Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	196403
Gene name Gene Name - the full gene name approved by the HGNC.	Deltex E3 ubiquitin ligase 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	DTX3
Synonyms (NCBI Gene) Gene synonyms aliases	RNF154, deltex3
Chromosome Chromosome number	12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	12q13.3
Summary Summary of gene provided in NCBI Entrez Gene.	DTX3 functions as an E3 ubiquitin ligase (Takeyama et al., 2003 [PubMed 12670957]).[supplied by OMIM, Nov 2009]

Show/Hide all(213)

miRTarBase ID	miRNA	Experiments	Reference
MIRT044416	hsa-miR-320a	CLASH	23622248
MIRT947010	hsa-miR-1207-5p	CLIP-seq
MIRT947011	hsa-miR-1234	CLIP-seq
MIRT947012	hsa-miR-146a	CLIP-seq
MIRT947013	hsa-miR-146b-5p	CLIP-seq
MIRT947014	hsa-miR-185	CLIP-seq
MIRT947015	hsa-miR-1908	CLIP-seq
MIRT947016	hsa-miR-3175	CLIP-seq
MIRT947017	hsa-miR-3184	CLIP-seq
MIRT947018	hsa-miR-3200-5p	CLIP-seq
MIRT947019	hsa-miR-3656	CLIP-seq
MIRT947020	hsa-miR-3670	CLIP-seq
MIRT947021	hsa-miR-3689d	CLIP-seq
MIRT947022	hsa-miR-423-5p	CLIP-seq
MIRT947023	hsa-miR-4300	CLIP-seq
MIRT947024	hsa-miR-4306	CLIP-seq
MIRT947025	hsa-miR-432	CLIP-seq
MIRT947026	hsa-miR-4440	CLIP-seq
MIRT947027	hsa-miR-4443	CLIP-seq
MIRT947028	hsa-miR-4475	CLIP-seq
MIRT947029	hsa-miR-4502	CLIP-seq
MIRT947030	hsa-miR-4644	CLIP-seq
MIRT947031	hsa-miR-4688	CLIP-seq
MIRT947032	hsa-miR-4690-3p	CLIP-seq
MIRT947033	hsa-miR-4728-5p	CLIP-seq
MIRT947034	hsa-miR-4763-3p	CLIP-seq
MIRT947035	hsa-miR-4768-3p	CLIP-seq
MIRT947036	hsa-miR-4773	CLIP-seq
MIRT947037	hsa-miR-4802-5p	CLIP-seq
MIRT947038	hsa-miR-486-3p	CLIP-seq
MIRT947039	hsa-miR-602	CLIP-seq
MIRT947040	hsa-miR-624	CLIP-seq
MIRT947041	hsa-miR-663	CLIP-seq
MIRT947042	hsa-miR-920	CLIP-seq
MIRT947043	hsa-miR-939	CLIP-seq
MIRT947010	hsa-miR-1207-5p	CLIP-seq
MIRT947011	hsa-miR-1234	CLIP-seq
MIRT947012	hsa-miR-146a	CLIP-seq
MIRT947013	hsa-miR-146b-5p	CLIP-seq
MIRT947014	hsa-miR-185	CLIP-seq
MIRT947015	hsa-miR-1908	CLIP-seq
MIRT1980442	hsa-miR-1909	CLIP-seq
MIRT1980443	hsa-miR-217	CLIP-seq
MIRT1980444	hsa-miR-24	CLIP-seq
MIRT1980445	hsa-miR-3151	CLIP-seq
MIRT1980446	hsa-miR-3154	CLIP-seq
MIRT947016	hsa-miR-3175	CLIP-seq
MIRT947018	hsa-miR-3200-5p	CLIP-seq
MIRT1980447	hsa-miR-33a	CLIP-seq
MIRT1980448	hsa-miR-33b	CLIP-seq
MIRT1980449	hsa-miR-342-3p	CLIP-seq
MIRT1980450	hsa-miR-3650	CLIP-seq
MIRT947021	hsa-miR-3689d	CLIP-seq
MIRT1980451	hsa-miR-4284	CLIP-seq
MIRT947024	hsa-miR-4306	CLIP-seq
MIRT947025	hsa-miR-432	CLIP-seq
MIRT947027	hsa-miR-4443	CLIP-seq
MIRT1980452	hsa-miR-4447	CLIP-seq
MIRT1980453	hsa-miR-4472	CLIP-seq
MIRT947028	hsa-miR-4475	CLIP-seq
MIRT1980454	hsa-miR-4499	CLIP-seq
MIRT947029	hsa-miR-4502	CLIP-seq
MIRT947030	hsa-miR-4644	CLIP-seq
MIRT1980455	hsa-miR-4727-5p	CLIP-seq
MIRT947033	hsa-miR-4728-5p	CLIP-seq
MIRT1980456	hsa-miR-4757-5p	CLIP-seq
