Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	199699
Gene name	DAN domain BMP antagonist family member 5
Gene symbol	DAND5
Synonyms (NCBI Gene)	CER2CERL2CKTSF1B3COCOCRL2DANTEGREM3HTX13SP1
Chromosome	19
Chromosome location	19p13.13
Summary	This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene bel

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miRTarBase ID	miRNA	Experiments	Reference
MIRT704383	hsa-miR-508-5p	HITS-CLIP	23313552
MIRT704382	hsa-miR-25-3p	HITS-CLIP	23313552
MIRT704381	hsa-miR-32-5p	HITS-CLIP	23313552
MIRT704380	hsa-miR-363-3p	HITS-CLIP	23313552
MIRT704379	hsa-miR-367-3p	HITS-CLIP	23313552
MIRT704378	hsa-miR-92a-3p	HITS-CLIP	23313552
MIRT704377	hsa-miR-92b-3p	HITS-CLIP	23313552
MIRT704376	hsa-miR-6849-3p	HITS-CLIP	23313552
MIRT704375	hsa-miR-6742-3p	HITS-CLIP	23313552
MIRT704374	hsa-miR-766-3p	HITS-CLIP	23313552
MIRT704373	hsa-miR-6776-5p	HITS-CLIP	23313552
MIRT704372	hsa-miR-661	HITS-CLIP	23313552
MIRT704371	hsa-miR-542-3p	HITS-CLIP	23313552
MIRT704370	hsa-miR-6512-3p	HITS-CLIP	23313552
MIRT704369	hsa-miR-6720-5p	HITS-CLIP	23313552
MIRT704368	hsa-miR-7703	HITS-CLIP	23313552
MIRT704367	hsa-miR-4325	HITS-CLIP	23313552
MIRT704366	hsa-miR-1262	HITS-CLIP	23313552
MIRT704365	hsa-miR-4701-3p	HITS-CLIP	23313552
MIRT704364	hsa-miR-6736-5p	HITS-CLIP	23313552
MIRT704383	hsa-miR-508-5p	HITS-CLIP	23313552
MIRT704382	hsa-miR-25-3p	HITS-CLIP	23313552
MIRT704381	hsa-miR-32-5p	HITS-CLIP	23313552
MIRT704380	hsa-miR-363-3p	HITS-CLIP	23313552
MIRT704379	hsa-miR-367-3p	HITS-CLIP	23313552
MIRT704378	hsa-miR-92a-3p	HITS-CLIP	23313552
MIRT704377	hsa-miR-92b-3p	HITS-CLIP	23313552
MIRT704376	hsa-miR-6849-3p	HITS-CLIP	23313552
MIRT704375	hsa-miR-6742-3p	HITS-CLIP	23313552
MIRT704374	hsa-miR-766-3p	HITS-CLIP	23313552
MIRT704373	hsa-miR-6776-5p	HITS-CLIP	23313552
MIRT704372	hsa-miR-661	HITS-CLIP	23313552
MIRT704371	hsa-miR-542-3p	HITS-CLIP	23313552
MIRT704370	hsa-miR-6512-3p	HITS-CLIP	23313552
MIRT704369	hsa-miR-6720-5p	HITS-CLIP	23313552
MIRT704368	hsa-miR-7703	HITS-CLIP	23313552
MIRT704367	hsa-miR-4325	HITS-CLIP	23313552
MIRT704366	hsa-miR-1262	HITS-CLIP	23313552
MIRT704365	hsa-miR-4701-3p	HITS-CLIP	23313552
MIRT704364	hsa-miR-6736-5p	HITS-CLIP	23313552
MIRT923002	hsa-miR-10a	CLIP-seq
MIRT923003	hsa-miR-10b	CLIP-seq
MIRT923004	hsa-miR-1273	CLIP-seq
MIRT923005	hsa-miR-1290	CLIP-seq
MIRT923006	hsa-miR-1908	CLIP-seq
MIRT923007	hsa-miR-2114	CLIP-seq
MIRT923008	hsa-miR-219-1-3p	CLIP-seq
MIRT923009	hsa-miR-25	CLIP-seq
MIRT923010	hsa-miR-3122	CLIP-seq
MIRT923011	hsa-miR-3160-3p	CLIP-seq
MIRT923012	hsa-miR-3167	CLIP-seq
