E2F5 (E2F transcription factor 5)

Gene

• Entrez ID: 1875
• Gene name: E2F transcription factor 5
• Gene symbol: E2F5
• Synonyms (NCBI Gene): E2F-5
• Chromosome: 8
• Chromosome location: 8q21.2
• Summary: The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DN

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT000750	hsa-miR-34a-5p	Review, Microarray	19461653
MIRT000750	hsa-miR-34a-5p	Review, Microarray	19461653
MIRT003321	hsa-miR-205-5p	Review	20026422
MIRT004134	hsa-miR-192-5p	Microarray	16822819
MIRT003833	hsa-let-7b-5p	Microarray	17699775
MIRT017999	hsa-miR-335-5p	Microarray	18185580
MIRT002917	hsa-miR-124-3p	Microarray	18668037
MIRT023808	hsa-miR-1-3p	Microarray	18668037
MIRT003321	hsa-miR-205-5p	Reporter assay	21454583
MIRT043926	hsa-miR-378a-3p	CLASH	23622248
MIRT053530	hsa-miR-106b-5p	qRT-PCR, Western blot	23803041
MIRT054422	hsa-miR-181a-5p	Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot	24529171
MIRT054422	hsa-miR-181a-5p	Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot	24529171
MIRT053530	hsa-miR-106b-5p	HITS-CLIP	22473208
MIRT173112	hsa-miR-20a-5p	HITS-CLIP	22473208
MIRT225969	hsa-let-7c-5p	3'LIFE	25074381
MIRT053530	hsa-miR-106b-5p	HITS-CLIP	22473208
MIRT173111	hsa-miR-17-5p	HITS-CLIP	22473208
MIRT173123	hsa-miR-20b-5p	HITS-CLIP	22473208
MIRT173113	hsa-miR-93-5p	HITS-CLIP	22473208
MIRT173131	hsa-miR-519d-3p	HITS-CLIP	22473208
MIRT173112	hsa-miR-20a-5p	HITS-CLIP	22473208
MIRT225969	hsa-let-7c-5p	3'LIFE	25074381
MIRT225973	hsa-miR-98-5p	qRT-PCR, Luciferase reporter assay, Immunofluorescence, Immunoprecipitaion, Western blot	25422988
MIRT732813	hsa-miR-584-5p	PAR-CLIP	27292025
MIRT732813	hsa-miR-584-5p	Luciferase reporter assay, Western blotting, Microarray, qRT-PCR	32420810
MIRT736700	hsa-miR-544a	Luciferase reporter assay, Western blotting, qRT-PCR, Flow cytometry	31579422
MIRT003321	hsa-miR-205-5p	Microarray, qRT-PCR	35816043
MIRT950630	hsa-let-7a	CLIP-seq
MIRT950631	hsa-let-7b	CLIP-seq
MIRT950632	hsa-let-7c	CLIP-seq
MIRT950633	hsa-let-7d	CLIP-seq
MIRT950634	hsa-let-7e	CLIP-seq
MIRT950635	hsa-let-7f	CLIP-seq
MIRT950636	hsa-let-7g	CLIP-seq
MIRT950637	hsa-let-7i	CLIP-seq
MIRT950638	hsa-miR-1	CLIP-seq
MIRT950639	hsa-miR-106a	CLIP-seq
MIRT950640	hsa-miR-106b	CLIP-seq
MIRT950641	hsa-miR-124	CLIP-seq
MIRT950642	hsa-miR-132	CLIP-seq
MIRT950643	hsa-miR-17	CLIP-seq
MIRT950644	hsa-miR-206	CLIP-seq
MIRT950645	hsa-miR-20a	CLIP-seq
MIRT950646	hsa-miR-20b	CLIP-seq
MIRT950647	hsa-miR-212	CLIP-seq
MIRT950648	hsa-miR-302a	CLIP-seq
MIRT950649	hsa-miR-302b	CLIP-seq
MIRT950650	hsa-miR-302c	CLIP-seq
MIRT950651	hsa-miR-302d	CLIP-seq
MIRT950652	hsa-miR-302e	CLIP-seq
MIRT950653	hsa-miR-3065-5p	CLIP-seq
