Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	191
Gene name	Adenosylhomocysteinase
Gene symbol	AHCY
Synonyms (NCBI Gene)	SAHHadoHcyase
Chromosome	20
Chromosome location	20q11.22
Summary	S-adenosylhomocysteine hydrolase belongs to the adenosylhomocysteinase family. It catalyzes the reversible hydrolysis of S-adenosylhomocysteine (AdoHcy) to adenosine (Ado) and L-homocysteine (Hcy). Thus, it regulates the intracellular S-adenosylhomocystei

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SNP ID	Visualize variation	Clinical significance	Consequence
rs11552695	T>C	Conflicting-interpretations-of-pathogenicity	Missense variant, coding sequence variant, 5 prime UTR variant
rs121918607	C>T	Pathogenic	Stop gained, coding sequence variant, 5 prime UTR variant
rs121918608	T>C	Likely-pathogenic, pathogenic	Coding sequence variant, missense variant
rs755222515	G>A	Uncertain-significance, likely-pathogenic	Coding sequence variant, missense variant, 5 prime UTR variant
rs757357954	G>A	Conflicting-interpretations-of-pathogenicity	Coding sequence variant, synonymous variant
rs757966746	G>A	Pathogenic	Coding sequence variant, missense variant, 5 prime UTR variant

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miRTarBase ID	miRNA	Experiments	Reference
MIRT724958	hsa-miR-3914	HITS-CLIP	19536157
MIRT724957	hsa-miR-29b-1-5p	HITS-CLIP	19536157
MIRT724956	hsa-miR-5681a	HITS-CLIP	19536157
MIRT724955	hsa-miR-6730-5p	HITS-CLIP	19536157
MIRT724954	hsa-miR-340-5p	HITS-CLIP	19536157
MIRT724953	hsa-miR-488-3p	HITS-CLIP	19536157
MIRT724952	hsa-miR-487a-5p	HITS-CLIP	19536157
MIRT724951	hsa-miR-487b-5p	HITS-CLIP	19536157
MIRT724950	hsa-miR-3611	HITS-CLIP	19536157
MIRT705850	hsa-miR-6732-3p	HITS-CLIP	23313552
MIRT705849	hsa-miR-10a-5p	HITS-CLIP	23313552
MIRT705848	hsa-miR-10b-5p	HITS-CLIP	23313552
MIRT705847	hsa-miR-6849-3p	HITS-CLIP	23313552
MIRT705846	hsa-miR-339-5p	HITS-CLIP	23313552
MIRT705845	hsa-miR-4421	HITS-CLIP	23313552
MIRT705844	hsa-miR-5699-3p	HITS-CLIP	23313552
MIRT705843	hsa-miR-1283	HITS-CLIP	23313552
MIRT705842	hsa-miR-3190-5p	HITS-CLIP	23313552
MIRT705841	hsa-miR-3926	HITS-CLIP	23313552
MIRT705840	hsa-miR-6895-3p	HITS-CLIP	23313552
MIRT705839	hsa-miR-593-3p	HITS-CLIP	23313552
MIRT705838	hsa-miR-4684-5p	HITS-CLIP	23313552
MIRT705837	hsa-miR-548s	HITS-CLIP	23313552
MIRT705836	hsa-miR-6818-3p	HITS-CLIP	23313552
MIRT660813	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT639808	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT660814	hsa-miR-4650-5p	HITS-CLIP	23824327
