Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	200576
Gene name Gene Name - the full gene name approved by the HGNC.	Phosphoinositide kinase, FYVE-type zinc finger containing
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	PIKFYVE
Synonyms (NCBI Gene) Gene synonyms aliases	CFD, FAB1, HEL37, PIP5K, PIP5K3, ZFYVE29
Disease Acronyms (UniProt) Disease acronyms from UniProt database	CFD
Chromosome Chromosome number	2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	2q34
Summary Summary of gene provided in NCBI Entrez Gene.	Phosphorylated derivatives of phosphatidylinositol (PtdIns) regulate cytoskeletal functions, membrane trafficking, and receptor signaling by recruiting protein complexes to cell- and endosomal-membranes. Humans have multiple PtdIns proteins that differ by

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SNP ID	Visualize variation	Clinical significance	Consequence
rs121918336	A>G	Pathogenic	Missense variant, coding sequence variant, genic downstream transcript variant
rs121918337	C>T	Pathogenic	Stop gained, coding sequence variant, genic downstream transcript variant
rs387907335	AGTA>-	Pathogenic	Terminator codon variant, coding sequence variant, genic downstream transcript variant, 3 prime UTR variant, frameshift variant
rs780579562	C>G	Likely-pathogenic	Genic downstream transcript variant, stop gained, coding sequence variant
rs869312464	->A	Pathogenic	Frameshift variant, genic downstream transcript variant, coding sequence variant
rs1553525857	C>T	Likely-pathogenic	Stop gained, coding sequence variant, genic downstream transcript variant

