Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
1974
Gene name Gene Name - the full gene name approved by the HGNC.
Eukaryotic translation initiation factor 4A2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
EIF4A2
Synonyms (NCBI Gene) Gene synonyms aliases
BM-010, DDX2B, EIF4A, EIF4F, NEDHSS, eIF-4A-II, eIF4A-II
Disease Acronyms (UniProt) Disease acronyms from UniProt database
NEDHSS
Chromosome Chromosome number
3
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
3q27.3
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT005772 hsa-miR-21-5p Immunoblot, Immunohistochemistry, Luciferase reporter assay, Microarray, qRT-PCR, Western blot 21219636
MIRT005772 hsa-miR-21-5p Immunoblot, Immunohistochemistry, Luciferase reporter assay, Microarray, qRT-PCR, Western blot 21219636
MIRT032347 hsa-let-7b-5p Proteomics 18668040
MIRT043428 hsa-miR-331-3p CLASH 23622248
MIRT037614 hsa-miR-744-5p CLASH 23622248
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0002183 Process Cytoplasmic translational initiation IBA 21873635
GO:0003723 Function RNA binding HDA 22658674, 22681889
GO:0003724 Function RNA helicase activity IEA
GO:0003743 Function Translation initiation factor activity IBA 21873635
GO:0004386 Function Helicase activity TAS 8521730
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
601102 3284 ENSG00000156976
Protein
UniProt ID Q14240
Protein name Eukaryotic initiation factor 4A-II (eIF-4A-II) (eIF4A-II) (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A-2)
Protein function ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of
PDB 3BOR
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00270 DEAD 57 224 DEAD/DEAH box helicase Domain
PF00271 Helicase_C 259 368 Helicase conserved C-terminal domain Family
Sequence
Sequence length 407
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    ISG15 antiviral mechanism
L13a-mediated translational silencing of Ceruloplasmin expression
Deadenylation of mRNA
Translation initiation complex formation
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Ribosomal scanning and start codon recognition
GTP hydrolysis and joining of the 60S ribosomal subunit
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Breast cancer Malignant neoplasm of breast rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158
View all (309 more)
Associations from Text Mining
Disease Name Relationship Type References
Acidosis Stimulate 26274822
Alzheimer Disease Associate 20927385, 22016602
Carcinogenesis Associate 20145189
Carcinoma Hepatocellular Associate 12521301
Colorectal Neoplasms Associate 24113185
Glioma Associate 37192718
Hypoxia Stimulate 26274822
Inflammation Associate 26986695
Leukemia Lymphocytic Chronic B Cell Associate 34398253
Leukemia Myeloid Acute Associate 35781533