MIRT950654	hsa-miR-3609	CLIP-seq
MIRT950655	hsa-miR-3653	CLIP-seq
MIRT950656	hsa-miR-3658	CLIP-seq
MIRT950657	hsa-miR-3662	CLIP-seq
MIRT950658	hsa-miR-3673	CLIP-seq
MIRT950659	hsa-miR-3689a-5p	CLIP-seq
MIRT950660	hsa-miR-3689b	CLIP-seq
MIRT950661	hsa-miR-3689e	CLIP-seq
MIRT950662	hsa-miR-3689f	CLIP-seq
MIRT950663	hsa-miR-372	CLIP-seq
MIRT950664	hsa-miR-373	CLIP-seq
MIRT950665	hsa-miR-3927	CLIP-seq
MIRT950666	hsa-miR-3935	CLIP-seq
MIRT950667	hsa-miR-3941	CLIP-seq
MIRT950668	hsa-miR-4458	CLIP-seq
MIRT950669	hsa-miR-4500	CLIP-seq
MIRT950670	hsa-miR-466	CLIP-seq
MIRT950671	hsa-miR-4672	CLIP-seq
MIRT950672	hsa-miR-4698	CLIP-seq
MIRT950673	hsa-miR-4796-3p	CLIP-seq
MIRT950674	hsa-miR-505	CLIP-seq
MIRT950675	hsa-miR-506	CLIP-seq
MIRT950676	hsa-miR-513b	CLIP-seq
MIRT950677	hsa-miR-519d	CLIP-seq
MIRT950678	hsa-miR-520a-3p	CLIP-seq
MIRT950679	hsa-miR-520b	CLIP-seq
MIRT950680	hsa-miR-520c-3p	CLIP-seq
MIRT950681	hsa-miR-520d-3p	CLIP-seq
MIRT950682	hsa-miR-520e	CLIP-seq
MIRT950683	hsa-miR-548ah	CLIP-seq
MIRT950684	hsa-miR-577	CLIP-seq
MIRT950685	hsa-miR-587	CLIP-seq
MIRT950686	hsa-miR-613	CLIP-seq
MIRT950687	hsa-miR-877	CLIP-seq
MIRT950688	hsa-miR-93	CLIP-seq
MIRT950689	hsa-miR-98	CLIP-seq
MIRT950690	hsa-miR-1271	CLIP-seq
MIRT950691	hsa-miR-154	CLIP-seq
MIRT950655	hsa-miR-3653	CLIP-seq
MIRT950656	hsa-miR-3658	CLIP-seq
MIRT950657	hsa-miR-3662	CLIP-seq
MIRT950667	hsa-miR-3941	CLIP-seq
MIRT950692	hsa-miR-4477a	CLIP-seq
MIRT950693	hsa-miR-4528	CLIP-seq
MIRT950670	hsa-miR-466	CLIP-seq
MIRT950671	hsa-miR-4672	CLIP-seq
MIRT950694	hsa-miR-495	CLIP-seq
MIRT950695	hsa-miR-548ac	CLIP-seq
MIRT950696	hsa-miR-548ae	CLIP-seq
MIRT950697	hsa-miR-548aj	CLIP-seq
MIRT950698	hsa-miR-548am	CLIP-seq
MIRT950699	hsa-miR-548d-3p	CLIP-seq
MIRT950700	hsa-miR-548x	CLIP-seq
MIRT950701	hsa-miR-548z	CLIP-seq
MIRT950702	hsa-miR-664	CLIP-seq
MIRT950703	hsa-miR-96	CLIP-seq
MIRT950641	hsa-miR-124	CLIP-seq
MIRT1981572	hsa-miR-1261	CLIP-seq
MIRT1981573	hsa-miR-186	CLIP-seq
MIRT1981574	hsa-miR-3133	CLIP-seq
MIRT1981575	hsa-miR-3162-5p	CLIP-seq
MIRT1981576	hsa-miR-34a	CLIP-seq
MIRT1981577	hsa-miR-34c-5p	CLIP-seq
MIRT1981578	hsa-miR-3611	CLIP-seq
MIRT1981579	hsa-miR-449a	CLIP-seq
MIRT1981580	hsa-miR-449b	CLIP-seq
MIRT1981581	hsa-miR-4719	CLIP-seq
MIRT950675	hsa-miR-506	CLIP-seq
MIRT950676	hsa-miR-513b	CLIP-seq
MIRT1981582	hsa-miR-548l	CLIP-seq
MIRT1981583	hsa-miR-758	CLIP-seq
MIRT950630	hsa-let-7a	CLIP-seq
MIRT950631	hsa-let-7b	CLIP-seq
MIRT950632	hsa-let-7c	CLIP-seq
MIRT950633	hsa-let-7d	CLIP-seq
MIRT950634	hsa-let-7e	CLIP-seq
MIRT950635	hsa-let-7f	CLIP-seq
MIRT950636	hsa-let-7g	CLIP-seq
MIRT950637	hsa-let-7i	CLIP-seq
MIRT950638	hsa-miR-1	CLIP-seq
MIRT950639	hsa-miR-106a	CLIP-seq