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miRTarBase ID	miRNA	Experiments	Reference
MIRT050096	hsa-miR-26a-5p	CLASH	23622248
MIRT048546	hsa-miR-100-5p	CLASH	23622248
MIRT043808	hsa-miR-328-3p	CLASH	23622248
MIRT042812	hsa-miR-324-3p	CLASH	23622248
MIRT037422	hsa-miR-744-5p	CLASH	23622248
MIRT037422	hsa-miR-744-5p	CLASH	23622248
MIRT086968	hsa-miR-4418	HITS-CLIP	23824327
MIRT086967	hsa-miR-509-3-5p	HITS-CLIP	23824327
MIRT086964	hsa-miR-509-5p	HITS-CLIP	23824327
MIRT655086	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT655085	hsa-miR-4267	HITS-CLIP	23824327
MIRT655084	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT655083	hsa-miR-1184	HITS-CLIP	23824327
MIRT655082	hsa-miR-7977	HITS-CLIP	23824327
MIRT655081	hsa-miR-7156-3p	HITS-CLIP	23824327
MIRT086968	hsa-miR-4418	HITS-CLIP	23824327
MIRT086967	hsa-miR-509-3-5p	HITS-CLIP	23824327
MIRT086964	hsa-miR-509-5p	HITS-CLIP	23824327
MIRT655086	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT655085	hsa-miR-4267	HITS-CLIP	23824327
MIRT655084	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT655083	hsa-miR-1184	HITS-CLIP	23824327
MIRT655082	hsa-miR-7977	HITS-CLIP	23824327
MIRT655081	hsa-miR-7156-3p	HITS-CLIP	23824327
MIRT439972	hsa-miR-376a-3p	HITS-CLIP	24374217
MIRT439972	hsa-miR-376a-3p	HITS-CLIP	24374217
MIRT086968	hsa-miR-4418	HITS-CLIP	23824327
MIRT086967	hsa-miR-509-3-5p	HITS-CLIP	23824327
MIRT086964	hsa-miR-509-5p	HITS-CLIP	23824327
MIRT655086	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT655085	hsa-miR-4267	HITS-CLIP	23824327
MIRT655084	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT655083	hsa-miR-1184	HITS-CLIP	23824327
MIRT655082	hsa-miR-7977	HITS-CLIP	23824327
MIRT655081	hsa-miR-7156-3p	HITS-CLIP	23824327
MIRT086968	hsa-miR-4418	HITS-CLIP	23824327
MIRT086967	hsa-miR-509-3-5p	HITS-CLIP	23824327
MIRT086964	hsa-miR-509-5p	HITS-CLIP	23824327
MIRT655086	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT655085	hsa-miR-4267	HITS-CLIP	23824327
MIRT655084	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT655083	hsa-miR-1184	HITS-CLIP	23824327
MIRT655082	hsa-miR-7977	HITS-CLIP	23824327
MIRT655081	hsa-miR-7156-3p	HITS-CLIP	23824327
MIRT1234915	hsa-miR-105	CLIP-seq
MIRT1234916	hsa-miR-106a	CLIP-seq
MIRT1234917	hsa-miR-106b	CLIP-seq
MIRT1234918	hsa-miR-1224-5p	CLIP-seq
MIRT1234919	hsa-miR-124	CLIP-seq
MIRT1234920	hsa-miR-1245b-5p	CLIP-seq
MIRT1234921	hsa-miR-1252	CLIP-seq
MIRT1234922	hsa-miR-1256	CLIP-seq
MIRT1234923	hsa-miR-1257	CLIP-seq
MIRT1234924	hsa-miR-125a-3p	CLIP-seq
MIRT1234925	hsa-miR-127-5p	CLIP-seq
MIRT1234926	hsa-miR-1279	CLIP-seq
MIRT1234927	hsa-miR-1281	CLIP-seq
MIRT1234928	hsa-miR-1283	CLIP-seq
MIRT1234929	hsa-miR-1297	CLIP-seq
MIRT1234930	hsa-miR-130a	CLIP-seq
MIRT1234931	hsa-miR-130b	CLIP-seq
MIRT1234932	hsa-miR-132	CLIP-seq
MIRT1234933	hsa-miR-141	CLIP-seq
MIRT1234934	hsa-miR-17	CLIP-seq
MIRT1234935	hsa-miR-1915	CLIP-seq
MIRT1234936	hsa-miR-19a	CLIP-seq
MIRT1234937	hsa-miR-19b	CLIP-seq
MIRT1234938	hsa-miR-200a	CLIP-seq
MIRT1234939	hsa-miR-200b	CLIP-seq
MIRT1234940	hsa-miR-200c	CLIP-seq
MIRT1234941	hsa-miR-203	CLIP-seq
MIRT1234942	hsa-miR-205	CLIP-seq
MIRT1234943	hsa-miR-20a	CLIP-seq
MIRT1234944	hsa-miR-20b	CLIP-seq
MIRT1234945	hsa-miR-212	CLIP-seq
MIRT1234946	hsa-miR-214	CLIP-seq
