Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
196403
Gene name Gene Name - the full gene name approved by the HGNC.
Deltex E3 ubiquitin ligase 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
DTX3
Synonyms (NCBI Gene) Gene synonyms aliases
RNF154, deltex3
Chromosome Chromosome number
12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
12q13.3
Summary Summary of gene provided in NCBI Entrez Gene.
DTX3 functions as an E3 ubiquitin ligase (Takeyama et al., 2003 [PubMed 12670957]).[supplied by OMIM, Nov 2009]
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT044416 hsa-miR-320a CLASH 23622248
MIRT947010 hsa-miR-1207-5p CLIP-seq
MIRT947011 hsa-miR-1234 CLIP-seq
MIRT947012 hsa-miR-146a CLIP-seq
MIRT947013 hsa-miR-146b-5p CLIP-seq
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 19549727, 22493164, 25416956, 32296183, 32814053
GO:0005654 Component Nucleoplasm IBA 21873635
GO:0005737 Component Cytoplasm IEA
GO:0007219 Process Notch signaling pathway IBA 21873635
GO:0016567 Process Protein ubiquitination IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
613142 24457 ENSG00000178498
Protein
UniProt ID Q8N9I9
Protein name Probable E3 ubiquitin-protein ligase DTX3 (EC 2.3.2.27) (Protein deltex-3) (Deltex3) (RING finger protein 154) (RING-type E3 ubiquitin transferase DTX3)
Protein function Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF13923 zf-C3HC4_2 163 202 Domain
PF18102 DTC 210 344 Deltex C-terminal domain Domain
Sequence
MSFVLSRMAACGGTCKNKVTVSKPVWDFLSKETPARLARLREEHRVSILIDGETSDIYVL
QLSPQGPPPAPPNGLYLARKALKGLLKEAEKELKKAQRQGELMGCLALGGGGEHPEMHRA
GPPPLRAAPLLPPGARGLPPPPPPLPPPLPPRLREEAEEQESTCPICLGEIQNAKTLEKC
RHSFCEGCITRALQVKKACPMC
GRFYGQLVGNQPQNGRMLVSKDATLLLPSYEKYGTIVI
QYVFPPGVQGAEHPNPGVRYPGTTRVAYLPDCPEGNKVLTLFRKAFDQRLTFTIGTSMTT
GRPNVITWNDIHHKTSCTGGPQLFGYPDPTYLTRVQEELRAKGI
TDD
Sequence length 347
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  
  Notch signaling pathway  
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Breast cancer Malignant neoplasm of breast rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158
View all (309 more)
25151356
Breast carcinoma Breast Carcinoma rs80359671, rs11540652, rs28934575, rs28897672, rs137886232, rs193922376, rs80357783, rs80359306, rs80359405, rs80359507, rs80359598, rs80358429, rs397507683, rs397515636, rs80359451
View all (71 more)
25151356
Marfan syndrome Mammary Carcinoma, Human rs137854456, rs137854457, rs267606796, rs137854458, rs137854459, rs137854460, rs137854470, rs137854471, rs267606797, rs137854461, rs137854462, rs137854463, rs869025419, rs137854464, rs137854465
View all (942 more)
25151356
Associations from Text Mining
Disease Name Relationship Type References
Breast Neoplasms Associate 25151356, 33616774
Colorectal Neoplasms Inhibit 35098394
Neoplasms Associate 33616774, 35098394
Triple Negative Breast Neoplasms Associate 33300431