ELAVL1 (ELAV like RNA binding protein 1)

Gene

• Entrez ID: 1994
• Gene name: ELAV like RNA binding protein 1
• Gene symbol: ELAVL1
• Synonyms (NCBI Gene): ELAV1, HUR, Hua, MelG
• Chromosome: 19
• Chromosome location: 19p13.2
• Summary: The protein encoded by this gene is a member of the ELAVL family of RNA-binding proteins that contain several RNA recognition motifs, and selectively bind AU-rich elements (AREs) found in the 3` untranslated regions of mRNAs. AREs signal degradation of mR

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT003731	hsa-miR-519b-3p	qRT-PCR, Western blot	19088191
MIRT003731	hsa-miR-519b-3p	qRT-PCR, Western blot	19088191
MIRT003732	hsa-miR-519c-3p	qRT-PCR, Western blot	19088191
MIRT003732	hsa-miR-519c-3p	qRT-PCR, Western blot	19088191
MIRT003733	hsa-miR-519a-3p	qRT-PCR, Western blot	19088191
MIRT003733	hsa-miR-519a-3p	qRT-PCR, Western blot	19088191
MIRT003731	hsa-miR-519b-3p	Western blot	19088191
MIRT003731	hsa-miR-519b-3p	qRT-PCR	19088191
MIRT003732	hsa-miR-519c-3p	Western blot	19088191
MIRT003732	hsa-miR-519c-3p	qRT-PCR	19088191
MIRT003733	hsa-miR-519a-3p	Western blot	19088191
MIRT003733	hsa-miR-519a-3p	qRT-PCR	19088191
MIRT003731	hsa-miR-519b-3p	Western blot	19088191
MIRT003731	hsa-miR-519b-3p	qRT-PCR	19088191
MIRT003732	hsa-miR-519c-3p	Western blot	19088191
MIRT003732	hsa-miR-519c-3p	qRT-PCR	19088191
MIRT003733	hsa-miR-519a-3p	qRT-PCR, Western blot	19088191
MIRT003733	hsa-miR-519a-3p	qRT-PCR	19088191
MIRT005421	hsa-miR-125a-5p	Luciferase reporter assay, Western blot	19875930
MIRT019606	hsa-miR-340-5p	Sequencing	20371350
MIRT048754	hsa-miR-93-5p	CLASH	23622248
MIRT054041	hsa-miR-9-5p	Luciferase reporter assay, qRT-PCR, Western blot	22310293
MIRT054580	hsa-miR-146a-5p	Immunoprecipitation, Luciferase reporter assay, QRTPCR, Western blot	23733368
MIRT574799	hsa-miR-4668-3p	PAR-CLIP	20371350
MIRT574798	hsa-miR-3121-3p	PAR-CLIP	20371350
MIRT574797	hsa-miR-8063	PAR-CLIP	20371350
MIRT498257	hsa-miR-4694-3p	PAR-CLIP	22291592
MIRT498256	hsa-miR-224-3p	PAR-CLIP	22291592
MIRT498255	hsa-miR-522-3p	PAR-CLIP	22291592
MIRT498254	hsa-miR-3926	PAR-CLIP	22291592
MIRT498253	hsa-miR-548s	PAR-CLIP	22291592
MIRT441589	hsa-miR-4769-3p	PAR-CLIP	22100165
MIRT441588	hsa-miR-6817-5p	PAR-CLIP	22100165
MIRT440727	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT440727	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT731587	hsa-miR-296-5p	Luciferase reporter assay	26898797
