Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
196527
Gene name Gene Name - the full gene name approved by the HGNC.
Anoctamin 6
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
ANO6
Synonyms (NCBI Gene) Gene synonyms aliases
BDPLT7, SCTS, TMEM16F
Disease Acronyms (UniProt) Disease acronyms from UniProt database
SCTS
Chromosome Chromosome number
12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
12q12
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a multi-pass transmembrane protein that belongs to the anoctamin family. This protein is an essential component for the calcium-dependent exposure of phosphatidylserine on the cell surface. The scrambling of phospholipid occurs in variou
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT022736 hsa-miR-124-3p Microarray 18668037
MIRT026632 hsa-miR-192-5p Microarray 19074876
MIRT052405 hsa-let-7a-5p CLASH 23622248
MIRT047637 hsa-miR-10a-5p CLASH 23622248
MIRT047212 hsa-miR-182-5p CLASH 23622248
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0002407 Process Dendritic cell chemotaxis IEA
GO:0002543 Process Activation of blood coagulation via clotting cascade IMP 21107324
GO:0005227 Function Calcium activated cation channel activity IDA 22946059
GO:0005227 Function Calcium activated cation channel activity IMP 25651887
GO:0005227 Function Calcium activated cation channel activity ISS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
608663 25240 ENSG00000177119
Protein
UniProt ID Q4KMQ2
Protein name Anoctamin-6 (Small-conductance calcium-activated nonselective cation channel) (SCAN channel) (Transmembrane protein 16F)
Protein function Small-conductance calcium-activated nonselective cation (SCAN) channel which acts as a regulator of phospholipid scrambling in platelets and osteoblasts (PubMed:20056604, PubMed:21107324, PubMed:21908539, PubMed:22006324, PubMed:22946059). Phosp
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF16178 Anoct_dimer 61 284 Dimerisation domain of Ca+-activated chloride-channel, anoctamin Family
PF04547 Anoctamin 287 870 Calcium-activated chloride channel Family
Tissue specificity TISSUE SPECIFICITY: Expressed in embryonic stem cell, fetal liver, retina, chronic myologenous leukemia and intestinal cancer. {ECO:0000269|PubMed:15067359}.
Sequence
MKKMSRNVLLQMEEEEDDDDGDIVLENLGQTIVPDLGSLESQHDFRTPEFEEFNGKPDSL
FFNDGQRRIDFVLVYEDESRKETNKKGTNEKQRRKRQAYESNLICHGLQLEATRSVLDDK
LVFVKVHAPWEVLCTYAEIMHIKLPLKPNDLKNRSSAFGTLNWFTKVLSVDESIIKPEQE
FFTAPFEKNRMNDFYIVDRDAFFNPATRSRIVYFILSRVKYQVINNVSKFGINRLVNSGI
YKAAFPLHDCKFRRQSEDPSCPNERYLLYREWAHPRSIYKKQPL
DLIRKYYGEKIGIYFA
WLGYYTQMLLLAAVVGVACFLYGYLNQDNCTWSKEVCHPDIGGKIIMCPQCDRLCPFWKL
NITCESSKKLCIFDSFGTLVFAVFMGVWVTLFLEFWKRRQAELEYEWDTVELQQEEQARP
EYEARCTHVVINEITQEEERIPFTAWGKCIRITLCASAVFFWILLIIASVIGIIVYRLSV
FIVFSAKLPKNINGTDPIQKYLTPQTATSITASIISFIIIMILNTIYEKVAIMITNFELP
RTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYPGDPVYWLGKYRNEECDPGGC
LLELTTQLTIIMGGKAIWNNIQEVLLPWIMNLIGRFHRVSGSEKITPRWEQDYHLQPMGK
LGLFYEYLEMIIQFGFVTLFVASFPLAPLLALVNNILEIRVDAWKLTTQFRRLVPEKAQD
IGAWQPIMQGIAILAVVTNAMIIAFTSDMIPRLVYYWSFSVPPYGDHTSYTMEGYINNTL
SIFKVADFKNKSKGNPYSDLGNHTTCRYRDFRYPPGHPQEYKHNIYYWHVIAAKLAFIIV
MEHVIYSVKFFISYAIPDVSKRTKSKIQRE
KYLTQKLLHENHLKDMTKNMGVIAERMIEA
VDNNLRPKSE
Sequence length 910
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Efferocytosis   Stimuli-sensing channels
Neutrophil degranulation
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Scott syndrome Scott Syndrome, Scott syndrome rs374664255 21107324, 27879994, 21511967
Unknown
Disease term Disease name Evidence References Source
Ankylosing Spondylitis Ankylosing Spondylitis GWAS
Insomnia Insomnia GWAS
Diabetes Diabetes GWAS
Dementia Dementia GWAS
Associations from Text Mining
Disease Name Relationship Type References
Blood Coagulation Disorders Associate 33346788, 40350307
Breast Neoplasms Associate 37643511, 37960776
Carcinoma Squamous Cell Associate 39526479
Hemorrhage Associate 27535140
HIV Infections Associate 33346788, 35670667
Inflammatory Bowel Diseases Associate 23308121
Neoplasms Associate 33346788, 37960776
Ovarian Neoplasms Associate 38238671
Scott Syndrome Associate 23303820, 23618909, 27535140, 40350307
Spondylitis Ankylosing Associate 23308121