Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	1852
Gene name	Dual specificity phosphatase 9
Gene symbol	DUSP9
Synonyms (NCBI Gene)	MKP-4MKP4
Chromosome	X
Chromosome location	Xq28
Summary	The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regu

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miRTarBase ID	miRNA	Experiments	Reference
MIRT027506	hsa-miR-98-5p	Microarray	19088304
MIRT494020	hsa-miR-1321	PAR-CLIP	23592263
MIRT494021	hsa-miR-4739	PAR-CLIP	23592263
MIRT494019	hsa-miR-4756-5p	PAR-CLIP	23592263
MIRT494018	hsa-miR-4716-3p	PAR-CLIP	23592263
MIRT494017	hsa-miR-6794-5p	PAR-CLIP	23592263
MIRT494016	hsa-miR-4270	PAR-CLIP	23592263
MIRT494015	hsa-miR-4441	PAR-CLIP	23592263
MIRT494014	hsa-miR-6754-5p	PAR-CLIP	23592263
MIRT494013	hsa-miR-7706	PAR-CLIP	23592263
MIRT494012	hsa-miR-7515	PAR-CLIP	23592263
MIRT494011	hsa-miR-3179	PAR-CLIP	23592263
MIRT494009	hsa-miR-3197	PAR-CLIP	23592263
MIRT494010	hsa-miR-4271	PAR-CLIP	23592263
MIRT494008	hsa-miR-4725-3p	PAR-CLIP	23592263
MIRT494007	hsa-miR-6780b-5p	PAR-CLIP	23592263
MIRT494006	hsa-miR-625-5p	PAR-CLIP	23592263
MIRT494005	hsa-miR-6864-5p	PAR-CLIP	23592263
MIRT494020	hsa-miR-1321	PAR-CLIP	27292025
MIRT494020	hsa-miR-1321	PAR-CLIP	27292025
MIRT494016	hsa-miR-4270	PAR-CLIP	27292025
MIRT494016	hsa-miR-4270	PAR-CLIP	27292025
MIRT494015	hsa-miR-4441	PAR-CLIP	27292025
MIRT494015	hsa-miR-4441	PAR-CLIP	27292025
MIRT494021	hsa-miR-4739	PAR-CLIP	27292025
MIRT494021	hsa-miR-4739	PAR-CLIP	27292025
MIRT494019	hsa-miR-4756-5p	PAR-CLIP	27292025
MIRT494019	hsa-miR-4756-5p	PAR-CLIP	27292025
MIRT494014	hsa-miR-6754-5p	PAR-CLIP	27292025
MIRT494014	hsa-miR-6754-5p	PAR-CLIP	27292025
MIRT494020	hsa-miR-1321	PAR-CLIP	23592263
MIRT494021	hsa-miR-4739	PAR-CLIP	23592263
MIRT494019	hsa-miR-4756-5p	PAR-CLIP	23592263
MIRT494018	hsa-miR-4716-3p	PAR-CLIP	23592263
MIRT494017	hsa-miR-6794-5p	PAR-CLIP	23592263
MIRT494016	hsa-miR-4270	PAR-CLIP	23592263
MIRT494015	hsa-miR-4441	PAR-CLIP	23592263
MIRT494014	hsa-miR-6754-5p	PAR-CLIP	23592263
MIRT494013	hsa-miR-7706	PAR-CLIP	23592263
MIRT494012	hsa-miR-7515	PAR-CLIP	23592263
MIRT494011	hsa-miR-3179	PAR-CLIP	23592263
MIRT494009	hsa-miR-3197	PAR-CLIP	23592263
MIRT494010	hsa-miR-4271	PAR-CLIP	23592263
MIRT494008	hsa-miR-4725-3p	PAR-CLIP	23592263
MIRT494007	hsa-miR-6780b-5p	PAR-CLIP	23592263
MIRT494006	hsa-miR-625-5p	PAR-CLIP	23592263
MIRT494005	hsa-miR-6864-5p	PAR-CLIP	23592263
MIRT948390	hsa-miR-1252	CLIP-seq
MIRT948391	hsa-miR-186	CLIP-seq
MIRT948392	hsa-miR-3133	CLIP-seq
MIRT948393	hsa-miR-4504	CLIP-seq
MIRT948394	hsa-miR-452	CLIP-seq
MIRT948395	hsa-miR-4676-3p	CLIP-seq
MIRT948396	hsa-miR-4731-3p	CLIP-seq
MIRT948397	hsa-miR-4801	CLIP-seq
MIRT948398	hsa-miR-549	CLIP-seq
MIRT1548079	hsa-miR-3921	CLIP-seq
MIRT1548080	hsa-miR-4251	CLIP-seq
MIRT1548081	hsa-miR-4279	CLIP-seq
MIRT1548082	hsa-miR-4329	CLIP-seq
MIRT1548083	hsa-miR-4653-5p	CLIP-seq
MIRT1548084	hsa-miR-4786-5p	CLIP-seq
MIRT1548085	hsa-miR-769-5p	CLIP-seq
MIRT1981003	hsa-miR-1184	CLIP-seq
MIRT1981004	hsa-miR-1301	CLIP-seq
MIRT1981005	hsa-miR-3127-3p	CLIP-seq
MIRT1981006	hsa-miR-3138	CLIP-seq
MIRT1981007	hsa-miR-328	CLIP-seq
MIRT1981008	hsa-miR-3911	CLIP-seq
MIRT1981009	hsa-miR-4258	CLIP-seq
MIRT1981010	hsa-miR-4453	CLIP-seq
MIRT1981011	hsa-miR-4520a-3p	CLIP-seq
MIRT1981012	hsa-miR-4538	CLIP-seq
MIRT1981013	hsa-miR-4660	CLIP-seq
MIRT1981014	hsa-miR-4800-5p	CLIP-seq
MIRT1981015	hsa-miR-5047	CLIP-seq
MIRT2216133	hsa-miR-615-3p	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000165	Process	MAPK cascade	TAS
GO:0004721	Function	Phosphoprotein phosphatase activity	IEA
GO:0004721	Function	Phosphoprotein phosphatase activity	TAS	9030581
GO:0004722	Function	Protein serine/threonine phosphatase activity	IEA
GO:0004725	Function	Protein tyrosine phosphatase activity	IEA
GO:0005515	Function	Protein binding	IPI	11988087, 21908610, 27880917, 31980649, 32707033, 33961781
GO:0005634	Component	Nucleus	TAS	9030581
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	TAS	9030581
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	TAS
GO:0006470	Process	Protein dephosphorylation	TAS	9030581
GO:0007165	Process	Signal transduction	IBA
GO:0007254	Process	JNK cascade	TAS	9030581
GO:0008138	Function	Protein tyrosine/serine/threonine phosphatase activity	IEA
GO:0008138	Function	Protein tyrosine/serine/threonine phosphatase activity	TAS
GO:0008330	Function	Protein tyrosine/threonine phosphatase activity	IBA
GO:0016787	Function	Hydrolase activity	IEA
GO:0017017	Function	MAP kinase tyrosine/serine/threonine phosphatase activity	IBA
GO:0017017	Function	MAP kinase tyrosine/serine/threonine phosphatase activity	IEA
GO:0033550	Function	MAP kinase tyrosine phosphatase activity	IBA
GO:0043409	Process	Negative regulation of MAPK cascade	IEA
GO:0070371	Process	ERK1 and ERK2 cascade	IEA
GO:0070371	Process	ERK1 and ERK2 cascade	TAS
GO:0070373	Process	Negative regulation of ERK1 and ERK2 cascade	IBA

