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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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P41091 |
| Protein name |
Eukaryotic translation initiation factor 2 subunit 3 (EC 3.6.5.3) (Eukaryotic translation initiation factor 2 subunit gamma X) (eIF2-gamma X) (eIF2gX) |
| Protein function |
Member of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA (PubMed:31836389). This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form the 43S |
| PDB |
6FEC
, 6K71
, 6K72
, 6O81
, 6O85
, 6YBV
, 6ZMW
, 6ZP4
, 7A09
, 7D43
, 7F66
, 7F67
, 7QP6
, 7QP7
, 8OZ0
, 8PHD
, 8PHV
, 8PJ1
, 8PJ2
, 8PJ3
, 8PJ4
, 8PPL
, 8QZZ
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| Family and domains |
Pfam
| Accession |
ID |
Position in sequence |
Description |
Type |
| PF00009 |
GTP_EFTU |
39 → 245 |
Elongation factor Tu GTP binding domain |
Domain |
| PF03144 |
GTP_EFTU_D2 |
276 → 359 |
Elongation factor Tu domain 2 |
Domain |
| PF09173 |
eIF2_C |
369 → 459 |
Initiation factor eIF2 gamma, C terminal |
Domain |
|
| Tissue specificity |
TISSUE SPECIFICITY: Expressed in testis, brain, liver and muscle. {ECO:0000269|PubMed:9736774}. |
| Sequence |
|
| Sequence length |
472 |
| Interactions |
View interactions |
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|
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| Disease Name |
Relationship Type |
References |
| ATR X syndrome |
Associate |
28055140 |
| Breast Neoplasms |
Associate |
28459209 |
| Carcinoma Non Small Cell Lung |
Associate |
27418131 |
| Carcinoma Ovarian Epithelial |
Associate |
35718769 |
| Chromosome Disorders |
Associate |
23063529 |
| Coloboma Obesity Hypogenitalism Mental Retardation Syndrome |
Associate |
32901502 |
| Colorectal Neoplasms |
Associate |
25339833, 25516661, 33237662 |
| Cystic Fibrosis |
Associate |
31474496 |
| Cystitis Interstitial |
Associate |
34876093 |
| Diabetes Mellitus |
Associate |
29303605, 32799315 |
| Diabetes Mellitus Type 1 |
Associate |
29303605 |
| Early Onset Glaucoma |
Associate |
29303605 |
| Eosinophilic enteropathy |
Associate |
35090021 |
| Epilepsy |
Associate |
32799315, 32901502 |
| Fatty Liver |
Associate |
23894275 |
| Fibrosis |
Associate |
23894275 |
| Glucose Intolerance |
Associate |
30878599 |
| Hypersensitivity Delayed |
Associate |
32799315 |
| Hypoglycemia |
Associate |
29303605 |
| Hypopituitarism |
Associate |
29303605, 30878599 |
| Infertility Male |
Associate |
36369953 |
| Intellectual Disability |
Associate |
23063529, 30878599, 31836389, 32901502 |
| Learning Disabilities |
Associate |
30878599 |
| MEHMO syndrome |
Associate |
28055140, 29303605, 30517694, 30878599, 31836389, 32799315, 32901502 |
| Microcephaly |
Associate |
23063529, 30878599, 32799315, 32901502 |
| Neoplasms |
Associate |
24416147, 38538250 |
| Nervous System Diseases |
Associate |
30878599 |
| Non alcoholic Fatty Liver Disease |
Associate |
23894275 |
| Obesity |
Associate |
32799315, 32901502 |
| Pancreatic Neoplasms |
Associate |
38538250 |
| Post Acute COVID 19 Syndrome |
Associate |
40655185 |
| Respiratory Tract Infections |
Associate |
32901502 |
| Seizures |
Associate |
30878599 |
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