Gene Gene information from NCBI Gene database.
Entrez ID 1849
Gene name Dual specificity phosphatase 7
Gene symbol DUSP7
Synonyms (NCBI Gene)
MKPXPYST2
Chromosome 3
Chromosome location 3p21.2
Summary Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues.
miRNA miRNA information provided by mirtarbase database.
621
miRTarBase ID miRNA Experiments Reference
MIRT029270 hsa-miR-26b-5p Microarray 19088304
MIRT051779 hsa-let-7c-5p CLASH 23622248
MIRT036734 hsa-miR-760 CLASH 23622248
MIRT568782 hsa-miR-4311 PAR-CLIP 20371350
MIRT494050 hsa-miR-6758-5p PAR-CLIP 20371350
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
26
GO ID Ontology Definition Evidence Reference
GO:0000165 Process MAPK cascade TAS
GO:0004721 Function Phosphoprotein phosphatase activity IEA
GO:0004722 Function Protein serine/threonine phosphatase activity IEA
GO:0004725 Function Protein tyrosine phosphatase activity IEA
GO:0004725 Function Protein tyrosine phosphatase activity TAS
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
602749 3073 ENSG00000164086
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q16829
Protein name Dual specificity protein phosphatase 7 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase PYST2)
Protein function Dual specificity protein phosphatase (PubMed:9788880). Shows high activity towards MAPK1/ERK2 (PubMed:9788880). Also has lower activity towards MAPK14 and MAPK8 (PubMed:9788880). In arrested oocytes, plays a role in meiotic resumption (By simila
PDB 4Y2E
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00581 Rhodanese 56 181 Rhodanese-like domain Domain
PF00782 DSPc 252 384 Dual specificity phosphatase, catalytic domain Domain
Tissue specificity TISSUE SPECIFICITY: Strongly expressed in liver (PubMed:8670865). Expressed at significantly higher levels in malignant hematopoietic cells than in corresponding non-malignant cells (PubMed:14576828). {ECO:0000269|PubMed:14576828, ECO:0000269|PubMed:86708
Sequence
Sequence length 419
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  MAPK signaling pathway
Efferocytosis
  RAF-independent MAPK1/3 activation
ERKs are inactivated
Negative regulation of MAPK pathway