Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	1806
Gene name	Dihydropyrimidine dehydrogenase
Gene symbol	DPYD
Synonyms (NCBI Gene)	DHPDHPDHASEDPDDYPD
Chromosome	1
Chromosome location	1p21.3
Summary	The protein encoded by this gene is a pyrimidine catabolic enzyme and the initial and rate-limiting factor in the pathway of uracil and thymidine catabolism. Mutations in this gene result in dihydropyrimidine dehydrogenase deficiency, an error in pyrimidi

Show/Hide all (50)

SNP ID	Visualize variation	Clinical significance	Consequence
rs1801158	C>T	Benign, conflicting-interpretations-of-pathogenicity	Intron variant, genic downstream transcript variant, coding sequence variant, missense variant
rs1801265	A>G	Pathogenic, benign, not-provided	Intron variant, missense variant, coding sequence variant, non coding transcript variant, 5 prime UTR variant
rs1801266	G>A	Drug-response, uncertain-significance	Genic downstream transcript variant, coding sequence variant, missense variant
rs1801268	C>A	Drug-response	Genic downstream transcript variant, coding sequence variant, missense variant
rs3918290	C>G,T	Pathogenic, drug-response, uncertain-significance, conflicting-interpretations-of-pathogenicity	Splice donor variant, genic downstream transcript variant
rs55886062	A>C,T	Pathogenic, drug-response, likely-pathogenic	Coding sequence variant, intron variant, missense variant, genic downstream transcript variant
rs59086055	G>A	Uncertain-significance, likely-pathogenic	Missense variant, genic downstream transcript variant, coding sequence variant
rs67376798	T>A	Uncertain-significance, drug-response, likely-pathogenic, other	Missense variant, genic downstream transcript variant, coding sequence variant
rs72547602	T>A,G	Pathogenic	Missense variant, genic downstream transcript variant, coding sequence variant
rs72549303	G>-	Drug-response	Genic downstream transcript variant, coding sequence variant, frameshift variant
rs72549309	ATGA>-	Drug-response, pathogenic	5 prime UTR variant, non coding transcript variant, coding sequence variant, frameshift variant
rs72549310	G>A	Likely-pathogenic	Coding sequence variant, stop gained, intron variant, non coding transcript variant, 5 prime UTR variant
rs75017182	G>C,T	Drug-response	Genic downstream transcript variant, intron variant
rs115232898	T>C	Drug-response, likely-benign, not-provided	Genic downstream transcript variant, downstream transcript variant, missense variant, coding sequence variant
rs141597515	G>A	Pathogenic-likely-pathogenic	Coding sequence variant, stop gained, 5 prime UTR variant, non coding transcript variant
rs146170505	C>A	Pathogenic-likely-pathogenic	Stop gained, genic downstream transcript variant, downstream transcript variant, coding sequence variant
rs189768576	G>A	Conflicting-interpretations-of-pathogenicity	Stop gained, coding sequence variant, 5 prime UTR variant, non coding transcript variant
rs367619008	T>C	Conflicting-interpretations-of-pathogenicity	Non coding transcript variant, 5 prime UTR variant, coding sequence variant, missense variant
rs377221676	C>T	Likely-pathogenic	Genic downstream transcript variant, splice acceptor variant
rs749571474	AT>-	Likely-pathogenic	Frameshift variant, coding sequence variant, genic downstream transcript variant