MIRT1234947	hsa-miR-217	CLIP-seq
MIRT1234948	hsa-miR-224	CLIP-seq
MIRT1234949	hsa-miR-23a	CLIP-seq
MIRT1234950	hsa-miR-23b	CLIP-seq
MIRT1234951	hsa-miR-23c	CLIP-seq
MIRT1234952	hsa-miR-25	CLIP-seq
MIRT1234953	hsa-miR-26a	CLIP-seq
MIRT1234954	hsa-miR-26b	CLIP-seq
MIRT1234955	hsa-miR-28-3p	CLIP-seq
MIRT1234956	hsa-miR-296-3p	CLIP-seq
MIRT1234957	hsa-miR-301a	CLIP-seq
MIRT1234958	hsa-miR-301b	CLIP-seq
MIRT1234959	hsa-miR-302f	CLIP-seq
MIRT1234960	hsa-miR-3124-3p	CLIP-seq
MIRT1234961	hsa-miR-3127-3p	CLIP-seq
MIRT1234962	hsa-miR-3130-3p	CLIP-seq
MIRT1234963	hsa-miR-3135	CLIP-seq
MIRT1234964	hsa-miR-3142	CLIP-seq
MIRT1234965	hsa-miR-3152-3p	CLIP-seq
MIRT1234966	hsa-miR-3160-5p	CLIP-seq
MIRT1234967	hsa-miR-3163	CLIP-seq
MIRT1234968	hsa-miR-3175	CLIP-seq
MIRT1234969	hsa-miR-3189-3p	CLIP-seq
MIRT1234970	hsa-miR-32	CLIP-seq
MIRT1234971	hsa-miR-320a	CLIP-seq
MIRT1234972	hsa-miR-320b	CLIP-seq
MIRT1234973	hsa-miR-320c	CLIP-seq
MIRT1234974	hsa-miR-320d	CLIP-seq
MIRT1234975	hsa-miR-338-5p	CLIP-seq
MIRT1234976	hsa-miR-34a	CLIP-seq
MIRT1234977	hsa-miR-34c-5p	CLIP-seq
MIRT1234978	hsa-miR-3545-3p	CLIP-seq
MIRT1234979	hsa-miR-3613-3p	CLIP-seq
MIRT1234980	hsa-miR-3617	CLIP-seq
MIRT1234981	hsa-miR-3619-5p	CLIP-seq
MIRT1234982	hsa-miR-363	CLIP-seq
MIRT1234983	hsa-miR-365	CLIP-seq
MIRT1234984	hsa-miR-3662	CLIP-seq
MIRT1234985	hsa-miR-3663-5p	CLIP-seq
MIRT1234986	hsa-miR-3666	CLIP-seq
MIRT1234987	hsa-miR-367	CLIP-seq
MIRT1234988	hsa-miR-3676	CLIP-seq
MIRT1234989	hsa-miR-3677-5p	CLIP-seq
MIRT1234990	hsa-miR-3679-3p	CLIP-seq
MIRT1234991	hsa-miR-3682-5p	CLIP-seq
MIRT1234992	hsa-miR-369-3p	CLIP-seq
MIRT1234993	hsa-miR-374a	CLIP-seq
MIRT1234994	hsa-miR-374b	CLIP-seq
MIRT1234995	hsa-miR-374c	CLIP-seq
MIRT1234996	hsa-miR-3915	CLIP-seq
MIRT1234997	hsa-miR-3928	CLIP-seq
MIRT1234998	hsa-miR-3934	CLIP-seq
MIRT1234999	hsa-miR-3935	CLIP-seq
MIRT1235000	hsa-miR-3941	CLIP-seq
MIRT1235001	hsa-miR-3942-3p	CLIP-seq
MIRT1235002	hsa-miR-3975	CLIP-seq
MIRT1235003	hsa-miR-421	CLIP-seq
MIRT1235004	hsa-miR-4261	CLIP-seq
MIRT1235005	hsa-miR-4263	CLIP-seq
MIRT1235006	hsa-miR-4272	CLIP-seq
MIRT1235007	hsa-miR-4278	CLIP-seq
MIRT1235008	hsa-miR-4282	CLIP-seq
MIRT1235009	hsa-miR-429	CLIP-seq
MIRT1235010	hsa-miR-4291	CLIP-seq
MIRT1235011	hsa-miR-4295	CLIP-seq
MIRT1235012	hsa-miR-4325	CLIP-seq
MIRT1235013	hsa-miR-4326	CLIP-seq
MIRT1235014	hsa-miR-4328	CLIP-seq
MIRT1235015	hsa-miR-4429	CLIP-seq
MIRT1235016	hsa-miR-4446-5p	CLIP-seq
MIRT1235017	hsa-miR-4465	CLIP-seq
MIRT1235018	hsa-miR-4480	CLIP-seq
MIRT1235019	hsa-miR-449a	CLIP-seq
MIRT1235020	hsa-miR-449b	CLIP-seq
MIRT1235021	hsa-miR-4502	CLIP-seq
MIRT1235022	hsa-miR-4506	CLIP-seq
MIRT1235023	hsa-miR-454	CLIP-seq
MIRT1235024	hsa-miR-4635	CLIP-seq
MIRT1235025	hsa-miR-4659a-3p	CLIP-seq
MIRT1235026	hsa-miR-4659b-3p	CLIP-seq
MIRT1235027	hsa-miR-466	CLIP-seq
MIRT1235028	hsa-miR-4660	CLIP-seq
MIRT1235029	hsa-miR-4662a-3p	CLIP-seq
MIRT1235030	hsa-miR-4672	CLIP-seq
MIRT1235031	hsa-miR-4677-3p	CLIP-seq
MIRT1235032	hsa-miR-4679	CLIP-seq
MIRT1235033	hsa-miR-4680-5p	CLIP-seq
MIRT1235034	hsa-miR-4689	CLIP-seq
MIRT1235035	hsa-miR-4691-3p	CLIP-seq
MIRT1235036	hsa-miR-4699-3p	CLIP-seq
MIRT1235037	hsa-miR-4714-3p	CLIP-seq
MIRT1235038	hsa-miR-4716-3p	CLIP-seq
MIRT1235039	hsa-miR-4719	CLIP-seq
MIRT1235040	hsa-miR-4723-5p	CLIP-seq
