRT1385763	hsa-miR-3941	CLIP-seq
MIRT1385764	hsa-miR-3977	CLIP-seq
MIRT1385859	hsa-miR-409-5p	CLIP-seq
MIRT1385768	hsa-miR-4257	CLIP-seq
MIRT1385860	hsa-miR-4265	CLIP-seq
MIRT1385771	hsa-miR-4269	CLIP-seq
MIRT1385861	hsa-miR-4296	CLIP-seq
MIRT1385862	hsa-miR-4302	CLIP-seq
MIRT1385863	hsa-miR-4306	CLIP-seq
MIRT1385864	hsa-miR-4322	CLIP-seq
MIRT1385865	hsa-miR-4417	CLIP-seq
MIRT1385866	hsa-miR-4429	CLIP-seq
MIRT1385867	hsa-miR-4445	CLIP-seq
MIRT1385868	hsa-miR-4453	CLIP-seq
MIRT1385869	hsa-miR-4470	CLIP-seq
MIRT1385870	hsa-miR-4474-3p	CLIP-seq
MIRT1385781	hsa-miR-4496	CLIP-seq
MIRT1385783	hsa-miR-450b-5p	CLIP-seq
MIRT1385785	hsa-miR-4514	CLIP-seq
MIRT1385871	hsa-miR-4538	CLIP-seq
MIRT1385872	hsa-miR-4644	CLIP-seq
MIRT1385788	hsa-miR-466	CLIP-seq
MIRT1385794	hsa-miR-4672	CLIP-seq
MIRT1385873	hsa-miR-4678	CLIP-seq
MIRT1385874	hsa-miR-4689	CLIP-seq
MIRT1385795	hsa-miR-4692	CLIP-seq
MIRT1385875	hsa-miR-4716-3p	CLIP-seq
MIRT1385876	hsa-miR-4723-5p	CLIP-seq
MIRT1385802	hsa-miR-4742-5p	CLIP-seq
MIRT1385877	hsa-miR-4762-3p	CLIP-seq
MIRT1385878	hsa-miR-4763-3p	CLIP-seq
MIRT1385804	hsa-miR-4764-5p	CLIP-seq
MIRT1385806	hsa-miR-4775	CLIP-seq
MIRT1385879	hsa-miR-4782-3p	CLIP-seq
MIRT1385808	hsa-miR-4795-3p	CLIP-seq
MIRT1385812	hsa-miR-485-3p	CLIP-seq
MIRT1385815	hsa-miR-487a	CLIP-seq
MIRT1385817	hsa-miR-499-3p	CLIP-seq
MIRT1385818	hsa-miR-499a-3p	CLIP-seq
MIRT1385880	hsa-miR-508-3p	CLIP-seq
MIRT1385881	hsa-miR-518a-5p	CLIP-seq
MIRT1385882	hsa-miR-527	CLIP-seq
MIRT1385825	hsa-miR-552	CLIP-seq
MIRT1385827	hsa-miR-568	CLIP-seq
MIRT1385883	hsa-miR-599	CLIP-seq
MIRT1385884	hsa-miR-604	CLIP-seq
MIRT1385835	hsa-miR-643	CLIP-seq
MIRT1385837	hsa-miR-659	CLIP-seq
MIRT2115462	hsa-miR-1207-3p	CLIP-seq
MIRT2115463	hsa-miR-1208	CLIP-seq
MIRT1385725	hsa-miR-1253	CLIP-seq
MIRT2115464	hsa-miR-1256	CLIP-seq
MIRT1385729	hsa-miR-1275	CLIP-seq
MIRT1385739	hsa-miR-2053	CLIP-seq
MIRT1385746	hsa-miR-3153	CLIP-seq
MIRT2115465	hsa-miR-3185	CLIP-seq
MIRT2115466	hsa-miR-3202	CLIP-seq
MIRT2115467	hsa-miR-329	CLIP-seq
MIRT2115468	hsa-miR-3605-5p	CLIP-seq
MIRT2115469	hsa-miR-362-3p	CLIP-seq
MIRT2115470	hsa-miR-3688-5p	CLIP-seq
MIRT1385763	hsa-miR-3941	CLIP-seq
MIRT1385764	hsa-miR-3977	CLIP-seq
MIRT2115471	hsa-miR-3978	CLIP-seq
MIRT1385771	hsa-miR-4269	CLIP-seq
MIRT2115472	hsa-miR-4271	CLIP-seq
MIRT1385862	hsa-miR-4302	CLIP-seq
MIRT2115473	hsa-miR-4423-3p	CLIP-seq
MIRT1385785	hsa-miR-4514	CLIP-seq
MIRT2115474	hsa-miR-4533	CLIP-seq
MIRT2115475	hsa-miR-4646-5p	CLIP-seq
MIRT1385791	hsa-miR-4665-5p	CLIP-seq
MIRT1385793	hsa-miR-4668-5p	CLIP-seq
MIRT1385795	hsa-miR-4692	CLIP-seq
MIRT1385796	hsa-miR-4699-3p	CLIP-seq
