Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	197257
Gene name Gene Name - the full gene name approved by the HGNC.	Lactate dehydrogenase D
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	LDHD
Synonyms (NCBI Gene) Gene synonyms aliases	DLACD, DLD
Chromosome Chromosome number	16
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	16q23.1
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. The similar protein in yeast has both D-lactate and D-glycerate dehydrogenase activities. Alternative splicing occurs at this locus and two transcript va

Show/Hide all(2)

SNP ID	Visualize variation	Clinical significance	Consequence
rs764877688	G>A,C	Uncertain-significance, likely-pathogenic	Missense variant, coding sequence variant
rs1567502487	C>A	Likely-pathogenic, uncertain-significance	Coding sequence variant, missense variant

Show/Hide all(248)

miRTarBase ID	miRNA	Experiments	Reference
MIRT704220	hsa-miR-106a-5p	HITS-CLIP	23313552
MIRT704219	hsa-miR-106b-5p	HITS-CLIP	23313552
MIRT704218	hsa-miR-17-5p	HITS-CLIP	23313552
MIRT704217	hsa-miR-20a-5p	HITS-CLIP	23313552
MIRT704216	hsa-miR-20b-5p	HITS-CLIP	23313552
MIRT704215	hsa-miR-519d-3p	HITS-CLIP	23313552
MIRT704214	hsa-miR-526b-3p	HITS-CLIP	23313552
MIRT704213	hsa-miR-93-5p	HITS-CLIP	23313552
MIRT704212	hsa-miR-302a-3p	HITS-CLIP	23313552
MIRT704211	hsa-miR-302b-3p	HITS-CLIP	23313552
MIRT704210	hsa-miR-302c-3p	HITS-CLIP	23313552
MIRT704209	hsa-miR-302d-3p	HITS-CLIP	23313552
MIRT704208	hsa-miR-302e	HITS-CLIP	23313552
MIRT704207	hsa-miR-372-3p	HITS-CLIP	23313552
MIRT704206	hsa-miR-373-3p	HITS-CLIP	23313552
MIRT704205	hsa-miR-520a-3p	HITS-CLIP	23313552
MIRT704204	hsa-miR-520b	HITS-CLIP	23313552
MIRT704203	hsa-miR-520c-3p	HITS-CLIP	23313552
MIRT704202	hsa-miR-520d-3p	HITS-CLIP	23313552
MIRT704201	hsa-miR-520e	HITS-CLIP	23313552
MIRT704200	hsa-miR-4700-3p	HITS-CLIP	23313552
MIRT704199	hsa-miR-512-3p	HITS-CLIP	23313552
MIRT704198	hsa-miR-6504-3p	HITS-CLIP	23313552
MIRT704197	hsa-miR-520g-3p	HITS-CLIP	23313552
MIRT704196	hsa-miR-520h	HITS-CLIP	23313552
MIRT704195	hsa-miR-186-3p	HITS-CLIP	23313552
MIRT704194	hsa-miR-4707-5p	HITS-CLIP	23313552
MIRT704193	hsa-miR-7108-3p	HITS-CLIP	23313552
MIRT704192	hsa-miR-150-5p	HITS-CLIP	23313552
MIRT704191	hsa-miR-619-5p	HITS-CLIP	23313552
MIRT704190	hsa-miR-6506-5p	HITS-CLIP	23313552