MIRT1235041	hsa-miR-4726-3p	CLIP-seq
MIRT1235042	hsa-miR-4729	CLIP-seq
MIRT1235043	hsa-miR-4755-3p	CLIP-seq
MIRT1235044	hsa-miR-4755-5p	CLIP-seq
MIRT1235045	hsa-miR-4760-3p	CLIP-seq
MIRT1235046	hsa-miR-4762-3p	CLIP-seq
MIRT1235047	hsa-miR-4763-5p	CLIP-seq
MIRT1235048	hsa-miR-4777-3p	CLIP-seq
MIRT1235049	hsa-miR-4788	CLIP-seq
MIRT1235050	hsa-miR-4790-3p	CLIP-seq
MIRT1235051	hsa-miR-490-5p	CLIP-seq
MIRT1235052	hsa-miR-502-5p	CLIP-seq
MIRT1235053	hsa-miR-506	CLIP-seq
MIRT1235054	hsa-miR-513a-3p	CLIP-seq
MIRT1235055	hsa-miR-519a	CLIP-seq
MIRT1235056	hsa-miR-519b-3p	CLIP-seq
MIRT1235057	hsa-miR-519c-3p	CLIP-seq
MIRT1235058	hsa-miR-519d	CLIP-seq
MIRT1235059	hsa-miR-520g	CLIP-seq
MIRT1235060	hsa-miR-520h	CLIP-seq
MIRT1235061	hsa-miR-545	CLIP-seq
MIRT1235062	hsa-miR-548aa	CLIP-seq
MIRT1235063	hsa-miR-548ac	CLIP-seq
MIRT1235064	hsa-miR-548an	CLIP-seq
MIRT1235065	hsa-miR-548d-3p	CLIP-seq
MIRT1235066	hsa-miR-548z	CLIP-seq
MIRT1235067	hsa-miR-552	CLIP-seq
MIRT1235068	hsa-miR-555	CLIP-seq
MIRT1235069	hsa-miR-556-3p	CLIP-seq
MIRT1235070	hsa-miR-562	CLIP-seq
MIRT1235071	hsa-miR-576-5p	CLIP-seq
MIRT1235072	hsa-miR-577	CLIP-seq
MIRT1235073	hsa-miR-590-3p	CLIP-seq
MIRT1235074	hsa-miR-606	CLIP-seq
MIRT1235075	hsa-miR-616	CLIP-seq
MIRT1235076	hsa-miR-629	CLIP-seq
MIRT1235077	hsa-miR-641	CLIP-seq
MIRT1235078	hsa-miR-645	CLIP-seq
MIRT1235079	hsa-miR-646	CLIP-seq
MIRT1235080	hsa-miR-655	CLIP-seq
MIRT1235081	hsa-miR-656	CLIP-seq
MIRT1235082	hsa-miR-662	CLIP-seq
MIRT1235083	hsa-miR-664	CLIP-seq
MIRT1235084	hsa-miR-761	CLIP-seq
MIRT1235085	hsa-miR-764	CLIP-seq
MIRT1235086	hsa-miR-802	CLIP-seq
MIRT1235087	hsa-miR-885-5p	CLIP-seq
MIRT1235088	hsa-miR-922	CLIP-seq
MIRT1235089	hsa-miR-92a	CLIP-seq
MIRT1235090	hsa-miR-92b	CLIP-seq
MIRT1235091	hsa-miR-93	CLIP-seq
MIRT1235092	hsa-miR-944	CLIP-seq
MIRT1235093	hsa-miR-3185	CLIP-seq
MIRT1235094	hsa-miR-3646	CLIP-seq
MIRT1234984	hsa-miR-3662	CLIP-seq
MIRT1235095	hsa-miR-4311	CLIP-seq
MIRT2069183	hsa-miR-1	CLIP-seq
MIRT2069184	hsa-miR-101	CLIP-seq
MIRT2069185	hsa-miR-1244	CLIP-seq
MIRT1234922	hsa-miR-1256	CLIP-seq
MIRT2069186	hsa-miR-1267	CLIP-seq
MIRT1234927	hsa-miR-1281	CLIP-seq
MIRT2069187	hsa-miR-129-3p	CLIP-seq
MIRT1234932	hsa-miR-132	CLIP-seq
MIRT2069188	hsa-miR-1324	CLIP-seq
MIRT2069189	hsa-miR-133a	CLIP-seq
MIRT2069190	hsa-miR-133b	CLIP-seq
MIRT1234933	hsa-miR-141	CLIP-seq
MIRT2069191	hsa-miR-144	CLIP-seq
MIRT1234935	hsa-miR-1915	CLIP-seq
MIRT2069192	hsa-miR-1976	CLIP-seq
MIRT1234938	hsa-miR-200a	CLIP-seq
MIRT1234939	hsa-miR-200b	CLIP-seq
MIRT1234940	hsa-miR-200c	CLIP-seq
MIRT1234942	hsa-miR-205	CLIP-seq
MIRT2069193	hsa-miR-206	CLIP-seq
MIRT2069194	hsa-miR-21	CLIP-seq
MIRT1234945	hsa-miR-212	CLIP-seq
MIRT1234946	hsa-miR-214	CLIP-seq
MIRT1234948	hsa-miR-224	CLIP-seq
MIRT2069195	hsa-miR-3121-5p	CLIP-seq
MIRT1234961	hsa-miR-3127-3p	CLIP-seq
MIRT2069196	hsa-miR-3157-5p	CLIP-seq
MIRT2069197	hsa-miR-3170	CLIP-seq
MIRT1234971	hsa-miR-320a	CLIP-seq
MIRT1234972	hsa-miR-320b	CLIP-seq
MIRT1234973	hsa-miR-320c	CLIP-seq
MIRT1234974	hsa-miR-320d	CLIP-seq
MIRT1234975	hsa-miR-338-5p	CLIP-seq
MIRT1234979	hsa-miR-3613-3p	CLIP-seq
MIRT1234981	hsa-miR-3619-5p	CLIP-seq
MIRT1234983	hsa-miR-365	CLIP-seq
MIRT2069198	hsa-miR-3652	CLIP-seq
MIRT1234984	hsa-miR-3662	CLIP-seq
MIRT2069199	hsa-miR-3673	CLIP-seq
