Gene Gene information from NCBI Gene database.
Entrez ID 1846
Gene name Dual specificity phosphatase 4
Gene symbol DUSP4
Synonyms (NCBI Gene)
HVH2MKP-2MKP2TYP
Chromosome 8
Chromosome location 8p12
Summary The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regu
miRNA miRNA information provided by mirtarbase database.
746
miRTarBase ID miRNA Experiments Reference
MIRT437484 hsa-miR-185-5p Luciferase reporter assayqRT-PCRWestern blot 24014023
MIRT650480 hsa-miR-5088-3p HITS-CLIP 23824327
MIRT650478 hsa-miR-3667-3p HITS-CLIP 23824327
MIRT650479 hsa-miR-3121-5p HITS-CLIP 23824327
MIRT650477 hsa-miR-4287 HITS-CLIP 23824327
Transcription factors Transcription factors information provided by TRRUST V2 database.
1
Transcription factor Regulation Reference
CREM Repression 21325296
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
24
GO ID Ontology Definition Evidence Reference
GO:0001706 Process Endoderm formation IBA
GO:0004721 Function Phosphoprotein phosphatase activity IBA
GO:0004721 Function Phosphoprotein phosphatase activity IEA
GO:0004722 Function Protein serine/threonine phosphatase activity IEA
GO:0004725 Function Protein tyrosine phosphatase activity IDA 7535768
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
602747 3070 ENSG00000120875
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q13115
Protein name Dual specificity protein phosphatase 4 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase hVH2) (Mitogen-activated protein kinase phosphatase 2) (MAP kinase phosphatase 2) (MKP-2)
Protein function Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2.
PDB 3EZZ
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00581 Rhodanese 37 153 Rhodanese-like domain Domain
PF00782 DSPc 203 333 Dual specificity phosphatase, catalytic domain Domain
Sequence
Sequence length 394
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  MAPK signaling pathway
Efferocytosis
  RAF-independent MAPK1/3 activation
ERKs are inactivated
Negative regulation of MAPK pathway