MIRT731587	hsa-miR-296-5p	Luciferase reporter assay	26898797
MIRT731587	hsa-miR-296-5p	Luciferase reporter assay	26898797
MIRT054580	hsa-miR-146a-5p	Western blotting, RNA-seq, qRT-PCR	31425002
MIRT734817	hsa-miR-16-5p	Microarray	33530159
MIRT736017	hsa-miR-1246	Western blotting, qRT-PCR	31506750
MIRT574799	hsa-miR-4668-3p	PAR-CLIP	20371350
MIRT574798	hsa-miR-3121-3p	PAR-CLIP	20371350
MIRT574797	hsa-miR-8063	PAR-CLIP	20371350
MIRT498257	hsa-miR-4694-3p	PAR-CLIP	22291592
MIRT498256	hsa-miR-224-3p	PAR-CLIP	22291592
MIRT498255	hsa-miR-522-3p	PAR-CLIP	22291592
MIRT498254	hsa-miR-3926	PAR-CLIP	22291592
MIRT498253	hsa-miR-548s	PAR-CLIP	22291592
MIRT441589	hsa-miR-4769-3p	PAR-CLIP	22100165
MIRT441588	hsa-miR-6817-5p	PAR-CLIP	22100165
MIRT959677	hsa-miR-1200	CLIP-seq
MIRT959678	hsa-miR-1254	CLIP-seq
MIRT959679	hsa-miR-1273e	CLIP-seq
MIRT959680	hsa-miR-1304	CLIP-seq
MIRT959681	hsa-miR-145	CLIP-seq
MIRT959682	hsa-miR-147	CLIP-seq
MIRT959683	hsa-miR-150	CLIP-seq
MIRT959684	hsa-miR-15a	CLIP-seq
MIRT959685	hsa-miR-15b	CLIP-seq
MIRT959686	hsa-miR-16	CLIP-seq
MIRT959687	hsa-miR-1827	CLIP-seq
MIRT959688	hsa-miR-1910	CLIP-seq
MIRT959689	hsa-miR-195	CLIP-seq
MIRT959690	hsa-miR-2110	CLIP-seq
MIRT959691	hsa-miR-300	CLIP-seq
MIRT959692	hsa-miR-3116	CLIP-seq
MIRT959693	hsa-miR-3140-3p	CLIP-seq
MIRT959694	hsa-miR-3140-5p	CLIP-seq
MIRT959695	hsa-miR-3143	CLIP-seq
MIRT959696	hsa-miR-3148	CLIP-seq
MIRT959697	hsa-miR-3152-3p	CLIP-seq
MIRT959698	hsa-miR-3154	CLIP-seq
MIRT959699	hsa-miR-3168	CLIP-seq
MIRT959700	hsa-miR-3199	CLIP-seq
MIRT959701	hsa-miR-3545-3p	CLIP-seq
MIRT959702	hsa-miR-3611	CLIP-seq
MIRT959703	hsa-miR-3613-3p	CLIP-seq
MIRT959704	hsa-miR-3647-3p	CLIP-seq
MIRT959705	hsa-miR-3649	CLIP-seq
MIRT959706	hsa-miR-3672	CLIP-seq
MIRT959707	hsa-miR-3688-5p	CLIP-seq
MIRT959708	hsa-miR-3689a-3p	CLIP-seq
MIRT959709	hsa-miR-3689c	CLIP-seq
MIRT959710	hsa-miR-3689d	CLIP-seq
MIRT959711	hsa-miR-3714	CLIP-seq
MIRT959712	hsa-miR-378g	CLIP-seq
MIRT959713	hsa-miR-381	CLIP-seq
MIRT959714	hsa-miR-3911	CLIP-seq
MIRT959715	hsa-miR-3922-5p	CLIP-seq
MIRT959716	hsa-miR-3940-3p	CLIP-seq
MIRT959717	hsa-miR-3945	CLIP-seq
MIRT959718	hsa-miR-424	CLIP-seq
MIRT959719	hsa-miR-4251	CLIP-seq
MIRT959720	hsa-miR-4253	CLIP-seq
MIRT959721	hsa-miR-4271	CLIP-seq
MIRT959722	hsa-miR-4277	CLIP-seq
MIRT959723	hsa-miR-4326	CLIP-seq
MIRT959724	hsa-miR-4421	CLIP-seq
