DTX3 (deltex E3 ubiquitin ligase 3)

Gene

• Entrez ID: 196403
• Gene name: Deltex E3 ubiquitin ligase 3
• Gene symbol: DTX3
• Synonyms (NCBI Gene): RNF154, deltex3
• Chromosome: 12
• Chromosome location: 12q13.3
• Summary: DTX3 functions as an E3 ubiquitin ligase (Takeyama et al., 2003 [PubMed 12670957]).[supplied by OMIM, Nov 2009]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT044416	hsa-miR-320a	CLASH	23622248
MIRT947010	hsa-miR-1207-5p	CLIP-seq
MIRT947011	hsa-miR-1234	CLIP-seq
MIRT947012	hsa-miR-146a	CLIP-seq
MIRT947013	hsa-miR-146b-5p	CLIP-seq
MIRT947014	hsa-miR-185	CLIP-seq
MIRT947015	hsa-miR-1908	CLIP-seq
MIRT947016	hsa-miR-3175	CLIP-seq
MIRT947017	hsa-miR-3184	CLIP-seq
MIRT947018	hsa-miR-3200-5p	CLIP-seq
MIRT947019	hsa-miR-3656	CLIP-seq
MIRT947020	hsa-miR-3670	CLIP-seq
MIRT947021	hsa-miR-3689d	CLIP-seq
MIRT947022	hsa-miR-423-5p	CLIP-seq
MIRT947023	hsa-miR-4300	CLIP-seq
MIRT947024	hsa-miR-4306	CLIP-seq
MIRT947025	hsa-miR-432	CLIP-seq
MIRT947026	hsa-miR-4440	CLIP-seq
MIRT947027	hsa-miR-4443	CLIP-seq
MIRT947028	hsa-miR-4475	CLIP-seq
MIRT947029	hsa-miR-4502	CLIP-seq
MIRT947030	hsa-miR-4644	CLIP-seq
MIRT947031	hsa-miR-4688	CLIP-seq
MIRT947032	hsa-miR-4690-3p	CLIP-seq
MIRT947033	hsa-miR-4728-5p	CLIP-seq
MIRT947034	hsa-miR-4763-3p	CLIP-seq
MIRT947035	hsa-miR-4768-3p	CLIP-seq
MIRT947036	hsa-miR-4773	CLIP-seq
MIRT947037	hsa-miR-4802-5p	CLIP-seq
MIRT947038	hsa-miR-486-3p	CLIP-seq
MIRT947039	hsa-miR-602	CLIP-seq
MIRT947040	hsa-miR-624	CLIP-seq
MIRT947041	hsa-miR-663	CLIP-seq
MIRT947042	hsa-miR-920	CLIP-seq
MIRT947043	hsa-miR-939	CLIP-seq
MIRT947010	hsa-miR-1207-5p	CLIP-seq
MIRT947011	hsa-miR-1234	CLIP-seq
MIRT947012	hsa-miR-146a	CLIP-seq
MIRT947013	hsa-miR-146b-5p	CLIP-seq
MIRT947014	hsa-miR-185	CLIP-seq
MIRT947015	hsa-miR-1908	CLIP-seq
MIRT1980442	hsa-miR-1909	CLIP-seq
MIRT1980443	hsa-miR-217	CLIP-seq
MIRT1980444	hsa-miR-24	CLIP-seq
MIRT1980445	hsa-miR-3151	CLIP-seq
MIRT1980446	hsa-miR-3154	CLIP-seq
MIRT947016	hsa-miR-3175	CLIP-seq
MIRT947018	hsa-miR-3200-5p	CLIP-seq
MIRT1980447	hsa-miR-33a	CLIP-seq
MIRT1980448	hsa-miR-33b	CLIP-seq
MIRT1980449	hsa-miR-342-3p	CLIP-seq
MIRT1980450	hsa-miR-3650	CLIP-seq
MIRT947021	hsa-miR-3689d	CLIP-seq
MIRT1980451	hsa-miR-4284	CLIP-seq
MIRT947024	hsa-miR-4306	CLIP-seq
MIRT947025	hsa-miR-432	CLIP-seq
MIRT947027	hsa-miR-4443	CLIP-seq
MIRT1980452	hsa-miR-4447	CLIP-seq
MIRT1980453	hsa-miR-4472	CLIP-seq
MIRT947028	hsa-miR-4475	CLIP-seq
MIRT1980454	hsa-miR-4499	CLIP-seq
MIRT947029	hsa-miR-4502	CLIP-seq
MIRT947030	hsa-miR-4644	CLIP-seq
MIRT1980455	hsa-miR-4727-5p	CLIP-seq
MIRT947033	hsa-miR-4728-5p	CLIP-seq
MIRT1980456	hsa-miR-4757-5p	CLIP-seq
MIRT947034	hsa-miR-4763-3p	CLIP-seq
MIRT947035	hsa-miR-4768-3p	CLIP-seq
MIRT1980457	hsa-miR-4769-3p	CLIP-seq
MIRT947036	hsa-miR-4773	CLIP-seq
