Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	1840
Gene name	Deltex E3 ubiquitin ligase 1
Gene symbol	DTX1
Synonyms (NCBI Gene)	RNF140hDx-1
Chromosome	12
Chromosome location	12q24.13
Summary	Studies in Drosophila have identified this gene as encoding a positive regulator of the Notch-signaling pathway. The human gene encodes a protein of unknown function; however, it may play a role in basic helix-loop-helix transcription factor activity. [pr

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miRTarBase ID	miRNA	Experiments	Reference
MIRT017334	hsa-miR-335-5p	Microarray	18185580
MIRT023569	hsa-miR-1-3p	Microarray	18668037
MIRT711752	hsa-miR-6849-3p	HITS-CLIP	19536157
MIRT711751	hsa-miR-6515-3p	HITS-CLIP	19536157
MIRT711750	hsa-miR-1236-3p	HITS-CLIP	19536157
MIRT711749	hsa-miR-3120-5p	HITS-CLIP	19536157
MIRT711748	hsa-miR-942-5p	HITS-CLIP	19536157
MIRT711747	hsa-miR-6895-3p	HITS-CLIP	19536157
MIRT711746	hsa-miR-593-3p	HITS-CLIP	19536157
MIRT711745	hsa-miR-6830-3p	HITS-CLIP	19536157
MIRT711744	hsa-miR-6512-3p	HITS-CLIP	19536157
MIRT711743	hsa-miR-6720-5p	HITS-CLIP	19536157
MIRT711742	hsa-miR-4753-3p	HITS-CLIP	19536157
MIRT711741	hsa-miR-6888-3p	HITS-CLIP	19536157
MIRT711740	hsa-miR-6818-3p	HITS-CLIP	19536157
MIRT711739	hsa-miR-6809-3p	HITS-CLIP	19536157
MIRT711738	hsa-miR-4743-3p	HITS-CLIP	19536157
MIRT711737	hsa-miR-4652-3p	HITS-CLIP	19536157
MIRT711752	hsa-miR-6849-3p	HITS-CLIP	19536157
MIRT711751	hsa-miR-6515-3p	HITS-CLIP	19536157
MIRT711750	hsa-miR-1236-3p	HITS-CLIP	19536157
MIRT711749	hsa-miR-3120-5p	HITS-CLIP	19536157
MIRT711748	hsa-miR-942-5p	HITS-CLIP	19536157
MIRT711747	hsa-miR-6895-3p	HITS-CLIP	19536157
MIRT711746	hsa-miR-593-3p	HITS-CLIP	19536157
MIRT711745	hsa-miR-6830-3p	HITS-CLIP	19536157
MIRT711744	hsa-miR-6512-3p	HITS-CLIP	19536157
MIRT711743	hsa-miR-6720-5p	HITS-CLIP	19536157
MIRT711742	hsa-miR-4753-3p	HITS-CLIP	19536157
MIRT711741	hsa-miR-6888-3p	HITS-CLIP	19536157
MIRT711740	hsa-miR-6818-3p	HITS-CLIP	19536157
MIRT711739	hsa-miR-6809-3p	HITS-CLIP	19536157
MIRT711738	hsa-miR-4743-3p	HITS-CLIP	19536157
MIRT711737	hsa-miR-4652-3p	HITS-CLIP	19536157
MIRT946954	hsa-miR-1254	CLIP-seq
MIRT946955	hsa-miR-1270	CLIP-seq
MIRT946956	hsa-miR-1273f	CLIP-seq
MIRT946957	hsa-miR-185	CLIP-seq
MIRT946958	hsa-miR-2392	CLIP-seq
MIRT946959	hsa-miR-3116	CLIP-seq
MIRT946960	hsa-miR-3165	CLIP-seq
MIRT946961	hsa-miR-3166	CLIP-seq
MIRT946962	hsa-miR-3202	CLIP-seq
MIRT946963	hsa-miR-3605-5p	CLIP-seq
MIRT946964	hsa-miR-3678-3p	CLIP-seq
MIRT946965	hsa-miR-4254	CLIP-seq
MIRT946966	hsa-miR-4306	CLIP-seq
MIRT946967	hsa-miR-4434	CLIP-seq
MIRT946968	hsa-miR-4516	CLIP-seq
MIRT946969	hsa-miR-4644	CLIP-seq
MIRT946970	hsa-miR-4683	CLIP-seq
MIRT946971	hsa-miR-4718	CLIP-seq
MIRT946972	hsa-miR-4747-5p	CLIP-seq
MIRT946973	hsa-miR-4771	CLIP-seq
MIRT946974	hsa-miR-620	CLIP-seq
MIRT1980434	hsa-miR-2115	CLIP-seq
MIRT946961	hsa-miR-3166	CLIP-seq
MIRT946964	hsa-miR-3678-3p	CLIP-seq
MIRT1980435	hsa-miR-4488	CLIP-seq
MIRT1980436	hsa-miR-4667-5p	CLIP-seq
MIRT1980437	hsa-miR-4697-5p	CLIP-seq
MIRT1980438	hsa-miR-4700-5p	CLIP-seq
MIRT946971	hsa-miR-4718	CLIP-seq
MIRT946973	hsa-miR-4771	CLIP-seq
MIRT1980439	hsa-miR-637	CLIP-seq
MIRT2215492	hsa-miR-1302	CLIP-seq
MIRT2215493	hsa-miR-1324	CLIP-seq
MIRT2215494	hsa-miR-3126-3p	CLIP-seq
MIRT946961	hsa-miR-3166	CLIP-seq
MIRT2215495	hsa-miR-3192	CLIP-seq
MIRT946964	hsa-miR-3678-3p	CLIP-seq
MIRT2215496	hsa-miR-4298	CLIP-seq
MIRT2215497	hsa-miR-4314	CLIP-seq
MIRT2215498	hsa-miR-4493	CLIP-seq
MIRT2215499	hsa-miR-4646-5p	CLIP-seq
MIRT946971	hsa-miR-4718	CLIP-seq
MIRT946973	hsa-miR-4771	CLIP-seq
MIRT946961	hsa-miR-3166	CLIP-seq
MIRT946964	hsa-miR-3678-3p	CLIP-seq
MIRT946971	hsa-miR-4718	CLIP-seq
MIRT946973	hsa-miR-4771	CLIP-seq
MIRT2448573	hsa-miR-1262	CLIP-seq
MIRT2448574	hsa-miR-1293	CLIP-seq
MIRT946961	hsa-miR-3166	CLIP-seq
MIRT2448575	hsa-miR-4483	CLIP-seq
MIRT2448576	hsa-miR-4701-3p	CLIP-seq
MIRT2448573	hsa-miR-1262	CLIP-seq
MIRT2448574	hsa-miR-1293	CLIP-seq
MIRT946961	hsa-miR-3166	CLIP-seq
MIRT2448575	hsa-miR-4483	CLIP-seq
MIRT2448576	hsa-miR-4701-3p	CLIP-seq

