Gene Gene information from NCBI Gene database.
Entrez ID 1915
Gene name Eukaryotic translation elongation factor 1 alpha 1
Gene symbol EEF1A1
Synonyms (NCBI Gene)
CCS-3CCS3EE1A1EEF-1EEF1AEF-TuEF1AEF1A1EF1alpha1GRAF-1EFLENG7PTI1eEF1A-1
Chromosome 6
Chromosome location 6q13
Summary This gene encodes an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha 1) is expressed in brain, placenta, lung, liver, kidney, and panc
miRNA miRNA information provided by mirtarbase database.
712
miRTarBase ID miRNA Experiments Reference
MIRT031618 hsa-miR-16-5p Proteomics 18668040
MIRT051968 hsa-let-7b-5p CLASH 23622248
MIRT031618 hsa-miR-16-5p CLASH 23622248
MIRT050841 hsa-miR-17-5p CLASH 23622248
MIRT050679 hsa-miR-18a-5p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
54
GO ID Ontology Definition Evidence Reference
GO:0000049 Function TRNA binding IDA 12426392
GO:0000166 Function Nucleotide binding IEA
GO:0003723 Function RNA binding HDA 22658674, 22681889
GO:0003746 Function Translation elongation factor activity IBA
GO:0003746 Function Translation elongation factor activity IDA 26593721, 36638793
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
130590 3189 ENSG00000156508
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P68104
Protein name Elongation factor 1-alpha 1 (EF-1-alpha-1) (EC 3.6.5.-) (Elongation factor Tu) (EF-Tu) (Eukaryotic elongation factor 1 A-1) (eEF1A-1) (Leukocyte receptor cluster member 7)
Protein function Translation elongation factor that catalyzes the GTP-dependent binding of aminoacyl-tRNA (aa-tRNA) to the A-site of ribosomes during the elongation phase of protein synthesis (PubMed:26593721, PubMed:26651998, PubMed:36123449, PubMed:36264623, P
PDB 3C5J , 6ZMO , 8G60 , 8G6J
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00009 GTP_EFTU 5 238 Elongation factor Tu GTP binding domain Domain
PF03144 GTP_EFTU_D2 260 327 Elongation factor Tu domain 2 Domain
PF03143 GTP_EFTU_D3 333 442 Elongation factor Tu C-terminal domain Domain
Sequence
Sequence length 462
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Nucleocytoplasmic transport
Legionellosis
Leishmaniasis
  Eukaryotic Translation Elongation
HSF1 activation
Neutrophil degranulation
Protein methylation