MIRT947034	hsa-miR-4763-3p	CLIP-seq
MIRT947035	hsa-miR-4768-3p	CLIP-seq
MIRT1980457	hsa-miR-4769-3p	CLIP-seq
MIRT947036	hsa-miR-4773	CLIP-seq
MIRT947038	hsa-miR-486-3p	CLIP-seq
MIRT1980458	hsa-miR-491-5p	CLIP-seq
MIRT947040	hsa-miR-624	CLIP-seq
MIRT947041	hsa-miR-663	CLIP-seq
MIRT2215500	hsa-miR-139-5p	CLIP-seq
MIRT947014	hsa-miR-185	CLIP-seq
MIRT2215501	hsa-miR-3128	CLIP-seq
MIRT2215502	hsa-miR-3173-3p	CLIP-seq
MIRT2215503	hsa-miR-3180-5p	CLIP-seq
MIRT947024	hsa-miR-4306	CLIP-seq
MIRT2215504	hsa-miR-4428	CLIP-seq
MIRT1980454	hsa-miR-4499	CLIP-seq
MIRT947030	hsa-miR-4644	CLIP-seq
MIRT2215505	hsa-miR-4720-5p	CLIP-seq
MIRT947035	hsa-miR-4768-3p	CLIP-seq
MIRT947036	hsa-miR-4773	CLIP-seq
MIRT2215506	hsa-miR-4799-3p	CLIP-seq
MIRT2215507	hsa-miR-520a-5p	CLIP-seq
MIRT2215508	hsa-miR-525-5p	CLIP-seq
MIRT2215509	hsa-miR-548v	CLIP-seq
MIRT2215510	hsa-miR-555	CLIP-seq
MIRT2215511	hsa-miR-622	CLIP-seq
MIRT947040	hsa-miR-624	CLIP-seq
MIRT2215512	hsa-miR-885-3p	CLIP-seq
MIRT947010	hsa-miR-1207-5p	CLIP-seq
MIRT2519891	hsa-miR-1275	CLIP-seq
MIRT2519892	hsa-miR-1324	CLIP-seq
MIRT947012	hsa-miR-146a	CLIP-seq
MIRT947013	hsa-miR-146b-5p	CLIP-seq
MIRT947014	hsa-miR-185	CLIP-seq
MIRT947015	hsa-miR-1908	CLIP-seq
MIRT1980442	hsa-miR-1909	CLIP-seq
MIRT1980443	hsa-miR-217	CLIP-seq
MIRT2519893	hsa-miR-3150b-3p	CLIP-seq
MIRT1980445	hsa-miR-3151	CLIP-seq
MIRT2519894	hsa-miR-3187-3p	CLIP-seq
MIRT947018	hsa-miR-3200-5p	CLIP-seq
MIRT2519895	hsa-miR-3202	CLIP-seq
MIRT1980447	hsa-miR-33a	CLIP-seq
MIRT1980448	hsa-miR-33b	CLIP-seq
MIRT2519896	hsa-miR-3614-5p	CLIP-seq
MIRT2519897	hsa-miR-3615	CLIP-seq
MIRT1980450	hsa-miR-3650	CLIP-seq
MIRT947019	hsa-miR-3656	CLIP-seq
MIRT947020	hsa-miR-3670	CLIP-seq
MIRT2519898	hsa-miR-3917	CLIP-seq
MIRT2519899	hsa-miR-3934	CLIP-seq
MIRT2519900	hsa-miR-4271	CLIP-seq
MIRT2519901	hsa-miR-4279	CLIP-seq
MIRT2519902	hsa-miR-4287	CLIP-seq
MIRT947023	hsa-miR-4300	CLIP-seq
MIRT947024	hsa-miR-4306	CLIP-seq
MIRT2519903	hsa-miR-4313	CLIP-seq
MIRT2519904	hsa-miR-4435	CLIP-seq
MIRT1980452	hsa-miR-4447	CLIP-seq
MIRT2519905	hsa-miR-4469	CLIP-seq
MIRT1980453	hsa-miR-4472	CLIP-seq
MIRT947028	hsa-miR-4475	CLIP-seq
MIRT947029	hsa-miR-4502	CLIP-seq
MIRT2519906	hsa-miR-4525	CLIP-seq
MIRT947030	hsa-miR-4644	CLIP-seq
MIRT2519907	hsa-miR-4665-5p	CLIP-seq
MIRT2519908	hsa-miR-4685-3p	CLIP-seq
MIRT947032	hsa-miR-4690-3p	CLIP-seq
MIRT2519909	hsa-miR-4701-5p	CLIP-seq
MIRT2519910	hsa-miR-4707-5p	CLIP-seq
MIRT2519911	hsa-miR-4723-5p	CLIP-seq
MIRT2519912	hsa-miR-4725-3p	CLIP-seq
MIRT2519913	hsa-miR-4747-5p	CLIP-seq
MIRT947034	hsa-miR-4763-3p	CLIP-seq
MIRT947035	hsa-miR-4768-3p	CLIP-seq
MIRT2519914	hsa-miR-4784	CLIP-seq
MIRT947038	hsa-miR-486-3p	CLIP-seq
MIRT1980458	hsa-miR-491-5p	CLIP-seq
MIRT2519915	hsa-miR-494	CLIP-seq
MIRT2519916	hsa-miR-548s	CLIP-seq
MIRT2519917	hsa-miR-552	CLIP-seq