MIRT2115476	hsa-miR-4725-3p	CLIP-seq
MIRT1385802	hsa-miR-4742-5p	CLIP-seq
MIRT1385804	hsa-miR-4764-5p	CLIP-seq
MIRT1385806	hsa-miR-4775	CLIP-seq
MIRT1385815	hsa-miR-487a	CLIP-seq
MIRT1385816	hsa-miR-493	CLIP-seq
MIRT2115477	hsa-miR-548c-3p	CLIP-seq
MIRT1385828	hsa-miR-569	CLIP-seq
MIRT2115478	hsa-miR-603	CLIP-seq
MIRT2115479	hsa-miR-605	CLIP-seq
MIRT2115480	hsa-miR-625	CLIP-seq
MIRT2115481	hsa-miR-644	CLIP-seq
MIRT2115482	hsa-miR-875-3p	CLIP-seq
MIRT2115462	hsa-miR-1207-3p	CLIP-seq
MIRT1385739	hsa-miR-2053	CLIP-seq
MIRT1385862	hsa-miR-4302	CLIP-seq
MIRT1385796	hsa-miR-4699-3p	CLIP-seq
MIRT2115466	hsa-miR-3202	CLIP-seq
MIRT2115474	hsa-miR-4533	CLIP-seq
MIRT1385735	hsa-miR-186	CLIP-seq
MIRT1385745	hsa-miR-3133	CLIP-seq
MIRT2631727	hsa-miR-3138	CLIP-seq
MIRT2631728	hsa-miR-3189-5p	CLIP-seq
MIRT2631729	hsa-miR-4261	CLIP-seq
MIRT2631730	hsa-miR-4323	CLIP-seq
MIRT2631731	hsa-miR-4487	CLIP-seq
MIRT1385796	hsa-miR-4699-3p	CLIP-seq
MIRT1385803	hsa-miR-4744	CLIP-seq
MIRT2631732	hsa-miR-4752	CLIP-seq
MIRT2631733	hsa-miR-4800-5p	CLIP-seq
MIRT1385816	hsa-miR-493	CLIP-seq
MIRT2631734	hsa-miR-556-5p	CLIP-seq
MIRT2115482	hsa-miR-875-3p	CLIP-seq
MIRT1385796	hsa-miR-4699-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005173	Function	Stem cell factor receptor binding	ISS
GO:0005515	Function	Protein binding	IPI	19822672, 24705354, 25416956, 28514442, 29892012, 31515488, 32296183, 32814053, 33961781, 34626534
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0009966	Process	Regulation of signal transduction	IEA
GO:0010719	Process	Negative regulation of epithelial to mesenchymal transition	ISS
GO:0016020	Component	Membrane	IEA
GO:0019901	Function	Protein kinase binding	IBA
GO:0019901	Function	Protein kinase binding	IPI	20736167
GO:0030291	Function	Protein serine/threonine kinase inhibitor activity	ISS	20736167
GO:0030512	Process	Negative regulation of transforming growth factor beta receptor signaling pathway	ISS
GO:0030658	Component	Transport vesicle membrane	IEA
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0043409	Process	Negative regulation of MAPK cascade	ISS
GO:0043517	Process	Positive regulation of DNA damage response, signal transduction by p53 class mediator	ISS	20736167
GO:0070373	Process	Negative regulation of ERK1 and ERK2 cascade	IBA
GO:0070373	Process	Negative regulation of ERK1 and ERK2 cascade	ISS
GO:1902532	Process	Negative regulation of intracellular signal transduction	IEA
GO:1902532	Process	Negative regulation of intracellular signal transduction	IMP	20736167
GO:1902747	Process	Negative regulation of lens fiber cell differentiation	ISS