MIRT704189	hsa-miR-4707-3p	HITS-CLIP	23313552
MIRT704188	hsa-miR-6778-3p	HITS-CLIP	23313552
MIRT704187	hsa-miR-4731-5p	HITS-CLIP	23313552
MIRT704186	hsa-miR-5589-5p	HITS-CLIP	23313552
MIRT704185	hsa-miR-5095	HITS-CLIP	23313552
MIRT704184	hsa-miR-7151-3p	HITS-CLIP	23313552
MIRT704183	hsa-miR-5089-5p	HITS-CLIP	23313552
MIRT524147	hsa-miR-548u	PAR-CLIP	20371350
MIRT524146	hsa-miR-7161-5p	PAR-CLIP	20371350
MIRT524145	hsa-miR-8087	PAR-CLIP	20371350
MIRT524144	hsa-miR-6512-5p	PAR-CLIP	20371350
MIRT524143	hsa-miR-506-5p	PAR-CLIP	20371350
MIRT524142	hsa-miR-4436a	PAR-CLIP	20371350
MIRT524141	hsa-miR-5000-3p	PAR-CLIP	20371350
MIRT524140	hsa-miR-3622b-5p	PAR-CLIP	20371350
MIRT524147	hsa-miR-548u	PAR-CLIP	20371350
MIRT524146	hsa-miR-7161-5p	PAR-CLIP	20371350
MIRT524145	hsa-miR-8087	PAR-CLIP	20371350
MIRT524144	hsa-miR-6512-5p	PAR-CLIP	20371350
MIRT524143	hsa-miR-506-5p	PAR-CLIP	20371350
MIRT524142	hsa-miR-4436a	PAR-CLIP	20371350
MIRT524141	hsa-miR-5000-3p	PAR-CLIP	20371350
MIRT524140	hsa-miR-3622b-5p	PAR-CLIP	20371350
MIRT561201	hsa-miR-4302	PAR-CLIP	20371350
MIRT561200	hsa-miR-4289	PAR-CLIP	20371350
MIRT561199	hsa-miR-7-5p	PAR-CLIP	20371350
MIRT561198	hsa-miR-6077	PAR-CLIP	20371350
MIRT561197	hsa-miR-3190-3p	PAR-CLIP	20371350
MIRT561196	hsa-miR-3688-5p	PAR-CLIP	20371350
MIRT561195	hsa-miR-891a-3p	PAR-CLIP	20371350
MIRT561194	hsa-miR-644a	PAR-CLIP	20371350
MIRT561193	hsa-miR-6833-5p	PAR-CLIP	20371350
MIRT561192	hsa-miR-4752	PAR-CLIP	20371350
MIRT561191	hsa-miR-670-3p	PAR-CLIP	20371350
MIRT532783	hsa-miR-3133	PAR-CLIP	22012620
MIRT532782	hsa-miR-186-5p	PAR-CLIP	22012620
MIRT532781	hsa-miR-425-5p	PAR-CLIP	22012620
MIRT532780	hsa-miR-1261	PAR-CLIP	22012620
MIRT532779	hsa-miR-548a-3p	PAR-CLIP	22012620
MIRT532778	hsa-miR-548ar-3p	PAR-CLIP	22012620
MIRT532777	hsa-miR-548az-3p	PAR-CLIP	22012620
MIRT532776	hsa-miR-548e-3p	PAR-CLIP	22012620
MIRT532775	hsa-miR-548f-3p	PAR-CLIP	22012620
MIRT532774	hsa-miR-4694-3p	PAR-CLIP	22012620
MIRT532773	hsa-miR-224-3p	PAR-CLIP	22012620
MIRT532772	hsa-miR-522-3p	PAR-CLIP	22012620
MIRT532771	hsa-miR-541-5p	PAR-CLIP	22012620
MIRT532770	hsa-miR-4731-3p	PAR-CLIP	22012620
MIRT532769	hsa-miR-4801	PAR-CLIP	22012620
MIRT532768	hsa-miR-892b	PAR-CLIP	22012620
MIRT532767	hsa-miR-5584-5p	PAR-CLIP	22012620
MIRT532766	hsa-miR-6750-5p	PAR-CLIP	22012620