MIRT660813	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT639807	hsa-miR-6072	HITS-CLIP	23824327
MIRT639806	hsa-miR-6891-3p	HITS-CLIP	23824327
MIRT660812	hsa-miR-3690	HITS-CLIP	23824327
MIRT660811	hsa-miR-4254	HITS-CLIP	23824327
MIRT639803	hsa-miR-1343-3p	HITS-CLIP	23824327
MIRT639802	hsa-miR-6783-3p	HITS-CLIP	23824327
MIRT639801	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT639800	hsa-miR-3074-5p	HITS-CLIP	23824327
MIRT639799	hsa-miR-7152-5p	HITS-CLIP	23824327
MIRT660813	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT639808	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT660814	hsa-miR-4650-5p	HITS-CLIP	23824327
MIRT660813	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT639807	hsa-miR-6072	HITS-CLIP	23824327
MIRT639806	hsa-miR-6891-3p	HITS-CLIP	23824327
MIRT660812	hsa-miR-3690	HITS-CLIP	23824327
MIRT660811	hsa-miR-4254	HITS-CLIP	23824327
MIRT639803	hsa-miR-1343-3p	HITS-CLIP	23824327
MIRT639802	hsa-miR-6783-3p	HITS-CLIP	23824327
MIRT639801	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT639800	hsa-miR-3074-5p	HITS-CLIP	23824327
MIRT639799	hsa-miR-7152-5p	HITS-CLIP	23824327
MIRT639808	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT639807	hsa-miR-6072	HITS-CLIP	23824327
MIRT639806	hsa-miR-6891-3p	HITS-CLIP	23824327
MIRT639805	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT639804	hsa-miR-3124-3p	HITS-CLIP	23824327
MIRT639803	hsa-miR-1343-3p	HITS-CLIP	23824327
MIRT639802	hsa-miR-6783-3p	HITS-CLIP	23824327
MIRT639801	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT639800	hsa-miR-3074-5p	HITS-CLIP	23824327
MIRT639799	hsa-miR-7152-5p	HITS-CLIP	23824327
MIRT639808	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT639807	hsa-miR-6072	HITS-CLIP	23824327
MIRT639806	hsa-miR-6891-3p	HITS-CLIP	23824327
MIRT639805	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT639804	hsa-miR-3124-3p	HITS-CLIP	23824327
MIRT639803	hsa-miR-1343-3p	HITS-CLIP	23824327
MIRT639802	hsa-miR-6783-3p	HITS-CLIP	23824327
MIRT639801	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT639800	hsa-miR-3074-5p	HITS-CLIP	23824327
MIRT639799	hsa-miR-7152-5p	HITS-CLIP	23824327
MIRT482239	hsa-miR-4699-3p	PAR-CLIP	23592263
MIRT482238	hsa-miR-4269	PAR-CLIP	23592263
MIRT482237	hsa-miR-6715b-5p	PAR-CLIP	23592263
MIRT482236	hsa-miR-4645-5p	PAR-CLIP	23592263
MIRT482235	hsa-miR-4673	PAR-CLIP	23592263
MIRT482234	hsa-miR-593-5p	PAR-CLIP	23592263
MIRT482233	hsa-miR-5591-3p	PAR-CLIP	23592263
MIRT482231	hsa-miR-6875-3p	PAR-CLIP	23592263
MIRT482238	hsa-miR-4269	PAR-CLIP	26701625
MIRT482238	hsa-miR-4269	PAR-CLIP	26701625
MIRT482238	hsa-miR-4269	PAR-CLIP	26701625
