Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
1846
Gene name Gene Name - the full gene name approved by the HGNC.
Dual specificity phosphatase 4
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
DUSP4
Synonyms (NCBI Gene) Gene synonyms aliases
HVH2, MKP-2, MKP2, TYP
Chromosome Chromosome number
8
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
8p12
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regu
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT437484 hsa-miR-185-5p Luciferase reporter assay, qRT-PCR, Western blot 24014023
MIRT650480 hsa-miR-5088-3p HITS-CLIP 23824327
MIRT650478 hsa-miR-3667-3p HITS-CLIP 23824327
MIRT650479 hsa-miR-3121-5p HITS-CLIP 23824327
MIRT650477 hsa-miR-4287 HITS-CLIP 23824327
Transcription factors
Transcription factor Regulation Reference
CREM Repression 21325296
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000188 Process Inactivation of MAPK activity IBA 21873635
GO:0000188 Process Inactivation of MAPK activity IDA 7535768
GO:0001706 Process Endoderm formation IBA 21873635
GO:0004721 Function Phosphoprotein phosphatase activity IBA 21873635
GO:0004725 Function Protein tyrosine phosphatase activity IDA 7535768
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
602747 3070 ENSG00000120875
Protein
UniProt ID Q13115
Protein name Dual specificity protein phosphatase 4 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase hVH2) (Mitogen-activated protein kinase phosphatase 2) (MAP kinase phosphatase 2) (MKP-2)
Protein function Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2.
PDB 3EZZ
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00581 Rhodanese 37 153 Rhodanese-like domain Domain
PF00782 DSPc 203 333 Dual specificity phosphatase, catalytic domain Domain
Sequence
Sequence length 394
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  MAPK signaling pathway
Efferocytosis
  RAF-independent MAPK1/3 activation
ERKs are inactivated
Negative regulation of MAPK pathway
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Arthritis Juvenile arthritis rs1594890601, rs1594882933, rs184370809, rs776489319, rs1594883470 19565504
Unknown
Disease term Disease name Evidence References Source
Mental depression Mental Depression, Depressive disorder 15496935, 11331420 ClinVar
Corticobasal Degeneration Corticobasal Degeneration GWAS
Colorectal Cancer Colorectal Cancer In summary, our data strongly demonstrated that upregulation of GRB7 conferred MEKi resistance in CRC cells with KRAS mutations by mediating RTK signaling through the recruitment of PLK1. GWAS, CBGDA
Prostate cancer Prostate cancer Together, these results show that PRRX2 is an oncogene and might play a role in the aggressiveness of PC within the DNPC population. GWAS, CBGDA
Associations from Text Mining
Disease Name Relationship Type References
Acute Kidney Injury Associate 30678657
Adenocarcinoma Associate 36308185
Adenocarcinoma of Lung Inhibit 19525976
Allergic Fungal Sinusitis Inhibit 30657646
Atrial Fibrillation Associate 30678657
Brain Diseases Associate 32890776
Breast Neoplasms Associate 23127286, 24658355, 25201346, 25629224, 26859151, 28400477, 36234680
Breast Neoplasms Inhibit 25281216
Carcinoma Hepatocellular Associate 20345479
Carcinoma Hepatocellular Stimulate 29425759