rs755031341	C>A	Likely-pathogenic	Coding sequence variant, genic downstream transcript variant, stop gained
rs764584080	A>-	Likely-pathogenic	Genic downstream transcript variant, intron variant, frameshift variant, coding sequence variant
rs768020954	C>T	Likely-pathogenic	Initiator codon variant, non coding transcript variant, missense variant, 5 prime UTR variant
rs776692894	T>A	Likely-pathogenic	Coding sequence variant, stop gained, non coding transcript variant, 5 prime UTR variant
rs779948148	->C	Likely-pathogenic	Coding sequence variant, frameshift variant, genic downstream transcript variant
rs867460475	C>A,T	Likely-pathogenic	Splice donor variant, genic downstream transcript variant, downstream transcript variant
rs1057516356	C>G	Likely-pathogenic	Splice acceptor variant
rs1057516357	C>A	Likely-pathogenic	Genic downstream transcript variant, splice donor variant
rs1057516388	C>T	Likely-pathogenic	Genic downstream transcript variant, stop gained, coding sequence variant
rs1057516405	A>T	Likely-pathogenic	Splice donor variant, intron variant
rs1057516615	G>-	Likely-pathogenic	Genic downstream transcript variant, stop gained, coding sequence variant
rs1057516671	C>A	Likely-pathogenic	Genic downstream transcript variant, stop gained, coding sequence variant
rs1057516696	C>G	Likely-pathogenic	Genic downstream transcript variant, splice acceptor variant
rs1057516711	A>-	Likely-pathogenic	Genic downstream transcript variant, coding sequence variant, frameshift variant
rs1057516713	T>C,G	Likely-pathogenic	Genic downstream transcript variant, splice acceptor variant
rs1057516761	C>-	Likely-pathogenic	Genic downstream transcript variant, coding sequence variant, frameshift variant
rs1057516763	C>A	Likely-pathogenic	Splice donor variant
rs1057516968	G>A	Likely-pathogenic	Genic downstream transcript variant, stop gained, intron variant, coding sequence variant
rs1057516997	A>-	Likely-pathogenic	Genic downstream transcript variant, frameshift variant, coding sequence variant, non coding transcript variant
rs1057517018	T>-	Likely-pathogenic	Genic downstream transcript variant, intron variant, coding sequence variant, frameshift variant
rs1057517065	A>G,T	Likely-pathogenic	Genic downstream transcript variant, splice donor variant
rs1057517126	C>T	Likely-pathogenic	Genic downstream transcript variant, splice donor variant
rs1057517189	G>-	Likely-pathogenic	Genic downstream transcript variant, coding sequence variant, frameshift variant
rs1207177925	GGATTTCT>-	Likely-pathogenic, pathogenic	Non coding transcript variant, intron variant, coding sequence variant, stop gained, 5 prime UTR variant
rs1220608789	G>A	Likely-pathogenic	Genic downstream transcript variant, stop gained, coding sequence variant, downstream transcript variant
rs1300669537	T>C	Pathogenic-likely-pathogenic	Splice acceptor variant, genic downstream transcript variant
rs1553197926	G>-	Likely-pathogenic	Genic downstream transcript variant, frameshift variant, coding sequence variant
rs1553201443	G>-	Likely-pathogenic	Genic downstream transcript variant, frameshift variant, coding sequence variant
rs1553201476	CA>-	Likely-pathogenic	Genic downstream transcript variant, frameshift variant, coding sequence variant
rs1553247675	C>A	Likely-pathogenic	Splice donor variant

