Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	1984
Gene name	Eukaryotic translation initiation factor 5A
Gene symbol	EIF5A
Synonyms (NCBI Gene)	EIF-5AEIF5A1FABASeIF-4DeIF5AI
Chromosome	17
Chromosome location	17p13.1

345

Show/Hide all (345)

miRTarBase ID	miRNA	Experiments	Reference
MIRT050318	hsa-miR-25-3p	CLASH	23622248
MIRT048616	hsa-miR-99a-5p	CLASH	23622248
MIRT048525	hsa-miR-100-5p	CLASH	23622248
MIRT047232	hsa-miR-181b-5p	CLASH	23622248
MIRT042623	hsa-miR-423-3p	CLASH	23622248
MIRT039182	hsa-miR-769-5p	CLASH	23622248
MIRT038418	hsa-miR-296-3p	CLASH	23622248
MIRT037297	hsa-miR-877-5p	CLASH	23622248
MIRT544712	hsa-miR-548aa	PAR-CLIP	20371350
MIRT544711	hsa-miR-548ap-3p	PAR-CLIP	20371350
MIRT544710	hsa-miR-548t-3p	PAR-CLIP	20371350
MIRT197996	hsa-miR-548ad-3p	PAR-CLIP	20371350
MIRT197990	hsa-miR-424-3p	PAR-CLIP	20371350
MIRT544709	hsa-miR-4695-5p	PAR-CLIP	20371350
MIRT574800	hsa-miR-4779	PAR-CLIP	20371350
MIRT251658	hsa-miR-4267	PAR-CLIP	20371350
MIRT197991	hsa-miR-765	PAR-CLIP	20371350
MIRT197992	hsa-miR-1289	PAR-CLIP	20371350
MIRT544708	hsa-miR-8065	PAR-CLIP	20371350
MIRT197993	hsa-miR-4266	PAR-CLIP	20371350
MIRT197994	hsa-miR-3671	PAR-CLIP	20371350
MIRT544712	hsa-miR-548aa	PAR-CLIP	21572407
MIRT544711	hsa-miR-548ap-3p	PAR-CLIP	21572407
MIRT544710	hsa-miR-548t-3p	PAR-CLIP	21572407
MIRT197996	hsa-miR-548ad-3p	PAR-CLIP	21572407
MIRT197990	hsa-miR-424-3p	PAR-CLIP	21572407
MIRT544709	hsa-miR-4695-5p	PAR-CLIP	21572407
MIRT251658	hsa-miR-4267	PAR-CLIP	21572407
MIRT197991	hsa-miR-765	PAR-CLIP	21572407
MIRT197992	hsa-miR-1289	PAR-CLIP	21572407
MIRT544708	hsa-miR-8065	PAR-CLIP	21572407
MIRT197993	hsa-miR-4266	PAR-CLIP	21572407
MIRT197994	hsa-miR-3671	PAR-CLIP	21572407
MIRT544712	hsa-miR-548aa	PAR-CLIP	20371350
MIRT544711	hsa-miR-548ap-3p	PAR-CLIP	20371350
MIRT544710	hsa-miR-548t-3p	PAR-CLIP	20371350
MIRT197996	hsa-miR-548ad-3p	PAR-CLIP	20371350
MIRT197990	hsa-miR-424-3p	PAR-CLIP	20371350
MIRT544709	hsa-miR-4695-5p	PAR-CLIP	20371350
MIRT574800	hsa-miR-4779	PAR-CLIP	20371350
MIRT251658	hsa-miR-4267	PAR-CLIP	20371350
MIRT197991	hsa-miR-765	PAR-CLIP	20371350
MIRT197992	hsa-miR-1289	PAR-CLIP	20371350
MIRT544708	hsa-miR-8065	PAR-CLIP	20371350
MIRT197993	hsa-miR-4266	PAR-CLIP	20371350
MIRT197994	hsa-miR-3671	PAR-CLIP	20371350
MIRT544712	hsa-miR-548aa	PAR-CLIP	21572407
MIRT544711	hsa-miR-548ap-3p	PAR-CLIP	21572407
MIRT544710	hsa-miR-548t-3p	PAR-CLIP	21572407
MIRT197996	hsa-miR-548ad-3p	PAR-CLIP	21572407
MIRT197990	hsa-miR-424-3p	PAR-CLIP	21572407
MIRT544709	hsa-miR-4695-5p	PAR-CLIP	21572407