MIRT482236	hsa-miR-4645-5p	PAR-CLIP	26701625
MIRT482236	hsa-miR-4645-5p	PAR-CLIP	26701625
MIRT482236	hsa-miR-4645-5p	PAR-CLIP	26701625
MIRT482235	hsa-miR-4673	PAR-CLIP	26701625
MIRT482235	hsa-miR-4673	PAR-CLIP	26701625
MIRT482235	hsa-miR-4673	PAR-CLIP	26701625
MIRT482239	hsa-miR-4699-3p	PAR-CLIP	26701625
MIRT482239	hsa-miR-4699-3p	PAR-CLIP	26701625
MIRT482239	hsa-miR-4699-3p	PAR-CLIP	26701625
MIRT482233	hsa-miR-5591-3p	PAR-CLIP	26701625
MIRT482233	hsa-miR-5591-3p	PAR-CLIP	26701625
MIRT482233	hsa-miR-5591-3p	PAR-CLIP	26701625
MIRT482234	hsa-miR-593-5p	PAR-CLIP	26701625
MIRT482234	hsa-miR-593-5p	PAR-CLIP	26701625
MIRT482234	hsa-miR-593-5p	PAR-CLIP	26701625
MIRT482237	hsa-miR-6715b-5p	PAR-CLIP	26701625
MIRT482237	hsa-miR-6715b-5p	PAR-CLIP	26701625
MIRT482237	hsa-miR-6715b-5p	PAR-CLIP	26701625
MIRT482231	hsa-miR-6875-3p	PAR-CLIP	26701625
MIRT482231	hsa-miR-6875-3p	PAR-CLIP	26701625
MIRT482231	hsa-miR-6875-3p	PAR-CLIP	26701625
MIRT724958	hsa-miR-3914	HITS-CLIP	19536157
MIRT724957	hsa-miR-29b-1-5p	HITS-CLIP	19536157
MIRT724956	hsa-miR-5681a	HITS-CLIP	19536157
MIRT724955	hsa-miR-6730-5p	HITS-CLIP	19536157
MIRT724954	hsa-miR-340-5p	HITS-CLIP	19536157
MIRT724953	hsa-miR-488-3p	HITS-CLIP	19536157
MIRT724952	hsa-miR-487a-5p	HITS-CLIP	19536157
MIRT724951	hsa-miR-487b-5p	HITS-CLIP	19536157
MIRT724950	hsa-miR-3611	HITS-CLIP	19536157
MIRT705850	hsa-miR-6732-3p	HITS-CLIP	23313552
MIRT705849	hsa-miR-10a-5p	HITS-CLIP	23313552
MIRT705848	hsa-miR-10b-5p	HITS-CLIP	23313552
MIRT705847	hsa-miR-6849-3p	HITS-CLIP	23313552
MIRT705846	hsa-miR-339-5p	HITS-CLIP	23313552
MIRT705845	hsa-miR-4421	HITS-CLIP	23313552
MIRT705844	hsa-miR-5699-3p	HITS-CLIP	23313552
MIRT705843	hsa-miR-1283	HITS-CLIP	23313552
MIRT705842	hsa-miR-3190-5p	HITS-CLIP	23313552
MIRT705841	hsa-miR-3926	HITS-CLIP	23313552
MIRT705840	hsa-miR-6895-3p	HITS-CLIP	23313552
MIRT705839	hsa-miR-593-3p	HITS-CLIP	23313552
MIRT705838	hsa-miR-4684-5p	HITS-CLIP	23313552
MIRT705837	hsa-miR-548s	HITS-CLIP	23313552
MIRT705836	hsa-miR-6818-3p	HITS-CLIP	23313552
MIRT660813	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT639808	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT660814	hsa-miR-4650-5p	HITS-CLIP	23824327
MIRT660813	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT639807	hsa-miR-6072	HITS-CLIP	23824327
MIRT639806	hsa-miR-6891-3p	HITS-CLIP	23824327
MIRT660812	hsa-miR-3690	HITS-CLIP	23824327
MIRT660811	hsa-miR-4254	HITS-CLIP	23824327
MIRT639803	hsa-miR-1343-3p	HITS-CLIP	23824327
MIRT639802	hsa-miR-6783-3p	HITS-CLIP	23824327
