EBF1 (EBF transcription factor 1)

Gene

• Entrez ID: 1879
• Gene name: EBF transcription factor 1
• Gene symbol: EBF1
• Synonyms (NCBI Gene): COE1, EBF, O/E-1, OLF1
• Chromosome: 5
• Chromosome location: 5q33.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT018619	hsa-miR-335-5p	Microarray	18185580
MIRT624076	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT624075	hsa-miR-5590-5p	HITS-CLIP	23824327
MIRT624074	hsa-miR-4659a-5p	HITS-CLIP	23824327
MIRT624073	hsa-miR-4659b-5p	HITS-CLIP	23824327
MIRT624072	hsa-miR-4776-3p	HITS-CLIP	23824327
MIRT624076	hsa-miR-129-5p	HITS-CLIP	27418678
MIRT624076	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT624075	hsa-miR-5590-5p	HITS-CLIP	23824327
MIRT624074	hsa-miR-4659a-5p	HITS-CLIP	23824327
MIRT624073	hsa-miR-4659b-5p	HITS-CLIP	23824327
MIRT624072	hsa-miR-4776-3p	HITS-CLIP	23824327
MIRT951319	hsa-miR-1252	CLIP-seq
MIRT951320	hsa-miR-1267	CLIP-seq
MIRT951321	hsa-miR-1269	CLIP-seq
MIRT951322	hsa-miR-1269b	CLIP-seq
MIRT951323	hsa-miR-1289	CLIP-seq
MIRT951324	hsa-miR-142-3p	CLIP-seq
MIRT951325	hsa-miR-216b	CLIP-seq
MIRT951326	hsa-miR-3121-3p	CLIP-seq
MIRT951327	hsa-miR-3125	CLIP-seq
MIRT951328	hsa-miR-3154	CLIP-seq
MIRT951329	hsa-miR-3185	CLIP-seq
MIRT951330	hsa-miR-3192	CLIP-seq
MIRT951331	hsa-miR-3198	CLIP-seq
MIRT951332	hsa-miR-3199	CLIP-seq
MIRT951333	hsa-miR-3202	CLIP-seq
MIRT951334	hsa-miR-326	CLIP-seq
MIRT951335	hsa-miR-330-5p	CLIP-seq
MIRT951336	hsa-miR-3620	CLIP-seq
MIRT951337	hsa-miR-3622b-5p	CLIP-seq
MIRT951338	hsa-miR-3647-3p	CLIP-seq
MIRT951339	hsa-miR-3657	CLIP-seq
MIRT951340	hsa-miR-3916	CLIP-seq
MIRT951341	hsa-miR-3936	CLIP-seq
MIRT951342	hsa-miR-4282	CLIP-seq
MIRT951343	hsa-miR-4294	CLIP-seq
MIRT951344	hsa-miR-4309	CLIP-seq
MIRT951345	hsa-miR-4314	CLIP-seq
MIRT951346	hsa-miR-4325	CLIP-seq
MIRT951347	hsa-miR-4436b-5p	CLIP-seq
MIRT951348	hsa-miR-448	CLIP-seq
MIRT951349	hsa-miR-4484	CLIP-seq
MIRT951350	hsa-miR-4520b-3p	CLIP-seq
MIRT951351	hsa-miR-4529-3p	CLIP-seq
MIRT951352	hsa-miR-4533	CLIP-seq
MIRT951353	hsa-miR-4639-5p	CLIP-seq
MIRT951354	hsa-miR-4643	CLIP-seq
MIRT951355	hsa-miR-4646-5p	CLIP-seq
MIRT951356	hsa-miR-4651	CLIP-seq
MIRT951357	hsa-miR-466	CLIP-seq
MIRT951358	hsa-miR-4668-5p	CLIP-seq
MIRT951359	hsa-miR-4742-3p	CLIP-seq
MIRT951360	hsa-miR-4761-5p	CLIP-seq
MIRT951361	hsa-miR-4789-3p	CLIP-seq
MIRT951362	hsa-miR-4789-5p	CLIP-seq
