Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	196441
Gene name	Zinc finger C3H1-type containing
Gene symbol	ZFC3H1
Synonyms (NCBI Gene)	CCDC131CSRC2PSRC2
Chromosome	12
Chromosome location	12q21.1

Show/Hide all (2)

SNP ID	Visualize variation	Clinical significance	Consequence
rs767539150	C>T	Likely-pathogenic	Coding sequence variant, missense variant
rs1565798439	A>G	Likely-pathogenic	Missense variant, coding sequence variant

230

Show/Hide all (230)

miRTarBase ID	miRNA	Experiments	Reference
MIRT028364	hsa-miR-32-5p	Sequencing	20371350
MIRT043726	hsa-miR-342-3p	CLASH	23622248
MIRT533021	hsa-miR-367-3p	PAR-CLIP	20371350
MIRT533020	hsa-miR-92b-3p	PAR-CLIP	20371350
MIRT533019	hsa-miR-25-3p	PAR-CLIP	20371350
MIRT028364	hsa-miR-32-5p	PAR-CLIP	20371350
MIRT533017	hsa-miR-363-3p	PAR-CLIP	20371350
MIRT533018	hsa-miR-92a-3p	PAR-CLIP	20371350
MIRT533016	hsa-miR-5692b	PAR-CLIP	20371350
MIRT533015	hsa-miR-5692c	PAR-CLIP	20371350
MIRT564779	hsa-miR-3613-3p	PAR-CLIP	20371350
MIRT533013	hsa-miR-5589-3p	PAR-CLIP	20371350
MIRT533012	hsa-miR-520d-5p	PAR-CLIP	20371350
MIRT533011	hsa-miR-524-5p	PAR-CLIP	20371350
MIRT533021	hsa-miR-367-3p	PAR-CLIP	22012620
MIRT533020	hsa-miR-92b-3p	PAR-CLIP	22012620
MIRT533019	hsa-miR-25-3p	PAR-CLIP	22012620
MIRT028364	hsa-miR-32-5p	PAR-CLIP	22012620
MIRT533017	hsa-miR-363-3p	PAR-CLIP	22012620
MIRT533018	hsa-miR-92a-3p	PAR-CLIP	22012620
MIRT533016	hsa-miR-5692b	PAR-CLIP	22012620
MIRT533015	hsa-miR-5692c	PAR-CLIP	22012620
MIRT533014	hsa-miR-6777-3p	PAR-CLIP	22012620
MIRT533013	hsa-miR-5589-3p	PAR-CLIP	22012620
MIRT533012	hsa-miR-520d-5p	PAR-CLIP	22012620
MIRT533011	hsa-miR-524-5p	PAR-CLIP	22012620
MIRT533018	hsa-miR-92a-3p	HITS-CLIP	22473208
MIRT533020	hsa-miR-92b-3p	HITS-CLIP	22473208
MIRT028364	hsa-miR-32-5p	HITS-CLIP	22473208
MIRT533021	hsa-miR-367-3p	PAR-CLIP	20371350
MIRT533020	hsa-miR-92b-3p	PAR-CLIP	20371350
MIRT533019	hsa-miR-25-3p	PAR-CLIP	20371350
MIRT028364	hsa-miR-32-5p	PAR-CLIP	20371350
MIRT533017	hsa-miR-363-3p	PAR-CLIP	20371350
MIRT533018	hsa-miR-92a-3p	PAR-CLIP	20371350
MIRT533016	hsa-miR-5692b	PAR-CLIP	20371350
MIRT533015	hsa-miR-5692c	PAR-CLIP	20371350
MIRT564779	hsa-miR-3613-3p	PAR-CLIP	20371350
MIRT533013	hsa-miR-5589-3p	PAR-CLIP	20371350
