Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	200539
Gene name Gene Name - the full gene name approved by the HGNC.	Ankyrin repeat domain 23
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	ANKRD23
Synonyms (NCBI Gene) Gene synonyms aliases	DARP, MARP3
Chromosome Chromosome number	2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	2q11.2
Summary Summary of gene provided in NCBI Entrez Gene.	This gene is a member of the muscle ankyrin repeat protein (MARP) family and encodes a protein with four tandem ankyrin-like repeats. The protein is localized to the nucleus, functioning as a transcriptional regulator. Expression of this protein is induce

Show/Hide all(114)

miRTarBase ID	miRNA	Experiments	Reference
MIRT509717	hsa-miR-6753-5p	PAR-CLIP	23446348
MIRT509716	hsa-miR-6502-3p	PAR-CLIP	23446348
MIRT509715	hsa-miR-6510-5p	PAR-CLIP	23446348
MIRT509714	hsa-miR-4733-3p	PAR-CLIP	23446348
MIRT509713	hsa-miR-4270	PAR-CLIP	23446348
MIRT509712	hsa-miR-4441	PAR-CLIP	23446348
MIRT509710	hsa-miR-6754-5p	PAR-CLIP	23446348
MIRT509711	hsa-miR-7113-5p	PAR-CLIP	23446348
MIRT509709	hsa-miR-6081	PAR-CLIP	23446348
MIRT509708	hsa-miR-3684	PAR-CLIP	23446348
MIRT509707	hsa-miR-4640-5p	PAR-CLIP	23446348
MIRT509717	hsa-miR-6753-5p	PAR-CLIP	23446348
MIRT509716	hsa-miR-6502-3p	PAR-CLIP	23446348
MIRT509715	hsa-miR-6510-5p	PAR-CLIP	23446348
MIRT509714	hsa-miR-4733-3p	PAR-CLIP	23446348
MIRT509713	hsa-miR-4270	PAR-CLIP	23446348
MIRT509712	hsa-miR-4441	PAR-CLIP	23446348
MIRT509710	hsa-miR-6754-5p	PAR-CLIP	23446348
MIRT509711	hsa-miR-7113-5p	PAR-CLIP	23446348
MIRT509709	hsa-miR-6081	PAR-CLIP	23446348
MIRT509708	hsa-miR-3684	PAR-CLIP	23446348
MIRT509707	hsa-miR-4640-5p	PAR-CLIP	23446348
MIRT783197	hsa-miR-1226	CLIP-seq
MIRT783198	hsa-miR-1273g	CLIP-seq
MIRT783199	hsa-miR-129-3p	CLIP-seq
MIRT783200	hsa-miR-1296	CLIP-seq
MIRT783201	hsa-miR-1321	CLIP-seq
MIRT783202	hsa-miR-1538	CLIP-seq
MIRT783203	hsa-miR-1972	CLIP-seq
MIRT783204	hsa-miR-2909	CLIP-seq
MIRT783205	hsa-miR-296-5p	CLIP-seq
MIRT783206	hsa-miR-3150b-3p	CLIP-seq
MIRT783207	hsa-miR-3152-5p	CLIP-seq
MIRT783208	hsa-miR-3157-5p	CLIP-seq
MIRT783209	hsa-miR-3158-5p	CLIP-seq
MIRT783210	hsa-miR-3166	CLIP-seq
MIRT783211	hsa-miR-3202	CLIP-seq
MIRT783212	hsa-miR-370	CLIP-seq
MIRT783213	hsa-miR-3909	CLIP-seq
MIRT783214	hsa-miR-3914	CLIP-seq
MIRT783215	hsa-miR-3928	CLIP-seq
MIRT783216	hsa-miR-412	CLIP-seq
MIRT783217	hsa-miR-4264	CLIP-seq
MIRT783218	hsa-miR-4310	CLIP-seq
MIRT783219	hsa-miR-4328	CLIP-seq
MIRT783220	hsa-miR-4419a	CLIP-seq
MIRT783221	hsa-miR-4436b-3p	CLIP-seq
MIRT783222	hsa-miR-4446-3p	CLIP-seq
MIRT783223	hsa-miR-4510	CLIP-seq
MIRT783224	hsa-miR-4656	CLIP-seq
MIRT783225	hsa-miR-4685-5p	CLIP-seq
MIRT783226	hsa-miR-4689	CLIP-seq
MIRT783227	hsa-miR-4690-3p	CLIP-seq
MIRT783228	hsa-miR-4731-5p	CLIP-seq
MIRT783229	hsa-miR-4739	CLIP-seq
MIRT783230	hsa-miR-4745-3p	CLIP-seq
MIRT783231	hsa-miR-4747-5p	CLIP-seq
MIRT783232	hsa-miR-4753-3p	CLIP-seq
MIRT783233	hsa-miR-4756-5p	CLIP-seq
MIRT783234	hsa-miR-4761-3p	CLIP-seq
MIRT783235	hsa-miR-4763-5p	CLIP-seq
MIRT783236	hsa-miR-4771	CLIP-seq
MIRT783237	hsa-miR-4774-3p	CLIP-seq
MIRT783238	hsa-miR-4777-5p	CLIP-seq
MIRT783239	hsa-miR-4783-3p	CLIP-seq
MIRT783240	hsa-miR-4784	CLIP-seq
MIRT783241	hsa-miR-4797-3p	CLIP-seq
MIRT783242	hsa-miR-511	CLIP-seq
MIRT783243	hsa-miR-518d-5p	CLIP-seq
MIRT783244	hsa-miR-519b-5p	CLIP-seq
MIRT783245	hsa-miR-519c-5p	CLIP-seq
MIRT783246	hsa-miR-520c-5p	CLIP-seq
MIRT783247	hsa-miR-526a	CLIP-seq
MIRT783248	hsa-miR-642a	CLIP-seq
MIRT1931083	hsa-miR-4292	CLIP-seq
MIRT783221	hsa-miR-4436b-3p	CLIP-seq
MIRT783222	hsa-miR-4446-3p	CLIP-seq
MIRT1931084	hsa-miR-4649-3p	CLIP-seq
MIRT783228	hsa-miR-4731-5p	CLIP-seq
MIRT2171698	hsa-miR-1245b-3p	CLIP-seq
MIRT2171699	hsa-miR-1267	CLIP-seq
MIRT2171700	hsa-miR-3650	CLIP-seq
MIRT783214	hsa-miR-3914	CLIP-seq
MIRT2171701	hsa-miR-3919	CLIP-seq
MIRT2171702	hsa-miR-4268	CLIP-seq
MIRT2171703	hsa-miR-4302	CLIP-seq
MIRT2171704	hsa-miR-4330	CLIP-seq
MIRT2171705	hsa-miR-4420	CLIP-seq
MIRT2171706	hsa-miR-4712-5p	CLIP-seq
MIRT2171707	hsa-miR-4726-5p	CLIP-seq
MIRT2171708	hsa-miR-4755-3p	CLIP-seq
MIRT2171709	hsa-miR-668	CLIP-seq
MIRT2171710	hsa-miR-744	CLIP-seq
MIRT2171711	hsa-miR-770-5p	CLIP-seq
MIRT2384194	hsa-miR-1908	CLIP-seq
MIRT2384195	hsa-miR-3180	CLIP-seq
MIRT2384196	hsa-miR-3180-3p	CLIP-seq
MIRT2384197	hsa-miR-3196	CLIP-seq
MIRT2384198	hsa-miR-4283	CLIP-seq
MIRT2384199	hsa-miR-4284	CLIP-seq
MIRT2384200	hsa-miR-4437	CLIP-seq
MIRT2384201	hsa-miR-4488	CLIP-seq
MIRT2384202	hsa-miR-4697-5p	CLIP-seq
MIRT2384203	hsa-miR-663	CLIP-seq
MIRT2474750	hsa-miR-1193	CLIP-seq
MIRT2474751	hsa-miR-3690	CLIP-seq
MIRT2474752	hsa-miR-4254	CLIP-seq
MIRT2474753	hsa-miR-4642	CLIP-seq
MIRT2474754	hsa-miR-4793-5p	CLIP-seq
MIRT2474750	hsa-miR-1193	CLIP-seq
MIRT2474751	hsa-miR-3690	CLIP-seq
MIRT2474752	hsa-miR-4254	CLIP-seq
MIRT2474753	hsa-miR-4642	CLIP-seq
MIRT2474754	hsa-miR-4793-5p	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000976	Function	Transcription cis-regulatory region binding	IBA
GO:0005515	Function	Protein binding	IPI	32296183, 32814053
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0006631	Process	Fatty acid metabolic process	IEA
GO:0009612	Process	Response to mechanical stimulus	IEA
GO:0014704	Component	Intercalated disc	IEA
GO:0015629	Component	Actin cytoskeleton	IDA
GO:0030016	Component	Myofibril	IEA
GO:0031432	Function	Titin binding	IPI	14583192
GO:0031674	Component	I band	IEA
GO:0035994	Process	Response to muscle stretch	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IBA
GO:0060297	Process	Regulation of sarcomere organization	IEA