Show/Hide all (33)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003713	Function	Transcription coactivator activity	TAS	9590294
GO:0005112	Function	Notch binding	IDA	11564735
GO:0005515	Function	Protein binding	IPI	7671825, 17028573, 21124883, 32296183
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IBA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	TAS	9590294
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0006351	Process	DNA-templated transcription	NAS	11564735
GO:0006366	Process	Transcription by RNA polymerase II	TAS	9590294
GO:0007166	Process	Cell surface receptor signaling pathway	TAS	9590294
GO:0007219	Process	Notch signaling pathway	IBA
GO:0007219	Process	Notch signaling pathway	IEA
GO:0007219	Process	Notch signaling pathway	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0008593	Process	Regulation of Notch signaling pathway	IGI	11564735
GO:0010001	Process	Glial cell differentiation	IEA
GO:0016567	Process	Protein ubiquitination	IBA
GO:0016567	Process	Protein ubiquitination	IEA
GO:0016604	Component	Nuclear body	IDA
GO:0016740	Function	Transferase activity	IEA
GO:0017124	Function	SH3 domain binding	IEA
GO:0030217	Process	T cell differentiation	IEA
GO:0031625	Function	Ubiquitin protein ligase binding	IPI	17028573
GO:0045581	Process	Negative regulation of T cell differentiation	IEA
GO:0045665	Process	Negative regulation of neuron differentiation	IGI	11564735
GO:0045893	Process	Positive regulation of DNA-templated transcription	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0061630	Function	Ubiquitin protein ligase activity	IBA
GO:0061630	Function	Ubiquitin protein ligase activity	IEA
GO:1990830	Process	Cellular response to leukemia inhibitory factor	IEA