MIRT533012	hsa-miR-520d-5p	PAR-CLIP	20371350
MIRT533011	hsa-miR-524-5p	PAR-CLIP	20371350
MIRT533021	hsa-miR-367-3p	PAR-CLIP	22012620
MIRT533020	hsa-miR-92b-3p	PAR-CLIP	22012620
MIRT533019	hsa-miR-25-3p	PAR-CLIP	22012620
MIRT028364	hsa-miR-32-5p	PAR-CLIP	22012620
MIRT533017	hsa-miR-363-3p	PAR-CLIP	22012620
MIRT533018	hsa-miR-92a-3p	PAR-CLIP	22012620
MIRT533016	hsa-miR-5692b	PAR-CLIP	22012620
MIRT533015	hsa-miR-5692c	PAR-CLIP	22012620
MIRT533014	hsa-miR-6777-3p	PAR-CLIP	22012620
MIRT533013	hsa-miR-5589-3p	PAR-CLIP	22012620
MIRT533012	hsa-miR-520d-5p	PAR-CLIP	22012620
MIRT533011	hsa-miR-524-5p	PAR-CLIP	22012620
MIRT1509794	hsa-miR-1206	CLIP-seq
MIRT1509795	hsa-miR-1224-5p	CLIP-seq
MIRT1509796	hsa-miR-1266	CLIP-seq
MIRT1509797	hsa-miR-1272	CLIP-seq
MIRT1509798	hsa-miR-1277	CLIP-seq
MIRT1509799	hsa-miR-1289	CLIP-seq
MIRT1509800	hsa-miR-1304	CLIP-seq
MIRT1509801	hsa-miR-1307	CLIP-seq
MIRT1509802	hsa-miR-132	CLIP-seq
MIRT1509803	hsa-miR-1322	CLIP-seq
MIRT1509804	hsa-miR-198	CLIP-seq
MIRT1509805	hsa-miR-2052	CLIP-seq
MIRT1509806	hsa-miR-2115	CLIP-seq
MIRT1509807	hsa-miR-212	CLIP-seq
MIRT1509808	hsa-miR-216b	CLIP-seq
MIRT1509809	hsa-miR-25	CLIP-seq
MIRT1509810	hsa-miR-3126-3p	CLIP-seq
MIRT1509811	hsa-miR-3128	CLIP-seq
MIRT1509812	hsa-miR-3174	CLIP-seq
MIRT1509813	hsa-miR-32	CLIP-seq
MIRT1509814	hsa-miR-3201	CLIP-seq
MIRT1509815	hsa-miR-363	CLIP-seq
MIRT1509816	hsa-miR-3664-3p	CLIP-seq
MIRT1509817	hsa-miR-367	CLIP-seq
MIRT1509818	hsa-miR-3915	CLIP-seq
MIRT1509819	hsa-miR-3919	CLIP-seq
MIRT1509820	hsa-miR-3928	CLIP-seq
MIRT1509821	hsa-miR-3977	CLIP-seq
MIRT1509822	hsa-miR-4269	CLIP-seq
MIRT1509823	hsa-miR-4282	CLIP-seq
MIRT1509824	hsa-miR-4317	CLIP-seq
MIRT1509825	hsa-miR-4514	CLIP-seq
MIRT1509826	hsa-miR-4518	CLIP-seq
MIRT1509827	hsa-miR-4638-5p	CLIP-seq
MIRT1509828	hsa-miR-4664-3p	CLIP-seq
MIRT1509829	hsa-miR-4671-5p	CLIP-seq
MIRT1509830	hsa-miR-4689	CLIP-seq
MIRT1509831	hsa-miR-4692	CLIP-seq
MIRT1509832	hsa-miR-4693-3p	CLIP-seq
MIRT1509833	hsa-miR-4711-5p	CLIP-seq
MIRT1509834	hsa-miR-4712-3p	CLIP-seq
MIRT1509835	hsa-miR-4720-5p	CLIP-seq
MIRT1509836	hsa-miR-4733-5p	CLIP-seq
MIRT1509837	hsa-miR-4742-5p	CLIP-seq
MIRT1509838	hsa-miR-4751	CLIP-seq
MIRT1509839	hsa-miR-4756-3p	CLIP-seq
MIRT1509840	hsa-miR-4791	CLIP-seq