MIM	HGNC	e!Ensembl
300134	3076	ENSG00000130829

Q99956

Protein name

Dual specificity protein phosphatase 9 (EC 3.1.3.16) (EC 3.1.3.48) (Mitogen-activated protein kinase phosphatase 4) (MAP kinase phosphatase 4) (MKP-4)

Protein function

Inactivates MAP kinases. Has a specificity for the ERK family.

PDB

2HXP , 3LJ8

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00581	Rhodanese	7 → 133	Rhodanese-like domain	Domain
PF00782	DSPc	211 → 343	Dual specificity phosphatase, catalytic domain	Domain

Sequence

MEGLGRSCLWLRRELSPPRPRLLLLDCRSRELYESARIGGALSVALPALLLRRLRRGSLS
VRALLPGPPLQPPPPAPVLLYDQGGGRRRRGEAEAEAEEWEAESVLGTLLQKLREEGYLA
YYLQGGFSRFQAECPHLCETSLAGRAGSSMAPVPGPVPVVGLGSLCLGSDCSDAESEADR
DSMSCGLDSEGATPPPVGLRASFPVQILPNLYLGSARDSANLESLAKLGIRYILNVTPNL
PNFFEKNGDFHYKQIPISDHWSQNLSRFFPEAIEFIDEALSQNCGVLVHCLAGVSRSVTV
TVAYLMQKLHLSLNDAYDLVKRKKSNISPNFNFMGQLLDFERSLRLEERHSQEQGSGGQA
SAASNPPSFFTTPTSDGAFELAPT

Sequence length

384

Interactions

View interactions

	KEGG		Reactome
	MAPK signaling pathway Signaling pathways regulating pluripotency of stem cells		RAF-independent MAPK1/3 activation Negative regulation of MAPK pathway

DUSP9 (dual specificity phosphatase 9)