MIRT532765	hsa-miR-6822-5p	PAR-CLIP	22012620
MIRT532764	hsa-miR-9500	PAR-CLIP	22012620
MIRT532763	hsa-miR-3938	PAR-CLIP	22012620
MIRT532762	hsa-miR-454-5p	PAR-CLIP	22012620
MIRT532761	hsa-miR-4794	PAR-CLIP	22012620
MIRT532760	hsa-miR-664a-5p	PAR-CLIP	22012620
MIRT532759	hsa-miR-6069	PAR-CLIP	22012620
MIRT532758	hsa-miR-4668-5p	PAR-CLIP	22012620
MIRT532757	hsa-miR-3153	PAR-CLIP	22012620
MIRT532756	hsa-miR-6733-5p	PAR-CLIP	22012620
MIRT532755	hsa-miR-6739-5p	PAR-CLIP	22012620
MIRT532754	hsa-miR-4694-5p	PAR-CLIP	22012620
MIRT532753	hsa-miR-4425	PAR-CLIP	22012620
MIRT532752	hsa-miR-3147	PAR-CLIP	22012620
MIRT532751	hsa-miR-6883-3p	PAR-CLIP	22012620
MIRT532750	hsa-miR-450a-1-3p	PAR-CLIP	22012620
MIRT524147	hsa-miR-548u	PAR-CLIP	23446348
MIRT524146	hsa-miR-7161-5p	PAR-CLIP	23446348
MIRT524145	hsa-miR-8087	PAR-CLIP	23446348
MIRT524144	hsa-miR-6512-5p	PAR-CLIP	23446348
MIRT524143	hsa-miR-506-5p	PAR-CLIP	23446348
MIRT524142	hsa-miR-4436a	PAR-CLIP	23446348
MIRT524141	hsa-miR-5000-3p	PAR-CLIP	23446348
MIRT524140	hsa-miR-3622b-5p	PAR-CLIP	23446348
MIRT704220	hsa-miR-106a-5p	HITS-CLIP	23313552
MIRT704219	hsa-miR-106b-5p	HITS-CLIP	23313552
MIRT704218	hsa-miR-17-5p	HITS-CLIP	23313552
MIRT704217	hsa-miR-20a-5p	HITS-CLIP	23313552
MIRT704216	hsa-miR-20b-5p	HITS-CLIP	23313552
MIRT704215	hsa-miR-519d-3p	HITS-CLIP	23313552
MIRT704214	hsa-miR-526b-3p	HITS-CLIP	23313552
MIRT704213	hsa-miR-93-5p	HITS-CLIP	23313552
MIRT704212	hsa-miR-302a-3p	HITS-CLIP	23313552
MIRT704211	hsa-miR-302b-3p	HITS-CLIP	23313552
MIRT704210	hsa-miR-302c-3p	HITS-CLIP	23313552
MIRT704209	hsa-miR-302d-3p	HITS-CLIP	23313552
MIRT704208	hsa-miR-302e	HITS-CLIP	23313552
MIRT704207	hsa-miR-372-3p	HITS-CLIP	23313552
MIRT704206	hsa-miR-373-3p	HITS-CLIP	23313552
MIRT704205	hsa-miR-520a-3p	HITS-CLIP	23313552
MIRT704204	hsa-miR-520b	HITS-CLIP	23313552
MIRT704203	hsa-miR-520c-3p	HITS-CLIP	23313552
MIRT704202	hsa-miR-520d-3p	HITS-CLIP	23313552
MIRT704201	hsa-miR-520e	HITS-CLIP	23313552
MIRT704200	hsa-miR-4700-3p	HITS-CLIP	23313552
MIRT704199	hsa-miR-512-3p	HITS-CLIP	23313552
MIRT704198	hsa-miR-6504-3p	HITS-CLIP	23313552
MIRT704197	hsa-miR-520g-3p	HITS-CLIP	23313552
MIRT704196	hsa-miR-520h	HITS-CLIP	23313552
MIRT704195	hsa-miR-186-3p	HITS-CLIP	23313552
MIRT704194	hsa-miR-4707-5p	HITS-CLIP	23313552
MIRT704193	hsa-miR-7108-3p	HITS-CLIP	23313552