MIRT639801	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT639800	hsa-miR-3074-5p	HITS-CLIP	23824327
MIRT639799	hsa-miR-7152-5p	HITS-CLIP	23824327
MIRT660813	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT639808	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT660814	hsa-miR-4650-5p	HITS-CLIP	23824327
MIRT660813	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT639807	hsa-miR-6072	HITS-CLIP	23824327
MIRT639806	hsa-miR-6891-3p	HITS-CLIP	23824327
MIRT660812	hsa-miR-3690	HITS-CLIP	23824327
MIRT660811	hsa-miR-4254	HITS-CLIP	23824327
MIRT639803	hsa-miR-1343-3p	HITS-CLIP	23824327
MIRT639802	hsa-miR-6783-3p	HITS-CLIP	23824327
MIRT639801	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT639800	hsa-miR-3074-5p	HITS-CLIP	23824327
MIRT639799	hsa-miR-7152-5p	HITS-CLIP	23824327
MIRT639808	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT639807	hsa-miR-6072	HITS-CLIP	23824327
MIRT639806	hsa-miR-6891-3p	HITS-CLIP	23824327
MIRT639805	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT639804	hsa-miR-3124-3p	HITS-CLIP	23824327
MIRT639803	hsa-miR-1343-3p	HITS-CLIP	23824327
MIRT639802	hsa-miR-6783-3p	HITS-CLIP	23824327
MIRT639801	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT639800	hsa-miR-3074-5p	HITS-CLIP	23824327
MIRT639799	hsa-miR-7152-5p	HITS-CLIP	23824327
MIRT639808	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT639807	hsa-miR-6072	HITS-CLIP	23824327
MIRT639806	hsa-miR-6891-3p	HITS-CLIP	23824327
MIRT639805	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT639804	hsa-miR-3124-3p	HITS-CLIP	23824327
MIRT639803	hsa-miR-1343-3p	HITS-CLIP	23824327
MIRT639802	hsa-miR-6783-3p	HITS-CLIP	23824327
MIRT639801	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT639800	hsa-miR-3074-5p	HITS-CLIP	23824327
MIRT639799	hsa-miR-7152-5p	HITS-CLIP	23824327
MIRT482239	hsa-miR-4699-3p	PAR-CLIP	23592263
MIRT482238	hsa-miR-4269	PAR-CLIP	23592263
MIRT482237	hsa-miR-6715b-5p	PAR-CLIP	23592263
MIRT482236	hsa-miR-4645-5p	PAR-CLIP	23592263
MIRT482235	hsa-miR-4673	PAR-CLIP	23592263
MIRT482234	hsa-miR-593-5p	PAR-CLIP	23592263
MIRT482233	hsa-miR-5591-3p	PAR-CLIP	23592263
MIRT482231	hsa-miR-6875-3p	PAR-CLIP	23592263
MIRT773353	hsa-miR-1207-3p	CLIP-seq
MIRT773354	hsa-miR-132	CLIP-seq
MIRT773355	hsa-miR-1587	CLIP-seq
MIRT773356	hsa-miR-2054	CLIP-seq
MIRT773357	hsa-miR-212	CLIP-seq
MIRT773358	hsa-miR-3064-3p	CLIP-seq
MIRT773359	hsa-miR-30a	CLIP-seq
MIRT773360	hsa-miR-30b	CLIP-seq
MIRT773361	hsa-miR-30c	CLIP-seq
MIRT773362	hsa-miR-30d	CLIP-seq
MIRT773363	hsa-miR-30e	CLIP-seq
MIRT773364	hsa-miR-3135b	CLIP-seq
MIRT773365	hsa-miR-3143	CLIP-seq
