DOK1 (docking protein 1)

Gene

• Entrez ID: 1796
• Gene name: Docking protein 1
• Gene symbol: DOK1
• Synonyms (NCBI Gene): P62DOK, pp62
• Chromosome: 2
• Chromosome location: 2p13.1
• Summary: The protein encoded by this gene is part of a signal transduction pathway downstream of receptor tyrosine kinases. The encoded protein is a scaffold protein that helps form a platform for the assembly of multiprotein signaling complexes. Several transcrip

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT440784	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT440784	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT1979248	hsa-miR-1343	CLIP-seq
MIRT2518677	hsa-miR-1224-3p	CLIP-seq
MIRT2518678	hsa-miR-1227	CLIP-seq
MIRT2518679	hsa-miR-1260	CLIP-seq
MIRT2518680	hsa-miR-1260b	CLIP-seq
MIRT2518681	hsa-miR-1280	CLIP-seq
MIRT2518682	hsa-miR-138	CLIP-seq
MIRT2518683	hsa-miR-149	CLIP-seq
MIRT2518684	hsa-miR-3064-5p	CLIP-seq
MIRT2518685	hsa-miR-371-3p	CLIP-seq
MIRT2518686	hsa-miR-371b-3p	CLIP-seq
MIRT2518687	hsa-miR-377	CLIP-seq
MIRT2518688	hsa-miR-4281	CLIP-seq
MIRT2518689	hsa-miR-4662a-5p	CLIP-seq
MIRT2518690	hsa-miR-4715-3p	CLIP-seq
MIRT2518691	hsa-miR-4749-3p	CLIP-seq
MIRT2518692	hsa-miR-4778-3p	CLIP-seq
MIRT2518693	hsa-miR-4794	CLIP-seq
MIRT2518694	hsa-miR-515-3p	CLIP-seq
MIRT2518695	hsa-miR-519e	CLIP-seq
MIRT2518696	hsa-miR-532-3p	CLIP-seq
MIRT2518697	hsa-miR-640	CLIP-seq
MIRT2518677	hsa-miR-1224-3p	CLIP-seq
MIRT2518678	hsa-miR-1227	CLIP-seq
MIRT2518679	hsa-miR-1260	CLIP-seq
MIRT2518680	hsa-miR-1260b	CLIP-seq
MIRT2518681	hsa-miR-1280	CLIP-seq
MIRT2518682	hsa-miR-138	CLIP-seq
MIRT2518683	hsa-miR-149	CLIP-seq
MIRT2518684	hsa-miR-3064-5p	CLIP-seq
MIRT2518685	hsa-miR-371-3p	CLIP-seq
MIRT2518686	hsa-miR-371b-3p	CLIP-seq
MIRT2518687	hsa-miR-377	CLIP-seq
MIRT2518691	hsa-miR-4749-3p	CLIP-seq
MIRT2518692	hsa-miR-4778-3p	CLIP-seq
MIRT2518693	hsa-miR-4794	CLIP-seq
MIRT2518694	hsa-miR-515-3p	CLIP-seq
MIRT2518695	hsa-miR-519e	CLIP-seq
MIRT2518696	hsa-miR-532-3p	CLIP-seq
MIRT2518697	hsa-miR-640	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
E2F1	Unknown	23028047

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	16273093, 22190034, 22252131, 23822091
GO:0005634	Component	Nucleus	IDA	23822091
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0007165	Process	Signal transduction	TAS	9008160, 10799545
GO:0007166	Process	Cell surface receptor signaling pathway	IEA
GO:0007166	Process	Cell surface receptor signaling pathway	TAS	10799545
GO:0007169	Process	Cell surface receptor protein tyrosine kinase signaling pathway	IBA
GO:0007169	Process	Cell surface receptor protein tyrosine kinase signaling pathway	IEA
GO:0007169	Process	Cell surface receptor protein tyrosine kinase signaling pathway	TAS	9008160
GO:0007265	Process	Ras protein signal transduction	IBA
GO:0007265	Process	Ras protein signal transduction	IEA
GO:0035556	Process	Intracellular signal transduction	IEA
GO:0038145	Process	Macrophage colony-stimulating factor signaling pathway	IEA
GO:0048471	Component	Perinuclear region of cytoplasm	IEA

Other IDs

• MIM: 602919
• HGNC: 2990
• e!Ensembl: ENSG00000115325

Protein

• UniProt ID: Q99704
• Protein name: Docking protein 1 (Downstream of tyrosine kinase 1) (p62(dok)) (pp62)
• Protein function: DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates int
• PDB: 2V76
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00169	PH	4 → 119	PH domain	Domain
  PF02174	IRS	151 → 254	PTB domain (IRS-1 type)	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed in pancreas, heart, leukocyte and spleen. Expressed in both resting and activated peripheral blood T-cells. Expressed in breast cancer. {ECO:0000269|PubMed:12595900}.
• Sequence:

  MDGAVMEGPLFLQSQRFGTKRWRKTWAVLYPASPHGVARLEFFDHKGSSSGGGRGSSRRL
  DCKVIRLAECVSVAPVTVETPPEPGATAFRLDTAQRSHLLAADAPSSAAWVQTLCRNAFP
  KGSWTLAPTDNPPKLSALEMLENSLYSPTWEGSQFWVTVQRTEAAERCGLHGSYVLRVEA
  ERLTLLTVGAQSQILEPLLSWPYTLLRRYGRDKVMFSFEAGRRCPSGPGTFTFQTAQGND
  IFQAVETAIHRQKAQGKAGQGHDVLRADSHEGEVAEGKLPSPPGPQELLDSPPALYAEPL
  DSLRIAPCPSQDSLYSDPLDSTSAQAGEGVQRKKPLYWDLYEHAQQQLLKAKLTDPKEDP
  IYDEPEGLAPVPPQGLYDLPREPKDAWWCQARVKEEGYELPYNPATDDYAVPPPRSTKPL
  LAPKPQGPAFPEPGTATGSGIKSHNSALYSQVQKSGASGSWDCGLSRVGTDKTGVKSEGS
  T

• Sequence length: 481

Pathways

Reactome:

PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
RET signaling