MIRT251658	hsa-miR-4267	PAR-CLIP	21572407
MIRT197991	hsa-miR-765	PAR-CLIP	21572407
MIRT197992	hsa-miR-1289	PAR-CLIP	21572407
MIRT544708	hsa-miR-8065	PAR-CLIP	21572407
MIRT197993	hsa-miR-4266	PAR-CLIP	21572407
MIRT197994	hsa-miR-3671	PAR-CLIP	21572407
MIRT959466	hsa-miR-1255b	CLIP-seq
MIRT959467	hsa-miR-1266	CLIP-seq
MIRT959468	hsa-miR-1267	CLIP-seq
MIRT959469	hsa-miR-1293	CLIP-seq
MIRT959470	hsa-miR-15a	CLIP-seq
MIRT959471	hsa-miR-15b	CLIP-seq
MIRT959472	hsa-miR-16	CLIP-seq
MIRT959473	hsa-miR-185	CLIP-seq
MIRT959474	hsa-miR-195	CLIP-seq
MIRT959475	hsa-miR-3065-3p	CLIP-seq
MIRT959476	hsa-miR-3127-3p	CLIP-seq
MIRT959477	hsa-miR-3147	CLIP-seq
MIRT959478	hsa-miR-3170	CLIP-seq
MIRT959479	hsa-miR-3202	CLIP-seq
MIRT959480	hsa-miR-342-5p	CLIP-seq
MIRT959481	hsa-miR-3907	CLIP-seq
MIRT959482	hsa-miR-424	CLIP-seq
MIRT959483	hsa-miR-4306	CLIP-seq
MIRT959484	hsa-miR-4425	CLIP-seq
MIRT959485	hsa-miR-4483	CLIP-seq
MIRT959486	hsa-miR-4488	CLIP-seq
MIRT959487	hsa-miR-4518	CLIP-seq
MIRT959488	hsa-miR-4640-3p	CLIP-seq
MIRT959489	hsa-miR-4641	CLIP-seq
MIRT959490	hsa-miR-4644	CLIP-seq
MIRT959491	hsa-miR-4651	CLIP-seq
MIRT959492	hsa-miR-4664-5p	CLIP-seq
MIRT959493	hsa-miR-4697-5p	CLIP-seq
MIRT959494	hsa-miR-4747-5p	CLIP-seq
MIRT959495	hsa-miR-495	CLIP-seq
MIRT959496	hsa-miR-497	CLIP-seq
MIRT959497	hsa-miR-542-5p	CLIP-seq
MIRT959498	hsa-miR-548ad	CLIP-seq
MIRT959499	hsa-miR-608	CLIP-seq
MIRT959500	hsa-miR-622	CLIP-seq
MIRT959501	hsa-miR-939	CLIP-seq
MIRT959502	hsa-miR-1236	CLIP-seq
MIRT959503	hsa-miR-1279	CLIP-seq
MIRT959504	hsa-miR-1470	CLIP-seq
MIRT959470	hsa-miR-15a	CLIP-seq
MIRT959471	hsa-miR-15b	CLIP-seq
MIRT959472	hsa-miR-16	CLIP-seq
MIRT959473	hsa-miR-185	CLIP-seq
MIRT959474	hsa-miR-195	CLIP-seq
MIRT959475	hsa-miR-3065-3p	CLIP-seq
MIRT959476	hsa-miR-3127-3p	CLIP-seq
MIRT959505	hsa-miR-3150b-3p	CLIP-seq
MIRT959479	hsa-miR-3202	CLIP-seq
MIRT959506	hsa-miR-3918	CLIP-seq
MIRT959482	hsa-miR-424	CLIP-seq
MIRT959507	hsa-miR-4279	CLIP-seq
MIRT959508	hsa-miR-4290	CLIP-seq
MIRT959483	hsa-miR-4306	CLIP-seq
MIRT959509	hsa-miR-4464	CLIP-seq
MIRT959486	hsa-miR-4488	CLIP-seq
MIRT959488	hsa-miR-4640-3p	CLIP-seq
MIRT959489	hsa-miR-4641	CLIP-seq
MIRT959490	hsa-miR-4644	CLIP-seq
MIRT959510	hsa-miR-4667-3p	CLIP-seq
MIRT959511	hsa-miR-4689	CLIP-seq
MIRT959493	hsa-miR-4697-5p	CLIP-seq
MIRT959512	hsa-miR-4703-3p	CLIP-seq
MIRT959513	hsa-miR-4736	CLIP-seq
MIRT959494	hsa-miR-4747-5p	CLIP-seq
MIRT959514	hsa-miR-4748	CLIP-seq
MIRT959515	hsa-miR-4784	CLIP-seq
MIRT959516	hsa-miR-486-3p	CLIP-seq
MIRT959495	hsa-miR-495	CLIP-seq
