Gene Gene information from NCBI Gene database.
Entrez ID 1810
Gene name Down-regulator of transcription 1
Gene symbol DR1
Synonyms (NCBI Gene)
NC2NC2-BETANC2BNCB2
Chromosome 1
Chromosome location 1p22.1
Summary This gene encodes a TBP- (TATA box-binding protein) associated phosphoprotein that represses both basal and activated levels of transcription. The encoded protein is phosphorylated in vivo and this phosphorylation affects its interaction with TBP. This pr
miRNA miRNA information provided by mirtarbase database.
438
miRTarBase ID miRNA Experiments Reference
MIRT020005 hsa-miR-375 Microarray 20215506
MIRT020974 hsa-miR-155-5p Proteomics 20584899
MIRT044688 hsa-miR-320a CLASH 23622248
MIRT054518 hsa-miR-513a-5p Luciferase reporter assayqRT-PCRWestern blot 24252134
MIRT054519 hsa-miR-513b-5p Luciferase reporter assayqRT-PCRWestern blot 24252134
Transcription factors Transcription factors information provided by TRRUST V2 database.
2
Transcription factor Regulation Reference
BTAF1 Repression 20627952
NR2F1 Repression 22357705
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
35
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IDA 8670811, 18838386
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IEA
GO:0003677 Function DNA binding IEA
GO:0005515 Function Protein binding IPI 8670811, 16189514, 18692475, 18838386, 29997244, 31467278, 31515488, 32296183, 32814053, 33961781, 34819669, 37398436
GO:0005634 Component Nucleus IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
601482 3017 ENSG00000117505
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q01658
Protein name Protein Dr1 (Down-regulator of transcription 1) (Negative cofactor 2-beta) (NC2-beta) (TATA-binding protein-associated phosphoprotein)
Protein function The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the
PDB 1JFI
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00808 CBFD_NFYB_HMF 11 75 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Domain
Sequence
MASSSGNDDDLTIPRAAINKMIKETLPNVRVANDARELVVNCCTEFIHLISSEANEICNK
SEKKTISPEHVIQAL
ESLGFGSYISEVKEVLQECKTVALKRRKASSRLENLGIPEEELLR
QQQELFAKARQQQAELAQQEWLQMQQAAQQAQLAAASASASNQAGSSQDEEDDDDI
Sequence length 176
Interactions View interactions