Show/Hide all (30)

miRTarBase ID	miRNA	Experiments	Reference
MIRT022744	hsa-miR-124-3p	Microarray	18668037
MIRT437994	hsa-miR-27a-3p	Luciferase reporter assay	24401318
MIRT437993	hsa-miR-27b-3p	Luciferase reporter assay	24401318
MIRT437993	hsa-miR-27b-3p	Luciferase reporter assay	24401318
MIRT437994	hsa-miR-27a-3p	Luciferase reporter assay	24401318
MIRT437993	hsa-miR-27b-3p	Luciferase reporter assay	24401318
MIRT437993	hsa-miR-27b-3p	Luciferase reporter assay	24401318
MIRT944925	hsa-miR-1290	CLIP-seq
MIRT944926	hsa-miR-302f	CLIP-seq
MIRT944927	hsa-miR-3179	CLIP-seq
MIRT944928	hsa-miR-3978	CLIP-seq
MIRT944929	hsa-miR-4261	CLIP-seq
MIRT944930	hsa-miR-4450	CLIP-seq
MIRT944931	hsa-miR-4738-3p	CLIP-seq
MIRT944932	hsa-miR-548g	CLIP-seq
MIRT944933	hsa-miR-1228	CLIP-seq
MIRT944934	hsa-miR-329	CLIP-seq
MIRT944935	hsa-miR-342-3p	CLIP-seq
MIRT944936	hsa-miR-362-3p	CLIP-seq
MIRT944937	hsa-miR-377	CLIP-seq
MIRT944938	hsa-miR-4753-3p	CLIP-seq
MIRT944939	hsa-miR-4768-5p	CLIP-seq
MIRT1979723	hsa-miR-4790-3p	CLIP-seq
MIRT2214903	hsa-miR-4633-3p	CLIP-seq
MIRT2214904	hsa-miR-4802-5p	CLIP-seq
MIRT2214905	hsa-miR-579	CLIP-seq
MIRT2214906	hsa-miR-610	CLIP-seq
MIRT944933	hsa-miR-1228	CLIP-seq
MIRT944934	hsa-miR-329	CLIP-seq
MIRT944936	hsa-miR-362-3p	CLIP-seq