MIRT959496	hsa-miR-497	CLIP-seq
MIRT959497	hsa-miR-542-5p	CLIP-seq
MIRT959517	hsa-miR-544b	CLIP-seq
MIRT959518	hsa-miR-642a	CLIP-seq
MIRT959491	hsa-miR-4651	CLIP-seq
MIRT959499	hsa-miR-608	CLIP-seq
MIRT1984156	hsa-miR-1202	CLIP-seq
MIRT1984157	hsa-miR-1205	CLIP-seq
MIRT1984158	hsa-miR-1207-5p	CLIP-seq
MIRT959466	hsa-miR-1255b	CLIP-seq
MIRT959503	hsa-miR-1279	CLIP-seq
MIRT959473	hsa-miR-185	CLIP-seq
MIRT1984159	hsa-miR-1909	CLIP-seq
MIRT1984160	hsa-miR-197	CLIP-seq
MIRT1984161	hsa-miR-2110	CLIP-seq
MIRT1984162	hsa-miR-3160-5p	CLIP-seq
MIRT1984163	hsa-miR-3179	CLIP-seq
MIRT1984164	hsa-miR-3180-5p	CLIP-seq
MIRT1984165	hsa-miR-3184	CLIP-seq
MIRT959479	hsa-miR-3202	CLIP-seq
MIRT1984166	hsa-miR-3619-3p	CLIP-seq
MIRT1984167	hsa-miR-3665	CLIP-seq
MIRT1984168	hsa-miR-3920	CLIP-seq
MIRT1984169	hsa-miR-3922-5p	CLIP-seq
MIRT1984170	hsa-miR-3926	CLIP-seq
MIRT1984171	hsa-miR-3972	CLIP-seq
MIRT1984172	hsa-miR-412	CLIP-seq
MIRT1984173	hsa-miR-423-5p	CLIP-seq
MIRT1984174	hsa-miR-4257	CLIP-seq
MIRT1984175	hsa-miR-4271	CLIP-seq
MIRT1984176	hsa-miR-4283	CLIP-seq
MIRT1984177	hsa-miR-4300	CLIP-seq
MIRT959483	hsa-miR-4306	CLIP-seq
MIRT1984178	hsa-miR-4315	CLIP-seq
MIRT1984179	hsa-miR-4436b-3p	CLIP-seq
MIRT1984180	hsa-miR-4452	CLIP-seq
MIRT959509	hsa-miR-4464	CLIP-seq
MIRT1984181	hsa-miR-4633-3p	CLIP-seq
MIRT959489	hsa-miR-4641	CLIP-seq
MIRT959490	hsa-miR-4644	CLIP-seq
MIRT959491	hsa-miR-4651	CLIP-seq
MIRT1984182	hsa-miR-4668-5p	CLIP-seq
MIRT959512	hsa-miR-4703-3p	CLIP-seq
MIRT1984183	hsa-miR-4715-3p	CLIP-seq
MIRT1984184	hsa-miR-4717-5p	CLIP-seq
MIRT1984185	hsa-miR-4725-3p	CLIP-seq
MIRT959494	hsa-miR-4747-5p	CLIP-seq
MIRT959514	hsa-miR-4748	CLIP-seq
MIRT1984186	hsa-miR-4753-5p	CLIP-seq
MIRT1984187	hsa-miR-4762-3p	CLIP-seq
MIRT1984188	hsa-miR-4763-3p	CLIP-seq
MIRT1984189	hsa-miR-4776-3p	CLIP-seq
MIRT959495	hsa-miR-495	CLIP-seq
MIRT1984190	hsa-miR-520a-5p	CLIP-seq
MIRT1984191	hsa-miR-525-5p	CLIP-seq
MIRT959497	hsa-miR-542-5p	CLIP-seq
MIRT1984192	hsa-miR-548s	CLIP-seq
MIRT959499	hsa-miR-608	CLIP-seq
MIRT1984193	hsa-miR-657	CLIP-seq
MIRT1984194	hsa-miR-920	CLIP-seq
MIRT959501	hsa-miR-939	CLIP-seq
MIRT2219290	hsa-miR-1184	CLIP-seq
MIRT1984157	hsa-miR-1205	CLIP-seq
MIRT1984158	hsa-miR-1207-5p	CLIP-seq
MIRT959502	hsa-miR-1236	CLIP-seq
MIRT959466	hsa-miR-1255b	CLIP-seq
MIRT2219291	hsa-miR-142-3p	CLIP-seq
MIRT959504	hsa-miR-1470	CLIP-seq
MIRT959470	hsa-miR-15a	CLIP-seq
MIRT959471	hsa-miR-15b	CLIP-seq
MIRT959472	hsa-miR-16	CLIP-seq
MIRT959473	hsa-miR-185	CLIP-seq
MIRT1984159	hsa-miR-1909	CLIP-seq