Other IDs

• MIM: 609292
• HGNC: 17722
• e!Ensembl: ENSG00000198369

Protein

• UniProt ID: Q7Z698
• Protein name: Sprouty-related, EVH1 domain-containing protein 2 (Spred-2)
• Protein function: Negatively regulates Ras signaling pathways and downstream activation of MAP kinases (PubMed:15683364, PubMed:34626534). Recruits and translocates NF1 to the cell membrane, thereby enabling NF1-dependent hydrolysis of active GTP-bound Ras to ina
• PDB: 2JP2, 8EQ5
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00568	WH1	7 → 119	WH1 domain	Domain
  PF05210	Sprouty	306 → 415	Sprouty protein (Spry)	Family

• Tissue specificity: TISSUE SPECIFICITY: Expressed in liver, skin, small intestine, salivary gland and prostate. {ECO:0000269|PubMed:15580519}.
• Sequence:

  MTEETHPDDDSYIVRVKAVVMTRDDSSGGWFPQEGGGISRVGVCKVMHPEGNGRSGFLIH
  GERQKDKLVVLECYVRKDLVYTKANPTFHHWKVDNRKFGLTFQSPADARAFDRGVRKAIE
  DLIEGSTTSSSTIHNEAELGDDDVFTTATDSSSNSSQKREQPTRTISSPTSCEHRRIYTL
  GHLHDSYPTDHYHLDQPMPRPYRQVSFPDDDEEIVRINPREKIWMTGYEDYRHAPVRGKY
  PDPSEDADSSYVRFAKGEVPKHDYNYPYVDSSDFGLGEDPKGRGGSVIKTQPSRGKSRRR
  KEDGERSRCVYCRDMFNHEENRRGHCQDAPDSVRTCIRRVSCMWCADSMLYHCMSDPEGD
  YTDPCSCDTSDEKFCLRWMALIALSFLAPCMCCYLPLRACYHCGVMCRCCGGKHKAAA

• Sequence length: 418

Pathways

Reactome:

Regulation of RAS by GAPs
FGFRL1 modulation of FGFR1 signaling
RAS signaling downstream of NF1 loss-of-function variants

Associated diseases

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Noonan syndrome	Pathogenic	rs2104102138, rs2104216988, rs780902942	RCV001720326 RCV001720327 RCV001580210
Noonan syndrome 14	Pathogenic	rs2104102138, rs2104216988, rs780902942	RCV001836617 RCV001836618 RCV001836619

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Severe postnatal growth retardation	Uncertain significance	rs2528767246	RCV003223495

Associations from Text Mining
Disease Name	Relationship Type	References
Adenocarcinoma	Inhibit	39580880
Adenocarcinoma in Situ	Inhibit	39580880
Adenocarcinoma of Lung	Associate	39580880
Arthritis Rheumatoid	Associate	32831971, 36924774, 36973646
Arthritis Rheumatoid	Inhibit	36924774
Carcinogenesis	Associate	34818323
Carcinoma Ductal Breast	Inhibit	34818323
Carcinoma Hepatocellular	Associate	36902429
Carcinoma in Situ	Inhibit	34818323
Carcinoma Papillary	Inhibit	34818323
Colorectal Neoplasms	Associate	32319644
Diabetes Mellitus	Associate	33621197
Inflammation	Associate	33621197, 35506187
Insulin Resistance	Associate	35506187
Leukemia Myelogenous Chronic BCR ABL Positive	Inhibit	25688862
Lung Neoplasms	Associate	27028858
Neoplasms	Associate	23169297
Neoplasms	Inhibit	27028858, 32319644, 33023313, 34818323, 36902429, 39580880
Noonan like syndrome	Associate	36608738, 38254922
Noonan Syndrome	Associate	36608738, 38254922
Osteosarcoma	Associate	33023313
Prostatic Neoplasms	Inhibit	23169297
Retinitis Pigmentosa	Associate	15215745
Schizophrenia	Associate	34323598
Urinary Bladder Neoplasms	Associate	34818323
Uterine Cervical Neoplasms	Associate	27028858