Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
1827
Gene name Gene Name - the full gene name approved by the HGNC.
Regulator of calcineurin 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
RCAN1
Synonyms (NCBI Gene) Gene synonyms aliases
ADAPT78, CSP1, DSC1, DSCR1, MCIP1, RCN1
Chromosome Chromosome number
21
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
21q22.12
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotyp
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT005055 hsa-let-7b-5p Microarray 17699775
MIRT018955 hsa-miR-335-5p Microarray 18185580
MIRT023116 hsa-miR-124-3p Microarray 18668037
MIRT049031 hsa-miR-92a-3p CLASH 23622248
MIRT627717 hsa-miR-4668-3p HITS-CLIP 23824327
Transcription factors
Transcription factor Regulation Reference
STAT2 Unknown 22426484
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0003676 Function Nucleic acid binding IEA
GO:0005515 Function Protein binding IPI 12809556
GO:0005634 Component Nucleus IBA 21873635
GO:0005737 Component Cytoplasm IBA 21873635
GO:0008597 Function Calcium-dependent protein serine/threonine phosphatase regulator activity IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
602917 3040 ENSG00000159200
Protein
UniProt ID P53805
Protein name Calcipressin-1 (Adapt78) (Down syndrome critical region protein 1) (Myocyte-enriched calcineurin-interacting protein 1) (MCIP1) (Regulator of calcineurin 1)
Protein function Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A (PubMed:12809556). Could play a role during central nervous system development (By similarity). {ECO:0000250|UniProtKB:Q9JHG6, ECO:00002
PDB 6UUQ
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF04847 Calcipressin 75 246 Calcipressin Family
Tissue specificity TISSUE SPECIFICITY: Highly expressed heart, brain and skeletal muscle. Also expressed in all other tissues.
Sequence
Sequence length 252
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  
  Thyroid hormone signaling pathway
Oxytocin signaling pathway
Kaposi sarcoma-associated herpesvirus infection
 
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Congenital heart defects Congenital Heart Defects rs267607101, rs121434422, rs387906498, rs397509416, rs587777371, rs587777372, rs587777374, rs367537998, rs797044882, rs886041730, rs768027510, rs1064793873, rs1555447012, rs1554263268, rs1554263321
View all (13 more)
15906378
Rheumatoid arthritis Rheumatoid Arthritis rs587776843 23143596, 30423114
Unknown
Disease term Disease name Evidence References Source
Huntington disease Huntington Disease, Huntington Disease, Late Onset, Juvenile Huntington Disease 19270310 ClinVar
Psoriasis Psoriasis GWAS
Associations from Text Mining
Disease Name Relationship Type References
Alzheimer Disease Associate 12716059, 21838211, 24735980, 27872486, 33633844, 39192218
Alzheimer Disease Stimulate 17331188, 21838211, 32566665
Atrial Fibrillation Associate 23863953, 34198460
Breast Neoplasms Inhibit 33742056
Carcinogenesis Associate 33827593, 39245738
Carcinoma Hepatocellular Associate 39192218
Carcinoma Ovarian Epithelial Associate 19331211
Cardiomegaly Associate 23863953
Cardiovascular Diseases Associate 39192218
Carotid Body Tumor Associate 30967136