MIRT951363	hsa-miR-4793-3p	CLIP-seq
MIRT951364	hsa-miR-4802-3p	CLIP-seq
MIRT951365	hsa-miR-548an	CLIP-seq
MIRT951366	hsa-miR-548n	CLIP-seq
MIRT951367	hsa-miR-548t	CLIP-seq
MIRT951368	hsa-miR-608	CLIP-seq
MIRT951369	hsa-miR-633	CLIP-seq
MIRT951370	hsa-miR-9	CLIP-seq
MIRT951371	hsa-miR-924	CLIP-seq
MIRT951372	hsa-miR-935	CLIP-seq
MIRT951319	hsa-miR-1252	CLIP-seq
MIRT951327	hsa-miR-3125	CLIP-seq
MIRT951328	hsa-miR-3154	CLIP-seq
MIRT1981807	hsa-miR-3180-5p	CLIP-seq
MIRT951329	hsa-miR-3185	CLIP-seq
MIRT1981808	hsa-miR-3190	CLIP-seq
MIRT951333	hsa-miR-3202	CLIP-seq
MIRT951340	hsa-miR-3916	CLIP-seq
MIRT1981809	hsa-miR-4303	CLIP-seq
MIRT951352	hsa-miR-4533	CLIP-seq
MIRT951356	hsa-miR-4651	CLIP-seq
MIRT951368	hsa-miR-608	CLIP-seq
MIRT2216658	hsa-miR-3168	CLIP-seq
MIRT2216659	hsa-miR-361-3p	CLIP-seq
MIRT2216660	hsa-miR-3679-3p	CLIP-seq
MIRT2216661	hsa-miR-4446-5p	CLIP-seq
MIRT2216662	hsa-miR-450b-5p	CLIP-seq
MIRT2216658	hsa-miR-3168	CLIP-seq
MIRT2520512	hsa-miR-1	CLIP-seq
MIRT2520513	hsa-miR-10a	CLIP-seq
MIRT2520514	hsa-miR-10b	CLIP-seq
MIRT2520515	hsa-miR-1227	CLIP-seq
MIRT2520516	hsa-miR-124	CLIP-seq
MIRT2520517	hsa-miR-1254	CLIP-seq
MIRT2520518	hsa-miR-1256	CLIP-seq
MIRT2520519	hsa-miR-1275	CLIP-seq
MIRT2520520	hsa-miR-1294	CLIP-seq
MIRT2520521	hsa-miR-1299	CLIP-seq
MIRT2520522	hsa-miR-138	CLIP-seq
MIRT2520523	hsa-miR-144	CLIP-seq
MIRT2520524	hsa-miR-155	CLIP-seq
MIRT2520525	hsa-miR-1827	CLIP-seq
MIRT2520526	hsa-miR-203	CLIP-seq
MIRT2520527	hsa-miR-2053	CLIP-seq
MIRT2520528	hsa-miR-206	CLIP-seq
MIRT2520529	hsa-miR-2682	CLIP-seq
MIRT2520530	hsa-miR-299-5p	CLIP-seq
MIRT2520531	hsa-miR-300	CLIP-seq
MIRT2520532	hsa-miR-3116	CLIP-seq
MIRT2520533	hsa-miR-3117-3p	CLIP-seq
MIRT951327	hsa-miR-3125	CLIP-seq
MIRT2520534	hsa-miR-3126-3p	CLIP-seq
MIRT2520535	hsa-miR-3140-3p	CLIP-seq
MIRT2520536	hsa-miR-3153	CLIP-seq
MIRT1981808	hsa-miR-3190	CLIP-seq
MIRT2520537	hsa-miR-331-5p	CLIP-seq
MIRT2520538	hsa-miR-337-3p	CLIP-seq
MIRT2520539	hsa-miR-33a	CLIP-seq
MIRT2520540	hsa-miR-33b	CLIP-seq
MIRT2520541	hsa-miR-3616-3p	CLIP-seq
MIRT2520542	hsa-miR-3646	CLIP-seq
MIRT2520543	hsa-miR-3653	CLIP-seq
MIRT2520544	hsa-miR-3658	CLIP-seq
MIRT2520545	hsa-miR-3673	CLIP-seq
MIRT2520546	hsa-miR-3690	CLIP-seq
MIRT2520547	hsa-miR-3714	CLIP-seq
MIRT2520548	hsa-miR-374c	CLIP-seq
MIRT2520549	hsa-miR-377	CLIP-seq
MIRT2520550	hsa-miR-381	CLIP-seq
