Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	1796
Gene name Gene Name - the full gene name approved by the HGNC.	Docking protein 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	DOK1
Synonyms (NCBI Gene) Gene synonyms aliases	P62DOK, pp62
Chromosome Chromosome number	2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	2p13.1
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene is part of a signal transduction pathway downstream of receptor tyrosine kinases. The encoded protein is a scaffold protein that helps form a platform for the assembly of multiprotein signaling complexes. Several transcrip

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miRTarBase ID	miRNA	Experiments	Reference
MIRT440784	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT440784	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT1979248	hsa-miR-1343	CLIP-seq
MIRT2518677	hsa-miR-1224-3p	CLIP-seq
MIRT2518678	hsa-miR-1227	CLIP-seq
MIRT2518679	hsa-miR-1260	CLIP-seq
MIRT2518680	hsa-miR-1260b	CLIP-seq
MIRT2518681	hsa-miR-1280	CLIP-seq
MIRT2518682	hsa-miR-138	CLIP-seq
MIRT2518683	hsa-miR-149	CLIP-seq
MIRT2518684	hsa-miR-3064-5p	CLIP-seq
MIRT2518685	hsa-miR-371-3p	CLIP-seq
MIRT2518686	hsa-miR-371b-3p	CLIP-seq
MIRT2518687	hsa-miR-377	CLIP-seq
MIRT2518688	hsa-miR-4281	CLIP-seq
MIRT2518689	hsa-miR-4662a-5p	CLIP-seq
MIRT2518690	hsa-miR-4715-3p	CLIP-seq
MIRT2518691	hsa-miR-4749-3p	CLIP-seq
MIRT2518692	hsa-miR-4778-3p	CLIP-seq
MIRT2518693	hsa-miR-4794	CLIP-seq
MIRT2518694	hsa-miR-515-3p	CLIP-seq
MIRT2518695	hsa-miR-519e	CLIP-seq
MIRT2518696	hsa-miR-532-3p	CLIP-seq
MIRT2518697	hsa-miR-640	CLIP-seq
MIRT2518677	hsa-miR-1224-3p	CLIP-seq
MIRT2518678	hsa-miR-1227	CLIP-seq
MIRT2518679	hsa-miR-1260	CLIP-seq
MIRT2518680	hsa-miR-1260b	CLIP-seq
MIRT2518681	hsa-miR-1280	CLIP-seq
MIRT2518682	hsa-miR-138	CLIP-seq
MIRT2518683	hsa-miR-149	CLIP-seq
MIRT2518684	hsa-miR-3064-5p	CLIP-seq
MIRT2518685	hsa-miR-371-3p	CLIP-seq
MIRT2518686	hsa-miR-371b-3p	CLIP-seq
MIRT2518687	hsa-miR-377	CLIP-seq
MIRT2518691	hsa-miR-4749-3p	CLIP-seq
MIRT2518692	hsa-miR-4778-3p	CLIP-seq
MIRT2518693	hsa-miR-4794	CLIP-seq
MIRT2518694	hsa-miR-515-3p	CLIP-seq
MIRT2518695	hsa-miR-519e	CLIP-seq
MIRT2518696	hsa-miR-532-3p	CLIP-seq
MIRT2518697	hsa-miR-640	CLIP-seq

Transcription factors

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Transcription factor	Regulation	Reference
E2F1	Unknown	23028047

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GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	16273093, 22190034, 22252131, 23822091
GO:0005634	Component	Nucleus	IDA	23822091
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0007165	Process	Signal transduction	TAS	9008160, 10799545
GO:0007166	Process	Cell surface receptor signaling pathway	TAS	10799545
GO:0007169	Process	Transmembrane receptor protein tyrosine kinase signaling pathway	IEA
GO:0007265	Process	Ras protein signal transduction	IEA
GO:0007411	Process	Axon guidance	TAS
GO:0038145	Process	Macrophage colony-stimulating factor signaling pathway	IEA
GO:0045742	Process	Positive regulation of epidermal growth factor receptor signaling pathway	TAS
GO:0048471	Component	Perinuclear region of cytoplasm	IEA

