Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
1808
Gene name Gene Name - the full gene name approved by the HGNC.
Dihydropyrimidinase like 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
DPYSL2
Synonyms (NCBI Gene) Gene synonyms aliases
CRMP-2, CRMP2, DHPRP2, DRP-2, DRP2, N2A3, ULIP-2, ULIP2
Chromosome Chromosome number
8
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
8p21.2
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the collapsin response mediator protein family. Collapsin response mediator proteins form homo- and hetero-tetramers and facilitate neuron guidance, growth and polarity. The encoded protein promotes microtubule assembly and i
SNPs SNP information provided by dbSNP.
SNP ID Visualize variation Clinical significance Consequence
rs138340807 C>A,T Benign, likely-pathogenic Synonymous variant, missense variant, coding sequence variant, 5 prime UTR variant
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT031306 hsa-miR-19a-3p Reporter assay 21654684
MIRT050956 hsa-miR-17-5p CLASH 23622248
MIRT047866 hsa-miR-30c-5p CLASH 23622248
MIRT047721 hsa-miR-10a-5p CLASH 23622248
MIRT044587 hsa-miR-320a CLASH 23622248
Transcription factors
Transcription factor Regulation Reference
GATA1 Unknown 15207709
GATA2 Unknown 15207709
PAX3 Unknown 17229153
SP1 Unknown 15207709
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0004157 Function Dihydropyrimidinase activity IBA 21873635
GO:0005515 Function Protein binding IPI 16260607, 19235893, 21900206, 24722188, 25416956, 28514442, 29892012, 31515488, 32296183, 32814053
GO:0005829 Component Cytosol IDA 20801876
GO:0005829 Component Cytosol TAS
GO:0005874 Component Microtubule IDA 20801876
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
602463 3014 ENSG00000092964
Protein
UniProt ID Q16555
Protein name Dihydropyrimidinase-related protein 2 (DRP-2) (Collapsin response mediator protein 2) (CRMP-2) (N2A3) (Unc-33-like phosphoprotein 2) (ULIP-2)
Protein function Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a
PDB 2GSE , 2VM8 , 5LXX , 5MKV , 5MLE , 5X1A , 5X1C , 5X1D , 5YZ5 , 5YZA , 5YZB , 6JV9 , 6JVB , 7X68 , 8DNM
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01979 Amidohydro_1 64 453 Amidohydrolase family Domain
Tissue specificity TISSUE SPECIFICITY: Ubiquitous.
Sequence
Sequence length 572
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Axon guidance   CRMPs in Sema3A signaling
Recycling pathway of L1
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Alzheimer disease Familial Alzheimer Disease (FAD), Alzheimer Disease, Late Onset, Alzheimer Disease, Early Onset, Alzheimer`s Disease, Alzheimer`s Disease, Focal Onset rs63750215, rs28936379, rs63749851, rs63749884, rs28936380, rs63750048, rs63750579, rs63750264, rs63749964, rs63750671, rs281865161, rs63750066, rs63750399, rs63750734, rs63751039
View all (65 more)
19374891
Arthritis Degenerative polyarthritis rs1594890601, rs1594882933, rs184370809, rs776489319, rs1594883470 18784066
Colorectal cancer Colorectal Carcinoma rs137854568, rs137854573, rs137854575, rs387906234, rs121908380, rs121908702, rs267606674, rs794729661, rs121909055, rs281865417, rs267606884, rs28934575, rs587776769, rs104893815, rs587776800
View all (467 more)
Unknown
Disease term Disease name Evidence References Source
Mental depression Mental Depression, Depressive disorder 19204725 ClinVar
Oligodendroglioma Oligodendroglioma GWAS
Atrial Fibrillation Atrial Fibrillation GWAS
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma of Lung Inhibit 34517904
Alzheimer Disease Associate 37479784
Bipolar Disorder Associate 37479784
Breast Neoplasms Associate 28731166, 35575798
Cancer Pain Associate 27456940
Carcinoma Hepatocellular Associate 36177006
Carcinoma Non Small Cell Lung Associate 38057344
Colorectal Neoplasms Associate 35203376
Developmental Disabilities Associate 37479784
Glioblastoma Associate 28498803