MIRT2519918	hsa-miR-583	CLIP-seq
MIRT2519919	hsa-miR-588	CLIP-seq
MIRT947040	hsa-miR-624	CLIP-seq
MIRT2519920	hsa-miR-625	CLIP-seq
MIRT2519921	hsa-miR-642a	CLIP-seq
MIRT947041	hsa-miR-663	CLIP-seq
MIRT947042	hsa-miR-920	CLIP-seq
MIRT947043	hsa-miR-939	CLIP-seq
MIRT947010	hsa-miR-1207-5p	CLIP-seq
MIRT2519891	hsa-miR-1275	CLIP-seq
MIRT2519892	hsa-miR-1324	CLIP-seq
MIRT947012	hsa-miR-146a	CLIP-seq
MIRT947013	hsa-miR-146b-5p	CLIP-seq
MIRT947014	hsa-miR-185	CLIP-seq
MIRT947015	hsa-miR-1908	CLIP-seq
MIRT1980442	hsa-miR-1909	CLIP-seq
MIRT1980443	hsa-miR-217	CLIP-seq
MIRT1980445	hsa-miR-3151	CLIP-seq
MIRT2519894	hsa-miR-3187-3p	CLIP-seq
MIRT947018	hsa-miR-3200-5p	CLIP-seq
MIRT2519895	hsa-miR-3202	CLIP-seq
MIRT1980447	hsa-miR-33a	CLIP-seq
MIRT1980448	hsa-miR-33b	CLIP-seq
MIRT2519896	hsa-miR-3614-5p	CLIP-seq
MIRT2519897	hsa-miR-3615	CLIP-seq
MIRT1980450	hsa-miR-3650	CLIP-seq
MIRT947019	hsa-miR-3656	CLIP-seq
MIRT947020	hsa-miR-3670	CLIP-seq
MIRT2519898	hsa-miR-3917	CLIP-seq
MIRT2519899	hsa-miR-3934	CLIP-seq
MIRT2519900	hsa-miR-4271	CLIP-seq
MIRT2519901	hsa-miR-4279	CLIP-seq
MIRT2519902	hsa-miR-4287	CLIP-seq
MIRT947023	hsa-miR-4300	CLIP-seq
MIRT947024	hsa-miR-4306	CLIP-seq
MIRT2519903	hsa-miR-4313	CLIP-seq
MIRT2519904	hsa-miR-4435	CLIP-seq
MIRT1980452	hsa-miR-4447	CLIP-seq
MIRT2519905	hsa-miR-4469	CLIP-seq
MIRT1980453	hsa-miR-4472	CLIP-seq
MIRT947028	hsa-miR-4475	CLIP-seq
MIRT947029	hsa-miR-4502	CLIP-seq
MIRT2519906	hsa-miR-4525	CLIP-seq
MIRT947030	hsa-miR-4644	CLIP-seq
MIRT2519907	hsa-miR-4665-5p	CLIP-seq
MIRT2519908	hsa-miR-4685-3p	CLIP-seq
MIRT947032	hsa-miR-4690-3p	CLIP-seq
MIRT2519909	hsa-miR-4701-5p	CLIP-seq
MIRT2519910	hsa-miR-4707-5p	CLIP-seq
MIRT2519911	hsa-miR-4723-5p	CLIP-seq
MIRT2519912	hsa-miR-4725-3p	CLIP-seq
MIRT2519913	hsa-miR-4747-5p	CLIP-seq
MIRT947034	hsa-miR-4763-3p	CLIP-seq
MIRT947035	hsa-miR-4768-3p	CLIP-seq
MIRT947038	hsa-miR-486-3p	CLIP-seq
MIRT1980458	hsa-miR-491-5p	CLIP-seq
MIRT2519915	hsa-miR-494	CLIP-seq
MIRT2519916	hsa-miR-548s	CLIP-seq
MIRT2519917	hsa-miR-552	CLIP-seq
MIRT2519919	hsa-miR-588	CLIP-seq
MIRT947040	hsa-miR-624	CLIP-seq
MIRT2519920	hsa-miR-625	CLIP-seq
MIRT2519921	hsa-miR-642a	CLIP-seq
MIRT947041	hsa-miR-663	CLIP-seq
MIRT947042	hsa-miR-920	CLIP-seq
MIRT947043	hsa-miR-939	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	19549727, 22493164, 25416956, 32296183, 32814053
GO:0005654	Component	Nucleoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0007219	Process	Notch signaling pathway	IBA
GO:0007219	Process	Notch signaling pathway	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0016567	Process	Protein ubiquitination	IBA
GO:0016567	Process	Protein ubiquitination	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0061630	Function	Ubiquitin protein ligase activity	IBA
GO:0061630	Function	Ubiquitin protein ligase activity	IEA