MIRT923013	hsa-miR-3174	CLIP-seq
MIRT923014	hsa-miR-3190	CLIP-seq
MIRT923015	hsa-miR-32	CLIP-seq
MIRT923016	hsa-miR-339-5p	CLIP-seq
MIRT923017	hsa-miR-3609	CLIP-seq
MIRT923018	hsa-miR-3613-3p	CLIP-seq
MIRT923019	hsa-miR-363	CLIP-seq
MIRT923020	hsa-miR-3656	CLIP-seq
MIRT923021	hsa-miR-3664-3p	CLIP-seq
MIRT923022	hsa-miR-367	CLIP-seq
MIRT923023	hsa-miR-3689a-3p	CLIP-seq
MIRT923024	hsa-miR-3689c	CLIP-seq
MIRT923025	hsa-miR-3689d	CLIP-seq
MIRT923026	hsa-miR-371-5p	CLIP-seq
MIRT923027	hsa-miR-371b-5p	CLIP-seq
MIRT923028	hsa-miR-3913-5p	CLIP-seq
MIRT923029	hsa-miR-3929	CLIP-seq
MIRT923030	hsa-miR-4252	CLIP-seq
MIRT923031	hsa-miR-4327	CLIP-seq
MIRT923032	hsa-miR-4329	CLIP-seq
MIRT923033	hsa-miR-4419b	CLIP-seq
MIRT923034	hsa-miR-4421	CLIP-seq
MIRT923035	hsa-miR-4433	CLIP-seq
MIRT923036	hsa-miR-4459	CLIP-seq
MIRT923037	hsa-miR-4478	CLIP-seq
MIRT923038	hsa-miR-4486	CLIP-seq
MIRT923039	hsa-miR-4487	CLIP-seq
MIRT923040	hsa-miR-4633-3p	CLIP-seq
MIRT923041	hsa-miR-4649-5p	CLIP-seq
MIRT923042	hsa-miR-4670-3p	CLIP-seq
MIRT923043	hsa-miR-4695-5p	CLIP-seq
MIRT923044	hsa-miR-4728-5p	CLIP-seq
MIRT923045	hsa-miR-4730	CLIP-seq
MIRT923046	hsa-miR-4768-3p	CLIP-seq
MIRT923047	hsa-miR-4793-3p	CLIP-seq
MIRT923048	hsa-miR-485-5p	CLIP-seq
MIRT923049	hsa-miR-510	CLIP-seq
MIRT923050	hsa-miR-511	CLIP-seq
MIRT923051	hsa-miR-512-5p	CLIP-seq
MIRT923052	hsa-miR-548ah	CLIP-seq
MIRT923053	hsa-miR-548c-3p	CLIP-seq
MIRT923054	hsa-miR-548t	CLIP-seq
MIRT923055	hsa-miR-550a	CLIP-seq
MIRT923056	hsa-miR-558	CLIP-seq
MIRT923057	hsa-miR-571	CLIP-seq
MIRT923058	hsa-miR-582-5p	CLIP-seq
MIRT923059	hsa-miR-640	CLIP-seq
MIRT923060	hsa-miR-663	CLIP-seq
MIRT923061	hsa-miR-766	CLIP-seq
MIRT923062	hsa-miR-876-5p	CLIP-seq
MIRT923063	hsa-miR-92a	CLIP-seq
MIRT923064	hsa-miR-92b	CLIP-seq
MIRT923004	hsa-miR-1273	CLIP-seq
MIRT923006	hsa-miR-1908	CLIP-seq
MIRT923007	hsa-miR-2114	CLIP-seq
MIRT923009	hsa-miR-25	CLIP-seq
MIRT923010	hsa-miR-3122	CLIP-seq
MIRT923011	hsa-miR-3160-3p	CLIP-seq
MIRT923014	hsa-miR-3190	CLIP-seq
MIRT923015	hsa-miR-32	CLIP-seq
MIRT1973455	hsa-miR-3618	CLIP-seq
MIRT1973456	hsa-miR-3622a-3p	CLIP-seq
MIRT1973457	hsa-miR-3622b-3p	CLIP-seq
MIRT923019	hsa-miR-363	CLIP-seq
MIRT923020	hsa-miR-3656	CLIP-seq
MIRT1973458	hsa-miR-3664-5p	CLIP-seq
MIRT923022	hsa-miR-367	CLIP-seq
MIRT1973459	hsa-miR-3672	CLIP-seq
MIRT923023	hsa-miR-3689a-3p	CLIP-seq
MIRT923024	hsa-miR-3689c	CLIP-seq
MIRT923028	hsa-miR-3913-5p	CLIP-seq
MIRT1973460	hsa-miR-3976	CLIP-seq
MIRT923030	hsa-miR-4252	CLIP-seq
MIRT923035	hsa-miR-4433	CLIP-seq
MIRT923036	hsa-miR-4459	CLIP-seq
MIRT923038	hsa-miR-4486	CLIP-seq