MIRT2520551	hsa-miR-3910	CLIP-seq
MIRT2520552	hsa-miR-3911	CLIP-seq
MIRT951340	hsa-miR-3916	CLIP-seq
MIRT2520553	hsa-miR-4277	CLIP-seq
MIRT2520554	hsa-miR-4280	CLIP-seq
MIRT2520555	hsa-miR-4299	CLIP-seq
MIRT2520556	hsa-miR-4436b-3p	CLIP-seq
MIRT2520557	hsa-miR-4456	CLIP-seq
MIRT2520558	hsa-miR-449c	CLIP-seq
MIRT2520559	hsa-miR-4501	CLIP-seq
MIRT2520560	hsa-miR-4517	CLIP-seq
MIRT2520561	hsa-miR-4525	CLIP-seq
MIRT2520562	hsa-miR-4529-5p	CLIP-seq
MIRT2520563	hsa-miR-4645-3p	CLIP-seq
MIRT2520564	hsa-miR-4662a-3p	CLIP-seq
MIRT2520565	hsa-miR-4665-5p	CLIP-seq
MIRT2520566	hsa-miR-4666-3p	CLIP-seq
MIRT951358	hsa-miR-4668-5p	CLIP-seq
MIRT2520567	hsa-miR-4678	CLIP-seq
MIRT2520568	hsa-miR-4686	CLIP-seq
MIRT2520569	hsa-miR-4698	CLIP-seq
MIRT2520570	hsa-miR-4715-3p	CLIP-seq
MIRT2520571	hsa-miR-4723-5p	CLIP-seq
MIRT2520572	hsa-miR-4725-5p	CLIP-seq
MIRT2520573	hsa-miR-4738-3p	CLIP-seq
MIRT2520574	hsa-miR-4771	CLIP-seq
MIRT2520575	hsa-miR-4778-5p	CLIP-seq
MIRT2520576	hsa-miR-494	CLIP-seq
MIRT2520577	hsa-miR-499a-5p	CLIP-seq
MIRT2520578	hsa-miR-504	CLIP-seq
MIRT2520579	hsa-miR-506	CLIP-seq
MIRT2520580	hsa-miR-516a-5p	CLIP-seq
MIRT2520581	hsa-miR-518a-5p	CLIP-seq
MIRT2520582	hsa-miR-527	CLIP-seq
MIRT2520583	hsa-miR-548c-3p	CLIP-seq
MIRT2520584	hsa-miR-548l	CLIP-seq
MIRT2520585	hsa-miR-548q	CLIP-seq
MIRT2520586	hsa-miR-550a	CLIP-seq
MIRT2520587	hsa-miR-574-5p	CLIP-seq
MIRT2520588	hsa-miR-582-3p	CLIP-seq
MIRT2520589	hsa-miR-613	CLIP-seq
MIRT2520590	hsa-miR-625	CLIP-seq
MIRT2520591	hsa-miR-651	CLIP-seq
MIRT2520592	hsa-miR-655	CLIP-seq
MIRT2520593	hsa-miR-661	CLIP-seq
MIRT2520594	hsa-miR-7	CLIP-seq
MIRT2520595	hsa-miR-711	CLIP-seq
MIRT2520596	hsa-miR-759	CLIP-seq
MIRT2520597	hsa-miR-875-3p	CLIP-seq
MIRT951372	hsa-miR-935	CLIP-seq
MIRT2520598	hsa-miR-939	CLIP-seq
MIRT2520512	hsa-miR-1	CLIP-seq
MIRT2520515	hsa-miR-1227	CLIP-seq
MIRT2520516	hsa-miR-124	CLIP-seq
MIRT2520518	hsa-miR-1256	CLIP-seq
MIRT2520519	hsa-miR-1275	CLIP-seq
MIRT2520520	hsa-miR-1294	CLIP-seq
MIRT2520521	hsa-miR-1299	CLIP-seq
MIRT2520522	hsa-miR-138	CLIP-seq
MIRT2520523	hsa-miR-144	CLIP-seq
MIRT2520524	hsa-miR-155	CLIP-seq
MIRT2520525	hsa-miR-1827	CLIP-seq
MIRT2520526	hsa-miR-203	CLIP-seq
MIRT2520527	hsa-miR-2053	CLIP-seq
MIRT2520528	hsa-miR-206	CLIP-seq
MIRT2520529	hsa-miR-2682	CLIP-seq
MIRT2520530	hsa-miR-299-5p	CLIP-seq
MIRT2520531	hsa-miR-300	CLIP-seq