MIRT947038	hsa-miR-486-3p	CLIP-seq
MIRT1980458	hsa-miR-491-5p	CLIP-seq
MIRT947040	hsa-miR-624	CLIP-seq
MIRT947041	hsa-miR-663	CLIP-seq
MIRT2215500	hsa-miR-139-5p	CLIP-seq
MIRT947014	hsa-miR-185	CLIP-seq
MIRT2215501	hsa-miR-3128	CLIP-seq
MIRT2215502	hsa-miR-3173-3p	CLIP-seq
MIRT2215503	hsa-miR-3180-5p	CLIP-seq
MIRT947024	hsa-miR-4306	CLIP-seq
MIRT2215504	hsa-miR-4428	CLIP-seq
MIRT1980454	hsa-miR-4499	CLIP-seq
MIRT947030	hsa-miR-4644	CLIP-seq
MIRT2215505	hsa-miR-4720-5p	CLIP-seq
MIRT947035	hsa-miR-4768-3p	CLIP-seq
MIRT947036	hsa-miR-4773	CLIP-seq
MIRT2215506	hsa-miR-4799-3p	CLIP-seq
MIRT2215507	hsa-miR-520a-5p	CLIP-seq
MIRT2215508	hsa-miR-525-5p	CLIP-seq
MIRT2215509	hsa-miR-548v	CLIP-seq
MIRT2215510	hsa-miR-555	CLIP-seq
MIRT2215511	hsa-miR-622	CLIP-seq
MIRT947040	hsa-miR-624	CLIP-seq
MIRT2215512	hsa-miR-885-3p	CLIP-seq
MIRT947010	hsa-miR-1207-5p	CLIP-seq
MIRT2519891	hsa-miR-1275	CLIP-seq
MIRT2519892	hsa-miR-1324	CLIP-seq
MIRT947012	hsa-miR-146a	CLIP-seq
MIRT947013	hsa-miR-146b-5p	CLIP-seq
MIRT947014	hsa-miR-185	CLIP-seq
MIRT947015	hsa-miR-1908	CLIP-seq
MIRT1980442	hsa-miR-1909	CLIP-seq
MIRT1980443	hsa-miR-217	CLIP-seq
MIRT2519893	hsa-miR-3150b-3p	CLIP-seq
MIRT1980445	hsa-miR-3151	CLIP-seq
MIRT2519894	hsa-miR-3187-3p	CLIP-seq
MIRT947018	hsa-miR-3200-5p	CLIP-seq
MIRT2519895	hsa-miR-3202	CLIP-seq
MIRT1980447	hsa-miR-33a	CLIP-seq
MIRT1980448	hsa-miR-33b	CLIP-seq
MIRT2519896	hsa-miR-3614-5p	CLIP-seq
MIRT2519897	hsa-miR-3615	CLIP-seq
MIRT1980450	hsa-miR-3650	CLIP-seq
MIRT947019	hsa-miR-3656	CLIP-seq
MIRT947020	hsa-miR-3670	CLIP-seq
MIRT2519898	hsa-miR-3917	CLIP-seq
MIRT2519899	hsa-miR-3934	CLIP-seq
MIRT2519900	hsa-miR-4271	CLIP-seq
MIRT2519901	hsa-miR-4279	CLIP-seq
MIRT2519902	hsa-miR-4287	CLIP-seq
MIRT947023	hsa-miR-4300	CLIP-seq
MIRT947024	hsa-miR-4306	CLIP-seq
MIRT2519903	hsa-miR-4313	CLIP-seq
MIRT2519904	hsa-miR-4435	CLIP-seq
MIRT1980452	hsa-miR-4447	CLIP-seq
MIRT2519905	hsa-miR-4469	CLIP-seq
MIRT1980453	hsa-miR-4472	CLIP-seq
MIRT947028	hsa-miR-4475	CLIP-seq
MIRT947029	hsa-miR-4502	CLIP-seq
MIRT2519906	hsa-miR-4525	CLIP-seq
MIRT947030	hsa-miR-4644	CLIP-seq
MIRT2519907	hsa-miR-4665-5p	CLIP-seq
MIRT2519908	hsa-miR-4685-3p	CLIP-seq
MIRT947032	hsa-miR-4690-3p	CLIP-seq
MIRT2519909	hsa-miR-4701-5p	CLIP-seq
MIRT2519910	hsa-miR-4707-5p	CLIP-seq
MIRT2519911	hsa-miR-4723-5p	CLIP-seq
MIRT2519912	hsa-miR-4725-3p	CLIP-seq
MIRT2519913	hsa-miR-4747-5p	CLIP-seq
MIRT947034	hsa-miR-4763-3p	CLIP-seq
MIRT947035	hsa-miR-4768-3p	CLIP-seq
MIRT2519914	hsa-miR-4784	CLIP-seq
MIRT947038	hsa-miR-486-3p	CLIP-seq
MIRT1980458	hsa-miR-491-5p	CLIP-seq
MIRT2519915	hsa-miR-494	CLIP-seq
MIRT2519916	hsa-miR-548s	CLIP-seq
MIRT2519917	hsa-miR-552	CLIP-seq
MIRT2519918	hsa-miR-583	CLIP-seq
MIRT2519919	hsa-miR-588	CLIP-seq