MIRT959725	hsa-miR-4426	CLIP-seq
MIRT959726	hsa-miR-4450	CLIP-seq
MIRT959727	hsa-miR-4459	CLIP-seq
MIRT959728	hsa-miR-4468	CLIP-seq
MIRT959729	hsa-miR-4539	CLIP-seq
MIRT959730	hsa-miR-455-3p	CLIP-seq
MIRT959731	hsa-miR-4647	CLIP-seq
MIRT959732	hsa-miR-4648	CLIP-seq
MIRT959733	hsa-miR-4652-3p	CLIP-seq
MIRT959734	hsa-miR-4654	CLIP-seq
MIRT959735	hsa-miR-4662b	CLIP-seq
MIRT959736	hsa-miR-4666-3p	CLIP-seq
MIRT959737	hsa-miR-4667-5p	CLIP-seq
MIRT959738	hsa-miR-4698	CLIP-seq
MIRT959739	hsa-miR-4700-5p	CLIP-seq
MIRT959740	hsa-miR-4722-5p	CLIP-seq
MIRT959741	hsa-miR-4725-3p	CLIP-seq
MIRT959742	hsa-miR-4728-5p	CLIP-seq
MIRT959743	hsa-miR-4740-5p	CLIP-seq
MIRT959744	hsa-miR-4760-5p	CLIP-seq
MIRT959745	hsa-miR-4765	CLIP-seq
MIRT959746	hsa-miR-4769-5p	CLIP-seq
MIRT959747	hsa-miR-4773	CLIP-seq
MIRT959748	hsa-miR-4803	CLIP-seq
MIRT959749	hsa-miR-492	CLIP-seq
MIRT959750	hsa-miR-497	CLIP-seq
MIRT959751	hsa-miR-505	CLIP-seq
MIRT959752	hsa-miR-509-3p	CLIP-seq
MIRT959753	hsa-miR-518e	CLIP-seq
MIRT959754	hsa-miR-539	CLIP-seq
MIRT959755	hsa-miR-548p	CLIP-seq
MIRT959756	hsa-miR-550a	CLIP-seq
MIRT959757	hsa-miR-580	CLIP-seq
MIRT959758	hsa-miR-637	CLIP-seq
MIRT959759	hsa-miR-644	CLIP-seq
MIRT959760	hsa-miR-661	CLIP-seq
MIRT959761	hsa-miR-875-3p	CLIP-seq
MIRT959762	hsa-miR-877	CLIP-seq
MIRT959763	hsa-miR-889	CLIP-seq
MIRT1984280	hsa-miR-1178	CLIP-seq
MIRT1984281	hsa-miR-1206	CLIP-seq
MIRT1984282	hsa-miR-1229	CLIP-seq
MIRT1984283	hsa-miR-1243	CLIP-seq
MIRT959678	hsa-miR-1254	CLIP-seq
MIRT1984284	hsa-miR-1299	CLIP-seq
MIRT1984285	hsa-miR-133a	CLIP-seq
MIRT1984286	hsa-miR-133b	CLIP-seq
MIRT1984287	hsa-miR-137	CLIP-seq
MIRT959682	hsa-miR-147	CLIP-seq
MIRT1984288	hsa-miR-197	CLIP-seq
MIRT959692	hsa-miR-3116	CLIP-seq
MIRT959696	hsa-miR-3148	CLIP-seq
MIRT959697	hsa-miR-3152-3p	CLIP-seq
MIRT1984289	hsa-miR-3194-3p	CLIP-seq
MIRT1984290	hsa-miR-330-3p	CLIP-seq
MIRT1984291	hsa-miR-345	CLIP-seq
MIRT959703	hsa-miR-3613-3p	CLIP-seq
MIRT959704	hsa-miR-3647-3p	CLIP-seq
MIRT959705	hsa-miR-3649	CLIP-seq
MIRT1984292	hsa-miR-3654	CLIP-seq
MIRT1984293	hsa-miR-3659	CLIP-seq
MIRT959707	hsa-miR-3688-5p	CLIP-seq
MIRT959710	hsa-miR-3689d	CLIP-seq
MIRT1984294	hsa-miR-377	CLIP-seq
MIRT959714	hsa-miR-3911	CLIP-seq
MIRT1984295	hsa-miR-3937	CLIP-seq
MIRT1984296	hsa-miR-3977	CLIP-seq
MIRT1984297	hsa-miR-4254	CLIP-seq
MIRT1984298	hsa-miR-4255	CLIP-seq
MIRT959724	hsa-miR-4421	CLIP-seq
