Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	1901
Gene name Gene Name - the full gene name approved by the HGNC.	Sphingosine-1-phosphate receptor 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	S1PR1
Synonyms (NCBI Gene) Gene synonyms aliases	CD363, CHEDG1, D1S3362, ECGF1, EDG-1, EDG1, S1P1
Chromosome Chromosome number	1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	1p21.2
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene is structurally similar to G protein-coupled receptors and is highly expressed in endothelial cells. It binds the ligand sphingosine-1-phosphate with high affinity and high specificity, and suggested to be involved in the

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miRTarBase ID	miRNA	Experiments	Reference
MIRT438751	hsa-miR-148a-3p	Hep3B	24798342
MIRT396670	hsa-miR-363-3p	Luciferase reporter assay, qRT-PCR, Western blot	24631531
MIRT396655	hsa-miR-125b-1-3p	Luciferase reporter assay, Western blot, qRT-PCR	25251470
MIRT396655	hsa-miR-125b-1-3p	Luciferase reporter assay, Western blot, qRT-PCR	25251470
MIRT438751	hsa-miR-148a-3p	Hep3B	24798342
MIRT396670	hsa-miR-363-3p	Luciferase reporter assay, qRT-PCR, Western blot	24631531
MIRT396655	hsa-miR-125b-1-3p	Luciferase reporter assay, Western blot, qRT-PCR	25251470
MIRT396655	hsa-miR-125b-1-3p	Luciferase reporter assay, Western blot, qRT-PCR	25251470
MIRT712216	hsa-miR-3177-3p	HITS-CLIP	19536157
MIRT712215	hsa-miR-4252	HITS-CLIP	19536157
MIRT712214	hsa-miR-6807-5p	HITS-CLIP	19536157
MIRT712216	hsa-miR-3177-3p	HITS-CLIP	19536157
MIRT712215	hsa-miR-4252	HITS-CLIP	19536157
MIRT712214	hsa-miR-6807-5p	HITS-CLIP	19536157
MIRT712216	hsa-miR-3177-3p	HITS-CLIP	19536157
MIRT712215	hsa-miR-4252	HITS-CLIP	19536157
MIRT712214	hsa-miR-6807-5p	HITS-CLIP	19536157
MIRT654062	hsa-miR-208a-5p	HITS-CLIP	23824327
MIRT654061	hsa-miR-208b-5p	HITS-CLIP	23824327
MIRT654060	hsa-miR-3675-3p	HITS-CLIP	23824327
MIRT654059	hsa-miR-3927-5p	HITS-CLIP	23824327
MIRT654058	hsa-miR-5193	HITS-CLIP	23824327
MIRT654057	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT654056	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT654055	hsa-miR-532-3p	HITS-CLIP	23824327
