Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	1933
Gene name Gene Name - the full gene name approved by the HGNC.	Eukaryotic translation elongation factor 1 beta 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	EEF1B2
Synonyms (NCBI Gene) Gene synonyms aliases	EEF1B, EEF1B1, EF1B
Chromosome Chromosome number	2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	2q33.3
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a translation elongation factor. The protein is a guanine nucleotide exchange factor involved in the transfer of aminoacylated tRNAs to the ribosome. Alternative splicing results in three transcript variants which differ only in the 5` U

Show/Hide all(34)

miRTarBase ID	miRNA	Experiments	Reference
MIRT050124	hsa-miR-26a-5p	CLASH	23622248
MIRT045403	hsa-miR-149-5p	CLASH	23622248
MIRT043864	hsa-miR-378a-3p	CLASH	23622248
MIRT650600	hsa-miR-548m	HITS-CLIP	23824327
MIRT650599	hsa-miR-548ag	HITS-CLIP	23824327
MIRT650598	hsa-miR-548ai	HITS-CLIP	23824327
MIRT650597	hsa-miR-548ba	HITS-CLIP	23824327
MIRT650596	hsa-miR-570-5p	HITS-CLIP	23824327
MIRT650600	hsa-miR-548m	HITS-CLIP	23824327
MIRT650599	hsa-miR-548ag	HITS-CLIP	23824327
MIRT650598	hsa-miR-548ai	HITS-CLIP	23824327
MIRT650597	hsa-miR-548ba	HITS-CLIP	23824327
MIRT650596	hsa-miR-570-5p	HITS-CLIP	23824327
MIRT953110	hsa-miR-1246	CLIP-seq
MIRT953111	hsa-miR-2392	CLIP-seq
MIRT953112	hsa-miR-3134	CLIP-seq
MIRT953113	hsa-miR-4659a-5p	CLIP-seq
MIRT953114	hsa-miR-4659b-5p	CLIP-seq
MIRT953115	hsa-miR-640	CLIP-seq
MIRT953116	hsa-miR-665	CLIP-seq
MIRT953110	hsa-miR-1246	CLIP-seq
MIRT953111	hsa-miR-2392	CLIP-seq
MIRT953112	hsa-miR-3134	CLIP-seq
MIRT953113	hsa-miR-4659a-5p	CLIP-seq
MIRT953114	hsa-miR-4659b-5p	CLIP-seq
MIRT953115	hsa-miR-640	CLIP-seq
MIRT953116	hsa-miR-665	CLIP-seq
MIRT953110	hsa-miR-1246	CLIP-seq
MIRT953111	hsa-miR-2392	CLIP-seq
MIRT953112	hsa-miR-3134	CLIP-seq
MIRT953113	hsa-miR-4659a-5p	CLIP-seq
MIRT953114	hsa-miR-4659b-5p	CLIP-seq
MIRT953115	hsa-miR-640	CLIP-seq
MIRT953116	hsa-miR-665	CLIP-seq

Show/Hide all(13)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003746	Function	Translation elongation factor activity	NAS	1886777
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IBA	21873635
GO:0005515	Function	Protein binding	IPI	16169070, 16189514, 25416956, 25959826, 28514442, 32296183, 32814053
GO:0005634	Component	Nucleus	IDA	12426392
GO:0005737	Component	Cytoplasm	IDA	8743958, 12426392
GO:0005783	Component	Endoplasmic reticulum	IDA	8743958
GO:0005829	Component	Cytosol	IBA	21873635
GO:0005829	Component	Cytosol	TAS
GO:0005853	Component	Eukaryotic translation elongation factor 1 complex	NAS	1886777
GO:0006414	Process	Translational elongation	IBA	21873635
GO:0006414	Process	Translational elongation	NAS	1886777
GO:0006414	Process	Translational elongation	TAS
GO:0050790	Process	Regulation of catalytic activity	IEA

MIM	HGNC	e!Ensembl
600655	3208	ENSG00000114942

Protein

UniProt ID

P24534

Protein name

Elongation factor 1-beta (EF-1-beta) (eEF-1B alpha)

Protein function

Catalytic subunit of the guanine nucleotide exchange factor (GEF) (eEF1B subcomplex) of the eukaryotic elongation factor 1 complex (eEF1) (By similarity). Stimulates the exchange of GDP for GTP on elongation factor 1A (eEF1A), probably by displa

PDB

1B64 , 5DQS

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF10587	EF-1_beta_acid	103 → 130	Eukaryotic elongation factor 1 beta central acidic region	Domain
PF00736	EF1_GNE	141 → 225	EF-1 guanine nucleotide exchange domain	Domain

Sequence

MGFGDLKSPAGLQVLNDYLADKSYIEGYVPSQADVAVFEAVSSPPPADLCHALRWYNHIK
SYEKEKASLPGVKKALGKYGPADVEDTTGSGATDSKDDDDIDLFGSDDEEESEEAKRLRE
ERLAQYESKKAKKPALVAKSSILLDVKPWDDETDMAKLEECVRSIQADGLVWGSSKLVPV
GYGIKKLQIQCVVEDDKVGTDMLEEQITAFEDYVQSMDVAAFNKI

Sequence length

225

Interactions

View interactions

	Reactome
			Eukaryotic Translation Elongation

Show/Hide Causal Diseases (4)

Disease term	Disease name	dbSNP ID	References
Causal
Breast cancer	Malignant neoplasm of breast	rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158 View all (309 more)	20562527
Breast carcinoma	Breast Carcinoma	rs80359671, rs11540652, rs28934575, rs28897672, rs137886232, rs193922376, rs80357783, rs80359306, rs80359405, rs80359507, rs80359598, rs80358429, rs397507683, rs397515636, rs80359451 View all (71 more)	20562527
Mental retardation	Profound Mental Retardation, Mental deficiency, Intellectual Disability	rs5742905, rs267607136, rs267607137, rs2131714307, rs267607038, rs267607042, rs80338685, rs137853127, rs80338815, rs28940893, rs387906309, rs121908096, rs121908099, rs587784365, rs121918315 View all (1024 more)	21937992
Marfan syndrome	Mammary Carcinoma, Human	rs137854456, rs137854457, rs267606796, rs137854458, rs137854459, rs137854460, rs137854470, rs137854471, rs267606797, rs137854461, rs137854462, rs137854463, rs869025419, rs137854464, rs137854465 View all (942 more)	20562527

Show/Hide Unknown Diseases (1)

Disease term	Disease name	Evidence	References	Source
Unknown
Neurodevelopmental Disorders	neurodevelopmental disorder			GenCC

Show/Hide Text Mining Associations (7)

Disease Name	Relationship Type	References
Associations from Text Mining
Alzheimer Disease	Associate	34225819
Breast Neoplasms	Associate	17127214, 20005186
Lung Neoplasms	Associate	29342219
Myocardial Infarction	Associate	35864510
Neoplasms	Associate	27225414
Neoplasms	Stimulate	29342219
Sarcoma Kaposi	Associate	40016701

EEF1B2 (eukaryotic translation elongation factor 1 beta 2)