MIRT1509841	hsa-miR-4799-3p	CLIP-seq
MIRT1509842	hsa-miR-513a-3p	CLIP-seq
MIRT1509843	hsa-miR-516a-3p	CLIP-seq
MIRT1509844	hsa-miR-580	CLIP-seq
MIRT1509845	hsa-miR-605	CLIP-seq
MIRT1509846	hsa-miR-671-3p	CLIP-seq
MIRT1509847	hsa-miR-873	CLIP-seq
MIRT1509848	hsa-miR-92a	CLIP-seq
MIRT1509849	hsa-miR-92b	CLIP-seq
MIRT1509794	hsa-miR-1206	CLIP-seq
MIRT1509795	hsa-miR-1224-5p	CLIP-seq
MIRT1509800	hsa-miR-1304	CLIP-seq
MIRT2153546	hsa-miR-1972	CLIP-seq
MIRT2153547	hsa-miR-223	CLIP-seq
MIRT1509818	hsa-miR-3915	CLIP-seq
MIRT2153548	hsa-miR-3926	CLIP-seq
MIRT1509820	hsa-miR-3928	CLIP-seq
MIRT1509824	hsa-miR-4317	CLIP-seq
MIRT1509829	hsa-miR-4671-5p	CLIP-seq
MIRT1509830	hsa-miR-4689	CLIP-seq
MIRT2153549	hsa-miR-4690-5p	CLIP-seq
MIRT2153550	hsa-miR-4697-3p	CLIP-seq
MIRT2153551	hsa-miR-4704-3p	CLIP-seq
MIRT2153552	hsa-miR-4729	CLIP-seq
MIRT2153553	hsa-miR-579	CLIP-seq
MIRT1509794	hsa-miR-1206	CLIP-seq
MIRT1509795	hsa-miR-1224-5p	CLIP-seq
MIRT2373851	hsa-miR-1256	CLIP-seq
MIRT1509797	hsa-miR-1272	CLIP-seq
MIRT1509799	hsa-miR-1289	CLIP-seq
MIRT2373852	hsa-miR-1297	CLIP-seq
MIRT1509800	hsa-miR-1304	CLIP-seq
MIRT1509801	hsa-miR-1307	CLIP-seq
MIRT1509802	hsa-miR-132	CLIP-seq
MIRT1509803	hsa-miR-1322	CLIP-seq
MIRT1509804	hsa-miR-198	CLIP-seq
MIRT1509805	hsa-miR-2052	CLIP-seq
MIRT1509806	hsa-miR-2115	CLIP-seq
MIRT1509807	hsa-miR-212	CLIP-seq
MIRT2153547	hsa-miR-223	CLIP-seq
MIRT2373853	hsa-miR-26a	CLIP-seq
MIRT2373854	hsa-miR-26b	CLIP-seq
MIRT1509812	hsa-miR-3174	CLIP-seq
MIRT1509818	hsa-miR-3915	CLIP-seq
MIRT1509819	hsa-miR-3919	CLIP-seq
MIRT1509820	hsa-miR-3928	CLIP-seq
MIRT1509821	hsa-miR-3977	CLIP-seq
MIRT1509824	hsa-miR-4317	CLIP-seq
MIRT2373855	hsa-miR-4465	CLIP-seq
MIRT2373856	hsa-miR-4502	CLIP-seq
MIRT1509827	hsa-miR-4638-5p	CLIP-seq
MIRT1509828	hsa-miR-4664-3p	CLIP-seq
MIRT1509830	hsa-miR-4689	CLIP-seq
MIRT1509832	hsa-miR-4693-3p	CLIP-seq
MIRT2153550	hsa-miR-4697-3p	CLIP-seq
MIRT2153551	hsa-miR-4704-3p	CLIP-seq
MIRT1509833	hsa-miR-4711-5p	CLIP-seq
MIRT1509834	hsa-miR-4712-3p	CLIP-seq
MIRT1509835	hsa-miR-4720-5p	CLIP-seq
MIRT2153552	hsa-miR-4729	CLIP-seq
MIRT1509838	hsa-miR-4751	CLIP-seq
MIRT1509839	hsa-miR-4756-3p	CLIP-seq
MIRT2373857	hsa-miR-4762-3p	CLIP-seq
MIRT1509841	hsa-miR-4799-3p	CLIP-seq
MIRT1509843	hsa-miR-516a-3p	CLIP-seq