MIRT950640	hsa-miR-106b	CLIP-seq
MIRT950641	hsa-miR-124	CLIP-seq
MIRT2216558	hsa-miR-1256	CLIP-seq
MIRT950642	hsa-miR-132	CLIP-seq
MIRT950643	hsa-miR-17	CLIP-seq
MIRT2216559	hsa-miR-181a	CLIP-seq
MIRT2216560	hsa-miR-181b	CLIP-seq
MIRT2216561	hsa-miR-181c	CLIP-seq
MIRT2216562	hsa-miR-181d	CLIP-seq
MIRT2216563	hsa-miR-205	CLIP-seq
MIRT2216564	hsa-miR-2053	CLIP-seq
MIRT950644	hsa-miR-206	CLIP-seq
MIRT950645	hsa-miR-20a	CLIP-seq
MIRT950646	hsa-miR-20b	CLIP-seq
MIRT950647	hsa-miR-212	CLIP-seq
MIRT950648	hsa-miR-302a	CLIP-seq
MIRT950649	hsa-miR-302b	CLIP-seq
MIRT950650	hsa-miR-302c	CLIP-seq
MIRT950651	hsa-miR-302d	CLIP-seq
MIRT950652	hsa-miR-302e	CLIP-seq
MIRT950653	hsa-miR-3065-5p	CLIP-seq
MIRT1981576	hsa-miR-34a	CLIP-seq
MIRT1981577	hsa-miR-34c-5p	CLIP-seq
MIRT950654	hsa-miR-3609	CLIP-seq
MIRT950657	hsa-miR-3662	CLIP-seq
MIRT950658	hsa-miR-3673	CLIP-seq
MIRT950659	hsa-miR-3689a-5p	CLIP-seq
MIRT950660	hsa-miR-3689b	CLIP-seq
MIRT950661	hsa-miR-3689e	CLIP-seq
MIRT950662	hsa-miR-3689f	CLIP-seq
MIRT950663	hsa-miR-372	CLIP-seq
MIRT950664	hsa-miR-373	CLIP-seq
MIRT950665	hsa-miR-3927	CLIP-seq
MIRT950666	hsa-miR-3935	CLIP-seq
MIRT950667	hsa-miR-3941	CLIP-seq
MIRT2216565	hsa-miR-4262	CLIP-seq
MIRT2216566	hsa-miR-4276	CLIP-seq
MIRT2216567	hsa-miR-4420	CLIP-seq
MIRT2216568	hsa-miR-4438	CLIP-seq
MIRT950668	hsa-miR-4458	CLIP-seq
MIRT2216569	hsa-miR-4496	CLIP-seq
MIRT1981579	hsa-miR-449a	CLIP-seq
MIRT1981580	hsa-miR-449b	CLIP-seq
MIRT950669	hsa-miR-4500	CLIP-seq
MIRT950693	hsa-miR-4528	CLIP-seq
MIRT950670	hsa-miR-466	CLIP-seq
MIRT950671	hsa-miR-4672	CLIP-seq
MIRT2216570	hsa-miR-4694-5p	CLIP-seq
MIRT950672	hsa-miR-4698	CLIP-seq
MIRT1981581	hsa-miR-4719	CLIP-seq
MIRT950673	hsa-miR-4796-3p	CLIP-seq
MIRT2216571	hsa-miR-494	CLIP-seq
MIRT950674	hsa-miR-505	CLIP-seq
MIRT950675	hsa-miR-506	CLIP-seq
MIRT2216572	hsa-miR-5095	CLIP-seq
MIRT950676	hsa-miR-513b	CLIP-seq
MIRT950677	hsa-miR-519d	CLIP-seq
MIRT950678	hsa-miR-520a-3p	CLIP-seq
MIRT950679	hsa-miR-520b	CLIP-seq
MIRT950680	hsa-miR-520c-3p	CLIP-seq
MIRT950681	hsa-miR-520d-3p	CLIP-seq
MIRT950682	hsa-miR-520e	CLIP-seq
MIRT950683	hsa-miR-548ah	CLIP-seq
MIRT2216573	hsa-miR-548c-3p	CLIP-seq
MIRT2216574	hsa-miR-569	CLIP-seq
MIRT950684	hsa-miR-577	CLIP-seq
MIRT950685	hsa-miR-587	CLIP-seq
MIRT950686	hsa-miR-613	CLIP-seq
MIRT950702	hsa-miR-664	CLIP-seq
MIRT950687	hsa-miR-877	CLIP-seq
MIRT950688	hsa-miR-93	CLIP-seq
MIRT950689	hsa-miR-98	CLIP-seq
MIRT950630	hsa-let-7a	CLIP-seq
MIRT950631	hsa-let-7b	CLIP-seq
MIRT950632	hsa-let-7c	CLIP-seq
MIRT950633	hsa-let-7d	CLIP-seq
MIRT950634	hsa-let-7e	CLIP-seq
MIRT950635	hsa-let-7f	CLIP-seq
MIRT950636	hsa-let-7g	CLIP-seq
MIRT950637	hsa-let-7i	CLIP-seq