MIRT959474	hsa-miR-195	CLIP-seq
MIRT1984160	hsa-miR-197	CLIP-seq
MIRT2219292	hsa-miR-1972	CLIP-seq
MIRT1984161	hsa-miR-2110	CLIP-seq
MIRT959475	hsa-miR-3065-3p	CLIP-seq
MIRT2219293	hsa-miR-3117-3p	CLIP-seq
MIRT959476	hsa-miR-3127-3p	CLIP-seq
MIRT2219294	hsa-miR-3155	CLIP-seq
MIRT2219295	hsa-miR-3155b	CLIP-seq
MIRT2219296	hsa-miR-3158-5p	CLIP-seq
MIRT1984163	hsa-miR-3179	CLIP-seq
MIRT1984165	hsa-miR-3184	CLIP-seq
MIRT2219297	hsa-miR-3192	CLIP-seq
MIRT2219298	hsa-miR-361-3p	CLIP-seq
MIRT1984166	hsa-miR-3619-3p	CLIP-seq
MIRT2219299	hsa-miR-3620	CLIP-seq
MIRT1984167	hsa-miR-3665	CLIP-seq
MIRT1984169	hsa-miR-3922-5p	CLIP-seq
MIRT1984170	hsa-miR-3926	CLIP-seq
MIRT2219300	hsa-miR-3936	CLIP-seq
MIRT1984172	hsa-miR-412	CLIP-seq
MIRT1984173	hsa-miR-423-5p	CLIP-seq
MIRT959482	hsa-miR-424	CLIP-seq
MIRT1984174	hsa-miR-4257	CLIP-seq
MIRT2219301	hsa-miR-4260	CLIP-seq
MIRT959507	hsa-miR-4279	CLIP-seq
MIRT1984176	hsa-miR-4283	CLIP-seq
MIRT2219302	hsa-miR-4292	CLIP-seq
MIRT1984177	hsa-miR-4300	CLIP-seq
MIRT959483	hsa-miR-4306	CLIP-seq
MIRT1984179	hsa-miR-4436b-3p	CLIP-seq
MIRT2219303	hsa-miR-4446-3p	CLIP-seq
MIRT2219304	hsa-miR-4514	CLIP-seq
MIRT1984181	hsa-miR-4633-3p	CLIP-seq
MIRT959488	hsa-miR-4640-3p	CLIP-seq
MIRT2219305	hsa-miR-4640-5p	CLIP-seq
MIRT959490	hsa-miR-4644	CLIP-seq
MIRT959491	hsa-miR-4651	CLIP-seq
MIRT959510	hsa-miR-4667-3p	CLIP-seq
MIRT2219306	hsa-miR-4675	CLIP-seq
MIRT2219307	hsa-miR-4685-5p	CLIP-seq
MIRT2219308	hsa-miR-4692	CLIP-seq
MIRT2219309	hsa-miR-4713-5p	CLIP-seq
MIRT1984183	hsa-miR-4715-3p	CLIP-seq
MIRT1984184	hsa-miR-4717-5p	CLIP-seq
MIRT2219310	hsa-miR-4726-5p	CLIP-seq
MIRT2219311	hsa-miR-4733-3p	CLIP-seq
MIRT959513	hsa-miR-4736	CLIP-seq
MIRT2219312	hsa-miR-4741	CLIP-seq
MIRT1984186	hsa-miR-4753-5p	CLIP-seq
MIRT2219313	hsa-miR-4755-3p	CLIP-seq
MIRT2219314	hsa-miR-4757-5p	CLIP-seq
MIRT1984188	hsa-miR-4763-3p	CLIP-seq
MIRT2219315	hsa-miR-484	CLIP-seq
MIRT959516	hsa-miR-486-3p	CLIP-seq
MIRT959496	hsa-miR-497	CLIP-seq
MIRT959497	hsa-miR-542-5p	CLIP-seq
MIRT1984192	hsa-miR-548s	CLIP-seq
MIRT959499	hsa-miR-608	CLIP-seq
MIRT959518	hsa-miR-642a	CLIP-seq
MIRT2219316	hsa-miR-648	CLIP-seq
MIRT1984193	hsa-miR-657	CLIP-seq
MIRT1984194	hsa-miR-920	CLIP-seq
MIRT959501	hsa-miR-939	CLIP-seq
MIRT2219317	hsa-miR-940	CLIP-seq
MIRT1984158	hsa-miR-1207-5p	CLIP-seq
MIRT2387323	hsa-miR-1253	CLIP-seq
MIRT1984159	hsa-miR-1909	CLIP-seq
MIRT1984160	hsa-miR-197	CLIP-seq
MIRT2219293	hsa-miR-3117-3p	CLIP-seq
MIRT1984172	hsa-miR-412	CLIP-seq
MIRT1984176	hsa-miR-4283	CLIP-seq
MIRT2387324	hsa-miR-4434	CLIP-seq