Show/Hide all (39)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0002058	Function	Uracil binding	IBA
GO:0005515	Function	Protein binding	IPI	25416956
GO:0005737	Component	Cytoplasm	IDA	1512248
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IDA	9348115
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006145	Process	Purine nucleobase catabolic process	IMP	11988088
GO:0006208	Process	Pyrimidine nucleobase catabolic process	IEA
GO:0006208	Process	Pyrimidine nucleobase catabolic process	IEA
GO:0006208	Process	Pyrimidine nucleobase catabolic process	IMP	11988088
GO:0006208	Process	Pyrimidine nucleobase catabolic process	ISS
GO:0006210	Process	Thymine catabolic process	IBA
GO:0006210	Process	Thymine catabolic process	IDA	10410956
GO:0006212	Process	Uracil catabolic process	IBA
GO:0006212	Process	Uracil catabolic process	IDA	1512248, 18075467
GO:0006214	Process	Thymidine catabolic process	IDA	1512248
GO:0006248	Process	CMP catabolic process	IEA
GO:0006249	Process	DCMP catabolic process	IEA
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0016627	Function	Oxidoreductase activity, acting on the CH-CH group of donors	IEA
GO:0017113	Function	Dihydropyrimidine dehydrogenase (NADP+) activity	IBA
GO:0017113	Function	Dihydropyrimidine dehydrogenase (NADP+) activity	IDA	1512248, 10410956, 18075467
GO:0017113	Function	Dihydropyrimidine dehydrogenase (NADP+) activity	IEA
GO:0017113	Function	Dihydropyrimidine dehydrogenase (NADP+) activity	IMP	11988088
GO:0017113	Function	Dihydropyrimidine dehydrogenase (NADP+) activity	ISS
GO:0019483	Process	Beta-alanine biosynthetic process	IEA
GO:0042803	Function	Protein homodimerization activity	IDA	1512248
GO:0042803	Function	Protein homodimerization activity	ISS
GO:0046050	Process	UMP catabolic process	IEA
GO:0046079	Process	DUMP catabolic process	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0050660	Function	Flavin adenine dinucleotide binding	ISS
GO:0050661	Function	NADP binding	IBA
GO:0050661	Function	NADP binding	ISS
GO:0051536	Function	Iron-sulfur cluster binding	IEA
GO:0051539	Function	4 iron, 4 sulfur cluster binding	IEA

MIM	HGNC	e!Ensembl
612779	3012	ENSG00000188641

Q12882

Protein name

Dihydropyrimidine dehydrogenase [NADP(+)] (DHPDHase) (DPD) (EC 1.3.1.2) (Dihydrothymine dehydrogenase) (Dihydrouracil dehydrogenase)

Protein function

Involved in pyrimidine base degradation (PubMed:1512248). Catalyzes the reduction of uracil and thymine (PubMed:1512248). Also involved the degradation of the chemotherapeutic drug 5-fluorouracil (PubMed:1512248).

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF14691	Fer4_20	55 → 168	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	Domain
PF07992	Pyr_redox_2	187 → 499	Pyridine nucleotide-disulphide oxidoreductase	Domain
PF01180	DHO_dh	532 → 838	Dihydroorotate dehydrogenase	Domain
PF14697	Fer4_21	946 → 1004		Domain

Tissue specificity

TISSUE SPECIFICITY: Found in most tissues with greatest activity found in liver and peripheral blood mononuclear cells.