MIRT2153553	hsa-miR-579	CLIP-seq
MIRT1509846	hsa-miR-671-3p	CLIP-seq
MIRT1509847	hsa-miR-873	CLIP-seq
MIRT2666453	hsa-miR-1179	CLIP-seq
MIRT2373851	hsa-miR-1256	CLIP-seq
MIRT2666454	hsa-miR-1271	CLIP-seq
MIRT1509798	hsa-miR-1277	CLIP-seq
MIRT1509799	hsa-miR-1289	CLIP-seq
MIRT2373852	hsa-miR-1297	CLIP-seq
MIRT1509801	hsa-miR-1307	CLIP-seq
MIRT1509802	hsa-miR-132	CLIP-seq
MIRT2666455	hsa-miR-182	CLIP-seq
MIRT1509804	hsa-miR-198	CLIP-seq
MIRT1509807	hsa-miR-212	CLIP-seq
MIRT2666456	hsa-miR-2278	CLIP-seq
MIRT2373853	hsa-miR-26a	CLIP-seq
MIRT2373854	hsa-miR-26b	CLIP-seq
MIRT2666457	hsa-miR-3185	CLIP-seq
MIRT2666458	hsa-miR-3671	CLIP-seq
MIRT2666459	hsa-miR-3941	CLIP-seq
MIRT2373855	hsa-miR-4465	CLIP-seq
MIRT2666460	hsa-miR-450b-5p	CLIP-seq
MIRT2666461	hsa-miR-4635	CLIP-seq
MIRT1509827	hsa-miR-4638-5p	CLIP-seq
MIRT2666462	hsa-miR-466	CLIP-seq
MIRT2666463	hsa-miR-4662a-5p	CLIP-seq
MIRT2666464	hsa-miR-4672	CLIP-seq
MIRT2666465	hsa-miR-4676-5p	CLIP-seq
MIRT2666466	hsa-miR-4709-3p	CLIP-seq
MIRT2666467	hsa-miR-4775	CLIP-seq
MIRT2666468	hsa-miR-4795-3p	CLIP-seq
MIRT2666469	hsa-miR-575	CLIP-seq
MIRT2666470	hsa-miR-590-3p	CLIP-seq
MIRT2666471	hsa-miR-607	CLIP-seq
MIRT2666472	hsa-miR-944	CLIP-seq
MIRT2666473	hsa-miR-96	CLIP-seq
MIRT2373851	hsa-miR-1256	CLIP-seq
MIRT2666454	hsa-miR-1271	CLIP-seq
MIRT1509798	hsa-miR-1277	CLIP-seq
MIRT1509799	hsa-miR-1289	CLIP-seq
MIRT2373852	hsa-miR-1297	CLIP-seq
MIRT1509801	hsa-miR-1307	CLIP-seq
MIRT2666455	hsa-miR-182	CLIP-seq
MIRT1509804	hsa-miR-198	CLIP-seq
MIRT2373853	hsa-miR-26a	CLIP-seq
MIRT2373854	hsa-miR-26b	CLIP-seq
MIRT2666457	hsa-miR-3185	CLIP-seq
MIRT2666458	hsa-miR-3671	CLIP-seq
MIRT2666459	hsa-miR-3941	CLIP-seq
MIRT2373855	hsa-miR-4465	CLIP-seq
MIRT2666460	hsa-miR-450b-5p	CLIP-seq
MIRT2666461	hsa-miR-4635	CLIP-seq
MIRT1509827	hsa-miR-4638-5p	CLIP-seq
MIRT2666462	hsa-miR-466	CLIP-seq
MIRT2666463	hsa-miR-4662a-5p	CLIP-seq
MIRT2666464	hsa-miR-4672	CLIP-seq
MIRT2666465	hsa-miR-4676-5p	CLIP-seq
MIRT2666466	hsa-miR-4709-3p	CLIP-seq
MIRT2666467	hsa-miR-4775	CLIP-seq
MIRT2666468	hsa-miR-4795-3p	CLIP-seq
MIRT2666469	hsa-miR-575	CLIP-seq
MIRT2666470	hsa-miR-590-3p	CLIP-seq
MIRT2666471	hsa-miR-607	CLIP-seq
MIRT2666472	hsa-miR-944	CLIP-seq
MIRT2666473	hsa-miR-96	CLIP-seq