MIRT1984179	hsa-miR-4436b-3p	CLIP-seq
MIRT2219303	hsa-miR-4446-3p	CLIP-seq
MIRT2387325	hsa-miR-4516	CLIP-seq
MIRT2219307	hsa-miR-4685-5p	CLIP-seq
MIRT2219311	hsa-miR-4733-3p	CLIP-seq
MIRT1984188	hsa-miR-4763-3p	CLIP-seq
MIRT959516	hsa-miR-486-3p	CLIP-seq
MIRT959517	hsa-miR-544b	CLIP-seq
MIRT2387323	hsa-miR-1253	CLIP-seq
MIRT959467	hsa-miR-1266	CLIP-seq
MIRT959468	hsa-miR-1267	CLIP-seq
MIRT959469	hsa-miR-1293	CLIP-seq
MIRT1984160	hsa-miR-197	CLIP-seq
MIRT1984161	hsa-miR-2110	CLIP-seq
MIRT2522689	hsa-miR-2355-5p	CLIP-seq
MIRT959477	hsa-miR-3147	CLIP-seq
MIRT959478	hsa-miR-3170	CLIP-seq
MIRT1984165	hsa-miR-3184	CLIP-seq
MIRT2219297	hsa-miR-3192	CLIP-seq
MIRT959480	hsa-miR-342-5p	CLIP-seq
MIRT2219299	hsa-miR-3620	CLIP-seq
MIRT959481	hsa-miR-3907	CLIP-seq
MIRT1984169	hsa-miR-3922-5p	CLIP-seq
MIRT1984170	hsa-miR-3926	CLIP-seq
MIRT1984172	hsa-miR-412	CLIP-seq
MIRT1984173	hsa-miR-423-5p	CLIP-seq
MIRT1984175	hsa-miR-4271	CLIP-seq
MIRT2522690	hsa-miR-4281	CLIP-seq
MIRT2219302	hsa-miR-4292	CLIP-seq
MIRT1984177	hsa-miR-4300	CLIP-seq
MIRT959484	hsa-miR-4425	CLIP-seq
MIRT2387324	hsa-miR-4434	CLIP-seq
MIRT1984179	hsa-miR-4436b-3p	CLIP-seq
MIRT959485	hsa-miR-4483	CLIP-seq
MIRT2522691	hsa-miR-4492	CLIP-seq
MIRT2522692	hsa-miR-4498	CLIP-seq
MIRT2219304	hsa-miR-4514	CLIP-seq
MIRT2387325	hsa-miR-4516	CLIP-seq
MIRT959487	hsa-miR-4518	CLIP-seq
MIRT1984181	hsa-miR-4633-3p	CLIP-seq
MIRT959491	hsa-miR-4651	CLIP-seq
MIRT959492	hsa-miR-4664-5p	CLIP-seq
MIRT1984182	hsa-miR-4668-5p	CLIP-seq
MIRT2219308	hsa-miR-4692	CLIP-seq
MIRT1984183	hsa-miR-4715-3p	CLIP-seq
MIRT1984184	hsa-miR-4717-5p	CLIP-seq
MIRT1984185	hsa-miR-4725-3p	CLIP-seq
MIRT1984186	hsa-miR-4753-5p	CLIP-seq
MIRT959498	hsa-miR-548ad	CLIP-seq
MIRT1984192	hsa-miR-548s	CLIP-seq
MIRT959499	hsa-miR-608	CLIP-seq
MIRT959500	hsa-miR-622	CLIP-seq
MIRT2522693	hsa-miR-762	CLIP-seq
MIRT1984194	hsa-miR-920	CLIP-seq
MIRT2219317	hsa-miR-940	CLIP-seq
MIRT959468	hsa-miR-1267	CLIP-seq
MIRT2522689	hsa-miR-2355-5p	CLIP-seq
MIRT959477	hsa-miR-3147	CLIP-seq
MIRT2219297	hsa-miR-3192	CLIP-seq
MIRT2219299	hsa-miR-3620	CLIP-seq
MIRT2522690	hsa-miR-4281	CLIP-seq
MIRT2219302	hsa-miR-4292	CLIP-seq
MIRT1984177	hsa-miR-4300	CLIP-seq
MIRT959484	hsa-miR-4425	CLIP-seq
MIRT2522691	hsa-miR-4492	CLIP-seq
MIRT2522692	hsa-miR-4498	CLIP-seq
MIRT2219304	hsa-miR-4514	CLIP-seq
MIRT2219308	hsa-miR-4692	CLIP-seq
MIRT1984183	hsa-miR-4715-3p	CLIP-seq
MIRT959500	hsa-miR-622	CLIP-seq
MIRT2522693	hsa-miR-762	CLIP-seq
MIRT1984194	hsa-miR-920	CLIP-seq
MIRT2219317	hsa-miR-940	CLIP-seq

