PHC2 (polyhomeotic homolog 2)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 1912 |
| Gene name | Polyhomeotic homolog 2 |
| Gene symbol | PHC2 |
| Synonyms (NCBI Gene) |
EDR2HPH2PH2
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| Chromosome | 1 |
| Chromosome location | 1p35.1 |
| Summary | In Drosophila melanogaster, the `Polycomb` group (PcG) of genes are part of a cellular memory system that is responsible for the stable inheritance of gene activity. PcG proteins form a large multimeric, chromatin-associated protein complex. The protein e |
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miRNA
miRNA information provided by mirtarbase database.
400
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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Q8IXK0 | |||||||||||||||
| Protein name | Polyhomeotic-like protein 2 (hPH2) (Early development regulatory protein 2) | |||||||||||||||
| Protein function | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remod | |||||||||||||||
| Family and domains |
Pfam
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| Sequence |
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| Sequence length | 858 | |||||||||||||||
| Interactions | View interactions | |||||||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
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Evidence Score:
★☆☆☆☆ Gene-disease association found in Text Mining only
★★☆☆☆ Found in Text Mining and Unknown/Other Associations
★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources
★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
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