MIRT1234988	hsa-miR-3676	CLIP-seq
MIRT1234989	hsa-miR-3677-5p	CLIP-seq
MIRT1234995	hsa-miR-374c	CLIP-seq
MIRT2069200	hsa-miR-375	CLIP-seq
MIRT2069201	hsa-miR-3978	CLIP-seq
MIRT2069202	hsa-miR-4259	CLIP-seq
MIRT1235004	hsa-miR-4261	CLIP-seq
MIRT2069203	hsa-miR-4279	CLIP-seq
MIRT1235008	hsa-miR-4282	CLIP-seq
MIRT1235009	hsa-miR-429	CLIP-seq
MIRT1235010	hsa-miR-4291	CLIP-seq
MIRT1235013	hsa-miR-4326	CLIP-seq
MIRT2069204	hsa-miR-4421	CLIP-seq
MIRT2069205	hsa-miR-4423-5p	CLIP-seq
MIRT1235015	hsa-miR-4429	CLIP-seq
MIRT2069206	hsa-miR-4430	CLIP-seq
MIRT1235016	hsa-miR-4446-5p	CLIP-seq
MIRT2069207	hsa-miR-4477a	CLIP-seq
MIRT1235022	hsa-miR-4506	CLIP-seq
MIRT2069208	hsa-miR-4653-3p	CLIP-seq
MIRT1235025	hsa-miR-4659a-3p	CLIP-seq
MIRT1235026	hsa-miR-4659b-3p	CLIP-seq
MIRT2069209	hsa-miR-4666-3p	CLIP-seq
MIRT2069210	hsa-miR-4668-3p	CLIP-seq
MIRT2069211	hsa-miR-4687-5p	CLIP-seq
MIRT1235035	hsa-miR-4691-3p	CLIP-seq
MIRT2069212	hsa-miR-4698	CLIP-seq
MIRT1235036	hsa-miR-4699-3p	CLIP-seq
MIRT2069213	hsa-miR-4700-3p	CLIP-seq
MIRT2069214	hsa-miR-4703-3p	CLIP-seq
MIRT1235037	hsa-miR-4714-3p	CLIP-seq
MIRT2069215	hsa-miR-4715-3p	CLIP-seq
MIRT2069216	hsa-miR-4715-5p	CLIP-seq
MIRT1235039	hsa-miR-4719	CLIP-seq
MIRT2069217	hsa-miR-4722-3p	CLIP-seq
MIRT1235041	hsa-miR-4726-3p	CLIP-seq
MIRT1235044	hsa-miR-4755-5p	CLIP-seq
MIRT1235045	hsa-miR-4760-3p	CLIP-seq
MIRT1235051	hsa-miR-490-5p	CLIP-seq
MIRT2069218	hsa-miR-5095	CLIP-seq
MIRT1235054	hsa-miR-513a-3p	CLIP-seq
MIRT1235067	hsa-miR-552	CLIP-seq
MIRT1235068	hsa-miR-555	CLIP-seq
MIRT2069219	hsa-miR-582-5p	CLIP-seq
MIRT2069220	hsa-miR-590-5p	CLIP-seq
MIRT2069221	hsa-miR-607	CLIP-seq
MIRT2069222	hsa-miR-613	CLIP-seq
MIRT1235075	hsa-miR-616	CLIP-seq
MIRT1235079	hsa-miR-646	CLIP-seq
MIRT1235080	hsa-miR-655	CLIP-seq
MIRT1235082	hsa-miR-662	CLIP-seq
MIRT1235084	hsa-miR-761	CLIP-seq
MIRT1235087	hsa-miR-885-5p	CLIP-seq
MIRT1235088	hsa-miR-922	CLIP-seq
MIRT1234918	hsa-miR-1224-5p	CLIP-seq
MIRT1234927	hsa-miR-1281	CLIP-seq
MIRT1234929	hsa-miR-1297	CLIP-seq
MIRT1234933	hsa-miR-141	CLIP-seq
MIRT1234935	hsa-miR-1915	CLIP-seq
MIRT2069192	hsa-miR-1976	CLIP-seq
MIRT1234938	hsa-miR-200a	CLIP-seq
MIRT1234939	hsa-miR-200b	CLIP-seq
MIRT1234940	hsa-miR-200c	CLIP-seq
MIRT1234947	hsa-miR-217	CLIP-seq
MIRT1234948	hsa-miR-224	CLIP-seq
MIRT1234953	hsa-miR-26a	CLIP-seq
MIRT1234954	hsa-miR-26b	CLIP-seq
MIRT1234975	hsa-miR-338-5p	CLIP-seq
MIRT1234996	hsa-miR-3915	CLIP-seq
MIRT1234997	hsa-miR-3928	CLIP-seq
MIRT2069203	hsa-miR-4279	CLIP-seq
MIRT1235009	hsa-miR-429	CLIP-seq
MIRT1235017	hsa-miR-4465	CLIP-seq
MIRT1235034	hsa-miR-4689	CLIP-seq
MIRT2069217	hsa-miR-4722-3p	CLIP-seq
MIRT1235041	hsa-miR-4726-3p	CLIP-seq
MIRT2296309	hsa-miR-570	CLIP-seq
MIRT1235081	hsa-miR-656	CLIP-seq
MIRT1235036	hsa-miR-4699-3p	CLIP-seq
MIRT1235042	hsa-miR-4729	CLIP-seq
MIRT2439491	hsa-miR-219-5p	CLIP-seq
MIRT2439492	hsa-miR-4445	CLIP-seq
MIRT2439493	hsa-miR-4642	CLIP-seq
MIRT2069214	hsa-miR-4703-3p	CLIP-seq
MIRT2439494	hsa-miR-4782-3p	CLIP-seq
MIRT2439495	hsa-miR-548a-3p	CLIP-seq
MIRT2439496	hsa-miR-548e	CLIP-seq
MIRT2439497	hsa-miR-548f	CLIP-seq
MIRT2439498	hsa-miR-642b	CLIP-seq
MIRT2439495	hsa-miR-548a-3p	CLIP-seq
MIRT2439496	hsa-miR-548e	CLIP-seq
MIRT2439497	hsa-miR-548f	CLIP-seq
MIRT2456509	hsa-miR-3150a-3p	CLIP-seq
MIRT1234968	hsa-miR-3175	CLIP-seq