MIM	HGNC	e!Ensembl
610736	24470	ENSG00000163126

Protein

UniProt ID

Q86SG2

Protein name

Ankyrin repeat domain-containing protein 23 (Diabetes-related ankyrin repeat protein) (Muscle ankyrin repeat protein 3)

Protein function

May be involved in the energy metabolism. Could be a molecular link between myofibrillar stretch-induced signaling pathways and muscle gene expression.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF12796	Ank_2	114 → 207	Ankyrin repeats (3 copies)	Repeat
PF12796	Ank_2	155 → 240	Ankyrin repeats (3 copies)	Repeat
PF12796	Ank_2	208 → 273	Ankyrin repeats (3 copies)	Repeat

Tissue specificity

TISSUE SPECIFICITY: Mainly expressed in heart, skeletal muscle and brown adipose tissues. {ECO:0000269|PubMed:12456686}.

Sequence

MDFISIQQLVSGERVEGKVLGFGHGVPDPGAWPSDWRRGPQEAVAREKLKLEEEKKKKLE
RFNSTRFNLDNLADLENLVQRRKKRLRHRVPPRKPEPLVKPQSQAQVEPVGLEMFLKAAA
ENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLDRTP
VFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQD
KEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLARDWQRGIREALQAHVAH
PRTRC

Sequence length

305

Interactions

View interactions

	KEGG
	Cytoskeleton in muscle cells

Show/Hide Unknown Diseases (2)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Bipolar Disorder	Bipolar I disorder	N/A	N/A	GWAS
Schizophrenia	Schizophrenia	N/A	N/A	GWAS

ANKRD23 (ankyrin repeat domain 23)