Gene Gene information from NCBI Gene database.
Entrez ID 1912
Gene name Polyhomeotic homolog 2
Gene symbol PHC2
Synonyms (NCBI Gene)
EDR2HPH2PH2
Chromosome 1
Chromosome location 1p35.1
Summary In Drosophila melanogaster, the `Polycomb` group (PcG) of genes are part of a cellular memory system that is responsible for the stable inheritance of gene activity. PcG proteins form a large multimeric, chromatin-associated protein complex. The protein e
miRNA miRNA information provided by mirtarbase database.
400
miRTarBase ID miRNA Experiments Reference
MIRT001526 hsa-miR-155-5p pSILAC 18668040
MIRT002500 hsa-miR-373-3p Microarray 15685193
MIRT002500 hsa-miR-373-3p Microarray;Other 15685193
MIRT001526 hsa-miR-155-5p Proteomics 18668040
MIRT001526 hsa-miR-155-5p Reporter assay;Other 20584899
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
19
GO ID Ontology Definition Evidence Reference
GO:0000792 Component Heterochromatin IEA
GO:0003677 Function DNA binding IEA
GO:0003682 Function Chromatin binding IBA
GO:0005515 Function Protein binding IPI 10976766, 12167701, 16189514, 17332741, 19369945, 19636380, 20601937, 21516116, 21988832, 24981860, 25416956, 25910212, 27705803, 31515488, 32814053, 33961781, 34316702
GO:0005634 Component Nucleus IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
602979 3183 ENSG00000134686
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q8IXK0
Protein name Polyhomeotic-like protein 2 (hPH2) (Early development regulatory protein 2)
Protein function Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remod
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF16616 PHC2_SAM_assoc 670 789 Disordered
PF00536 SAM_1 792 856 SAM domain (Sterile alpha motif) Domain
Sequence
MENELPVPHTSSSACATSSTSGASSSSGCNNSSSGGSGRPTGPQISVYSGIPDRQTVQVI
QQALHRQPSTAAQYLQQMYAAQQQHLMLQTAALQQQHLSSAQLQSLAAVQQASLVSNRQG
STSGSNVSAQAPAQSSSINLAASPAAAQLLNRAQSVNSAAASGIAQQAVLLGNTSSPALT
ASQAQMYLRAQMLIFTPTATVATVQPELGTGSPARPPTPAQVQNLTLRTQQTPAAAASGP
TPTQPVLPSLALKPTPGGSQPLPTPAQSRNTAQASPAGAKPGIADSVMEPHKKGDGNSSV
PGSMEGRAGLSRTVPAVAAHPLIAPAYAQLQPHQLLPQPSSKHLQPQFVIQQQPQPQQQQ
PPPQQSRPVLQAEPHPQLASVSPSVALQPSSEAHAMPLGPVTPALPLQCPTANLHKPGGS
QQCHPPTPDTGPQNGHPEGVPHTPQRRFQHTSAVILQLQPASPPQQCVPDDWKEVAPGEK
SVPETRSGPSPHQQAIVTAMPGGLPVPTSPNIQPSPAHETGQGIVHALTDLSSPGMTSGN
GNSASSIAGTAPQNGENKPPQAIVKPQILTHVIEGFVIQEGAEPFPVGRSSLLVGNLKKK
YAQGFLPEKLPQQDHTTTTDSEMEEPYLQESKEEGAPLKLKCELCGRVDFAYKFKRSKRF
CSMACAKRYNVGCTKRVGLFHSDRSKLQKAGAATHNRRRASKASLPPLTKDTKKQPTGTV
PLSVTAALQLTHSQEDSSRCSDNSSYEEPLSPISASSSTSRRRQGQRDLELPDMHMRDLV
GMGHHFLPS
EPTKWNVEDVYEFIRSLPGCQEIAEEFRAQEIDGQALLLLKEDHLMSAMNI
KLGPALKIYARISMLK
DS
Sequence length 858
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Polycomb repressive complex   Oxidative Stress Induced Senescence
SUMOylation of DNA damage response and repair proteins
SUMOylation of transcription cofactors
SUMOylation of chromatin organization proteins
SUMOylation of RNA binding proteins
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Regulation of PTEN gene transcription
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
11
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ATTENTION DEFICIT HYPERACTIVITY DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
BREAST CANCER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
COLOR VISION DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CROHN'S DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Arthritis Rheumatoid Associate 34079550
★☆☆☆☆
Found in Text Mining only
Composite Lymphoma Associate 37658696
★☆☆☆☆
Found in Text Mining only
Glioblastoma Associate 24260522
★☆☆☆☆
Found in Text Mining only
Metabolic Syndrome Associate 37138862
★☆☆☆☆
Found in Text Mining only
Neuroendocrine Tumors Associate 37658696
★☆☆☆☆
Found in Text Mining only
Osteoarthritis Associate 37138862
★☆☆☆☆
Found in Text Mining only
Prostatic Neoplasms Associate 32366400
★☆☆☆☆
Found in Text Mining only