Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
2000
Gene name Gene Name - the full gene name approved by the HGNC.
E74 like ETS transcription factor 4
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
ELF4
Synonyms (NCBI Gene) Gene synonyms aliases
AIFBL2, ELFR, MEF
Disease Acronyms (UniProt) Disease acronyms from UniProt database
AIFBL2
Chromosome Chromosome number
X
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
Xq26.1
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a transcriptional activator that binds and activates the promoters of the CSF2, IL3, IL8, and PRF1 genes. The encoded protein is involved in natural killer cell development and function, innate immunity, and induction o
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT002580 hsa-miR-124-3p Microarray 15685193
MIRT002580 hsa-miR-124-3p Microarray 15685193
MIRT002580 hsa-miR-124-3p Microarray 18668037
MIRT029730 hsa-miR-26b-5p Microarray 19088304
MIRT050308 hsa-miR-25-3p CLASH 23622248
Transcription factors
Transcription factor Regulation Reference
NPM1 Unknown 23393136
SP1 Activation 15907486
TP53 Unknown 20805247
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000785 Component Chromatin ISA
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA 14625302
GO:0000981 Function DNA-binding transcription factor activity, RNA polymerase II-specific IBA 21873635
GO:0000981 Function DNA-binding transcription factor activity, RNA polymerase II-specific ISA
GO:0001228 Function DNA-binding transcription activator activity, RNA polymerase II-specific IDA 14625302
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
300775 3319 ENSG00000102034
Protein
UniProt ID Q99607
Protein name ETS-related transcription factor Elf-4 (E74-like factor 4) (Myeloid Elf-1-like factor)
Protein function Transcriptional activator that binds to DNA sequences containing the consensus 5'-WGGA-3'. Transactivates promoters of the hematopoietic growth factor genes CSF2, IL3, IL8, and of the bovine lysozyme gene. Acts synergistically with RUNX1 to tran
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF12310 Elf-1_N 2 104 Transcription factor protein N terminal Family
PF00178 Ets 210 291 Ets-domain Domain
Tissue specificity TISSUE SPECIFICITY: Abundantly expressed in the placenta and in a variety of myeloid leukemia cell lines. Moderate levels of expression in heart, lung, spleen, thymus, peripheral blood lymphocytes, ovary and colon. Lower levels of expression in Jurkat T-c
Sequence
MAITLQPSDLIFEFASNGMDDDIHQLEDPSVFPAVIVEQVPYPDLLHLYSGLELDDVHNG
IITDGTLCMTQDQILEGSFLLTDDNEATSHTMSTAEVLLNMESP
SDILDEKQIFSTSEML
PDSDPAPAVTLPNYLFPASEPDALNRAGDTSDQEGHSLEEKASREESAKKTGKSKKRIRK
TKGNRSTSPVTDPSIPIRKKSKDGKGSTIYLWEFLLALLQDRNTCPKYIKWTQREKGIFK
LVDSKAVSKLWGKQKNKPDMNYETMGRALRYYYQRGILAKVEGQRLVYQFK
EMPKDLVVI
EDEDESSEATAAPPQASTASVASASTTRRTSSRVSSRSAPQGKGSSSWEKPKIQHVGLQP
SASLELGPSLDEEIPTTSTMLVSPAEGQVKLTKAVSASSVPSNIHLGVAPVGSGSALTLQ
TIPLTTVLTNGPPASTTAPTQLVLQSVPAASTFKDTFTLQASFPLNASFQDSQVAAPGAP
LILSGLPQLLAGANRPTNPAPPTVTGAGPAGPSSQPPGTVIAAFIRTSGTTAAPRVKEGP
LRSSSYVQGMVTGAPMEGLLVPEETLRELLRDQAHLQPLPTQVVSRGSHNPSLLGNQTLS
PPSRPTVGLTPVAELELSSGSGSLLMAEPSVTTSGSLLTRSPTPAPFSPFNPTSLIKMEP
HDI
Sequence length 663
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Agammaglobulinemia with growth hormone deficiency, x-linked X-linked agammaglobulinemia with growth hormone deficiency rs128620183, rs128620187, rs128620188, rs864321659, rs128620185, rs128620186, rs864321660, rs864321662, rs864321664, rs864321665, rs128621192, rs128621193, rs128621194, rs128621197, rs128621201
View all (51 more)
18180883
Unknown
Disease term Disease name Evidence References Source
Hypogammaglobulinemia short stature due to isolated growth hormone deficiency with X-linked hypogammaglobulinemia GenCC
Dental caries Dental caries GWAS
Associations from Text Mining
Disease Name Relationship Type References
Carcinogenesis Associate 19457610
Carcinoma Hepatocellular Associate 32170761
Cholangiocarcinoma Associate 36158120
Colorectal Neoplasms Associate 36923538
Delirium Associate 29991314
Familial Mediterranean Fever Associate 9152834
Glioblastoma Associate 35862252
Glioma Associate 35862252
Hereditary Autoinflammatory Diseases Associate 36263058
Inflammation Associate 37942546