MIRT654054	hsa-miR-2116-3p	HITS-CLIP	23824327
MIRT654053	hsa-miR-6845-3p	HITS-CLIP	23824327
MIRT654052	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT654051	hsa-miR-7977	HITS-CLIP	23824327
MIRT654050	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT654049	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT654047	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT654048	hsa-miR-4713-5p	HITS-CLIP	23824327
MIRT128036	hsa-miR-155-5p	HITS-CLIP	22473208
MIRT128036	hsa-miR-155-5p	HITS-CLIP	22473208
MIRT438751	hsa-miR-148a-3p	qRT-PCR, Luciferase reporter assay, Western blot	25574238
MIRT438751	hsa-miR-148a-3p	qRT-PCR, Luciferase reporter assay, Western blot	25574238
MIRT438751	hsa-miR-148a-3p	Luciferase reporter assay, qRT-PCR, Western blot	26004261
MIRT438751	hsa-miR-148a-3p	Luciferase reporter assay, qRT-PCR, Western blot	26004261
MIRT734561	hsa-miR-223-3p	Luciferase reporter assay, Western blotting, Immunofluorescence, qRT-PCR	33574820
MIRT712216	hsa-miR-3177-3p	HITS-CLIP	19536157
MIRT712215	hsa-miR-4252	HITS-CLIP	19536157
MIRT712214	hsa-miR-6807-5p	HITS-CLIP	19536157
MIRT712216	hsa-miR-3177-3p	HITS-CLIP	19536157
MIRT712215	hsa-miR-4252	HITS-CLIP	19536157
MIRT712214	hsa-miR-6807-5p	HITS-CLIP	19536157
MIRT712216	hsa-miR-3177-3p	HITS-CLIP	19536157
MIRT712215	hsa-miR-4252	HITS-CLIP	19536157
MIRT712214	hsa-miR-6807-5p	HITS-CLIP	19536157
MIRT654062	hsa-miR-208a-5p	HITS-CLIP	23824327
MIRT654061	hsa-miR-208b-5p	HITS-CLIP	23824327
MIRT654060	hsa-miR-3675-3p	HITS-CLIP	23824327
MIRT654059	hsa-miR-3927-5p	HITS-CLIP	23824327
MIRT654058	hsa-miR-5193	HITS-CLIP	23824327
MIRT654057	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT654056	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT654055	hsa-miR-532-3p	HITS-CLIP	23824327
MIRT654054	hsa-miR-2116-3p	HITS-CLIP	23824327
MIRT654053	hsa-miR-6845-3p	HITS-CLIP	23824327
MIRT654052	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT654051	hsa-miR-7977	HITS-CLIP	23824327
MIRT654050	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT654049	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT654047	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT654048	hsa-miR-4713-5p	HITS-CLIP	23824327