MIM	HGNC	e!Ensembl
613142	24457	ENSG00000178498

Protein

UniProt ID

Q8N9I9

Protein name

Probable E3 ubiquitin-protein ligase DTX3 (EC 2.3.2.27) (Protein deltex-3) (Deltex3) (RING finger protein 154) (RING-type E3 ubiquitin transferase DTX3)

Protein function

Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF13923	zf-C3HC4_2	163 → 202		Domain
PF18102	DTC	210 → 344	Deltex C-terminal domain	Domain

Sequence

MSFVLSRMAACGGTCKNKVTVSKPVWDFLSKETPARLARLREEHRVSILIDGETSDIYVL
QLSPQGPPPAPPNGLYLARKALKGLLKEAEKELKKAQRQGELMGCLALGGGGEHPEMHRA
GPPPLRAAPLLPPGARGLPPPPPPLPPPLPPRLREEAEEQESTCPICLGEIQNAKTLEKC
RHSFCEGCITRALQVKKACPMCGRFYGQLVGNQPQNGRMLVSKDATLLLPSYEKYGTIVI
QYVFPPGVQGAEHPNPGVRYPGTTRVAYLPDCPEGNKVLTLFRKAFDQRLTFTIGTSMTT
GRPNVITWNDIHHKTSCTGGPQLFGYPDPTYLTRVQEELRAKGITDD

Sequence length

347

Interactions

View interactions

	KEGG
	Notch signaling pathway

DTX3 (deltex E3 ubiquitin ligase 3)