MIRT1984299	hsa-miR-4422	CLIP-seq
MIRT959727	hsa-miR-4459	CLIP-seq
MIRT959728	hsa-miR-4468	CLIP-seq
MIRT1984300	hsa-miR-4522	CLIP-seq
MIRT1984301	hsa-miR-4633-3p	CLIP-seq
MIRT959733	hsa-miR-4652-3p	CLIP-seq
MIRT1984302	hsa-miR-4653-3p	CLIP-seq
MIRT1984303	hsa-miR-4658	CLIP-seq
MIRT1984304	hsa-miR-4663	CLIP-seq
MIRT959738	hsa-miR-4698	CLIP-seq
MIRT1984305	hsa-miR-4712-3p	CLIP-seq
MIRT959740	hsa-miR-4722-5p	CLIP-seq
MIRT1984306	hsa-miR-4734	CLIP-seq
MIRT1984307	hsa-miR-4753-3p	CLIP-seq
MIRT1984308	hsa-miR-4767	CLIP-seq
MIRT1984309	hsa-miR-485-3p	CLIP-seq
MIRT959749	hsa-miR-492	CLIP-seq
MIRT959751	hsa-miR-505	CLIP-seq
MIRT959754	hsa-miR-539	CLIP-seq
MIRT1984310	hsa-miR-544	CLIP-seq
MIRT1984311	hsa-miR-548ac	CLIP-seq
MIRT1984312	hsa-miR-548ae	CLIP-seq
MIRT1984313	hsa-miR-548aj	CLIP-seq
MIRT1984314	hsa-miR-548am	CLIP-seq
MIRT1984315	hsa-miR-548d-3p	CLIP-seq
MIRT959755	hsa-miR-548p	CLIP-seq
MIRT1984316	hsa-miR-548x	CLIP-seq
MIRT1984317	hsa-miR-548z	CLIP-seq
MIRT959756	hsa-miR-550a	CLIP-seq
MIRT1984318	hsa-miR-561	CLIP-seq
MIRT1984319	hsa-miR-574-5p	CLIP-seq
MIRT959757	hsa-miR-580	CLIP-seq
MIRT1984320	hsa-miR-603	CLIP-seq
MIRT959759	hsa-miR-644	CLIP-seq
MIRT959760	hsa-miR-661	CLIP-seq
MIRT1984321	hsa-miR-758	CLIP-seq
MIRT1984322	hsa-miR-759	CLIP-seq
MIRT959761	hsa-miR-875-3p	CLIP-seq
MIRT959680	hsa-miR-1304	CLIP-seq
MIRT2219403	hsa-miR-1305	CLIP-seq
MIRT1984288	hsa-miR-197	CLIP-seq
MIRT2219404	hsa-miR-219-1-3p	CLIP-seq
MIRT2219405	hsa-miR-2278	CLIP-seq
MIRT2219406	hsa-miR-3126-5p	CLIP-seq
MIRT2219407	hsa-miR-3133	CLIP-seq
MIRT959699	hsa-miR-3168	CLIP-seq
MIRT959700	hsa-miR-3199	CLIP-seq
MIRT2219408	hsa-miR-324-5p	CLIP-seq
MIRT1984290	hsa-miR-330-3p	CLIP-seq
MIRT2219409	hsa-miR-342-5p	CLIP-seq
MIRT2219410	hsa-miR-3613-5p	CLIP-seq
MIRT2219411	hsa-miR-3662	CLIP-seq
MIRT1984294	hsa-miR-377	CLIP-seq
MIRT959722	hsa-miR-4277	CLIP-seq
MIRT959724	hsa-miR-4421	CLIP-seq
MIRT1984299	hsa-miR-4422	CLIP-seq
MIRT2219412	hsa-miR-4515	CLIP-seq
MIRT2219413	hsa-miR-4520a-3p	CLIP-seq
MIRT2219414	hsa-miR-4520b-3p	CLIP-seq
MIRT2219415	hsa-miR-4529-3p	CLIP-seq
MIRT2219416	hsa-miR-4651	CLIP-seq
MIRT2219417	hsa-miR-4664-5p	CLIP-seq
MIRT959738	hsa-miR-4698	CLIP-seq
MIRT2219418	hsa-miR-4704-5p	CLIP-seq
MIRT959751	hsa-miR-505	CLIP-seq
MIRT2219419	hsa-miR-520a-5p	CLIP-seq
MIRT2219420	hsa-miR-525-5p	CLIP-seq
MIRT2219421	hsa-miR-571	CLIP-seq
MIRT2219422	hsa-miR-577	CLIP-seq