MIRT947040	hsa-miR-624	CLIP-seq
MIRT2519920	hsa-miR-625	CLIP-seq
MIRT2519921	hsa-miR-642a	CLIP-seq
MIRT947041	hsa-miR-663	CLIP-seq
MIRT947042	hsa-miR-920	CLIP-seq
MIRT947043	hsa-miR-939	CLIP-seq
MIRT947010	hsa-miR-1207-5p	CLIP-seq
MIRT2519891	hsa-miR-1275	CLIP-seq
MIRT2519892	hsa-miR-1324	CLIP-seq
MIRT947012	hsa-miR-146a	CLIP-seq
MIRT947013	hsa-miR-146b-5p	CLIP-seq
MIRT947014	hsa-miR-185	CLIP-seq
MIRT947015	hsa-miR-1908	CLIP-seq
MIRT1980442	hsa-miR-1909	CLIP-seq
MIRT1980443	hsa-miR-217	CLIP-seq
MIRT1980445	hsa-miR-3151	CLIP-seq
MIRT2519894	hsa-miR-3187-3p	CLIP-seq
MIRT947018	hsa-miR-3200-5p	CLIP-seq
MIRT2519895	hsa-miR-3202	CLIP-seq
MIRT1980447	hsa-miR-33a	CLIP-seq
MIRT1980448	hsa-miR-33b	CLIP-seq
MIRT2519896	hsa-miR-3614-5p	CLIP-seq
MIRT2519897	hsa-miR-3615	CLIP-seq
MIRT1980450	hsa-miR-3650	CLIP-seq
MIRT947019	hsa-miR-3656	CLIP-seq
MIRT947020	hsa-miR-3670	CLIP-seq
MIRT2519898	hsa-miR-3917	CLIP-seq
MIRT2519899	hsa-miR-3934	CLIP-seq
MIRT2519900	hsa-miR-4271	CLIP-seq
MIRT2519901	hsa-miR-4279	CLIP-seq
MIRT2519902	hsa-miR-4287	CLIP-seq
MIRT947023	hsa-miR-4300	CLIP-seq
MIRT947024	hsa-miR-4306	CLIP-seq
MIRT2519903	hsa-miR-4313	CLIP-seq
MIRT2519904	hsa-miR-4435	CLIP-seq
MIRT1980452	hsa-miR-4447	CLIP-seq
MIRT2519905	hsa-miR-4469	CLIP-seq
MIRT1980453	hsa-miR-4472	CLIP-seq
MIRT947028	hsa-miR-4475	CLIP-seq
MIRT947029	hsa-miR-4502	CLIP-seq
MIRT2519906	hsa-miR-4525	CLIP-seq
MIRT947030	hsa-miR-4644	CLIP-seq
MIRT2519907	hsa-miR-4665-5p	CLIP-seq
MIRT2519908	hsa-miR-4685-3p	CLIP-seq
MIRT947032	hsa-miR-4690-3p	CLIP-seq
MIRT2519909	hsa-miR-4701-5p	CLIP-seq
MIRT2519910	hsa-miR-4707-5p	CLIP-seq
MIRT2519911	hsa-miR-4723-5p	CLIP-seq
MIRT2519912	hsa-miR-4725-3p	CLIP-seq
MIRT2519913	hsa-miR-4747-5p	CLIP-seq
MIRT947034	hsa-miR-4763-3p	CLIP-seq
MIRT947035	hsa-miR-4768-3p	CLIP-seq
MIRT947038	hsa-miR-486-3p	CLIP-seq
MIRT1980458	hsa-miR-491-5p	CLIP-seq
MIRT2519915	hsa-miR-494	CLIP-seq
MIRT2519916	hsa-miR-548s	CLIP-seq
MIRT2519917	hsa-miR-552	CLIP-seq
MIRT2519919	hsa-miR-588	CLIP-seq
MIRT947040	hsa-miR-624	CLIP-seq
MIRT2519920	hsa-miR-625	CLIP-seq
MIRT2519921	hsa-miR-642a	CLIP-seq
MIRT947041	hsa-miR-663	CLIP-seq
MIRT947042	hsa-miR-920	CLIP-seq
MIRT947043	hsa-miR-939	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	19549727, 22493164, 25416956, 32296183, 32814053
GO:0005654	Component	Nucleoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0007219	Process	Notch signaling pathway	IBA
GO:0007219	Process	Notch signaling pathway	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0016567	Process	Protein ubiquitination	IBA
GO:0016567	Process	Protein ubiquitination	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0061630	Function	Ubiquitin protein ligase activity	IBA
GO:0061630	Function	Ubiquitin protein ligase activity	IEA