MIRT756272	hsa-miR-130a-3p	Luciferase reporter assay, Western blotting, qRT-PCR, Immunohistochemistry (IHC), Immunofluorescence, Flow cytometry, ELISA, RNA pull down assay	36582210
MIRT1324329	hsa-miR-4307	CLIP-seq
MIRT1553212	hsa-miR-330-3p	CLIP-seq
MIRT2393999	hsa-miR-186	CLIP-seq
MIRT2394000	hsa-miR-3133	CLIP-seq
MIRT2616415	hsa-miR-106a	CLIP-seq
MIRT2616416	hsa-miR-106b	CLIP-seq
MIRT2616417	hsa-miR-1231	CLIP-seq
MIRT2616418	hsa-miR-1260	CLIP-seq
MIRT2616419	hsa-miR-1260b	CLIP-seq
MIRT2616420	hsa-miR-1273e	CLIP-seq
MIRT2616421	hsa-miR-127-3p	CLIP-seq
MIRT2616422	hsa-miR-1279	CLIP-seq
MIRT2616423	hsa-miR-1293	CLIP-seq
MIRT2616424	hsa-miR-130a	CLIP-seq
MIRT2616425	hsa-miR-130b	CLIP-seq
MIRT2616426	hsa-miR-148a	CLIP-seq
MIRT2616427	hsa-miR-148b	CLIP-seq
MIRT2616428	hsa-miR-151-3p	CLIP-seq
MIRT2616429	hsa-miR-152	CLIP-seq
MIRT2616430	hsa-miR-155	CLIP-seq
MIRT2616431	hsa-miR-17	CLIP-seq
MIRT2616432	hsa-miR-181a	CLIP-seq
MIRT2616433	hsa-miR-181b	CLIP-seq
MIRT2616434	hsa-miR-181c	CLIP-seq
MIRT2616435	hsa-miR-181d	CLIP-seq
MIRT2616436	hsa-miR-188-3p	CLIP-seq
MIRT2616437	hsa-miR-19a	CLIP-seq
MIRT2616438	hsa-miR-19b	CLIP-seq
MIRT2616439	hsa-miR-2052	CLIP-seq
MIRT2616440	hsa-miR-20a	CLIP-seq
MIRT2616441	hsa-miR-20b	CLIP-seq
MIRT2616442	hsa-miR-24	CLIP-seq
MIRT2616443	hsa-miR-301a	CLIP-seq
MIRT2616444	hsa-miR-301b	CLIP-seq
MIRT2616445	hsa-miR-3065-5p	CLIP-seq
MIRT2616446	hsa-miR-3132	CLIP-seq
MIRT2616447	hsa-miR-3140-3p	CLIP-seq
MIRT2616448	hsa-miR-3146	CLIP-seq
MIRT2616449	hsa-miR-3156-3p	CLIP-seq
MIRT2616450	hsa-miR-3162-3p	CLIP-seq
MIRT1553212	hsa-miR-330-3p	CLIP-seq
MIRT2616451	hsa-miR-3613-3p	CLIP-seq
MIRT2616452	hsa-miR-3653	CLIP-seq
MIRT2616453	hsa-miR-3658	CLIP-seq
MIRT2616454	hsa-miR-3666	CLIP-seq
MIRT2616455	hsa-miR-3684	CLIP-seq
MIRT2616456	hsa-miR-3688-3p	CLIP-seq
MIRT2616457	hsa-miR-377	CLIP-seq
MIRT2616458	hsa-miR-4261	CLIP-seq
MIRT2616459	hsa-miR-4262	CLIP-seq
MIRT2616460	hsa-miR-4279	CLIP-seq
MIRT2616461	hsa-miR-4284	CLIP-seq
MIRT2616462	hsa-miR-4287	CLIP-seq
MIRT2616463	hsa-miR-4288	CLIP-seq
MIRT2616464	hsa-miR-4295	CLIP-seq
MIRT2616465	hsa-miR-4469	CLIP-seq
MIRT2616466	hsa-miR-4477b	CLIP-seq
MIRT2616467	hsa-miR-4483	CLIP-seq
MIRT2616468	hsa-miR-450b-5p	CLIP-seq