MIRT2219423	hsa-miR-579	CLIP-seq
MIRT2219424	hsa-miR-608	CLIP-seq
MIRT2219425	hsa-miR-653	CLIP-seq
MIRT2219426	hsa-miR-664	CLIP-seq
MIRT2219406	hsa-miR-3126-5p	CLIP-seq
MIRT2219409	hsa-miR-342-5p	CLIP-seq
MIRT2219416	hsa-miR-4651	CLIP-seq
MIRT2219417	hsa-miR-4664-5p	CLIP-seq
MIRT2219424	hsa-miR-608	CLIP-seq
MIRT1984281	hsa-miR-1206	CLIP-seq
MIRT959678	hsa-miR-1254	CLIP-seq
MIRT1984285	hsa-miR-133a	CLIP-seq
MIRT1984286	hsa-miR-133b	CLIP-seq
MIRT1984288	hsa-miR-197	CLIP-seq
MIRT2522713	hsa-miR-31	CLIP-seq
MIRT959692	hsa-miR-3116	CLIP-seq
MIRT2219406	hsa-miR-3126-5p	CLIP-seq
MIRT959697	hsa-miR-3152-3p	CLIP-seq
MIRT959699	hsa-miR-3168	CLIP-seq
MIRT959700	hsa-miR-3199	CLIP-seq
MIRT1984293	hsa-miR-3659	CLIP-seq
MIRT959712	hsa-miR-378g	CLIP-seq
MIRT1984296	hsa-miR-3977	CLIP-seq
MIRT1984298	hsa-miR-4255	CLIP-seq
MIRT959722	hsa-miR-4277	CLIP-seq
MIRT1984299	hsa-miR-4422	CLIP-seq
MIRT2219412	hsa-miR-4515	CLIP-seq
MIRT1984303	hsa-miR-4658	CLIP-seq
MIRT1984304	hsa-miR-4663	CLIP-seq
MIRT2522714	hsa-miR-4738-3p	CLIP-seq
MIRT1984309	hsa-miR-485-3p	CLIP-seq
MIRT2219419	hsa-miR-520a-5p	CLIP-seq
MIRT2219420	hsa-miR-525-5p	CLIP-seq
MIRT1984310	hsa-miR-544	CLIP-seq
MIRT959755	hsa-miR-548p	CLIP-seq
MIRT959756	hsa-miR-550a	CLIP-seq
MIRT1984319	hsa-miR-574-5p	CLIP-seq
MIRT959760	hsa-miR-661	CLIP-seq
MIRT1984322	hsa-miR-759	CLIP-seq
MIRT959762	hsa-miR-877	CLIP-seq
MIRT2522715	hsa-miR-9	CLIP-seq
MIRT1984281	hsa-miR-1206	CLIP-seq
MIRT2219403	hsa-miR-1305	CLIP-seq
MIRT2679886	hsa-miR-205	CLIP-seq
MIRT2522713	hsa-miR-31	CLIP-seq
MIRT2679887	hsa-miR-3144-5p	CLIP-seq
MIRT959697	hsa-miR-3152-3p	CLIP-seq
MIRT2679888	hsa-miR-3191	CLIP-seq
MIRT1984289	hsa-miR-3194-3p	CLIP-seq
MIRT2679889	hsa-miR-326	CLIP-seq
MIRT2679890	hsa-miR-330-5p	CLIP-seq
MIRT1984293	hsa-miR-3659	CLIP-seq
MIRT2679891	hsa-miR-3661	CLIP-seq
MIRT1984298	hsa-miR-4255	CLIP-seq
MIRT1984299	hsa-miR-4422	CLIP-seq
MIRT2679892	hsa-miR-4639-3p	CLIP-seq
MIRT2679893	hsa-miR-4652-5p	CLIP-seq
MIRT1984303	hsa-miR-4658	CLIP-seq
MIRT1984304	hsa-miR-4663	CLIP-seq
MIRT959737	hsa-miR-4667-5p	CLIP-seq
MIRT959739	hsa-miR-4700-5p	CLIP-seq
MIRT1984309	hsa-miR-485-3p	CLIP-seq
MIRT1984310	hsa-miR-544	CLIP-seq
MIRT1984319	hsa-miR-574-5p	CLIP-seq
MIRT2679894	hsa-miR-631	CLIP-seq
MIRT959758	hsa-miR-637	CLIP-seq
MIRT1984322	hsa-miR-759	CLIP-seq
MIRT959762	hsa-miR-877	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
ZFP36	Activation	15158469