MIRT923039	hsa-miR-4487	CLIP-seq
MIRT1973461	hsa-miR-4522	CLIP-seq
MIRT1973462	hsa-miR-4649-3p	CLIP-seq
MIRT923041	hsa-miR-4649-5p	CLIP-seq
MIRT1973463	hsa-miR-4711-3p	CLIP-seq
MIRT923044	hsa-miR-4728-5p	CLIP-seq
MIRT923046	hsa-miR-4768-3p	CLIP-seq
MIRT1973464	hsa-miR-4786-5p	CLIP-seq
MIRT923047	hsa-miR-4793-3p	CLIP-seq
MIRT1973465	hsa-miR-4793-5p	CLIP-seq
MIRT1973466	hsa-miR-4794	CLIP-seq
MIRT923050	hsa-miR-511	CLIP-seq
MIRT1973467	hsa-miR-541	CLIP-seq
MIRT1973468	hsa-miR-544b	CLIP-seq
MIRT923055	hsa-miR-550a	CLIP-seq
MIRT923056	hsa-miR-558	CLIP-seq
MIRT923059	hsa-miR-640	CLIP-seq
MIRT1973469	hsa-miR-654-5p	CLIP-seq
MIRT923060	hsa-miR-663	CLIP-seq
MIRT1973470	hsa-miR-665	CLIP-seq
MIRT923061	hsa-miR-766	CLIP-seq
MIRT923063	hsa-miR-92a	CLIP-seq
MIRT923064	hsa-miR-92b	CLIP-seq
MIRT1973471	hsa-miR-934	CLIP-seq
MIRT1973472	hsa-miR-940	CLIP-seq
MIRT923004	hsa-miR-1273	CLIP-seq
MIRT2209026	hsa-miR-1285	CLIP-seq
MIRT2209027	hsa-miR-1293	CLIP-seq
MIRT923006	hsa-miR-1908	CLIP-seq
MIRT923007	hsa-miR-2114	CLIP-seq
MIRT923009	hsa-miR-25	CLIP-seq
MIRT2209028	hsa-miR-3151	CLIP-seq
MIRT2209029	hsa-miR-3187-5p	CLIP-seq
MIRT923015	hsa-miR-32	CLIP-seq
MIRT1973456	hsa-miR-3622a-3p	CLIP-seq
MIRT1973457	hsa-miR-3622b-3p	CLIP-seq
MIRT2209030	hsa-miR-3622b-5p	CLIP-seq
MIRT923019	hsa-miR-363	CLIP-seq
MIRT923020	hsa-miR-3656	CLIP-seq
MIRT1973458	hsa-miR-3664-5p	CLIP-seq
MIRT923022	hsa-miR-367	CLIP-seq
MIRT2209031	hsa-miR-3714	CLIP-seq
MIRT923029	hsa-miR-3929	CLIP-seq
MIRT2209032	hsa-miR-3945	CLIP-seq
MIRT1973460	hsa-miR-3976	CLIP-seq
MIRT923030	hsa-miR-4252	CLIP-seq
MIRT2209033	hsa-miR-4253	CLIP-seq
MIRT923032	hsa-miR-4329	CLIP-seq
MIRT923033	hsa-miR-4419b	CLIP-seq
MIRT923035	hsa-miR-4433	CLIP-seq
MIRT923036	hsa-miR-4459	CLIP-seq
MIRT923037	hsa-miR-4478	CLIP-seq
MIRT2209034	hsa-miR-4483	CLIP-seq
MIRT923038	hsa-miR-4486	CLIP-seq
MIRT2209035	hsa-miR-4514	CLIP-seq
MIRT2209036	hsa-miR-4517	CLIP-seq
MIRT2209037	hsa-miR-4529-5p	CLIP-seq
MIRT1973462	hsa-miR-4649-3p	CLIP-seq
MIRT923041	hsa-miR-4649-5p	CLIP-seq
MIRT2209038	hsa-miR-4692	CLIP-seq
MIRT2209039	hsa-miR-4755-3p	CLIP-seq
MIRT923046	hsa-miR-4768-3p	CLIP-seq
MIRT1973464	hsa-miR-4786-5p	CLIP-seq
MIRT923047	hsa-miR-4793-3p	CLIP-seq
MIRT1973465	hsa-miR-4793-5p	CLIP-seq
MIRT923048	hsa-miR-485-5p	CLIP-seq
MIRT1973468	hsa-miR-544b	CLIP-seq
MIRT923055	hsa-miR-550a	CLIP-seq
MIRT2209040	hsa-miR-612	CLIP-seq
MIRT923060	hsa-miR-663	CLIP-seq
MIRT1973470	hsa-miR-665	CLIP-seq
MIRT923061	hsa-miR-766	CLIP-seq
MIRT923063	hsa-miR-92a	CLIP-seq
MIRT923064	hsa-miR-92b	CLIP-seq
MIRT1973472	hsa-miR-940	CLIP-seq