MIRT2456510	hsa-miR-3675-5p	CLIP-seq
MIRT2456511	hsa-miR-3689d	CLIP-seq
MIRT2456512	hsa-miR-4648	CLIP-seq
MIRT2456513	hsa-miR-4654	CLIP-seq
MIRT2456514	hsa-miR-4769-5p	CLIP-seq
MIRT2456515	hsa-miR-539	CLIP-seq
MIRT2456516	hsa-miR-765	CLIP-seq
MIRT2456517	hsa-miR-939	CLIP-seq
MIRT1234921	hsa-miR-1252	CLIP-seq
MIRT2594007	hsa-miR-128	CLIP-seq
MIRT1234927	hsa-miR-1281	CLIP-seq
MIRT2069189	hsa-miR-133a	CLIP-seq
MIRT2069190	hsa-miR-133b	CLIP-seq
MIRT1234935	hsa-miR-1915	CLIP-seq
MIRT2069194	hsa-miR-21	CLIP-seq
MIRT2439491	hsa-miR-219-5p	CLIP-seq
MIRT2594008	hsa-miR-27a	CLIP-seq
MIRT2594009	hsa-miR-27b	CLIP-seq
MIRT2594010	hsa-miR-297	CLIP-seq
MIRT2069195	hsa-miR-3121-5p	CLIP-seq
MIRT2594011	hsa-miR-3149	CLIP-seq
MIRT1235093	hsa-miR-3185	CLIP-seq
MIRT2594012	hsa-miR-3613-5p	CLIP-seq
MIRT2069200	hsa-miR-375	CLIP-seq
MIRT2594013	hsa-miR-4275	CLIP-seq
MIRT1235013	hsa-miR-4326	CLIP-seq
MIRT2069204	hsa-miR-4421	CLIP-seq
MIRT2439492	hsa-miR-4445	CLIP-seq
MIRT2594014	hsa-miR-4476	CLIP-seq
MIRT2069207	hsa-miR-4477a	CLIP-seq
MIRT2594015	hsa-miR-4477b	CLIP-seq
MIRT2594016	hsa-miR-4533	CLIP-seq
MIRT2594017	hsa-miR-455-3p	CLIP-seq
MIRT2594018	hsa-miR-455-5p	CLIP-seq
MIRT2439493	hsa-miR-4642	CLIP-seq
MIRT1235025	hsa-miR-4659a-3p	CLIP-seq
MIRT1235026	hsa-miR-4659b-3p	CLIP-seq
MIRT2069212	hsa-miR-4698	CLIP-seq
MIRT2069214	hsa-miR-4703-3p	CLIP-seq
MIRT1235041	hsa-miR-4726-3p	CLIP-seq
MIRT2594019	hsa-miR-4753-3p	CLIP-seq
MIRT2594020	hsa-miR-4768-5p	CLIP-seq
MIRT2439494	hsa-miR-4782-3p	CLIP-seq
MIRT2594021	hsa-miR-513a-5p	CLIP-seq
MIRT2439495	hsa-miR-548a-3p	CLIP-seq
MIRT2439496	hsa-miR-548e	CLIP-seq
MIRT2439497	hsa-miR-548f	CLIP-seq
MIRT2594022	hsa-miR-567	CLIP-seq
MIRT2069220	hsa-miR-590-5p	CLIP-seq
MIRT2069221	hsa-miR-607	CLIP-seq
MIRT2439498	hsa-miR-642b	CLIP-seq
MIRT1235092	hsa-miR-944	CLIP-seq
MIRT1234921	hsa-miR-1252	CLIP-seq
MIRT1234927	hsa-miR-1281	CLIP-seq
MIRT2069189	hsa-miR-133a	CLIP-seq
MIRT2069190	hsa-miR-133b	CLIP-seq
MIRT1234935	hsa-miR-1915	CLIP-seq
MIRT2069192	hsa-miR-1976	CLIP-seq
MIRT2069194	hsa-miR-21	CLIP-seq
MIRT2439491	hsa-miR-219-5p	CLIP-seq
MIRT2594010	hsa-miR-297	CLIP-seq
MIRT2594011	hsa-miR-3149	CLIP-seq
MIRT2069196	hsa-miR-3157-5p	CLIP-seq
MIRT1235093	hsa-miR-3185	CLIP-seq
MIRT2594012	hsa-miR-3613-5p	CLIP-seq
MIRT2594013	hsa-miR-4275	CLIP-seq
MIRT2069203	hsa-miR-4279	CLIP-seq
MIRT2687920	hsa-miR-4422	CLIP-seq
MIRT2439492	hsa-miR-4445	CLIP-seq
MIRT2594014	hsa-miR-4476	CLIP-seq
MIRT2069207	hsa-miR-4477a	CLIP-seq
MIRT2594015	hsa-miR-4477b	CLIP-seq
MIRT2687921	hsa-miR-4509	CLIP-seq
MIRT2594016	hsa-miR-4533	CLIP-seq
MIRT2439493	hsa-miR-4642	CLIP-seq
MIRT1235025	hsa-miR-4659a-3p	CLIP-seq
MIRT1235026	hsa-miR-4659b-3p	CLIP-seq
MIRT2687922	hsa-miR-4684-5p	CLIP-seq
MIRT1235035	hsa-miR-4691-3p	CLIP-seq
MIRT2069214	hsa-miR-4703-3p	CLIP-seq
MIRT2069217	hsa-miR-4722-3p	CLIP-seq
MIRT1235041	hsa-miR-4726-3p	CLIP-seq
MIRT2687923	hsa-miR-4744	CLIP-seq
MIRT2594019	hsa-miR-4753-3p	CLIP-seq
MIRT2594020	hsa-miR-4768-5p	CLIP-seq
MIRT2439494	hsa-miR-4782-3p	CLIP-seq
MIRT2439495	hsa-miR-548a-3p	CLIP-seq
MIRT2439496	hsa-miR-548e	CLIP-seq
MIRT2439497	hsa-miR-548f	CLIP-seq
MIRT2594022	hsa-miR-567	CLIP-seq
MIRT2069220	hsa-miR-590-5p	CLIP-seq
MIRT2439498	hsa-miR-642b	CLIP-seq
MIRT1235092	hsa-miR-944	CLIP-seq