Sequence

MAPVLSKDSADIESILALNPRTQTHATLCSTSAKKLDKKHWKRNPDKNCFNCEKLENNFD
DIKHTTLGERGALREAMRCLKCADAPCQKSCPTNLDIKSFITSIANKNYYGAAKMIFSDN
PLGLTCGMVCPTSDLCVGGCNLYATEEGPINIGGLQQFATEVFKAMSIPQIRNPSLPPPE
KMSEAYSAKIALFGAGPASISCASFLARLGYSDITIFEKQEYVGGLSTSEIPQFRLPYDV
VNFEIELMKDLGVKIICGKSLSVNEMTLSTLKEKGYKAAFIGIGLPEPNKDAIFQGLTQD
QGFYTSKDFLPLVAKGSKAGMCACHSPLPSIRGVVIVLGAGDTAFDCATSALRCGARRVF
IVFRKGFVNIRAVPEEMELAKEEKCEFLPFLSPRKVIVKGGRIVAMQFVRTEQDETGKWN
EDEDQMVHLKADVVISAFGSVLSDPKVKEALSPIKFNRWGLPEVDPETMQTSEAWVFAGG
DVVGLANTTVESVNDGKQASWYIHKYVQSQYGASVSAKPELPLFYTPIDLVDISVEMAGL
KFINPFGLASATPATSTSMIRRAFEAGWGFALTKTFSLDKDIVTNVSPRIIRGTTSGPMY
GPGQSSFLNIELISEKTAAYWCQSVTELKADFPDNIVIASIMCSYNKNDWTELAKKSEDS
GADALELNLSCPHGMGERGMGLACGQDPELVRNICRWVRQAVQIPFFAKLTPNVTDIVSI
ARAAKEGGANGVTATNTVSGLMGLKSDGTPWPAVGIAKRTTYGGVSGTAIRPIALRAVTS
IARALPGFPILATGGIDSAESGLQFLHSGASVLQVCSAIQNQDFTVIEDYCTGLKALLYL
KSIEELQDWDGQSPATVSHQKGKPVPRIAELMDKKLPSFGPYLEQRKKIIAENKIRLKEQ
NVAFSPLKRNCFIPKRPIPTIKDVIGKALQYLGTFGELSNVEQVVAMIDEEMCINCGKCY
MTCNDSGYQAIQFDPETHLPTITDTCTGCTLCLSVCPIVDCIKMVSRTTPYEPKRGVPLS
VNPVC

Sequence length

1025

Interactions

View interactions

	KEGG		Reactome
	Pyrimidine metabolism beta-Alanine metabolism Pantothenate and CoA biosynthesis Drug metabolism - other enzymes Metabolic pathways		Pyrimidine catabolism