MIRT2209026	hsa-miR-1285	CLIP-seq
MIRT2448023	hsa-miR-3120-5p	CLIP-seq
MIRT2209029	hsa-miR-3187-5p	CLIP-seq
MIRT2209030	hsa-miR-3622b-5p	CLIP-seq
MIRT1973458	hsa-miR-3664-5p	CLIP-seq
MIRT2209032	hsa-miR-3945	CLIP-seq
MIRT2209033	hsa-miR-4253	CLIP-seq
MIRT2448024	hsa-miR-4684-5p	CLIP-seq
MIRT2448025	hsa-miR-4738-3p	CLIP-seq
MIRT923053	hsa-miR-548c-3p	CLIP-seq
MIRT2448026	hsa-miR-593	CLIP-seq
MIRT2209040	hsa-miR-612	CLIP-seq
MIRT923002	hsa-miR-10a	CLIP-seq
MIRT923003	hsa-miR-10b	CLIP-seq
MIRT923004	hsa-miR-1273	CLIP-seq
MIRT2209026	hsa-miR-1285	CLIP-seq
MIRT923006	hsa-miR-1908	CLIP-seq
MIRT2448023	hsa-miR-3120-5p	CLIP-seq
MIRT2209029	hsa-miR-3187-5p	CLIP-seq
MIRT923016	hsa-miR-339-5p	CLIP-seq
MIRT923018	hsa-miR-3613-3p	CLIP-seq
MIRT2209030	hsa-miR-3622b-5p	CLIP-seq
MIRT923020	hsa-miR-3656	CLIP-seq
MIRT1973458	hsa-miR-3664-5p	CLIP-seq
MIRT923026	hsa-miR-371-5p	CLIP-seq
MIRT923027	hsa-miR-371b-5p	CLIP-seq
MIRT2209032	hsa-miR-3945	CLIP-seq
MIRT923030	hsa-miR-4252	CLIP-seq
MIRT2209033	hsa-miR-4253	CLIP-seq
MIRT923034	hsa-miR-4421	CLIP-seq
MIRT923038	hsa-miR-4486	CLIP-seq
MIRT2209036	hsa-miR-4517	CLIP-seq
MIRT923041	hsa-miR-4649-5p	CLIP-seq
MIRT2448024	hsa-miR-4684-5p	CLIP-seq
MIRT2448025	hsa-miR-4738-3p	CLIP-seq
MIRT923047	hsa-miR-4793-3p	CLIP-seq
MIRT923050	hsa-miR-511	CLIP-seq
MIRT923053	hsa-miR-548c-3p	CLIP-seq
MIRT923055	hsa-miR-550a	CLIP-seq
MIRT2448026	hsa-miR-593	CLIP-seq
MIRT2209040	hsa-miR-612	CLIP-seq
MIRT923060	hsa-miR-663	CLIP-seq
MIRT923061	hsa-miR-766	CLIP-seq
MIRT923002	hsa-miR-10a	CLIP-seq
MIRT923003	hsa-miR-10b	CLIP-seq
MIRT923004	hsa-miR-1273	CLIP-seq
MIRT2209026	hsa-miR-1285	CLIP-seq
MIRT923006	hsa-miR-1908	CLIP-seq
MIRT2448023	hsa-miR-3120-5p	CLIP-seq
MIRT2209029	hsa-miR-3187-5p	CLIP-seq
MIRT923016	hsa-miR-339-5p	CLIP-seq
MIRT923018	hsa-miR-3613-3p	CLIP-seq
MIRT2209030	hsa-miR-3622b-5p	CLIP-seq
MIRT923020	hsa-miR-3656	CLIP-seq
MIRT1973458	hsa-miR-3664-5p	CLIP-seq
MIRT923026	hsa-miR-371-5p	CLIP-seq
MIRT923027	hsa-miR-371b-5p	CLIP-seq
MIRT2209032	hsa-miR-3945	CLIP-seq
MIRT923030	hsa-miR-4252	CLIP-seq
MIRT2209033	hsa-miR-4253	CLIP-seq
MIRT923034	hsa-miR-4421	CLIP-seq
MIRT923038	hsa-miR-4486	CLIP-seq
MIRT2209036	hsa-miR-4517	CLIP-seq
MIRT923041	hsa-miR-4649-5p	CLIP-seq
MIRT2448024	hsa-miR-4684-5p	CLIP-seq
MIRT2448025	hsa-miR-4738-3p	CLIP-seq
MIRT923047	hsa-miR-4793-3p	CLIP-seq
MIRT923050	hsa-miR-511	CLIP-seq
MIRT923053	hsa-miR-548c-3p	CLIP-seq
MIRT923055	hsa-miR-550a	CLIP-seq
MIRT2448026	hsa-miR-593	CLIP-seq
MIRT2209040	hsa-miR-612	CLIP-seq
MIRT923060	hsa-miR-663	CLIP-seq
MIRT923061	hsa-miR-766	CLIP-seq