MIRT2616469	hsa-miR-454	CLIP-seq
MIRT2616470	hsa-miR-4639-5p	CLIP-seq
MIRT2616471	hsa-miR-4643	CLIP-seq
MIRT2616472	hsa-miR-4645-5p	CLIP-seq
MIRT2616473	hsa-miR-4650-3p	CLIP-seq
MIRT2616474	hsa-miR-466	CLIP-seq
MIRT2616475	hsa-miR-4666-5p	CLIP-seq
MIRT2616476	hsa-miR-4673	CLIP-seq
MIRT2616477	hsa-miR-4685-3p	CLIP-seq
MIRT2616478	hsa-miR-4685-5p	CLIP-seq
MIRT2616479	hsa-miR-4694-5p	CLIP-seq
MIRT2616480	hsa-miR-4757-5p	CLIP-seq
MIRT2616481	hsa-miR-4766-5p	CLIP-seq
MIRT2616482	hsa-miR-4780	CLIP-seq
MIRT2616483	hsa-miR-4789-3p	CLIP-seq
MIRT2616484	hsa-miR-4802-3p	CLIP-seq
MIRT2616485	hsa-miR-518a-5p	CLIP-seq
MIRT2616486	hsa-miR-519d	CLIP-seq
MIRT2616487	hsa-miR-527	CLIP-seq
MIRT2616488	hsa-miR-543	CLIP-seq
MIRT2616489	hsa-miR-548a-5p	CLIP-seq
MIRT2616490	hsa-miR-548ab	CLIP-seq
MIRT2616491	hsa-miR-548ak	CLIP-seq
MIRT2616492	hsa-miR-548b-5p	CLIP-seq
MIRT2616493	hsa-miR-548c-5p	CLIP-seq
MIRT2616494	hsa-miR-548d-5p	CLIP-seq
MIRT2616495	hsa-miR-548h	CLIP-seq
MIRT2616496	hsa-miR-548i	CLIP-seq
MIRT2616497	hsa-miR-548j	CLIP-seq
MIRT2616498	hsa-miR-548k	CLIP-seq
MIRT2616499	hsa-miR-548l	CLIP-seq
MIRT2616500	hsa-miR-548n	CLIP-seq
MIRT2616501	hsa-miR-548t	CLIP-seq
MIRT2616502	hsa-miR-548w	CLIP-seq
MIRT2616503	hsa-miR-548y	CLIP-seq
MIRT2616504	hsa-miR-559	CLIP-seq
MIRT2616505	hsa-miR-561	CLIP-seq
MIRT2616506	hsa-miR-579	CLIP-seq
MIRT2616507	hsa-miR-602	CLIP-seq
MIRT2616508	hsa-miR-623	CLIP-seq
MIRT2616509	hsa-miR-632	CLIP-seq
MIRT2616510	hsa-miR-93	CLIP-seq
MIRT2616415	hsa-miR-106a	CLIP-seq
MIRT2616416	hsa-miR-106b	CLIP-seq
MIRT2616418	hsa-miR-1260	CLIP-seq
MIRT2616419	hsa-miR-1260b	CLIP-seq
MIRT2616421	hsa-miR-127-3p	CLIP-seq
MIRT2616422	hsa-miR-1279	CLIP-seq
MIRT2616423	hsa-miR-1293	CLIP-seq
MIRT2616424	hsa-miR-130a	CLIP-seq
MIRT2616425	hsa-miR-130b	CLIP-seq
MIRT2616426	hsa-miR-148a	CLIP-seq
MIRT2616427	hsa-miR-148b	CLIP-seq
MIRT2616428	hsa-miR-151-3p	CLIP-seq
MIRT2616429	hsa-miR-152	CLIP-seq
MIRT2616430	hsa-miR-155	CLIP-seq
MIRT2616431	hsa-miR-17	CLIP-seq
MIRT2616432	hsa-miR-181a	CLIP-seq
MIRT2616433	hsa-miR-181b	CLIP-seq
MIRT2616434	hsa-miR-181c	CLIP-seq
MIRT2616435	hsa-miR-181d	CLIP-seq
MIRT2616436	hsa-miR-188-3p	CLIP-seq
MIRT2616437	hsa-miR-19a	CLIP-seq