Show/Hide all(44)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	TAS
GO:0000285	Function	1-phosphatidylinositol-3-phosphate 5-kinase activity	IDA	22621786
GO:0000285	Function	1-phosphatidylinositol-3-phosphate 5-kinase activity	ISS
GO:0004674	Function	Protein serine/threonine kinase activity	ISS
GO:0005515	Function	Protein binding	IPI	15046600, 17556371, 17909029, 19037259, 25416956, 29892012
GO:0005524	Function	ATP binding	IEA
GO:0005829	Component	Cytosol	IEA
GO:0005911	Component	Cell-cell junction	IEA
GO:0006612	Process	Protein targeting to membrane	ISS
GO:0006661	Process	Phosphatidylinositol biosynthetic process	TAS
GO:0006898	Process	Receptor-mediated endocytosis	IMP	14551253
GO:0008270	Function	Zinc ion binding	IEA
GO:0010008	Component	Endosome membrane	IDA	17556371
GO:0016308	Function	1-phosphatidylinositol-4-phosphate 5-kinase activity	TAS	15046600
GO:0019065	Process	Receptor-mediated endocytosis of virus by host cell	IDA	32221306
GO:0019886	Process	Antigen processing and presentation of exogenous peptide antigen via MHC class II	IDA	30612035
GO:0030593	Process	Neutrophil chemotaxis	IDA	28779020
GO:0030670	Component	Phagocytic vesicle membrane	IDA	30612035
GO:0031901	Component	Early endosome membrane	IDA	16448788, 16954148, 30612035
GO:0031901	Component	Early endosome membrane	TAS
GO:0031902	Component	Late endosome membrane	TAS
GO:0032288	Process	Myelin assembly	IEA
GO:0032438	Process	Melanosome organization	IDA	29584722
GO:0034504	Process	Protein localization to nucleus	IMP	17909029
GO:0035556	Process	Intracellular signal transduction	IEA
GO:0036092	Process	Phosphatidylinositol-3-phosphate biosynthetic process	IEA
GO:0036289	Process	Peptidyl-serine autophosphorylation	ISS
GO:0042147	Process	Retrograde transport, endosome to Golgi	IMP	14551253, 16954148
GO:0043231	Component	Intracellular membrane-bounded organelle	IDA
GO:0043813	Function	Phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity	TAS
GO:0045121	Component	Membrane raft	IDA	15046600
GO:0046854	Process	Phosphatidylinositol phosphorylation	IEA
GO:0048471	Component	Perinuclear region of cytoplasm	IEA
GO:0052810	Function	1-phosphatidylinositol-5-kinase activity	IDA	22621786
GO:0052810	Function	1-phosphatidylinositol-5-kinase activity	ISS
GO:0090382	Process	Phagosome maturation	IDA	27623384
GO:0090385	Process	Phagosome-lysosome fusion	IDA	28779020
GO:0106310	Function	Protein serine kinase activity	IEA
GO:0106311	Function	Protein threonine kinase activity	IEA
GO:1903100	Process	1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process	ISS
GO:1903426	Process	Regulation of reactive oxygen species biosynthetic process	IDA	28779020
GO:1904562	Process	Phosphatidylinositol 5-phosphate metabolic process	IC	25578879
GO:1904562	Process	Phosphatidylinositol 5-phosphate metabolic process	ISS
GO:2000785	Process	Regulation of autophagosome assembly	IMP	25578879