Show/Hide all (33)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003723	Function	RNA binding	HDA	22681889
GO:0003723	Function	RNA binding	IDA	15303967
GO:0003723	Function	RNA binding	IEA
GO:0003746	Function	Translation elongation factor activity	IBA
GO:0003746	Function	Translation elongation factor activity	IEA
GO:0003746	Function	Translation elongation factor activity	ISS
GO:0005515	Function	Protein binding	IPI	9442029, 9465063, 10381392, 10944119, 14622290, 15371445, 17213197, 25416956, 32296183, 33961781
GO:0005634	Component	Nucleus	IDA	12210765, 17187778
GO:0005634	Component	Nucleus	IEA
GO:0005642	Component	Annulate lamellae	IDA	12210765
GO:0005643	Component	Nuclear pore	IDA	10381392
GO:0005737	Component	Cytoplasm	IDA	12210765, 17187778
GO:0005737	Component	Cytoplasm	IEA
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006412	Process	Translation	IEA
GO:0006414	Process	Translational elongation	IBA
GO:0006414	Process	Translational elongation	IEA
GO:0006414	Process	Translational elongation	IMP	29712776
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IEA
GO:0017070	Function	U6 snRNA binding	IDA	9285100
GO:0033209	Process	Tumor necrosis factor-mediated signaling pathway	IDA	17187778
GO:0043022	Function	Ribosome binding	IEA
GO:0043065	Process	Positive regulation of apoptotic process	IEA
GO:0045202	Component	Synapse	IEA
GO:0045901	Process	Positive regulation of translational elongation	IEA
GO:0045901	Process	Positive regulation of translational elongation	ISS
GO:0045905	Process	Positive regulation of translational termination	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IMP	15371445
GO:0098586	Process	Cellular response to virus	IMP	8596953, 9465063
GO:1902255	Process	Positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator	IDA	15371445