MIRT2520533	hsa-miR-3117-3p	CLIP-seq
MIRT951327	hsa-miR-3125	CLIP-seq
MIRT2520534	hsa-miR-3126-3p	CLIP-seq
MIRT2520535	hsa-miR-3140-3p	CLIP-seq
MIRT2520536	hsa-miR-3153	CLIP-seq
MIRT1981808	hsa-miR-3190	CLIP-seq
MIRT2520537	hsa-miR-331-5p	CLIP-seq
MIRT2520538	hsa-miR-337-3p	CLIP-seq
MIRT2520539	hsa-miR-33a	CLIP-seq
MIRT2520540	hsa-miR-33b	CLIP-seq
MIRT2520541	hsa-miR-3616-3p	CLIP-seq
MIRT2520542	hsa-miR-3646	CLIP-seq
MIRT2520545	hsa-miR-3673	CLIP-seq
MIRT2520547	hsa-miR-3714	CLIP-seq
MIRT2520549	hsa-miR-377	CLIP-seq
MIRT2520550	hsa-miR-381	CLIP-seq
MIRT2520551	hsa-miR-3910	CLIP-seq
MIRT2520552	hsa-miR-3911	CLIP-seq
MIRT951340	hsa-miR-3916	CLIP-seq
MIRT2520553	hsa-miR-4277	CLIP-seq
MIRT2520555	hsa-miR-4299	CLIP-seq
MIRT2520556	hsa-miR-4436b-3p	CLIP-seq
MIRT2520557	hsa-miR-4456	CLIP-seq
MIRT2520558	hsa-miR-449c	CLIP-seq
MIRT2520559	hsa-miR-4501	CLIP-seq
MIRT2520560	hsa-miR-4517	CLIP-seq
MIRT2520561	hsa-miR-4525	CLIP-seq
MIRT2520562	hsa-miR-4529-5p	CLIP-seq
MIRT2520563	hsa-miR-4645-3p	CLIP-seq
MIRT2520564	hsa-miR-4662a-3p	CLIP-seq
MIRT2520565	hsa-miR-4665-5p	CLIP-seq
MIRT2520566	hsa-miR-4666-3p	CLIP-seq
MIRT951358	hsa-miR-4668-5p	CLIP-seq
MIRT2520567	hsa-miR-4678	CLIP-seq
MIRT2520568	hsa-miR-4686	CLIP-seq
MIRT2520569	hsa-miR-4698	CLIP-seq
MIRT2520570	hsa-miR-4715-3p	CLIP-seq
MIRT2520571	hsa-miR-4723-5p	CLIP-seq
MIRT2520573	hsa-miR-4738-3p	CLIP-seq
MIRT2520575	hsa-miR-4778-5p	CLIP-seq
MIRT2520579	hsa-miR-506	CLIP-seq
MIRT2520580	hsa-miR-516a-5p	CLIP-seq
MIRT2520581	hsa-miR-518a-5p	CLIP-seq
MIRT2520582	hsa-miR-527	CLIP-seq
MIRT2520585	hsa-miR-548q	CLIP-seq
MIRT2520587	hsa-miR-574-5p	CLIP-seq
MIRT2520588	hsa-miR-582-3p	CLIP-seq
MIRT2520589	hsa-miR-613	CLIP-seq
MIRT2520590	hsa-miR-625	CLIP-seq
MIRT2520591	hsa-miR-651	CLIP-seq
MIRT2520594	hsa-miR-7	CLIP-seq
MIRT2520596	hsa-miR-759	CLIP-seq
MIRT2520597	hsa-miR-875-3p	CLIP-seq
MIRT951372	hsa-miR-935	CLIP-seq
MIRT2520598	hsa-miR-939	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	ISA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0003677	Function	DNA binding	IEA
GO:0003700	Function	DNA-binding transcription factor activity	IEA
GO:0005515	Function	Protein binding	IPI	25416956, 25910212, 32296183, 32814053
GO:0005634	Component	Nucleus	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0008270	Function	Zinc ion binding	IEA
GO:0046872	Function	Metal ion binding	IEA