MIRT950638	hsa-miR-1	CLIP-seq
MIRT950642	hsa-miR-132	CLIP-seq
MIRT950644	hsa-miR-206	CLIP-seq
MIRT950647	hsa-miR-212	CLIP-seq
MIRT950653	hsa-miR-3065-5p	CLIP-seq
MIRT950657	hsa-miR-3662	CLIP-seq
MIRT950658	hsa-miR-3673	CLIP-seq
MIRT950659	hsa-miR-3689a-5p	CLIP-seq
MIRT950660	hsa-miR-3689b	CLIP-seq
MIRT950661	hsa-miR-3689e	CLIP-seq
MIRT950662	hsa-miR-3689f	CLIP-seq
MIRT950665	hsa-miR-3927	CLIP-seq
MIRT950666	hsa-miR-3935	CLIP-seq
MIRT950667	hsa-miR-3941	CLIP-seq
MIRT950668	hsa-miR-4458	CLIP-seq
MIRT950669	hsa-miR-4500	CLIP-seq
MIRT950670	hsa-miR-466	CLIP-seq
MIRT950671	hsa-miR-4672	CLIP-seq
MIRT950672	hsa-miR-4698	CLIP-seq
MIRT950674	hsa-miR-505	CLIP-seq
MIRT950684	hsa-miR-577	CLIP-seq
MIRT950686	hsa-miR-613	CLIP-seq
MIRT950687	hsa-miR-877	CLIP-seq
MIRT950689	hsa-miR-98	CLIP-seq
MIRT2216566	hsa-miR-4276	CLIP-seq
MIRT2216570	hsa-miR-4694-5p	CLIP-seq
MIRT2216566	hsa-miR-4276	CLIP-seq
MIRT2216570	hsa-miR-4694-5p	CLIP-seq
MIRT950638	hsa-miR-1	CLIP-seq
MIRT1981572	hsa-miR-1261	CLIP-seq
MIRT2216563	hsa-miR-205	CLIP-seq
MIRT950644	hsa-miR-206	CLIP-seq
MIRT2520452	hsa-miR-3154	CLIP-seq
MIRT1981576	hsa-miR-34a	CLIP-seq
MIRT1981577	hsa-miR-34c-5p	CLIP-seq
MIRT950658	hsa-miR-3673	CLIP-seq
MIRT2216568	hsa-miR-4438	CLIP-seq
MIRT2216569	hsa-miR-4496	CLIP-seq
MIRT1981579	hsa-miR-449a	CLIP-seq
MIRT1981580	hsa-miR-449b	CLIP-seq
MIRT950673	hsa-miR-4796-3p	CLIP-seq
MIRT2216571	hsa-miR-494	CLIP-seq
MIRT2216572	hsa-miR-5095	CLIP-seq
MIRT950686	hsa-miR-613	CLIP-seq
MIRT950638	hsa-miR-1	CLIP-seq
MIRT950644	hsa-miR-206	CLIP-seq
MIRT950658	hsa-miR-3673	CLIP-seq
MIRT2216569	hsa-miR-4496	CLIP-seq
MIRT950673	hsa-miR-4796-3p	CLIP-seq
MIRT950686	hsa-miR-613	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	ISA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0001216	Function	DNA-binding transcription activator activity	IDA	17062573
GO:0001650	Component	Fibrillar center	IDA
GO:0003677	Function	DNA binding	IEA
GO:0003700	Function	DNA-binding transcription factor activity	IEA
GO:0003700	Function	DNA-binding transcription factor activity	NAS	7892279
GO:0005515	Function	Protein binding	IPI	12502741, 16360038, 17062573, 35512704
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005667	Component	Transcription regulator complex	IEA
GO:0005730	Component	Nucleolus	IDA
GO:0005737	Component	Cytoplasm	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IEA
GO:0009887	Process	Animal organ morphogenesis	IEA
GO:0030030	Process	Cell projection organization	IEA
GO:0045893	Process	Positive regulation of DNA-templated transcription	IEA
GO:0046983	Function	Protein dimerization activity	IEA
GO:0090575	Component	RNA polymerase II transcription regulator complex	IBA