Show/Hide all (10)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	20195357, 26496610, 27871484, 31413325, 32814053, 35914814
GO:0005615	Component	Extracellular space	HDA	22664934
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	27871484
GO:0005634	Component	Nucleus	IEA
GO:0005730	Component	Nucleolus	IDA	27871484
GO:0006396	Process	RNA processing	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:1990477	Component	MTREC complex	IDA	27871484

MIM	HGNC	e!Ensembl
620956	28328	ENSG00000133858

O60293

Protein name

Zinc finger C3H1 domain-containing protein (Coiled-coil domain-containing protein 131) (Proline/serine-rich coiled-coil protein 2)

Protein function

Subunit of the trimeric poly(A) tail exosome targeting (PAXT) complex, a complex that directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nucl

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF10650	zf-C3H1	1185 → 1205	Putative zinc-finger domain	Domain

Sequence

MATADTPAPASSGLSPKEEGELEDGEISDDDNNSQIRSRSSSSSSGGGLLPYPRRRPPHS
ARGGGSGGGGGSSSSSSSSQQQLRNFSRSRHASERGHLRGPSSYRPKEPFRSHPPSVRMP
SSSLSESSPRPSFWERSHLALDRFRFRGRPYRGGSRWSRGRGVGERGGKPGCRPPLGGGA
GSGFSSSQSWREPSPPRKSSKSFGRSPSRKQNYSSKNENCVEETFEDLLLKYKQIQLELE
CINKDEKLALSSKEENVQEDPKTLNFEDQTSTDNVSITKDSSKEVAPEEKTQVKTFQAFE
LKPLRQKLTLPGDKNRLKKVKDGAKPLSLKSDTTDSSQGLQDKEQNLTRRISTSDILSEK
KLGEDEEELSELQLRLLALQSASKKWQQKEQQVMKESKEKLTKTKTVQQKVKTSTKTHSA
KKVSTTAKQALRKQQTKAWKKLQQQKEQERQKEEDQRKQAEEEERRKREEEIRKIRDLSN
QEEQYNRFMKLVGGKRRSRSKSSDPDLRRSLDKQPTDSGGGIYQYDNYEEVAMDTDSETS
SPAPSPVQPPFFSECSLGYFSPAPSLSLPPPPQVSSLPPLSQPYVEGLCVSLEPLPPLPP
LPPLPPEDPEQPPKPPFADEEEEEEMLLREELLKSLANKRAFKPEETSSNSDPPSPPVLN
NSHPVPRSNLSIVSINTVSQPRIQNPKFHRGPRLPRTVISLPKHKSVVVTLNDSDDSESD
GEASKSTNSVFGGLESMIKEARRTAEQASKPKVPPKSEKENDPLRTPEALPEEKKIEYRL
LKEEIANREKQRLIKSDQLKTSSSSPANSDVEIDGIGRIAMVTKQVTDAESKLKKHRILL
MKDESVLKNLVQQEAKKKESVRNAEAKITKLTEQLQATEKILNVNRMFLKKLQEQIHRVQ
QRVTIKKALTLKYGEELARAKAVASKEIGKRKLEQDRFGPNKMMRLDSSPVSSPRKHSAE
LIAMEKRRLQKLEYEYALKIQKLKEARALKAKEQQNISPVVEEEPEFSLPQPSLHDLTQD
KLTLDTEENDVDDEILSGSSRERRRSFLESNYFTKPNLKHTDTANKECINKLNKNTVEKP
ELFLGLKIGELQKLYSKADSLKQLILKTTTGITEKVLHGQEISVDVDFVTAQSKTMEVKP
CPFRPYHSPLLVFKSYRFSPYYRTKEKLPLSSVSYSNMIEPDQCFCRFDLTGTCNDDDCQ
WQHIQDYTLSRKQLFQDILSYNLSLIGCAETSTNEEITASAEKYVEKLFGVNKDRMSMDQ
MAVLLVSNINESKGHTPPFTTYKDKRKWKPKFWRKPISDNSFSSDEEQSTGPIKYAFQPE
NQINVPALDTVVTPDDVRYFTNETDDIANLEASVLENPSHVQLWLKLAYKYLNQNEGECS
ESLDSALNVLARALENNKDNPEIWCHYLRLFSKRGTKDEVQEMCETAVEYAPDYQSFWTF
LHLESTFEEKDYVCERMLEFLMGAAKQETSNILSFQLLEALLFRVQLHIFTGRCQSALAI
LQNALKSANDGIVAEYLKTSDRCLAWLAYIHLIEFNILPSKFYDPSNDNPSRIVNTESFV
MPWQAVQDVKTNPDMLLAVFEDAVKACTDESLAVEERIEACLPLYTNMIALHQLLERYEA
AMELCKSLLESCPINCQLLEALVALYLQTNQHDKARAVWLTAFEKNPQNAEVFYHMCKFF
ILQNRGDNLLPFLRKFIASFFKPGFEKYNNLDLFRYLLNIPGPIDIPSRLCKGNFDDDMF
NHQVPYLWLIYCLCHPLQSSIKETVEAYEAALGVAMRCDIVQKIWMDYLVFANNRAAGSR
NKVQEFKFFTDLVNRCLVTVPARYPIPFSSADYWSNYEFHNRVIFFYLSCVPKTQHSKTL
ERFCSVMPANSGLALRLLQHEWEESNVQILKLQAKMFTYNIPTCLATWKIAIAAEIVLKG
QREVHRLYQRALQKLPLCASLWKDQLLFEASEGGKTDNLRKLVSKCQEIGVSLNELLNLN
SNKTESKNH

Sequence length

1989

Interactions

View interactions

Show/Hide Causal Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Short stature	Likely pathogenic	rs1565798439, rs767539150	RCV000736166 RCV000736167

Show/Hide Text Mining Associations (1)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Adenocarcinoma	Associate	34514952

ZFC3H1 (zinc finger C3H1-type containing)