MIRT773366	hsa-miR-3160-3p	CLIP-seq
MIRT773367	hsa-miR-3160-5p	CLIP-seq
MIRT773368	hsa-miR-3174	CLIP-seq
MIRT773369	hsa-miR-3185	CLIP-seq
MIRT773370	hsa-miR-3606	CLIP-seq
MIRT773371	hsa-miR-3607-3p	CLIP-seq
MIRT773372	hsa-miR-3649	CLIP-seq
MIRT773373	hsa-miR-3652	CLIP-seq
MIRT773374	hsa-miR-3654	CLIP-seq
MIRT773375	hsa-miR-3658	CLIP-seq
MIRT773376	hsa-miR-3664-5p	CLIP-seq
MIRT773377	hsa-miR-3667-3p	CLIP-seq
MIRT773378	hsa-miR-3670	CLIP-seq
MIRT773379	hsa-miR-370	CLIP-seq
MIRT773380	hsa-miR-4289	CLIP-seq
MIRT773381	hsa-miR-4430	CLIP-seq
MIRT773382	hsa-miR-4474-3p	CLIP-seq
MIRT773383	hsa-miR-4487	CLIP-seq
MIRT773384	hsa-miR-4492	CLIP-seq
MIRT773385	hsa-miR-4498	CLIP-seq
MIRT773386	hsa-miR-4505	CLIP-seq
MIRT773387	hsa-miR-4528	CLIP-seq
MIRT773388	hsa-miR-4535	CLIP-seq
MIRT773389	hsa-miR-4656	CLIP-seq
MIRT773390	hsa-miR-4675	CLIP-seq
MIRT773391	hsa-miR-4714-5p	CLIP-seq
MIRT773392	hsa-miR-4717-5p	CLIP-seq
MIRT773393	hsa-miR-4741	CLIP-seq
MIRT773394	hsa-miR-492	CLIP-seq
MIRT773395	hsa-miR-543	CLIP-seq
MIRT773396	hsa-miR-548b-3p	CLIP-seq
MIRT773397	hsa-miR-558	CLIP-seq
MIRT773398	hsa-miR-646	CLIP-seq
MIRT773399	hsa-miR-670	CLIP-seq
MIRT773400	hsa-miR-762	CLIP-seq
MIRT773401	hsa-miR-921	CLIP-seq
MIRT773354	hsa-miR-132	CLIP-seq
MIRT773402	hsa-miR-2116	CLIP-seq
MIRT773357	hsa-miR-212	CLIP-seq
MIRT773358	hsa-miR-3064-3p	CLIP-seq
MIRT773403	hsa-miR-3169	CLIP-seq
MIRT773368	hsa-miR-3174	CLIP-seq
MIRT773370	hsa-miR-3606	CLIP-seq
MIRT773376	hsa-miR-3664-5p	CLIP-seq
MIRT773404	hsa-miR-4264	CLIP-seq
MIRT773405	hsa-miR-4476	CLIP-seq
MIRT773406	hsa-miR-4513	CLIP-seq
MIRT773407	hsa-miR-4521	CLIP-seq
MIRT773408	hsa-miR-4533	CLIP-seq
MIRT773409	hsa-miR-4677-5p	CLIP-seq
MIRT773391	hsa-miR-4714-5p	CLIP-seq
MIRT773410	hsa-miR-4740-5p	CLIP-seq
MIRT773411	hsa-miR-4749-3p	CLIP-seq
MIRT773412	hsa-miR-4797-3p	CLIP-seq
MIRT773413	hsa-miR-617	CLIP-seq
MIRT773401	hsa-miR-921	CLIP-seq
MIRT773414	hsa-miR-942	CLIP-seq
MIRT1928258	hsa-miR-1266	CLIP-seq
MIRT773356	hsa-miR-2054	CLIP-seq
MIRT773358	hsa-miR-3064-3p	CLIP-seq
MIRT1928259	hsa-miR-3155	CLIP-seq
MIRT1928260	hsa-miR-3155b	CLIP-seq
MIRT1928261	hsa-miR-3647-3p	CLIP-seq
MIRT773375	hsa-miR-3658	CLIP-seq
MIRT1928262	hsa-miR-3664-3p	CLIP-seq
MIRT773376	hsa-miR-3664-5p	CLIP-seq
MIRT773380	hsa-miR-4289	CLIP-seq
MIRT1928263	hsa-miR-4323	CLIP-seq
MIRT1928264	hsa-miR-4326	CLIP-seq
MIRT1928265	hsa-miR-4518	CLIP-seq
MIRT1928266	hsa-miR-4709-5p	CLIP-seq
MIRT773391	hsa-miR-4714-5p	CLIP-seq
MIRT1928267	hsa-miR-4755-3p	CLIP-seq
MIRT1928268	hsa-miR-484	CLIP-seq
MIRT1928269	hsa-miR-873	CLIP-seq