Show/Hide all (31)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003140	Process	Determination of left/right asymmetry in lateral mesoderm	IEA
GO:0003140	Process	Determination of left/right asymmetry in lateral mesoderm	ISS
GO:0003140	Process	Determination of left/right asymmetry in lateral mesoderm	NAS	17507406
GO:0003281	Process	Ventricular septum development	IEA
GO:0003281	Process	Ventricular septum development	ISS
GO:0003283	Process	Atrial septum development	IEA
GO:0003283	Process	Atrial septum development	ISS
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	NAS	15466485
GO:0005615	Component	Extracellular space	IBA
GO:0007368	Process	Determination of left/right symmetry	IEA
GO:0007368	Process	Determination of left/right symmetry	ISS
GO:0009966	Process	Regulation of signal transduction	IEA
GO:0016015	Function	Morphogen activity	IBA
GO:0016015	Function	Morphogen activity	IEA
GO:0016015	Function	Morphogen activity	ISS
GO:0017015	Process	Regulation of transforming growth factor beta receptor signaling pathway	IEA
GO:0023019	Process	Signal transduction involved in regulation of gene expression	IBA
GO:0030512	Process	Negative regulation of transforming growth factor beta receptor signaling pathway	IEA
GO:0030512	Process	Negative regulation of transforming growth factor beta receptor signaling pathway	ISS
GO:0030514	Process	Negative regulation of BMP signaling pathway	IEA
GO:0030514	Process	Negative regulation of BMP signaling pathway	ISS
GO:0035582	Process	Sequestering of BMP in extracellular matrix	IBA
GO:0038092	Process	Nodal signaling pathway	NAS	17507406
GO:0038101	Process	Sequestering of nodal from receptor via nodal binding	IEA
GO:0038101	Process	Sequestering of nodal from receptor via nodal binding	ISS
GO:0061371	Process	Determination of heart left/right asymmetry	IBA
GO:0061371	Process	Determination of heart left/right asymmetry	IEA
GO:0061371	Process	Determination of heart left/right asymmetry	ISS
GO:1900108	Process	Negative regulation of nodal signaling pathway	IEA
GO:1900108	Process	Negative regulation of nodal signaling pathway	ISS