MIM	HGNC	e!Ensembl
602582	3060	ENSG00000135144

Q86Y01

Protein name

E3 ubiquitin-protein ligase DTX1 (EC 2.3.2.27) (Protein deltex-1) (Deltex1) (hDTX1) (RING-type E3 ubiquitin transferase DTX1)

Protein function

Functions as a ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of MEKK1, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity (By similarity). Regulator of Notch signaling, a s

PDB

6Y5N , 6Y5P , 8R5N , 8R6A , 8R6B

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02825	WWE	26 → 94	WWE domain	Family
PF02825	WWE	107 → 171	WWE domain	Family
PF00097	zf-C3HC4	411 → 471	Zinc finger, C3HC4 type (RING finger)	Domain
PF18102	DTC	479 → 613	Deltex C-terminal domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Widely expressed. Strongly expressed in blood vessel. Also expressed in embryonic nervous system, pancreas, lung, adrenal gland, digestive tube and muscles. Expressed in MZB cells and developing B- and T-cells. {ECO:0000269|PubMed:1275

Sequence

MSRPGHGGLMPVNGLGFPPQNVARVVVWEWLNEHSRWRPYTATVCHHIENVLKEDARGSV
VLGQVDAQLVPYIIDLQSMHQFRQDTGTMRPVRRNFYDPSSAPGKGIVWEWENDGGAWTA
YDMDICITIQNAYEKQHPWLDLSSLGFCYLIYFNSMSQMNRQTRRRRRLRRRLDLAYPLT
VGSIPKSQSWPVGASSGQPCSCQQCLLVNSTRAASNAILASQRRKAPPAPPLPPPPPPGG
PPGALAVRPSATFTGAALWAAPAAGPAEPAPPPGAPPRSPGAPGGARTPGQNNLNRPGPQ
RTTSVSARASIPPGVPALPVKNLNGTGPVHPALAGMTGILLCAAGLPVCLTRAPKPILHP
PPVSKSDVKPVPGVPGVCRKTKKKHLKKSKNPEDVVRRYMQKVKNPPDEDCTICMERLVT
ASGYEGVLRHKGVRPELVGRLGRCGHMYHLLCLVAMYSNGNKDGSLQCPTCKAIYGEKTG
TQPPGKMEFHLIPHSLPGFPDTQTIRIVYDIPTGIQGPEHPNPGKKFTARGFPRHCYLPN
NEKGRKVLRLLITAWERRLIFTIGTSNTTGESDTVVWNEIHHKTEFGSNLTGHGYPDASY
LDNVLAELTAQGVSEAAAKA

Sequence length

620

Interactions

View interactions

	KEGG		Reactome
	Notch signaling pathway		Activated NOTCH1 Transmits Signal to the Nucleus

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
EBV-positive nodal T- and NK-cell lymphoma	Likely benign	rs2044645304	RCV004560245

Show/Hide Text Mining Associations (22)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Carcinoma Non Small Cell Lung	Associate	27557513, 32700476
Colorectal Neoplasms	Associate	36160034
COVID 19	Associate	34799557
Fatigue	Associate	39661563
Glioblastoma	Associate	23451269, 26662803
Hereditary Breast and Ovarian Cancer Syndrome	Associate	35937947
Leukemia Lymphocytic Chronic B Cell	Associate	28931525
Lymphoma B Cell	Associate	33945543
Lymphoma B Cell Marginal Zone	Associate	22891273
Lymphoma Follicular	Associate	30802265
Lymphoma Large B Cell Diffuse	Associate	36215154
Neoplasms	Associate	23451269, 25740824, 28146432, 33945543
Neoplasms	Inhibit	29374180
Osteosarcoma	Inhibit	20208568
Ovarian Diseases	Associate	27557513
Purpura Thrombocytopenic Idiopathic	Inhibit	39661563
Sjogren's Syndrome	Inhibit	39661563
Small Cell Lung Carcinoma	Associate	32700476
Squamous Cell Carcinoma of Head and Neck	Inhibit	28146432
Stomach Neoplasms	Inhibit	29374180
Thyroiditis Autoimmune	Inhibit	39661563
Vasculitis	Inhibit	39661563

DTX1 (deltex E3 ubiquitin ligase 1)