ECM2 (extracellular matrix protein 2)

Gene

• Entrez ID: 1842
• Gene name: Extracellular matrix protein 2
• Gene symbol: ECM2
• Synonyms (NCBI Gene): -
• Chromosome: 9
• Chromosome location: 9q22.31
• Summary: ECM2 encodes extracellular matrix protein 2, so named because it shares extensive similarity with known extracelluar matrix proteins. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT027441	hsa-miR-98-5p	Microarray	19088304
MIRT037131	hsa-miR-877-3p	CLASH	23622248
MIRT951792	hsa-miR-3144-3p	CLIP-seq
MIRT951793	hsa-miR-3606	CLIP-seq
MIRT951794	hsa-miR-3915	CLIP-seq
MIRT951795	hsa-miR-3928	CLIP-seq
MIRT951796	hsa-miR-4658	CLIP-seq
MIRT951797	hsa-miR-4724-3p	CLIP-seq
MIRT951798	hsa-miR-4758-5p	CLIP-seq
MIRT951799	hsa-miR-4765	CLIP-seq
MIRT951800	hsa-miR-493	CLIP-seq
MIRT951801	hsa-miR-526b	CLIP-seq
MIRT951802	hsa-miR-875-5p	CLIP-seq
MIRT951803	hsa-miR-452	CLIP-seq
MIRT951804	hsa-miR-4676-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005178	Function	Integrin binding	TAS	9790758
GO:0005518	Function	Collagen binding	IEA
GO:0005576	Component	Extracellular region	IEA
GO:0005614	Component	Interstitial matrix	IEA
GO:0007160	Process	Cell-matrix adhesion	TAS	9790758
GO:0008201	Function	Heparin binding	IBA
GO:0008201	Function	Heparin binding	IEA
GO:0010811	Process	Positive regulation of cell-substrate adhesion	IBA
GO:0010811	Process	Positive regulation of cell-substrate adhesion	IEA
GO:0030198	Process	Extracellular matrix organization	IBA
GO:0030198	Process	Extracellular matrix organization	IEA
GO:0031012	Component	Extracellular matrix	IBA
GO:0031012	Component	Extracellular matrix	IEA
GO:0031012	Component	Extracellular matrix	TAS	9790758
GO:0044877	Function	Protein-containing complex binding	IEA
GO:0070052	Function	Collagen V binding	IBA
GO:0070052	Function	Collagen V binding	IEA

Other IDs

• MIM: 603479
• HGNC: 3154
• e!Ensembl: ENSG00000106823

Protein

• UniProt ID: O94769
• Protein name: Extracellular matrix protein 2 (Matrix glycoprotein SC1/ECM2)
• Protein function: Promotes matrix assembly and cell adhesiveness.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00093	VWC	103 → 157	von Willebrand factor type C domain	Family
  PF13855	LRR_8	485 → 547	Leucine rich repeat	Repeat

• Tissue specificity: TISSUE SPECIFICITY: Expressed predominantly in adipose tissue as well as female-specific organs such as mammary gland, ovary, and uterus. {ECO:0000269|PubMed:9790758}.
• Sequence:

  MKIAVLFCFFLLIIFQTDFGKNEEIPRKQRRKIYHRRLRKSSTSHKHRSNRQLGIQQTTV
  FTPVARLPIVNFDYSMEEKFESFSSFPGVESSYNVLPGKKGHCLVKGITMYNKAVWSPEP
  CTTCLCSDGRVLCDETMCHPQRCPQTVIPEGECCPVCSATVSYSLLSGIALNDRNEFSGD
  SSEQREPTNLLHKQLPPPQVGMDRIVRKEALQSEEDEEVKEEDTEQKRETPESRNQGQLY
  SEGDSRGGDRKQRPGEERRLAHQQQRQGREEEEDEEEEGEEGEEDEEDEEDPVRGDMFRM
  PSRSPLPAPPRGTLRLPSGCSLSYRTISCINAMLTQIPPLTAPQITSLELTGNSIASIPD
  EAFNGLPNLERLDLSKNNITSSGIGPKAFKLLKKLMRLNMDGNNLIQIPSQLPSTLEELK
  VNENNLQAIDEESLSDLNQLVTLELEGNNLSEANVNPLAFKPLKSLAYLRLGKNKFRIIP
  QGLPGSIEELYLENNQIEEITEICFNHTRKINVIVLRYNKIEENRIAPLAWINQENLESI
  DLSYNKLYHVPSYLPKSLLHLVLLGNQIERIPGYVFGHMEPGLEYLYLSFNKLADDGMDR
  VSFYGAYHSLRELFLDHNDLKSIPPGIQEMKALHFLRLNNNKIRNILPEEICNAEEDDDS
  NLEHLHLENNYIKIREIPSYTFSCIRSYSSIVLKPQNIK

• Sequence length: 699