MIRT2616438	hsa-miR-19b	CLIP-seq
MIRT2616440	hsa-miR-20a	CLIP-seq
MIRT2616441	hsa-miR-20b	CLIP-seq
MIRT2616442	hsa-miR-24	CLIP-seq
MIRT2616443	hsa-miR-301a	CLIP-seq
MIRT2616444	hsa-miR-301b	CLIP-seq
MIRT2616445	hsa-miR-3065-5p	CLIP-seq
MIRT2616447	hsa-miR-3140-3p	CLIP-seq
MIRT2616448	hsa-miR-3146	CLIP-seq
MIRT2616449	hsa-miR-3156-3p	CLIP-seq
MIRT2616450	hsa-miR-3162-3p	CLIP-seq
MIRT1553212	hsa-miR-330-3p	CLIP-seq
MIRT2616451	hsa-miR-3613-3p	CLIP-seq
MIRT2616452	hsa-miR-3653	CLIP-seq
MIRT2616453	hsa-miR-3658	CLIP-seq
MIRT2616454	hsa-miR-3666	CLIP-seq
MIRT2616455	hsa-miR-3684	CLIP-seq
MIRT2616456	hsa-miR-3688-3p	CLIP-seq
MIRT2616457	hsa-miR-377	CLIP-seq
MIRT2616458	hsa-miR-4261	CLIP-seq
MIRT2616459	hsa-miR-4262	CLIP-seq
MIRT2616461	hsa-miR-4284	CLIP-seq
MIRT2616462	hsa-miR-4287	CLIP-seq
MIRT2616464	hsa-miR-4295	CLIP-seq
MIRT2616465	hsa-miR-4469	CLIP-seq
MIRT2616466	hsa-miR-4477b	CLIP-seq
MIRT2616467	hsa-miR-4483	CLIP-seq
MIRT2616469	hsa-miR-454	CLIP-seq
MIRT2616470	hsa-miR-4639-5p	CLIP-seq
MIRT2616471	hsa-miR-4643	CLIP-seq
MIRT2616474	hsa-miR-466	CLIP-seq
MIRT2616475	hsa-miR-4666-5p	CLIP-seq
MIRT2616477	hsa-miR-4685-3p	CLIP-seq
MIRT2616478	hsa-miR-4685-5p	CLIP-seq
MIRT2616479	hsa-miR-4694-5p	CLIP-seq
MIRT2616480	hsa-miR-4757-5p	CLIP-seq
MIRT2616481	hsa-miR-4766-5p	CLIP-seq
MIRT2616482	hsa-miR-4780	CLIP-seq
MIRT2616483	hsa-miR-4789-3p	CLIP-seq
MIRT2616484	hsa-miR-4802-3p	CLIP-seq
MIRT2616486	hsa-miR-519d	CLIP-seq
MIRT2616488	hsa-miR-543	CLIP-seq
MIRT2616489	hsa-miR-548a-5p	CLIP-seq
MIRT2616490	hsa-miR-548ab	CLIP-seq
MIRT2616491	hsa-miR-548ak	CLIP-seq
MIRT2616492	hsa-miR-548b-5p	CLIP-seq
MIRT2690112	hsa-miR-548c-3p	CLIP-seq
MIRT2616493	hsa-miR-548c-5p	CLIP-seq
MIRT2616494	hsa-miR-548d-5p	CLIP-seq
MIRT2616495	hsa-miR-548h	CLIP-seq
MIRT2616496	hsa-miR-548i	CLIP-seq
MIRT2616497	hsa-miR-548j	CLIP-seq
MIRT2616498	hsa-miR-548k	CLIP-seq
MIRT2616499	hsa-miR-548l	CLIP-seq
MIRT2616500	hsa-miR-548n	CLIP-seq
MIRT2616501	hsa-miR-548t	CLIP-seq
MIRT2616502	hsa-miR-548w	CLIP-seq
MIRT2616503	hsa-miR-548y	CLIP-seq
MIRT2616504	hsa-miR-559	CLIP-seq
MIRT2616505	hsa-miR-561	CLIP-seq
MIRT2616506	hsa-miR-579	CLIP-seq
MIRT2616508	hsa-miR-623	CLIP-seq
MIRT2616510	hsa-miR-93	CLIP-seq