400

Show/Hide Causal Diseases (6)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
5-fluorouracil response	Likely pathogenic	rs755416212	RCV003332223
Dihydropyrimidine dehydrogenase deficiency	Likely pathogenic; Pathogenic	rs568132506, rs769925158, rs1669337684, rs2101026231, rs2102259303, rs778614771, rs2524094344, rs773499329, rs72549310, rs772950053, rs2100972370, rs372307932, rs1057516713, rs2524373926, rs72549304 View all (117 more)	RCV001329029 RCV002308674 RCV001335115 RCV001553731 RCV003470927 RCV002302445 RCV002471719 RCV000169225 RCV000169198 RCV003236367 RCV003315140 RCV003331802 RCV003466077 RCV004572972 RCV000393255 RCV003466228 RCV003466229 RCV003466230 RCV003475588 RCV003466231 RCV003466232 RCV003466233 RCV003466234 RCV003466235 RCV003459988 RCV003466236 RCV003459989 RCV003466237 RCV003466238 RCV003466239 RCV003459990 RCV003467837 RCV003467838 RCV003459991 RCV003459992 RCV003467839 RCV003467840 RCV003475590 RCV003459993 RCV003467842 RCV003467843 RCV003467844 RCV003467845 RCV003467846 RCV003467847 RCV003467848 RCV003467849 RCV003475591 RCV003459995 RCV003467850 RCV003467851 RCV003467852 RCV003459997 RCV003467853 RCV003467854 RCV003467855 RCV003467856 RCV003467857 RCV003467858 RCV003459998 RCV003459999 RCV003467860 RCV003467861 RCV004575841 RCV004575842 RCV004575843 RCV004575844 RCV004575846 RCV004575847 RCV004575848 RCV004575849 RCV004575850 RCV004575851 RCV004575852 RCV004575853 RCV004575854 RCV004575855 RCV004575856 RCV000412342 RCV000411760 RCV000409198 RCV000410613 RCV000411332 RCV000412100 RCV000409891 RCV000412243 RCV000409049 RCV000412376 RCV000411299 RCV000411454 RCV000410448 RCV000409426 RCV000410030 RCV000411893 RCV000409394 RCV000412205 RCV000412072 RCV000409377 RCV000409743 RCV000411699 RCV000412433 RCV000411796 RCV000410794 RCV000411600 RCV000411932 RCV000409515 RCV000409929 RCV000409534 RCV000410667 RCV000410066 RCV000410851 RCV000409647 RCV000410763 RCV000409115 RCV000410919 RCV000409638 RCV003123363 RCV003470615 RCV003465287 RCV000589260 RCV000591104 RCV000666149 RCV000674165 RCV000667742 RCV000669120 RCV000665415 RCV000666839 RCV000670707 RCV000675011 RCV000671470 RCV000669906 RCV000779011 RCV000780216 RCV001004162
DPYD-related disorder	Likely pathogenic; Pathogenic	rs1057516713, rs2524373926, rs1057516968	RCV003391615 RCV003427915 RCV003409565
Fluorouracil response	Pathogenic	rs72547602	RCV000030869
Neurodevelopmental delay	Likely pathogenic; Pathogenic	rs779948148	RCV002274021
See cases	Likely pathogenic; Pathogenic	rs1207177925	RCV002252176

Show/Hide Unknown Diseases (29)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Acute myeloid leukemia	drug response	rs3918290	RCV005887125
Adrenocortical carcinoma, hereditary	drug response	rs2297595	RCV005887739
capecitabine response - Toxicity	drug response	rs1801160, rs17376848, rs1801159, rs1801158, rs56038477, rs2297595, rs3918290, rs1801265, rs75017182, rs67376798, rs55886062	RCV001787903 RCV001787905 RCV001787907 RCV001787909 RCV001787911 RCV001787915 RCV001787360 RCV001787362 RCV001788348 RCV001787864 RCV001787867
Cervical cancer	drug response	rs3918290	RCV005887129
Cholangiocarcinoma	drug response	rs3918290	RCV005887140
Clear cell carcinoma of kidney	drug response	rs3918290	RCV005887131
Colon adenocarcinoma	drug response	rs3918290	RCV005887124
Colorectal cancer	drug response	rs2297595, rs3918290	RCV005887740 RCV005887133
Familial cancer of breast	drug response	rs3918290	RCV005887123
Familial pancreatic carcinoma	drug response	rs3918290	RCV005887132
fluorouracil response - Other	drug response	rs78060119, rs1801160, rs115232898, rs72549306, rs148994843, rs3918290, rs59086055, rs56005131, rs1801266, rs1801268, rs72549303, rs75017182, rs67376798, rs55886062	RCV001788460 RCV001787902 RCV001787913 RCV001787696 RCV001787699 RCV001787359 RCV001788185 RCV001788190 RCV000786703 RCV000786704 RCV000786628 RCV001788347 RCV001787863 RCV001787866
fluorouracil response - Toxicity	drug response	rs78060119, rs1801160, rs17376848, rs1801159, rs1801158, rs56038477, rs115232898, rs2297595, rs3918290, rs1801265, rs59086055, rs75017182, rs67376798, rs55886062	RCV001788461 RCV001787904 RCV001787906 RCV001787908 RCV001787910 RCV001787912 RCV001787914 RCV001787916 RCV001787337 RCV001787363 RCV001788186 RCV001788349 RCV001787336 RCV001787326
Gastric cancer	drug response	rs3918290	RCV005887135
Hirschsprung disease, susceptibility to, 1	drug response	rs3918290	RCV000201291
Lung cancer	drug response	rs3918290	RCV005887141
Lymphoma	drug response	rs3918290	RCV005887136
Malignant tumor of esophagus	drug response	rs3918290	RCV005887127
Malignant tumor of urinary bladder	drug response	rs3918290	RCV005887126
Melanoma	drug response	rs3918290	RCV005887139
Nonpapillary renal cell carcinoma	drug response	rs3918290	RCV005887128
Ovarian cancer	drug response	rs3918290	RCV005887130
Ovarian serous cystadenocarcinoma	drug response; Uncertain significance	rs3918290, rs41285690	RCV005887137 RCV005913681
Prostate cancer	Uncertain significance	rs193920862	RCV000148993
Sarcoma	drug response	rs3918290	RCV005887134
tegafur response - Toxicity	drug response	rs3918290, rs67376798, rs55886062	RCV001787361 RCV001787865 RCV001787868
Thymoma	Benign	rs6657204	RCV005924799
Thyroid cancer, nonmedullary, 1	drug response	rs3918290	RCV005887138
Uterine carcinosarcoma	Conflicting classifications of pathogenicity	rs772254904	RCV005901181
Uterine corpus endometrial carcinoma	Benign	rs6657204	RCV005924800