MIRT704192	hsa-miR-150-5p	HITS-CLIP	23313552
MIRT704191	hsa-miR-619-5p	HITS-CLIP	23313552
MIRT704190	hsa-miR-6506-5p	HITS-CLIP	23313552
MIRT704189	hsa-miR-4707-3p	HITS-CLIP	23313552
MIRT704188	hsa-miR-6778-3p	HITS-CLIP	23313552
MIRT704187	hsa-miR-4731-5p	HITS-CLIP	23313552
MIRT704186	hsa-miR-5589-5p	HITS-CLIP	23313552
MIRT704185	hsa-miR-5095	HITS-CLIP	23313552
MIRT704184	hsa-miR-7151-3p	HITS-CLIP	23313552
MIRT704183	hsa-miR-5089-5p	HITS-CLIP	23313552
MIRT524147	hsa-miR-548u	PAR-CLIP	20371350
MIRT524146	hsa-miR-7161-5p	PAR-CLIP	20371350
MIRT524145	hsa-miR-8087	PAR-CLIP	20371350
MIRT524144	hsa-miR-6512-5p	PAR-CLIP	20371350
MIRT524143	hsa-miR-506-5p	PAR-CLIP	20371350
MIRT524142	hsa-miR-4436a	PAR-CLIP	20371350
MIRT524141	hsa-miR-5000-3p	PAR-CLIP	20371350
MIRT524140	hsa-miR-3622b-5p	PAR-CLIP	20371350
MIRT524147	hsa-miR-548u	PAR-CLIP	20371350
MIRT524146	hsa-miR-7161-5p	PAR-CLIP	20371350
MIRT524145	hsa-miR-8087	PAR-CLIP	20371350
MIRT524144	hsa-miR-6512-5p	PAR-CLIP	20371350
MIRT524143	hsa-miR-506-5p	PAR-CLIP	20371350
MIRT524142	hsa-miR-4436a	PAR-CLIP	20371350
MIRT524141	hsa-miR-5000-3p	PAR-CLIP	20371350
MIRT524140	hsa-miR-3622b-5p	PAR-CLIP	20371350
MIRT561201	hsa-miR-4302	PAR-CLIP	20371350
MIRT561200	hsa-miR-4289	PAR-CLIP	20371350
MIRT561199	hsa-miR-7-5p	PAR-CLIP	20371350
MIRT561198	hsa-miR-6077	PAR-CLIP	20371350
MIRT561197	hsa-miR-3190-3p	PAR-CLIP	20371350
MIRT561196	hsa-miR-3688-5p	PAR-CLIP	20371350
MIRT561195	hsa-miR-891a-3p	PAR-CLIP	20371350
MIRT561194	hsa-miR-644a	PAR-CLIP	20371350
MIRT561193	hsa-miR-6833-5p	PAR-CLIP	20371350
MIRT561192	hsa-miR-4752	PAR-CLIP	20371350
MIRT561191	hsa-miR-670-3p	PAR-CLIP	20371350
MIRT532783	hsa-miR-3133	PAR-CLIP	22012620
MIRT532782	hsa-miR-186-5p	PAR-CLIP	22012620
MIRT532781	hsa-miR-425-5p	PAR-CLIP	22012620
MIRT532780	hsa-miR-1261	PAR-CLIP	22012620
MIRT532779	hsa-miR-548a-3p	PAR-CLIP	22012620
MIRT532778	hsa-miR-548ar-3p	PAR-CLIP	22012620
MIRT532777	hsa-miR-548az-3p	PAR-CLIP	22012620
MIRT532776	hsa-miR-548e-3p	PAR-CLIP	22012620
MIRT532775	hsa-miR-548f-3p	PAR-CLIP	22012620
MIRT532774	hsa-miR-4694-3p	PAR-CLIP	22012620
MIRT532773	hsa-miR-224-3p	PAR-CLIP	22012620
MIRT532772	hsa-miR-522-3p	PAR-CLIP	22012620
MIRT532771	hsa-miR-541-5p	PAR-CLIP	22012620
MIRT532770	hsa-miR-4731-3p	PAR-CLIP	22012620
MIRT532769	hsa-miR-4801	PAR-CLIP	22012620
MIRT532768	hsa-miR-892b	PAR-CLIP	22012620