MIM	HGNC	e!Ensembl
602919	2990	ENSG00000115325

Protein

UniProt ID

Q99704

Protein name

Docking protein 1 (Downstream of tyrosine kinase 1) (p62(dok)) (pp62)

Protein function

DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates int

PDB

2V76

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00169	PH	4 → 119	PH domain	Domain
PF02174	IRS	151 → 254	PTB domain (IRS-1 type)	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in pancreas, heart, leukocyte and spleen. Expressed in both resting and activated peripheral blood T-cells. Expressed in breast cancer. {ECO:0000269|PubMed:12595900}.

Sequence

MDGAVMEGPLFLQSQRFGTKRWRKTWAVLYPASPHGVARLEFFDHKGSSSGGGRGSSRRL
DCKVIRLAECVSVAPVTVETPPEPGATAFRLDTAQRSHLLAADAPSSAAWVQTLCRNAFP
KGSWTLAPTDNPPKLSALEMLENSLYSPTWEGSQFWVTVQRTEAAERCGLHGSYVLRVEA
ERLTLLTVGAQSQILEPLLSWPYTLLRRYGRDKVMFSFEAGRRCPSGPGTFTFQTAQGND
IFQAVETAIHRQKAQGKAGQGHDVLRADSHEGEVAEGKLPSPPGPQELLDSPPALYAEPL
DSLRIAPCPSQDSLYSDPLDSTSAQAGEGVQRKKPLYWDLYEHAQQQLLKAKLTDPKEDP
IYDEPEGLAPVPPQGLYDLPREPKDAWWCQARVKEEGYELPYNPATDDYAVPPPRSTKPL
LAPKPQGPAFPEPGTATGSGIKSHNSALYSQVQKSGASGSWDCGLSRVGTDKTGVKSEGS
T

Sequence length

481

Interactions

View interactions

	Reactome
			PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 RET signaling

Show/Hide Causal Diseases (2)

Disease term	Disease name	dbSNP ID	References
Causal
Lung cancer	Malignant neoplasm of lung	rs121913530, rs121913529, rs878855122, rs1057519784, rs770315135	20139980
Ovarian cancer	Malignant neoplasm of ovary	rs34424986, rs137853060, rs28934575, rs79658334, rs121913021, rs62625308, rs80356898, rs80357579, rs41293497, rs80356904, rs80357471, rs80357522, rs80357234, rs80357912, rs80357828 View all (31 more)	21856257

Show/Hide Text Mining Associations (23)

Disease Name	Relationship Type	References
Associations from Text Mining
Adenoma	Associate	34941983
Anodontia	Associate	28844109
Burkitt Lymphoma	Associate	21796618
Carcinogenesis	Associate	21536658, 21796618, 21856257, 24809689
Carcinoma Hepatocellular	Associate	27078152
Carcinoma Ovarian Epithelial	Associate	21856257
Colorectal Neoplasms	Associate	27428427, 28844109, 34941983
Epstein Barr Virus Infections	Inhibit	24809689
Head and Neck Neoplasms	Inhibit	21796618
Head and Neck Neoplasms	Associate	23028047
Leukemia	Associate	16823827, 20697350, 21856257, 27428427
Leukemia Myelogenous Chronic BCR ABL Positive	Associate	16823827
Leukemia T Cell	Associate	21796618
Liver Diseases	Associate	27078152
Lung Neoplasms	Associate	21796618
Lymphoproliferative Disorders	Associate	10852966
Mouth Diseases	Inhibit	34941983
Neointima	Associate	24523872
Neoplasm Metastasis	Inhibit	21856257
Neoplasms	Inhibit	21536658, 21856257, 23028047, 24523872, 24809689
Neoplasms	Associate	21796618, 27428427, 28844109, 35127166
Triple Negative Breast Neoplasms	Associate	24773628
Tyrosine Kinase 2 Deficiency	Associate	21536658

DOK1 (docking protein 1)