TMT1B (thiol methyltransferase 1B)

Gene

• Entrez ID: 196410
• Gene name: Thiol methyltransferase 1B
• Gene symbol: TMT1B
• Synonyms (NCBI Gene): ALDI, METTL7B
• Chromosome: 12
• Chromosome location: 12q13.2

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1144932	hsa-miR-1208	CLIP-seq
MIRT1144933	hsa-miR-1238	CLIP-seq
MIRT1144934	hsa-miR-3185	CLIP-seq
MIRT1144935	hsa-miR-361-3p	CLIP-seq
MIRT1144936	hsa-miR-3664-3p	CLIP-seq
MIRT1144937	hsa-miR-4255	CLIP-seq
MIRT1144938	hsa-miR-4267	CLIP-seq
MIRT1144939	hsa-miR-4292	CLIP-seq
MIRT1144940	hsa-miR-4308	CLIP-seq
MIRT1144941	hsa-miR-4313	CLIP-seq
MIRT1144942	hsa-miR-4420	CLIP-seq
MIRT1144943	hsa-miR-4691-5p	CLIP-seq
MIRT1144944	hsa-miR-4732-5p	CLIP-seq
MIRT1144945	hsa-miR-5096	CLIP-seq
MIRT1144946	hsa-miR-873	CLIP-seq
MIRT1144932	hsa-miR-1208	CLIP-seq
MIRT2041200	hsa-miR-2110	CLIP-seq
MIRT2041201	hsa-miR-325	CLIP-seq
MIRT2041202	hsa-miR-3612	CLIP-seq
MIRT2041203	hsa-miR-3616-5p	CLIP-seq
MIRT2041204	hsa-miR-3647-5p	CLIP-seq
MIRT2041205	hsa-miR-3689a-3p	CLIP-seq
MIRT2041206	hsa-miR-3689c	CLIP-seq
MIRT2041207	hsa-miR-3923	CLIP-seq
MIRT2041208	hsa-miR-4271	CLIP-seq
MIRT1144942	hsa-miR-4420	CLIP-seq
MIRT2041209	hsa-miR-4443	CLIP-seq
MIRT2041210	hsa-miR-4470	CLIP-seq
MIRT2041211	hsa-miR-4475	CLIP-seq
MIRT2041212	hsa-miR-4505	CLIP-seq
MIRT2041213	hsa-miR-4533	CLIP-seq
MIRT2041214	hsa-miR-4667-5p	CLIP-seq
MIRT2041215	hsa-miR-4670-3p	CLIP-seq
MIRT2041216	hsa-miR-4700-5p	CLIP-seq
MIRT2041217	hsa-miR-4725-3p	CLIP-seq
MIRT2041218	hsa-miR-4728-5p	CLIP-seq
MIRT2041219	hsa-miR-4731-5p	CLIP-seq
MIRT1144944	hsa-miR-4732-5p	CLIP-seq
MIRT2041220	hsa-miR-4735-5p	CLIP-seq
MIRT2041221	hsa-miR-4747-5p	CLIP-seq
MIRT2041222	hsa-miR-485-5p	CLIP-seq
MIRT1144945	hsa-miR-5096	CLIP-seq
MIRT2041223	hsa-miR-573	CLIP-seq
MIRT2041224	hsa-miR-576-5p	CLIP-seq
MIRT2041225	hsa-miR-650	CLIP-seq
MIRT2270898	hsa-miR-185	CLIP-seq
MIRT2041202	hsa-miR-3612	CLIP-seq
MIRT2041205	hsa-miR-3689a-3p	CLIP-seq
MIRT2041206	hsa-miR-3689c	CLIP-seq
MIRT2270899	hsa-miR-4306	CLIP-seq
MIRT2041210	hsa-miR-4470	CLIP-seq
MIRT2041211	hsa-miR-4475	CLIP-seq
MIRT2270900	hsa-miR-4644	CLIP-seq
MIRT2041218	hsa-miR-4728-5p	CLIP-seq
MIRT2041225	hsa-miR-650	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0008168	Function	Methyltransferase activity	IBA	21873635
GO:0032259	Process	Methylation	IEA

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q6UX53
• Protein name: Thiol S-methyltransferase TMT1B (EC 2.1.1.9) (Methyltransferase-like protein 7B) (Thiol S-methyltransferase METTL7B)
• Protein function: Thiol S-methyltransferase that catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to alkyl and phenolic thiol-containing acceptor substrates. Together with TMT1B accounts for most of S-thiol methylation activity in the endopla
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF08241	Methyltransf_11	75 → 172	Methyltransferase domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed in the liver. {ECO:0000269|PubMed:37137720}.
• Sequence:

  MDILVPLLQLLVLLLTLPLHLMALLGCWQPLCKSYFPYLMAVLTPKSNRKMESKKRELFS
  QIKGLTGASGKVALLELGCGTGANFQFYPPGCRVTCLDPNPHFEKFLTKSMAENRHLQYE
  RFVVAPGEDMRQLADGSMDVVVCTLVLCSVQSPRKVLQEVRRVLRPGGVLFFWEHVAEPY
  GSWAFMWQQVFEPTWKHIGDGCCLTRETWKDLENAQFSEIQMERQPPPLKWLPVGPHIMG
  KAVK

• Sequence length: 244

Associated diseases

Unknown
Disease term	Disease name	Evidence	References	Source
Atrial Fibrillation	Atrial Fibrillation			GWAS