Transcription factors

Show/Hide all(1)

Transcription factor	Regulation	Reference
STAT3	Activation	21102457

Show/Hide all(68)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001525	Process	Angiogenesis	IBA
GO:0001525	Process	Angiogenesis	IEA
GO:0001525	Process	Angiogenesis	IEA
GO:0001664	Function	G protein-coupled receptor binding	IPI	24851274
GO:0001955	Process	Blood vessel maturation	IEA
GO:0001955	Process	Blood vessel maturation	ISS
GO:0003245	Process	Cardiac muscle tissue growth involved in heart morphogenesis	IEA
GO:0003245	Process	Cardiac muscle tissue growth involved in heart morphogenesis	ISS
GO:0003376	Process	Sphingosine-1-phosphate receptor signaling pathway	IBA
GO:0003376	Process	Sphingosine-1-phosphate receptor signaling pathway	IDA	22344443
GO:0003376	Process	Sphingosine-1-phosphate receptor signaling pathway	IEA
GO:0004930	Function	G protein-coupled receptor activity	IEA
GO:0004930	Function	G protein-coupled receptor activity	TAS	8626678
GO:0005515	Function	Protein binding	IPI	16525420
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IBA
GO:0005768	Component	Endosome	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	22344443
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	8626678
GO:0006935	Process	Chemotaxis	IEA
GO:0006935	Process	Chemotaxis	ISS
GO:0007155	Process	Cell adhesion	TAS	9488656, 10555146
GO:0007165	Process	Signal transduction	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS	8626678
GO:0007189	Process	Adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA
GO:0007193	Process	Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IEA
GO:0007193	Process	Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IEA
GO:0007200	Process	Phospholipase C-activating G protein-coupled receptor signaling pathway	IEA
GO:0007420	Process	Brain development	IEA
GO:0008283	Process	Cell population proliferation	IEA
GO:0008284	Process	Positive regulation of cell population proliferation	IEA
GO:0009897	Component	External side of plasma membrane	IEA
GO:0016020	Component	Membrane	IEA
GO:0016477	Process	Cell migration	IEA
GO:0016477	Process	Cell migration	ISS
GO:0019226	Process	Transmission of nerve impulse	IEA
GO:0030032	Process	Lamellipodium assembly	IEA
GO:0030032	Process	Lamellipodium assembly	ISS
GO:0030036	Process	Actin cytoskeleton organization	IEA
GO:0030036	Process	Actin cytoskeleton organization	ISS
GO:0030155	Process	Regulation of cell adhesion	IEA
GO:0030182	Process	Neuron differentiation	IEA
GO:0030335	Process	Positive regulation of cell migration	IEA
GO:0030500	Process	Regulation of bone mineralization	IEA
GO:0030500	Process	Regulation of bone mineralization	ISS
GO:0030595	Process	Leukocyte chemotaxis	IEA
GO:0038036	Function	Sphingosine-1-phosphate receptor activity	IBA
GO:0038036	Function	Sphingosine-1-phosphate receptor activity	IDA	22344443
GO:0038036	Function	Sphingosine-1-phosphate receptor activity	IEA
GO:0045121	Component	Membrane raft	IEA
GO:0045124	Process	Regulation of bone resorption	IEA
GO:0045124	Process	Regulation of bone resorption	ISS
GO:0045446	Process	Endothelial cell differentiation	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IEA
GO:0046625	Function	Sphingolipid binding	IEA
GO:0048661	Process	Positive regulation of smooth muscle cell proliferation	IEA
GO:0050927	Process	Positive regulation of positive chemotaxis	IEA
GO:0051497	Process	Negative regulation of stress fiber assembly	IEA
GO:0061384	Process	Heart trabecula morphogenesis	IEA
GO:0061384	Process	Heart trabecula morphogenesis	ISS
GO:0072678	Process	T cell migration	IDA	20829352
GO:0072678	Process	T cell migration	IDA	37039481
GO:0072678	Process	T cell migration	IEA
GO:0072678	Process	T cell migration	ISS
GO:0098793	Component	Presynapse	IEA

MIM	HGNC	e!Ensembl
601974	3165	ENSG00000170989

Protein

UniProt ID

P21453

Protein name

Sphingosine 1-phosphate receptor 1 (S1P receptor 1) (S1P1) (Endothelial differentiation G-protein coupled receptor 1) (Sphingosine 1-phosphate receptor Edg-1) (S1P receptor Edg-1) (CD antigen CD363)

Protein function

G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays

PDB

3V2W , 3V2Y , 7EO2 , 7EO4 , 7EVY , 7EVZ , 7EW0 , 7EW7 , 7TD3 , 7TD4 , 7VIE , 7VIF , 7VIG , 7VIH , 7WF7 , 8G94 , 8YIC

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00001	7tm_1	62 → 311	7 transmembrane receptor (rhodopsin family)	Family

Tissue specificity

TISSUE SPECIFICITY: Endothelial cells, and to a lesser extent, in vascular smooth muscle cells, fibroblasts, melanocytes, and cells of epithelioid origin.

Sequence

MGPTSVPLVKAHRSSVSDYVNYDIIVRHYNYTGKLNISADKENSIKLTSVVFILICCFII
LENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLR
EGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNNFRLFLLISACWVISLILGGLPIM
GWNCISALSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKN
ISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVKTCDILFRAEYFLVLA
VLNSGTNPIIYTLTNKEMRRAFIRIMSCCKCPSGDSAGKFKRPIIAGMEFSRSKSDNSSH
PQKDEGDNPETIMSSGNVNSSS

Sequence length

382

Interactions

View interactions

	KEGG		Reactome
	FoxO signaling pathway Sphingolipid signaling pathway Neuroactive ligand-receptor interaction Efferocytosis		G alpha (i) signalling events Lysosphingolipid and LPA receptors Interleukin-4 and Interleukin-13 signaling

Show/Hide Unknown Diseases (1)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Irritable Bowel Syndrome	Irritable bowel syndrome	N/A	N/A	GWAS