Other IDs

• MIM: 613142
• HGNC: 24457
• e!Ensembl: ENSG00000178498

Protein

• UniProt ID: Q8N9I9
• Protein name: Probable E3 ubiquitin-protein ligase DTX3 (EC 2.3.2.27) (Protein deltex-3) (Deltex3) (RING finger protein 154) (RING-type E3 ubiquitin transferase DTX3)
• Protein function: Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13923	zf-C3HC4_2	163 → 202		Domain
  PF18102	DTC	210 → 344	Deltex C-terminal domain	Domain

• Sequence:

  MSFVLSRMAACGGTCKNKVTVSKPVWDFLSKETPARLARLREEHRVSILIDGETSDIYVL
  QLSPQGPPPAPPNGLYLARKALKGLLKEAEKELKKAQRQGELMGCLALGGGGEHPEMHRA
  GPPPLRAAPLLPPGARGLPPPPPPLPPPLPPRLREEAEEQESTCPICLGEIQNAKTLEKC
  RHSFCEGCITRALQVKKACPMCGRFYGQLVGNQPQNGRMLVSKDATLLLPSYEKYGTIVI
  QYVFPPGVQGAEHPNPGVRYPGTTRVAYLPDCPEGNKVLTLFRKAFDQRLTFTIGTSMTT
  GRPNVITWNDIHHKTSCTGGPQLFGYPDPTYLTRVQEELRAKGITDD

• Sequence length: 347

Pathways

KEGG:

Notch signaling pathway