MIM	HGNC	e!Ensembl
609414	23785	ENSG00000115020

Protein

UniProt ID

Q9Y2I7

Protein name

1-phosphatidylinositol 3-phosphate 5-kinase (Phosphatidylinositol 3-phosphate 5-kinase) (EC 2.7.1.150) (FYVE finger-containing phosphoinositide kinase) (PIKfyve) (Phosphatidylinositol 3-phosphate 5-kinase type III) (PIPkin-III) (Type III PIP kinase) (Seri

Protein function

Dual specificity kinase implicated in myriad essential cellular processes such as maintenance of endomembrane homeostasis, and endocytic-vacuolar pathway, lysosomal trafficking, nuclear transport, stress- or hormone-induced signaling and cell cy

PDB

7K2V

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01363	FYVE	153 → 219	FYVE zinc finger	Domain
PF00610	DEP	368 → 438	Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)	Domain
PF00118	Cpn60_TCP1	591 → 863	TCP-1/cpn60 chaperonin family	Family
PF01504	PIP5K	1852 → 2030	Phosphatidylinositol-4-phosphate 5-Kinase	Family
PF01504	PIP5K	2023 → 2083	Phosphatidylinositol-4-phosphate 5-Kinase	Family

Sequence

MATDDKTSPTLDSANDLPRSPTSPSHLTHFKPLTPDQDEPPFKSAYSSFVNLFRFNKERA
EGGQGEQQPLSGSWTSPQLPSRTQSVRSPTPYKKQLNEELQRRSSALDTRRKAEPTFGGH
DPRTAVQLRSLSTVLKRLKEIMEGKSQDSDLKQYWMPDSQCKECYDCSEKFTTFRRRHHC
RLCGQIFCSRCCNQEIPGKFMGYTGDLRACTYCRKIALSYAHSTDSNSIGEDLNALSDSA
CSVSVLDPSEPRTPVGSRKASRNIFLEDDLAWQSLIHPDSSNTPLSTRLVSVQEDAGKSP
ARNRSASITNLSLDRSGSPMVPSYETSVSPQANRTYVRTETTEDERKILLDSVQLKDLWK
KICHHSSGMEFQDHRYWLRTHPNCIVGKELVNWLIRNGHIATRAQAIAIGQAMVDGRWLD
CVSHHDQLFRDEYALYRPLQSTEFSETPSPDSDSVNSVEGHSEPSWFKDIKFDDSDTEQI
AEEGDDNLANSASPSKRTSVSSFQSTVDSDSAASISLNVELDNVNFHIKKPSKYPHVPPH
PADQKEYLISDTGGQQLSISDAFIKESLFNRRVEEKSKELPFTPLGWHHNNLELLREENG
EKQAMERLLSANHNHMMALLQQLLHSDSLSSSWRDIIVSLVCQVVQTVRPDVKNQDDDMD
IRQFVHIKKIPGGKKFDSVVVNGFVCTKNIAHKKMSSCIKNPKILLLKCSIEYLYREETK
FTCIDPIVLQEREFLKNYVQRIVDVRPTLVLVEKTVSRIAQDMLLEHGITLVINVKSQVL
ERISRMTQGDLVMSMDQLLTKPHLGTCHKFYMQIFQLPNEQTKTLMFFEGCPQHLGCTIK
LRGGSDYELARVKEILIFMICVAYHSQLEISFLMDEFAMPPTLMQNPSFHSLIEGRGHEG
AVQEQYGGGSIPWDPDIPPESLPCDDSSLLELRIVFEKGEQENKNLPQAVASVKHQEHST
TACPAGLPCAFFAPVPESLLPLPVDDQQDALGSEQPETLQQTVVLQDPKSQIRAFRDPLQ
DDTGLYVTEEVTSSEDKRKTYSLAFKQELKDVILCISPVITFREPFLLTEKGMRCSTRDY
FAEQVYWSPLLNKEFKEMENRRKKQLLRDLSGLQGMNGSIQAKSIQVLPSHELVSTRIAE
HLGDSQSLGRMLADYRARGGRIQPKNSDPFAHSKDASSTSSGQSGSKNEGDEERGLILSD
AVWSTKVDCLNPINHQRLCVLFSSSSAQSSNAPSACVSPWIVTMEFYGKNDLTLGIFLER
YCFRPSYQCPSMFCDTPMVHHIRRFVHGQGCVQIILKELDSPVPGYQHTILTYSWCRICK
QVTPVVALSNESWSMSFAKYLELRFYGHQYTRRANAEPCGHSIHHDYHQYFSYNQMVASF
SYSPIRLLEVCVPLPKIFIKRQAPLKVSLLQDLKDFFQKVSQVYVAIDERLASLKTDTFS
KTREEKMEDIFAQKEMEEGEFKNWIEKMQARLMSSSVDTPQQLQSVFESLIAKKQSLCEV
LQAWNNRLQDLFQQEKGRKRPSVPPSPGRLRQGEESKISAMDASPRNISPGLQNGEKEDR
FLTTLSSQSSTSSTHLQLPTPPEVMSEQSVGGPPELDTASSSEDVFDGHLLGSTDSQVKE
KSTMKAIFANLLPGNSYNPIPFPFDPDKHYLMYEHERVPIAVCEKEPSSIIAFALSCKEY
RNALEELSKATQWNSAEEGLPTNSTSDSRPKSSSPIRLPEMSGGQTNRTTETEPQPTKKA
SGMLSFFRGTAGKSPDLSSQKRETLRGADSAYYQVGQTGKEGTENQGVEPQDEVDGGDTQ
KKQLINPHVELQFSDANAKFYCRLYYAGEFHKMREVILDSSEEDFIRSLSHSSPWQARGG
KSGAAFYATEDDRFILKQMPRLEVQSFLDFAPHYFNYITNAVQQKRPTALAKILGVYRIG
YKNSQNNTEKKLDLLVMENLFYGRKMAQVFDLKGSLRNRNVKTDTGKESCDVVLLDENLL
KMVRDNPLYIRSHSKAVLRTSIHSDSHFLSSHLIIDYSLLVGRDDTSNELVVGIIDYIRT
FTWDKKLEMVVKSTGILGGQGKMPTVVSPELYRTRFCEAMDKYFLMVPDHWTGLGLNC

Sequence length

2098

Interactions

View interactions

	KEGG		Reactome
	Inositol phosphate metabolism Metabolic pathways Phosphatidylinositol signaling system Phagosome Regulation of actin cytoskeleton		Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the late endosome membrane

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Fleck corneal dystrophy	Fleck corneal dystrophy	rs121918336, rs121918337, rs387907335, rs869312464, rs780579562	23288988, 15902656, 26396486, 22065932

Show/Hide Unknown Diseases (1)

Disease term	Disease name	Evidence	References	Source
Unknown
Asthma	Asthma			GWAS

Show/Hide Text Mining Associations (13)

Disease Name	Relationship Type	References
Associations from Text Mining
Carcinogenesis	Associate	17909029
Carcinoma Transitional Cell	Associate	17909029
Cataract	Associate	37511188
Corneal dystrophy epithelial basement membrane	Associate	19710953
Corneal Dystrophy Fleck	Associate	15902656, 22065932, 23288988, 26396486
Demyelinating Diseases	Associate	26293489
Diabetes Gestational	Inhibit	26302821
Drug Related Side Effects and Adverse Reactions	Associate	28104689
Neoplasms	Associate	34738088, 36803256
Neurodegenerative Diseases	Associate	26216398
Precursor T Cell Lymphoblastic Leukemia Lymphoma	Associate	33467550
Prostatic Neoplasms	Associate	34738088
Vision Disorders	Associate	23288988

PIKFYVE (phosphoinositide kinase, FYVE-type zinc finger containing)