MIM	HGNC	e!Ensembl
609068	26780	ENSG00000179284

Q8N907

Protein name

DAN domain family member 5 (Cerberus-like protein 2) (Cerl-2) (Cysteine knot superfamily 1, BMP antagonist 3) (Gremlin-3)

Protein function

Antagonist of the extracellular signaling protein NODAL, which is required for correct left-right patterning during embryonic development (By similarity). Antagonist of BMP and TGF-beta signaling (PubMed:33587337). Independently of its role in l

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03045	DAN	76 → 188	DAN domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in the retina, in inner segments of photoreceptors, at or close to the outer plexiform layer and in the ganglion cell layer (at protein level). {ECO:0000269|PubMed:33587337}.

Sequence

MLLGQLSTLLCLLSGALPTGSGRPEPQSPRPQSWAAANQTWALGPGALPPLVPASALGSW
KAFLGLQKARQLGMGRLQRGQDEVAAVTLPLNPQEVIQGMCKAVPFVQVFSRPGCSAIRL
RNHLCFGHCSSLYIPGSDPTPLVLCNSCMPARKRWAPVVLWCLTGSSASRRRVKISTMLI
EGCHCSPKA

Sequence length

189

Interactions

View interactions

Show/Hide Causal Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Heterotaxy	Likely pathogenic; Pathogenic	rs768842269	RCV001732154

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Heterotaxy, visceral, 13, autosomal	Uncertain significance	rs2512665729	RCV005051954

Show/Hide Text Mining Associations (12)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Breast Neoplasms	Associate	28990063
Cleft Lip	Associate	28230599
Heart Defects Congenital	Associate	28738792, 29136563
Heart Septal Defects Ventricular	Associate	28738792
Heterotaxy Syndrome	Associate	36316122
Hypertrophy Right Ventricular	Associate	28738792
Hypoxia Brain	Associate	37850636
Kidney Failure Chronic	Associate	30212930
Laterality Defects Autosomal Dominant	Associate	28738792, 29136563
Pulmonary Atresia	Associate	28738792
Tetralogy of Fallot	Associate	28738792
von Hippel Lindau Disease	Associate	34174286, 37850636

DAND5 (DAN domain BMP antagonist family member 5)