Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
1869
Gene name Gene Name - the full gene name approved by the HGNC.
E2F transcription factor 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
E2F1
Synonyms (NCBI Gene) Gene synonyms aliases
E2F-1, RBAP1, RBBP3, RBP3
Chromosome Chromosome number
20
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
20q11.22
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DN
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT003045 hsa-miR-106b-5p Luciferase reporter assay 18676839
MIRT003045 hsa-miR-106b-5p qRT-PCR 18676839
MIRT001191 hsa-miR-21-5p qRT-PCR, Western blot 19906824
MIRT001124 hsa-miR-98-5p Luciferase reporter assay 19528081
MIRT001191 hsa-miR-21-5p Luciferase reporter assay 19528081
Transcription factors
Transcription factor Regulation Reference
ARID3A Unknown 23659165
E2F1 Unknown 7958836
E2F6 Repression 18562691
E2F7 Repression 18202719
E2F8 Repression 18202719
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000077 Process DNA damage checkpoint IMP 12717439
GO:0000082 Process G1/S transition of mitotic cell cycle IBA 21873635
GO:0000083 Process Regulation of transcription involved in G1/S transition of mitotic cell cycle TAS
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IMP 20224733
GO:0000785 Component Chromatin IDA 21454377
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
189971 3113 ENSG00000101412
Protein
UniProt ID Q01094
Protein name Transcription factor E2F1 (E2F-1) (PBR3) (Retinoblastoma-associated protein 1) (RBAP-1) (Retinoblastoma-binding protein 3) (RBBP-3) (pRB-binding protein E2F-1)
Protein function Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication
PDB 1H24 , 1O9K , 2AZE , 5M9N , 5M9O , 6G0P , 6ULS , 9CB3
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02319 E2F_TDP 128 192 E2F/DP family winged-helix DNA-binding domain Domain
PF16421 E2F_CC-MB 206 299 E2F transcription factor CC-MB domain Domain
Sequence
MALAGAPAGGPCAPALEALLGAGALRLLDSSQIVIISAAQDASAPPAPTGPAAPAAGPCD
PDLLLFATPQAPRPTPSAPRPALGRPPVKRRLDLETDHQYLAESSGPARGRGRHPGKGVK
SPGEKSRYETSLNLTTKRFLELLSHSADGVVDLNWAAEVLKVQKRRIYDITNVLEGIQLI
AKKSKNHIQWLG
SHTTVGVGGRLEGLTQDLRQLQESEQQLDHLMNICTTQLRLLSEDTDS
QRLAYVTCQDLRSIADPAEQMVMVIKAPPETQLQAVDSSENFQISLKSKQGPIDVFLCP
E
ETVGGISPGKTPSQEVTSEEENRATDSATIVSPPPSSPPSSLTTDPSQSLLSLEQEPLLS
RMGSLRAPVDEDRLSPLVAADSLLEHVREDFSGLLPEEFISLSPPHEALDYHFGLEEGEG
IRDLFDCDFGDLTPLDF
Sequence length 437
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Endocrine resistance
Cell cycle
Mitophagy - animal
Cellular senescence
Cushing syndrome
Hepatitis C
Hepatitis B
Human cytomegalovirus infection
Human papillomavirus infection
Human T-cell leukemia virus 1 infection
Kaposi sarcoma-associated herpesvirus infection
Epstein-Barr virus infection
Pathways in cancer
MicroRNAs in cancer
Chemical carcinogenesis - receptor activation
Pancreatic cancer
Glioma
Prostate cancer
Melanoma
Bladder cancer
Chronic myeloid leukemia
Small cell lung cancer
Non-small cell lung cancer
Breast cancer
Hepatocellular carcinoma
Gastric cancer
  Activation of NOXA and translocation to mitochondria
Transcription of E2F targets under negative control by DREAM complex
Activation of PUMA and translocation to mitochondria
Pre-NOTCH Transcription and Translation
Oxidative Stress Induced Senescence
Oncogene Induced Senescence
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
CDC6 association with the ORC:origin complex
G2 Phase
Cyclin E associated events during G1/S transition
G1/S-Specific Transcription
Cyclin D associated events in G1
Cyclin A:Cdk2-associated events at S phase entry
Transcriptional Regulation by E2F6
Transcriptional regulation of granulopoiesis
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Breast cancer Malignant neoplasm of breast rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158
View all (309 more)
14672398
Breast carcinoma Breast Carcinoma rs80359671, rs11540652, rs28934575, rs28897672, rs137886232, rs193922376, rs80357783, rs80359306, rs80359405, rs80359507, rs80359598, rs80358429, rs397507683, rs397515636, rs80359451
View all (71 more)
14672398
Lung carcinoma Non-Small Cell Lung Carcinoma rs1805076, rs121909071, rs121913530, rs112445441, rs121913529, rs121913535, rs121913297, rs121913279, rs104886003, rs397516975, rs11554290, rs121913364, rs121913351, rs121913369, rs121913355
View all (44 more)
29754146
Marfan syndrome Mammary Carcinoma, Human rs137854456, rs137854457, rs267606796, rs137854458, rs137854459, rs137854460, rs137854470, rs137854471, rs267606797, rs137854461, rs137854462, rs137854463, rs869025419, rs137854464, rs137854465
View all (942 more)
14672398
Associations from Text Mining
Disease Name Relationship Type References
ACTH Secreting Pituitary Adenoma Associate 25942479
Adenocarcinoma Stimulate 26349752
Adenocarcinoma Associate 26404133
Adenocarcinoma of Lung Associate 16052233, 22970185, 24341432, 27655285, 28926105, 33734616, 35068325
Adenocarcinoma of Lung Stimulate 39735672
Adenomatous Polyposis Coli Associate 18794899
Alzheimer Disease Associate 11939591
Amyotrophic Lateral Sclerosis Associate 12598317
Anemia Dyserythropoietic Congenital Associate 19336738
Astrocytoma Associate 28042322