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000512	Process	LncRNA-mediated post-transcriptional gene silencing	IEA
GO:0000932	Component	P-body	IEA
GO:0003676	Function	Nucleic acid binding	IEA
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003723	Function	RNA binding	IDA	19561594, 21613615
GO:0003723	Function	RNA binding	IEA
GO:0003725	Function	Double-stranded RNA binding	IDA	21266579
GO:0003729	Function	MRNA binding	IEA
GO:0003729	Function	MRNA binding	TAS	10660597
GO:0003730	Function	MRNA 3'-UTR binding	IDA	26595526
GO:0003730	Function	MRNA 3'-UTR binding	IEA
GO:0003730	Function	MRNA 3'-UTR binding	ISS
GO:0005515	Function	Protein binding	IPI	14731398, 17632515, 17932509, 18191643, 19322201, 25416956, 25959826, 26489465, 27616329, 27974568, 31358969, 32814053
GO:0005634	Component	Nucleus	IDA	14517288
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA	17632515
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IDA	14517288, 19029303
GO:0005737	Component	Cytoplasm	IEA
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005829	Component	Cytosol	IDA	17632515
GO:0005829	Component	Cytosol	TAS
GO:0006606	Process	Protein import into nucleus	IEA
GO:0008283	Process	Cell population proliferation	IEA
GO:0009749	Process	Response to glucose	IEA
GO:0010494	Component	Cytoplasmic stress granule	IEA
GO:0010494	Component	Cytoplasmic stress granule	ISS
GO:0010508	Process	Positive regulation of autophagy	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016441	Process	Post-transcriptional gene silencing	IEA
GO:0016528	Component	Sarcoplasm	IEA
GO:0019901	Function	Protein kinase binding	IEA
GO:0019901	Function	Protein kinase binding	IPI	14517288
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0032930	Process	Positive regulation of superoxide anion generation	IEA
GO:0035198	Function	MiRNA binding	IDA	26595526
GO:0035925	Function	MRNA 3'-UTR AU-rich region binding	IDA	8626503, 14517288, 14731398, 16126846, 23056314, 23519412, 26489465
GO:0035925	Function	MRNA 3'-UTR AU-rich region binding	IEA
GO:0042803	Function	Protein homodimerization activity	IPI	17632515
GO:0043488	Process	Regulation of mRNA stability	IEA
GO:0045727	Process	Positive regulation of translation	IDA	21613615
GO:0045727	Process	Positive regulation of translation	IEA
GO:0045772	Process	Positive regulation of autophagosome size	IEA
GO:0048255	Process	MRNA stabilization	IDA	21613615
GO:0048255	Process	MRNA stabilization	IDA	31358969
GO:0048255	Process	MRNA stabilization	IEA
GO:0048255	Process	MRNA stabilization	IMP	19029303
GO:0051260	Process	Protein homooligomerization	IDA	26595526
GO:0060965	Process	Negative regulation of miRNA-mediated gene silencing	IMP	26595526
GO:0061157	Process	MRNA destabilization	IEA
GO:0070935	Process	3'-UTR-mediated mRNA stabilization	IDA	14517288, 26489465, 29180010
GO:0070935	Process	3'-UTR-mediated mRNA stabilization	IEA
GO:0070935	Process	3'-UTR-mediated mRNA stabilization	IMP	19029303
GO:0098794	Component	Postsynapse	IEA
GO:0098978	Component	Glutamatergic synapse	IEA
GO:0106222	Function	LncRNA binding	IEA
GO:1990904	Component	Ribonucleoprotein complex	IEA
GO:1990904	Component	Ribonucleoprotein complex	ISS
GO:2000036	Process	Regulation of stem cell population maintenance	IEA
GO:2000036	Process	Regulation of stem cell population maintenance	ISS

