EIF5 (eukaryotic translation initiation factor 5)
| Gene | |
|
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
1983 |
|
Gene name
Gene Name - the full gene name approved by the HGNC.
|
Eukaryotic translation initiation factor 5 |
|
Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
|
EIF5 |
|
Synonyms (NCBI Gene)
Gene synonyms aliases
|
EIF-5, EIF-5A |
|
Chromosome
Chromosome number
|
14 |
|
Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
14q32.32 |
|
Summary
Summary of gene provided in NCBI Entrez Gene.
|
Eukaryotic translation initiation factor-5 (EIF5) interacts with the 40S initiation complex to promote hydrolysis of bound GTP with concomitant joining of the 60S ribosomal subunit to the 40S initiation complex. The resulting functional 80S ribosomal init |
|
miRNA
miRNA information provided by mirtarbase database.
|
|||||||||||||||||||||||||
|
|||||||||||||||||||||||||
|
Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
|
|||||||||||||||||||||||||||||||
|
|||||||||||||||||||||||||||||||
|
Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
|
|||||||
|
|||||||
| Protein | ||||||||||||||||
| UniProt ID | P55010 | |||||||||||||||
| Protein name | Eukaryotic translation initiation factor 5 (eIF-5) | |||||||||||||||
| Protein function | Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon (PubMed:11166181, PubMed:22813744, PubMed:24319994). In this complex, acts as | |||||||||||||||
| PDB | 2E9H , 2G2K , 2IU1 , 8OZ0 , 8PJ2 , 8PJ3 | |||||||||||||||
| Family and domains |
Pfam
|
|||||||||||||||
| Sequence |
|
|||||||||||||||
| Sequence length | 431 | |||||||||||||||
| Interactions | View interactions | |||||||||||||||
|
Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
|
|||||||
|
|||||||
|
Associated diseases
Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
|
||||||||||||||||||||||||||||||||||
|
||||||||||||||||||||||||||||||||||
|
||||||||||||||||||||||||||||||||||