MIRT2169051	hsa-miR-296-3p	CLIP-seq
MIRT1928263	hsa-miR-4323	CLIP-seq
MIRT2169052	hsa-miR-488	CLIP-seq
MIRT773358	hsa-miR-3064-3p	CLIP-seq
MIRT773376	hsa-miR-3664-5p	CLIP-seq
MIRT773391	hsa-miR-4714-5p	CLIP-seq
MIRT773372	hsa-miR-3649	CLIP-seq
MIRT773373	hsa-miR-3652	CLIP-seq
MIRT773381	hsa-miR-4430	CLIP-seq
MIRT773382	hsa-miR-4474-3p	CLIP-seq
MIRT773386	hsa-miR-4505	CLIP-seq
MIRT773399	hsa-miR-670	CLIP-seq
MIRT2471605	hsa-miR-103a	CLIP-seq
MIRT2471606	hsa-miR-107	CLIP-seq
MIRT2471607	hsa-miR-1184	CLIP-seq
MIRT773354	hsa-miR-132	CLIP-seq
MIRT2471608	hsa-miR-144	CLIP-seq
MIRT773402	hsa-miR-2116	CLIP-seq
MIRT773357	hsa-miR-212	CLIP-seq
MIRT2471609	hsa-miR-2467-3p	CLIP-seq
MIRT773358	hsa-miR-3064-3p	CLIP-seq
MIRT773366	hsa-miR-3160-3p	CLIP-seq
MIRT773368	hsa-miR-3174	CLIP-seq
MIRT773370	hsa-miR-3606	CLIP-seq
MIRT773372	hsa-miR-3649	CLIP-seq
MIRT773373	hsa-miR-3652	CLIP-seq
MIRT773378	hsa-miR-3670	CLIP-seq
MIRT773404	hsa-miR-4264	CLIP-seq
MIRT773381	hsa-miR-4430	CLIP-seq
MIRT773382	hsa-miR-4474-3p	CLIP-seq
MIRT773383	hsa-miR-4487	CLIP-seq
MIRT773386	hsa-miR-4505	CLIP-seq
MIRT773409	hsa-miR-4677-5p	CLIP-seq
MIRT773411	hsa-miR-4749-3p	CLIP-seq
MIRT2471610	hsa-miR-4757-3p	CLIP-seq
MIRT773412	hsa-miR-4797-3p	CLIP-seq
MIRT773397	hsa-miR-558	CLIP-seq
MIRT2471611	hsa-miR-668	CLIP-seq
MIRT773399	hsa-miR-670	CLIP-seq
MIRT773401	hsa-miR-921	CLIP-seq
MIRT2471612	hsa-miR-922	CLIP-seq
MIRT773414	hsa-miR-942	CLIP-seq
MIRT2471605	hsa-miR-103a	CLIP-seq
MIRT2471606	hsa-miR-107	CLIP-seq
MIRT2471607	hsa-miR-1184	CLIP-seq
MIRT2674759	hsa-miR-1245	CLIP-seq
MIRT773354	hsa-miR-132	CLIP-seq
MIRT2471608	hsa-miR-144	CLIP-seq
MIRT773402	hsa-miR-2116	CLIP-seq
MIRT773357	hsa-miR-212	CLIP-seq
MIRT2471609	hsa-miR-2467-3p	CLIP-seq
MIRT773358	hsa-miR-3064-3p	CLIP-seq
MIRT773366	hsa-miR-3160-3p	CLIP-seq
MIRT773368	hsa-miR-3174	CLIP-seq
MIRT773370	hsa-miR-3606	CLIP-seq
MIRT773373	hsa-miR-3652	CLIP-seq
MIRT773378	hsa-miR-3670	CLIP-seq
MIRT773404	hsa-miR-4264	CLIP-seq
MIRT773381	hsa-miR-4430	CLIP-seq
MIRT773382	hsa-miR-4474-3p	CLIP-seq
MIRT773383	hsa-miR-4487	CLIP-seq
MIRT773386	hsa-miR-4505	CLIP-seq
MIRT773409	hsa-miR-4677-5p	CLIP-seq
MIRT773411	hsa-miR-4749-3p	CLIP-seq
MIRT2471610	hsa-miR-4757-3p	CLIP-seq
MIRT773412	hsa-miR-4797-3p	CLIP-seq
MIRT2674760	hsa-miR-548ae	CLIP-seq
MIRT2674761	hsa-miR-548aj	CLIP-seq
MIRT2674762	hsa-miR-548am	CLIP-seq
MIRT2674763	hsa-miR-548x	CLIP-seq
MIRT773397	hsa-miR-558	CLIP-seq
MIRT2471611	hsa-miR-668	CLIP-seq
MIRT773399	hsa-miR-670	CLIP-seq
MIRT773401	hsa-miR-921	CLIP-seq
MIRT2471612	hsa-miR-922	CLIP-seq
MIRT773414	hsa-miR-942	CLIP-seq