Show/Hide Text Mining Associations (96)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Adenocarcinoma	Associate	15868929, 20543560, 28835573, 36289279
Adenocarcinoma	Stimulate	18360075
Adenocarcinoma Mucinous	Associate	20570913
Adenocarcinoma of Lung	Associate	25573239, 36289279
Adenocarcinoma Scirrhous	Associate	16080558
Adenoma Pleomorphic	Associate	26031756
Adrenal Insufficiency	Associate	23070091
Angina Stable	Associate	23079156
Aortic Dissection	Associate	37684281
Autism Spectrum Disorder	Associate	18252227, 23275889
Bipolar Disorder	Associate	28632202
Bone Marrow Diseases	Associate	28278081
Borderline Personality Disorder	Associate	28632202
Breast Neoplasms	Associate	11870510, 18319546, 19104657, 19596923, 28481884, 30746637, 39596349
Calcinosis Cutis	Associate	19105824
Cancer Pain	Associate	37014829
Carcinoma Hepatocellular	Associate	29358721
Carcinoma Neuroendocrine	Associate	31852810
Carcinoma Non Small Cell Lung	Associate	15868929, 16880781, 17695427, 27268079, 37372990
Carcinoma Squamous Cell	Associate	36289279
Carcinoma Squamous Cell	Stimulate	36289279
Cardiovascular Diseases	Associate	34780066
Chemical and Drug Induced Liver Injury	Associate	26846104
Chemotherapy Related Cognitive Impairment	Associate	21999595
Cholangiocarcinoma	Associate	15884115, 22912546
Colorectal Neoplasms	Associate	11501504, 12841874, 12870370, 14562021, 15015608, 16251201, 16302736, 16568373, 17094418, 18225548, 18245778, 18360075, 18383874, 18443386, 18630501 View all (33 more)
Death	Associate	17335544, 19154585, 21498394, 22799365, 25253112, 31124962, 8735686
Dehydration	Associate	23079156, 25381393
Diabetes Mellitus Type 1	Associate	24601691
Diarrhea	Associate	21410976, 21498394, 23079156, 23736036, 24817302, 25381393, 28278081, 34780066
Dihydropyrimidine Dehydrogenase Deficiency	Associate	12668826, 18937829, 19296131, 20803296, 24648345, 26804652, 28024938, 28481884, 30898145, 32595208, 32973300, 33361878, 33704179, 34773566, 36430399 View all (6 more)
Dihydropyrimidine Dehydrogenase Deficiency	Inhibit	20803296, 28024938, 35397172
Disease Resistance	Associate	15884115
Drug Related Side Effects and Adverse Reactions	Associate	11267945, 11953843, 15274386, 17335544, 18225548, 18443386, 19104657, 20507294, 20653680, 20803296, 20809970, 20819423, 20926004, 21498394, 23070091 View all (66 more)
Esophageal Neoplasms	Associate	27741011
Fatigue	Associate	23079156
Fatty Liver	Associate	21999595, 35982095
Gallbladder Neoplasms	Associate	16619549
Gastrointestinal Diseases	Associate	30723313, 30746637, 33035787
Gastrointestinal Neoplasms	Associate	14716816, 16302736, 18652704, 20809970, 23139054, 37101114
Genetic Diseases Inborn	Associate	15274386
Hand Foot Syndrome	Associate	24647007, 24817302, 35473510
Head and Neck Neoplasms	Associate	10206306
Hematologic Diseases	Associate	30723313, 33035787
Hepatolenticular Degeneration	Associate	39809184
Hyperbilirubinemia	Associate	31124962
Hypoxia	Associate	39317456
Infections	Associate	26846104
Leukopenia	Associate	23079156, 25381393, 39596349
Liver Diseases	Associate	15865071
Liver Failure	Associate	36918744
Lung Neoplasms	Associate	28835573
Lymphatic Metastasis	Stimulate	29358721
Lymphatic Metastasis	Associate	34612540
Melanoma Cutaneous Malignant	Associate	26609109
Metabolism Inborn Errors	Associate	18937829, 36357675
Neoplasm Metastasis	Associate	18630501, 19052026, 34612540, 36918744
Neoplasm Metastasis	Inhibit	29358721
Neoplasm Metastasis	Stimulate	29358721
Neoplasms	Associate	11092985, 11267945, 11501504, 11870510, 12870370, 14562021, 15015608, 15330204, 15492566, 15865071, 15868929, 16080558, 16251201, 16880781, 17695427 View all (37 more)
Neoplasms	Inhibit	27733154
Neoplasms	Stimulate	28835573
Neurologic Manifestations	Associate	28481884
Neurotoxicity Syndromes	Associate	33035787
Neutropenia	Associate	20037211, 21410976, 25381393, 29065426, 30723313, 30858516, 34780066, 39596349
Non Muscle Invasive Bladder Neoplasms	Associate	27626805, 35595780
Oligodendroglioma	Associate	20164239
Oropharyngeal Neoplasms	Associate	35200545
Ovarian Neoplasms	Associate	20570913, 25066213
Paget Disease Extramammary	Inhibit	28603180
Pancreatic Neoplasms	Associate	15492566, 21487324, 29515256
Pancytopenia	Associate	33305610
Porokeratosis punctata palmaris et plantaris	Associate	30746637
Postpartum Hemorrhage	Associate	39885444
Precursor Cell Lymphoblastic Leukemia Lymphoma	Associate	26846104, 28618970
Protein S Deficiency	Inhibit	23169295
Pyruvate Dehydrogenase Complex Deficiency Disease	Associate	37758638
Rectal Neoplasms	Associate	24455740
Respiratory Tract Diseases	Associate	33035787
Rufous oculocutaneous albinism	Associate	18245778, 19104657
Schizophrenia	Associate	24556472, 28632202
Sepsis	Associate	24700034
Sexual Dysfunction Physiological	Associate	23079156
Squamous Cell Carcinoma of Head and Neck	Associate	30803213, 31871216
Stomach Diseases	Associate	29906295
Stomach Neoplasms	Associate	15330198, 15330204, 15354215, 16302736, 18231104, 20857529, 23794300, 25112781, 25793299, 33361878, 34525956
Stomach Neoplasms	Stimulate	18652704
Stomatitis	Associate	22448752, 23079156, 28278081
Syndrome	Associate	15858133
Tertiary Lymphoid Structures	Associate	15015608
Thalassemia Beta+ Silent Allele	Associate	38060335
Thiopurine S methyltranferase deficiency	Associate	32973300
Thrombocytopenia	Associate	25381393
Turcot syndrome	Associate	24800948
Urinary Bladder Neoplasms	Associate	25218240, 35595780
Uterine Cervical Neoplasms	Associate	12967482

DPYD (dihydropyrimidine dehydrogenase)