MIM	HGNC	e!Ensembl
600187	3300	ENSG00000132507

P63241

Protein name

Eukaryotic translation initiation factor 5A-1 (eIF-5A-1) (eIF-5A1) (Eukaryotic initiation factor 5A isoform 1) (eIF-5A) (Rev-binding factor) (eIF-4D)

Protein function

Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts (PubMed:33547280). Binds between the exit (E) and peptidyl (P) site of the ribosome and promote

PDB

3CPF , 5DLQ , 8A0E , 8Y0W

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01287	eIF-5a	83 → 150	Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in umbilical vein endothelial cells and several cancer cell lines (at protein level). {ECO:0000269|PubMed:16519677}.

Sequence

MADDLDFETGDAGASATFPMQCSALRKNGFVVLKGRPCKIVEMSTSKTGKHGHAKVHLVG
IDIFTGKKYEDICPSTHNMDVPNIKRNDFQLIGIQDGYLSLLQDSGEVREDLRLPEGDLG
KEIEQKYDCGEEILITVLSAMTEEAAVAIKAMAK

Sequence length

154

Interactions

View interactions

	Reactome
			Hypusine synthesis from eIF5A-lysine

Show/Hide Causal Diseases (2)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Faundes-Banka syndrome	Pathogenic; Likely pathogenic	rs2143008762, rs2143009613, rs2143009611, rs2508673713	RCV001509560 RCV001509561 RCV001509562 RCV001509563 RCV003110193
Neurodevelopmental disorder	Likely pathogenic	rs2143008740	RCV001374964

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
EIF5A-related disorder	Uncertain significance	rs192093777, rs2508675773	RCV003421054 RCV003391447

Show/Hide Text Mining Associations (39)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Abortion Habitual	Inhibit	30206208
Acidosis	Associate	33188200
Breast Neoplasms	Associate	31558321, 31839604
Carcinoma Non Small Cell Lung	Associate	34921595
Carcinoma Ovarian Epithelial	Associate	35718769
Carcinoma Pancreatic Ductal	Associate	26483550, 28381547
Cell Transformation Neoplastic	Associate	32802869
Central Nervous System Diseases	Associate	37047039
Colorectal Neoplasms	Associate	32802869
Developmental Disabilities	Associate	36973244
Diabetes Mellitus	Associate	37047039
DNA Virus Infections	Associate	35486659
Fibrosis	Associate	37137790
Frontotemporal Dementia	Associate	32792518
Glioblastoma	Associate	22927971
Infections	Associate	35486659
Inflammation	Associate	30661771
Iron Deficiencies	Associate	19384939
Leiomyoma	Associate	37137790
Leiomyosarcoma	Associate	37137790
Leukemia	Associate	17008552
Lung Neoplasms	Associate	12869532, 24685647
Lymphoma	Associate	37070973, 37314811
Myelodysplastic Syndromes	Associate	36735910
Neoplasm Metastasis	Associate	23217164, 26483550
Neoplasms	Associate	12869532, 16519677, 22927971, 24220243, 28381547, 28549188, 37047039
Neurodegenerative Diseases	Associate	36789492, 36973244
Niemann Pick Disease Type C	Associate	23217164
Pancreatic Neoplasms	Associate	26483550, 28381547
Primary Ovarian Insufficiency	Associate	37460774
Prostatic Neoplasms	Associate	22908221
Sarcoma Kaposi	Associate	35486659
Stomach Neoplasms	Associate	35421138
TDP 43 Proteinopathies	Associate	36789492
Thyroid Carcinoma Anaplastic	Associate	32138807
Uterine Cervical Neoplasms	Associate	24220243
Venous Thromboembolism	Associate	31420334
Virus Diseases	Stimulate	35967877
Virus Diseases	Associate	37047039

EIF5A (eukaryotic translation initiation factor 5A)