Show/Hide Text Mining Associations (70)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Abortion Habitual	Stimulate	34552206
Adenocarcinoma of Lung	Associate	23111975, 31558162, 32384511, 32799825
Alzheimer Disease	Associate	33788842
Anemia Aplastic	Associate	30889317
Arthritis Rheumatoid	Associate	16508938, 18658144, 22326262
Asthma	Associate	20624651
Atherosclerosis	Stimulate	18765664
Autoimmune Diseases	Associate	23674616, 31968593
Bipolar Disorder	Associate	24387768
Bone Diseases	Associate	31935914
Breast Neoplasms	Associate	20889557, 24263101, 28121348, 28224210, 29923327, 31935914
Breast Neoplasms	Inhibit	32799825
Carcinogenesis	Associate	32799825, 34301921
Carcinoma Hepatocellular	Associate	27556509, 34301921, 36068200
Carcinoma Squamous Cell	Associate	32799825
Central Nervous System Diseases	Associate	37882753
Cerebral Hemorrhage	Associate	30836997
Cholangitis Sclerosing	Associate	35563301
Colorectal Neoplasms	Associate	24972972, 28121348, 31534132
COVID 19	Associate	36652045
Crohn Disease	Associate	31968593
Dementia	Associate	33788842
Demyelinating Diseases	Associate	37882753
Diabetes Mellitus	Stimulate	22480845
Diabetes Mellitus	Associate	22916176, 24751283
Diabetic Angiopathies	Associate	22916176
Endometriosis	Associate	22277765, 32907751, 36524127
Glioblastoma	Associate	24903384
Glioblastoma	Stimulate	26887055
Glioma	Associate	17376432
Graft vs Host Disease	Inhibit	36071219
Heart Diseases	Associate	22916176
Hodgkin Disease	Associate	23419711, 28878352
Hyperplasia	Associate	22326262
Hypoxia	Associate	19240180, 33788630
IgA Vasculitis	Associate	16508938
Inflammation	Associate	16508938, 18209090, 22326262, 25496321, 29873694, 32889908, 33788842
Influenza Human	Associate	30304001
Leukemia	Associate	18477771, 36071219
Leukemia Lymphocytic Chronic B Cell	Associate	25632006
Lung Neoplasms	Associate	30082521, 36380607
Lupus Erythematosus Systemic	Associate	23028528, 37858140
Lymphoma	Associate	27389057
Lymphoma Large B Cell Diffuse	Associate	20081804, 25472725, 27061580
Lymphoma Mantle Cell	Associate	20081804, 27224912, 29549086
Metabolic Syndrome	Stimulate	22480845
Mouth Diseases	Associate	37882753, 38287231
Mouth Neoplasms	Associate	34092610
Multiple Myeloma	Associate	27405725
Multiple Sclerosis	Associate	24511991, 31968593, 32322257, 37882753
Myoclonic Epilepsies Progressive	Associate	23419711, 28878352
Neoplasm Metastasis	Stimulate	24972972
Neoplasm Metastasis	Associate	27556509, 31534132
Neoplasms	Associate	18209090, 23419711, 24263101, 24972972, 25084322, 28224210, 30091994, 31359505, 32799825, 37828220
Neuroinflammatory Diseases	Associate	30836997
Ovarian Neoplasms	Associate	37828220
Parkinson Disease	Associate	24511991
Pelvic Organ Prolapse	Stimulate	25692679
Pneumonia	Associate	20624651
Schizophrenia	Associate	24387768
Sepsis	Associate	15710622
Sjogren's Syndrome	Associate	18209090
Status Asthmaticus	Inhibit	20624651
Status Asthmaticus	Associate	20624651
Stomach Neoplasms	Associate	30106120
Testicular Diseases	Stimulate	27061580
Thyroid cancer follicular	Associate	25971967
Vascular Diseases	Associate	34873055
Vascular System Injuries	Associate	33788630
Wilms Tumor	Associate	19131156

S1PR1 (sphingosine-1-phosphate receptor 1)