Other IDs

• MIM: 603466
• HGNC: 3312
• e!Ensembl: ENSG00000066044

Protein

• UniProt ID: Q15717
• Protein name: ELAV-like protein 1 (Hu-antigen R) (HuR)
• Protein function: RNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability (PubMed:14517288, PubMed:18285462, PubMed:31358969). Involved in embryonic stem cell (ESC) differentiation: preferentially binds mRNAs that are not methyl
• PDB: 3HI9, 4ED5, 4EGL, 4FXV, 5SZW, 6G2K, 6GC5, 6GD1, 6GD2, 6GD3
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00076	RRM_1	22 → 92	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	Domain
  PF00076	RRM_1	108 → 176	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	Domain
  PF00076	RRM_1	246 → 316	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	Domain

• Tissue specificity: TISSUE SPECIFICITY: Ubiquitous. Detected in brain, liver, thymus and muscle. {ECO:0000269|PubMed:8626503}.
• Sequence:

  MSNGYEDHMAEDCRGDIGRTNLIVNYLPQNMTQDELRSLFSSIGEVESAKLIRDKVAGHS
  LGYGFVNYVTAKDAERAINTLNGLRLQSKTIKVSYARPSSEVIKDANLYISGLPRTMTQK
  DVEDMFSRFGRIINSRVLVDQTTGLSRGVAFIRFDKRSEAEEAITSFNGHKPPGSSEPIT
  VKFAANPNQNKNVALLSQLYHSPARRFGGPVHHQAQRFRFSPMGVDHMSGLSGVNVPGNA
  SSGWCIFIYNLGQDADEGILWQMFGPFGAVTNVKVIRDFNTNKCKGFGFVTMTNYEEAAM
  AIASLNGYRLGDKILQVSFKTNKSHK

• Sequence length: 326

Pathways

KEGG:

AMPK signaling pathway
IL-17 signaling pathway

Reactome:

HuR (ELAVL1) binds and stabilizes mRNA
mRNA Splicing - Major Pathway