MIRT532767	hsa-miR-5584-5p	PAR-CLIP	22012620
MIRT532766	hsa-miR-6750-5p	PAR-CLIP	22012620
MIRT532765	hsa-miR-6822-5p	PAR-CLIP	22012620
MIRT532764	hsa-miR-9500	PAR-CLIP	22012620
MIRT532763	hsa-miR-3938	PAR-CLIP	22012620
MIRT532762	hsa-miR-454-5p	PAR-CLIP	22012620
MIRT532761	hsa-miR-4794	PAR-CLIP	22012620
MIRT532760	hsa-miR-664a-5p	PAR-CLIP	22012620
MIRT532759	hsa-miR-6069	PAR-CLIP	22012620
MIRT532758	hsa-miR-4668-5p	PAR-CLIP	22012620
MIRT532757	hsa-miR-3153	PAR-CLIP	22012620
MIRT532756	hsa-miR-6733-5p	PAR-CLIP	22012620
MIRT532755	hsa-miR-6739-5p	PAR-CLIP	22012620
MIRT532754	hsa-miR-4694-5p	PAR-CLIP	22012620
MIRT532753	hsa-miR-4425	PAR-CLIP	22012620
MIRT532752	hsa-miR-3147	PAR-CLIP	22012620
MIRT532751	hsa-miR-6883-3p	PAR-CLIP	22012620
MIRT532750	hsa-miR-450a-1-3p	PAR-CLIP	22012620
MIRT524147	hsa-miR-548u	PAR-CLIP	23446348
MIRT524146	hsa-miR-7161-5p	PAR-CLIP	23446348
MIRT524145	hsa-miR-8087	PAR-CLIP	23446348
MIRT524144	hsa-miR-6512-5p	PAR-CLIP	23446348
MIRT524143	hsa-miR-506-5p	PAR-CLIP	23446348
MIRT524142	hsa-miR-4436a	PAR-CLIP	23446348
MIRT524141	hsa-miR-5000-3p	PAR-CLIP	23446348
MIRT524140	hsa-miR-3622b-5p	PAR-CLIP	23446348
MIRT1106406	hsa-miR-1253	CLIP-seq
MIRT1106407	hsa-miR-1275	CLIP-seq
MIRT1106408	hsa-miR-4428	CLIP-seq
MIRT1106409	hsa-miR-4434	CLIP-seq
MIRT1106410	hsa-miR-4516	CLIP-seq
MIRT1106411	hsa-miR-4525	CLIP-seq
MIRT1106412	hsa-miR-4665-5p	CLIP-seq
MIRT1106413	hsa-miR-4723-5p	CLIP-seq
MIRT1106414	hsa-miR-556-3p	CLIP-seq
MIRT1106415	hsa-miR-625	CLIP-seq
MIRT1106416	hsa-miR-1226	CLIP-seq
MIRT1106417	hsa-miR-125a-3p	CLIP-seq
MIRT1106418	hsa-miR-3179	CLIP-seq
MIRT1106419	hsa-miR-3670	CLIP-seq
MIRT1106420	hsa-miR-4300	CLIP-seq
MIRT1106421	hsa-miR-4326	CLIP-seq
MIRT1106422	hsa-miR-4421	CLIP-seq
MIRT1106423	hsa-miR-4716-3p	CLIP-seq
MIRT1106424	hsa-miR-4733-3p	CLIP-seq
MIRT1106425	hsa-miR-587	CLIP-seq
MIRT1106415	hsa-miR-625	CLIP-seq
MIRT1106426	hsa-miR-920	CLIP-seq
MIRT1106419	hsa-miR-3670	CLIP-seq
MIRT1106420	hsa-miR-4300	CLIP-seq
MIRT1106425	hsa-miR-587	CLIP-seq
MIRT1106426	hsa-miR-920	CLIP-seq
MIRT1106419	hsa-miR-3670	CLIP-seq
MIRT1106420	hsa-miR-4300	CLIP-seq
MIRT1106425	hsa-miR-587	CLIP-seq
MIRT1106426	hsa-miR-920	CLIP-seq
MIRT1106419	hsa-miR-3670	CLIP-seq
MIRT1106420	hsa-miR-4300	CLIP-seq
MIRT1106425	hsa-miR-587	CLIP-seq
MIRT1106426	hsa-miR-920	CLIP-seq