Other IDs

• MIM: 164343
• HGNC: 3126
• e!Ensembl: ENSG00000164330

Protein

• UniProt ID: Q9UH73
• Protein name: Transcription factor COE1 (O/E-1) (OE-1) (Early B-cell factor)
• Protein function: Key pioneer transcription factor of B-cell specification and commitment (PubMed:27807034). Recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3'. Operates in a transcription factor network to activate B-cell-specific genes and
• PDB: 3LYR, 3MQI
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF16422	COE1_DBD	17 → 247	Transcription factor COE1 DNA-binding domain	Domain
  PF01833	TIG	262 → 344	IPT/TIG domain	Domain
  PF16423	COE1_HLH	347 → 390	Transcription factor COE1 helix-loop-helix domain	Domain

• Sequence:

  MFGIQESIQRSGSSMKEEPLGSGMNAVRTWMQGAGVLDANTAAQSGVGLARAHFEKQPPS
  NLRKSNFFHFVLALYDRQGQPVEIERTAFVGFVEKEKEANSEKTNNGIHYRLQLLYSNGI
  RTEQDFYVRLIDSMTKQAIVYEGQDKNPEMCRVLLTHEIMCSRCCDKKSCGNRNETPSDP
  VIIDRFFLKFFLKCNQNCLKNAGNPRDMRRFQVVVSTTVNVDGHVLAVSDNMFVHNNSKH
  GRRARRLDPSEGTPSYLEHATPCIKAISPSEGWTTGGATVIIIGDNFFDGLQVIFGTMLV
  WSELITPHAIRVQTPPRHIPGVVEVTLSYKSKQFCKGTPGRFIYTALNEPTIDYGFQRLQ
  KVIPRHPGDPERLPKEVILKRAADLVEALYGMPHNNQEIILKRAADIAEALYSVPRNHNQ
  LPALANTSVHAGMMGVNSFSGQLAVNVSEASQATNQGFTRNSSSVSPHGYVPSTTPQQTN
  YNSVTTSMNGYGSAAMSNLGGSPTFLNGSAANSPYAIVPSSPTMASSTSLPSNCSSSSGI
  FSFSPANMVSAVKQKSAFAPVVRPQTSPPPTCTSTNGNSLQAISGMIVPPM

• Sequence length: 591