Show/Hide all (16)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004013	Function	Adenosylhomocysteinase activity	IBA
GO:0004013	Function	Adenosylhomocysteinase activity	IDA	10933798
GO:0004013	Function	Adenosylhomocysteinase activity	IEA
GO:0004013	Function	Adenosylhomocysteinase activity	TAS	2596825
GO:0005515	Function	Protein binding	IPI	25416956, 25910212, 28514442, 31515488, 32296183, 33961781, 35271311
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0006730	Process	One-carbon metabolic process	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0033353	Process	S-adenosylmethionine cycle	IBA
GO:0042470	Component	Melanosome	IEA
GO:0070062	Component	Extracellular exosome	HDA	19056867, 20458337, 23533145

MIM	HGNC	e!Ensembl
180960	343	ENSG00000101444

P23526

Protein name

Adenosylhomocysteinase (AdoHcyase) (EC 3.13.2.1) (S-adenosyl-L-homocysteine hydrolase)

Protein function

Catalyzes the hydrolysis of S-adenosyl-L-homocysteine to form adenosine and homocysteine (PubMed:10933798). Binds copper ions (By similarity).

PDB

1A7A , 1LI4 , 3NJ4 , 4PFJ , 4PGF , 4YVF , 5W49 , 5W4B

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF05221	AdoHcyase	6 → 142	S-adenosyl-L-homocysteine hydrolase	Domain
PF05221	AdoHcyase	140 → 431	S-adenosyl-L-homocysteine hydrolase	Domain
PF00670	AdoHcyase_NAD	191 → 352	S-adenosyl-L-homocysteine hydrolase, NAD binding domain	Domain

Sequence

MSDKLPYKVADIGLAAWGRKALDIAENEMPGLMRMRERYSASKPLKGARIAGCLHMTVET
AVLIETLVTLGAEVQWSSCNIFSTQDHAAAAIAKAGIPVYAWKGETDEEYLWCIEQTLYF
KDGPLNMILDDGGDLTNLIHTKYPQLLPGIRGISEETTTGVHNLYKMMANGILKVPAINV
NDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVI
ITEIDPINALQAAMEGYEVTTMDEACQEGNIFVTTTGCIDIILGRHFEQMKDDAIVCNIG
HFDVEIDVKWLNENAVEKVNIKPQVDRYRLKNGRRIILLAEGRLVNLGCAMGHPSFVMSN
SFTNQVMAQIELWTHPDKYPVGVHFLPKKLDEAVAEAHLGKLNVKLTKLTEKQAQYLGMS
CDGPFKPDHYRY

Sequence length

432

Interactions

View interactions

	KEGG		Reactome
	Cysteine and methionine metabolism One carbon pool by folate Metabolic pathways		Methylation Sulfur amino acid metabolism Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD)

257

Show/Hide Causal Diseases (2)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Hypermethioninemia with deficiency of S-adenosylhomocysteine hydrolase	Pathogenic; Likely pathogenic	rs2515172714, rs757966746, rs2036548764, rs121918607, rs121918608, rs2515204321, rs2515176184, rs772729103, rs2515180222, rs773162208, rs369428934	RCV002829264 RCV005025372 RCV003335928 RCV000013818 RCV000013819 RCV003494579 RCV003494580 RCV003638512 RCV003639217 RCV000778630 RCV001813819
Rhabdomyolysis	Likely pathogenic; Pathogenic	rs121918608	RCV000662292

Show/Hide Unknown Diseases (4)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
AHCY-related disorder	Likely benign; Conflicting classifications of pathogenicity	rs372649332, rs41301825, rs116846245	RCV003914067 RCV003918056 RCV003955940
Familial cancer of breast	Conflicting classifications of pathogenicity	rs757357954	RCV005898002
Hypermethioninemia	Uncertain significance; Benign	rs886056636, rs886056637, rs819146	RCV000358309 RCV000283737 RCV000348058
See cases	Uncertain significance	rs142847412	RCV002252431

Show/Hide Text Mining Associations (22)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Aortic Aneurysm Abdominal	Associate	20871623
Aortic Dissection	Associate	20871623
Brain Ischemia	Associate	32020847
Breast Neoplasms	Associate	18084325, 36361596
Carcinoma Hepatocellular	Associate	26527160, 28459194, 31959915
Carcinoma Pancreatic Ductal	Associate	33753854
Cerebral Infarction	Associate	32020847, 33138824
Colorectal Neoplasms	Associate	23341073
Dissection Thoracic Aorta	Associate	20871623
Hypermethioninemia	Associate	26527160
Hypermethioninemia	Inhibit	38003292
Immune System Diseases	Associate	312296
Leukemia	Associate	37951201
Leukemia Myeloid Acute	Associate	37951201
Liver Diseases	Associate	26527160
Neoplasms	Associate	23341073, 30228286, 37299011
Neuroblastoma	Associate	25477524, 36361596
Severe combined immunodeficiency due to adenosine deaminase deficiency	Stimulate	312296
Squamous Cell Carcinoma of Head and Neck	Associate	34709988
Stomach Neoplasms	Associate	35036435
Urethral Neoplasms	Associate	29472622
Urinary Bladder Neoplasms	Associate	32065779

AHCY (adenosylhomocysteinase)