Show/Hide all(18)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003824	Function	Catalytic activity	IEA
GO:0004457	Function	Lactate dehydrogenase activity	IDA	38373542
GO:0004458	Function	D-lactate dehydrogenase (cytochrome) activity	IBA
GO:0004458	Function	D-lactate dehydrogenase (cytochrome) activity	IEA
GO:0005515	Function	Protein binding	IPI	12127981
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IBA
GO:0005739	Component	Mitochondrion	IEA
GO:0005739	Component	Mitochondrion	ISS
GO:0005743	Component	Mitochondrial inner membrane	IEA
GO:0005743	Component	Mitochondrial inner membrane	TAS
GO:0008720	Function	D-lactate dehydrogenase (NAD+) activity	IBA
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0050660	Function	Flavin adenine dinucleotide binding	IBA
GO:0050660	Function	Flavin adenine dinucleotide binding	IEA
GO:0071949	Function	FAD binding	IEA
GO:1903457	Process	Lactate catabolic process	IBA
GO:1903457	Process	Lactate catabolic process	IMP	30931947

MIM	HGNC	e!Ensembl
607490	19708	ENSG00000166816

Protein

UniProt ID

Q86WU2

Protein name

Probable D-lactate dehydrogenase, mitochondrial (DLD) (Lactate dehydrogenase D) (EC 1.1.2.4)

Protein function

Involved in D-lactate, but not L-lactate catabolic process.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01565	FAD_binding_4	66 → 203	FAD binding domain	Domain
PF02913	FAD-oxidase_C	265 → 506	FAD linked oxidases, C-terminal domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed moderately in heart and liver and at lower levels in skeletal muscle and kidney. {ECO:0000269|PubMed:12127981}.

Sequence

MARLLRSATWELFPWRGYCSQKAKGELCRDFVEALKAVVGGSHVSTAAVVREQHGRDESV
HRCEPPDAVVWPQNVEQVSRLAALCYRQGVPIIPFGTGTGLEGGVCAVQGGVCVNLTHMD
RILELNQEDFSVVVEPGVTRKALNAHLRDSGLWFPVDPGADASLCGMAATGASGTNAVRY
GTMRDNVLNLEVVLPDGRLLHTAGRGRHFRFGFWPEIPHHTAWYSPCVSLGRRKSAAGYN
LTGLFVGSEGTLGLITATTLRLHPAPEATVAATCAFPSVQAAVDSTVHILQAAVPVARIE
FLDEVMMDACNRYSKLNCLVAPTLFLEFHGSQQALEEQLQRTEEIVQQNGASDFSWAKEA
EERSRLWTARHNAWYAALATRPGCKGYSTDVCVPISRLPEIVVQTKEDLNASGLTGSIVG
HVGDGNFHCILLVNPDDAEELGRVKAFAEQLGRRALALHGTCTGEHGIGMGKRQLLQEEV
GAVGVETMRQLKAVLDPQGLMNPGKVL

Sequence length

507

Interactions

View interactions

	KEGG		Reactome
	Pyruvate metabolism Metabolic pathways		Mitochondrial protein import

Show/Hide Unknown Diseases (1)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Crohn Disease	Crohn's disease (time to surgery)	N/A	N/A	GWAS

Show/Hide Text Mining Associations (9)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Adenocarcinoma of Lung	Associate	37587457
Carcinoma Hepatocellular	Associate	38291366
Cholangiocarcinoma	Associate	36158120
Colitis Ulcerative	Associate	37090740
Esophageal Neoplasms	Associate	37582812
Esophageal Squamous Cell Carcinoma	Associate	37582812
Myoma	Associate	29620641
Neoplasms	Associate	29620641, 38291366
Sarcoma	Associate	29620641

LDHD (lactate dehydrogenase D)