Other IDs

• MIM: 600967
• HGNC: 3119
• e!Ensembl: ENSG00000133740

Protein

• UniProt ID: Q15329
• Protein name: Transcription factor E2F5 (E2F-5)
• Protein function: Transcriptional activator that binds to E2F sites, these sites are present in the promoter of many genes whose products are involved in cell proliferation. May mediate growth factor-initiated signal transduction. It is likely involved in the ear
• PDB: 5TUV
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02319	E2F_TDP	51 → 116	E2F/DP family winged-helix DNA-binding domain	Domain
  PF16421	E2F_CC-MB	133 → 230	E2F transcription factor CC-MB domain	Domain

• Sequence:

  MAAAEPASSGQQAPAGQGQGQRPPPQPPQAQAPQPPPPPQLGGAGGGSSRHEKSLGLLTT
  KFVSLLQEAKDGVLDLKAAADTLAVRQKRRIYDITNVLEGIDLIEKKSKNSIQWKGVGAG
  CNTKEVIDRLRYLKAEIEDLELKERELDQQKLWLQQSIKNVMDDSINNRFSYVTHEDICN
  CFNGDTLLAIQAPSGTQLEVPIPEMGQNGQKKYQINLKSHSGPIHVLLINKESSSSKPVV
  FPVPPPDDLTQPSSQSLTPVTPQKSSMATQNLPEQHVSERSQALQQTSATDISSAGSISG
  DIIDELMSSDVFPLLRLSPTPADDYNFNLDDNEGVCDLFDVQILNY

• Sequence length: 346

Pathways

KEGG:

Cell cycle
Cellular senescence
TGF-beta signaling pathway

Reactome:

Transcription of E2F targets under negative control by DREAM complex
G0 and Early G1
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Cyclin E associated events during G1/S transition
G1/S-Specific Transcription
Cyclin D associated events in G1
Cyclin A:Cdk2-associated events at S phase entry