Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	1777
Gene name Gene Name - the full gene name approved by the HGNC.	Deoxyribonuclease 2, lysosomal
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	DNASE2
Synonyms (NCBI Gene) Gene synonyms aliases	AIPCS, DNASE2A, DNL, DNL2
Chromosome Chromosome number	19
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	19p13.13
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a member of the DNase family. The protein, located in the lysosome, hydrolyzes DNA under acidic conditions and mediates the breakdown of DNA during erythropoiesis and apoptosis. Two codominant alleles have been characterized, DNASE2*L (l

Show/Hide all(379)

miRTarBase ID	miRNA	Experiments	Reference
MIRT045041	hsa-miR-186-5p	CLASH	23622248
MIRT036213	hsa-miR-320b	CLASH	23622248
MIRT519402	hsa-miR-3675-5p	HITS-CLIP	21572407
MIRT519401	hsa-miR-6890-5p	HITS-CLIP	21572407
MIRT519400	hsa-miR-4781-3p	HITS-CLIP	21572407
MIRT519399	hsa-miR-4716-5p	HITS-CLIP	21572407
MIRT519398	hsa-miR-4755-3p	HITS-CLIP	21572407
MIRT519397	hsa-miR-3201	HITS-CLIP	21572407
MIRT519396	hsa-miR-4791	HITS-CLIP	21572407
MIRT519395	hsa-miR-193b-5p	HITS-CLIP	21572407
MIRT519394	hsa-miR-197-3p	HITS-CLIP	21572407
MIRT519393	hsa-miR-548s	HITS-CLIP	21572407
MIRT519392	hsa-miR-4701-5p	HITS-CLIP	21572407
MIRT519390	hsa-miR-588	HITS-CLIP	21572407
MIRT519391	hsa-miR-4435	HITS-CLIP	21572407
MIRT519389	hsa-miR-3187-3p	HITS-CLIP	21572407
MIRT519388	hsa-miR-3170	HITS-CLIP	21572407
MIRT519387	hsa-miR-6855-5p	HITS-CLIP	21572407
MIRT519386	hsa-miR-5096	HITS-CLIP	21572407
MIRT665119	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT665118	hsa-miR-6787-3p	HITS-CLIP	23824327
MIRT665117	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT665116	hsa-miR-1913	HITS-CLIP	23824327
MIRT665115	hsa-miR-324-3p	HITS-CLIP	23824327
MIRT665114	hsa-miR-18a-3p	HITS-CLIP	23824327
MIRT665113	hsa-miR-4641	HITS-CLIP	23824327
MIRT665112	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT519402	hsa-miR-3675-5p	PAR-CLIP	23446348
MIRT519401	hsa-miR-6890-5p	PAR-CLIP	23446348
MIRT519400	hsa-miR-4781-3p	PAR-CLIP	23446348
MIRT519399	hsa-miR-4716-5p	PAR-CLIP	23446348
MIRT519398	hsa-miR-4755-3p	PAR-CLIP	23446348
MIRT519397	hsa-miR-3201	PAR-CLIP	23446348
MIRT519396	hsa-miR-4791	PAR-CLIP	23446348
MIRT519395	hsa-miR-193b-5p	PAR-CLIP	23446348
MIRT519394	hsa-miR-197-3p	PAR-CLIP	23446348
MIRT519393	hsa-miR-548s	PAR-CLIP	23446348
MIRT519392	hsa-miR-4701-5p	PAR-CLIP	23446348
MIRT519390	hsa-miR-588	PAR-CLIP	23446348
MIRT519391	hsa-miR-4435	PAR-CLIP	23446348
MIRT519389	hsa-miR-3187-3p	PAR-CLIP	23446348
MIRT519388	hsa-miR-3170	PAR-CLIP	23446348
MIRT519387	hsa-miR-6855-5p	PAR-CLIP	23446348
MIRT519386	hsa-miR-5096	PAR-CLIP	23446348
MIRT665112	hsa-miR-6778-3p	PAR-CLIP	27292025
MIRT519402	hsa-miR-3675-5p	HITS-CLIP	21572407
MIRT519401	hsa-miR-6890-5p	HITS-CLIP	21572407
MIRT519400	hsa-miR-4781-3p	HITS-CLIP	21572407
MIRT519399	hsa-miR-4716-5p	HITS-CLIP	21572407
MIRT519398	hsa-miR-4755-3p	HITS-CLIP	21572407
MIRT519397	hsa-miR-3201	HITS-CLIP	21572407
MIRT519396	hsa-miR-4791	HITS-CLIP	21572407
MIRT519395	hsa-miR-193b-5p	HITS-CLIP	21572407
MIRT519394	hsa-miR-197-3p	HITS-CLIP	21572407
MIRT519393	hsa-miR-548s	HITS-CLIP	21572407
MIRT519392	hsa-miR-4701-5p	HITS-CLIP	21572407
MIRT519390	hsa-miR-588	HITS-CLIP	21572407
MIRT519391	hsa-miR-4435	HITS-CLIP	21572407
MIRT519389	hsa-miR-3187-3p	HITS-CLIP	21572407
MIRT519388	hsa-miR-3170	HITS-CLIP	21572407
MIRT519387	hsa-miR-6855-5p	HITS-CLIP	21572407
MIRT519386	hsa-miR-5096	HITS-CLIP	21572407
MIRT665119	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT665118	hsa-miR-6787-3p	HITS-CLIP	23824327
MIRT665117	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT665116	hsa-miR-1913	HITS-CLIP	23824327
MIRT665115	hsa-miR-324-3p	HITS-CLIP	23824327
MIRT665114	hsa-miR-18a-3p	HITS-CLIP	23824327
MIRT665113	hsa-miR-4641	HITS-CLIP	23824327
MIRT665112	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT519402	hsa-miR-3675-5p	PAR-CLIP	23446348
MIRT519401	hsa-miR-6890-5p	PAR-CLIP	23446348
MIRT519400	hsa-miR-4781-3p	PAR-CLIP	23446348
MIRT519399	hsa-miR-4716-5p	PAR-CLIP	23446348
MIRT519398	hsa-miR-4755-3p	PAR-CLIP	23446348
MIRT519397	hsa-miR-3201	PAR-CLIP	23446348
MIRT519396	hsa-miR-4791	PAR-CLIP	23446348
MIRT519395	hsa-miR-193b-5p	PAR-CLIP	23446348
MIRT519394	hsa-miR-197-3p	PAR-CLIP	23446348
MIRT519393	hsa-miR-548s	PAR-CLIP	23446348
MIRT519392	hsa-miR-4701-5p	PAR-CLIP	23446348
MIRT519390	hsa-miR-588	PAR-CLIP	23446348
MIRT519391	hsa-miR-4435	PAR-CLIP	23446348
MIRT519389	hsa-miR-3187-3p	PAR-CLIP	23446348
MIRT519388	hsa-miR-3170	PAR-CLIP	23446348
MIRT519387	hsa-miR-6855-5p	PAR-CLIP	23446348
MIRT519386	hsa-miR-5096	PAR-CLIP	23446348
MIRT942183	hsa-miR-1245	CLIP-seq
MIRT942184	hsa-miR-149	CLIP-seq
MIRT942185	hsa-miR-151-5p	CLIP-seq
MIRT942186	hsa-miR-151b	CLIP-seq
MIRT942187	hsa-miR-197	CLIP-seq
MIRT942188	hsa-miR-28-5p	CLIP-seq
MIRT942189	hsa-miR-3064-5p	CLIP-seq
MIRT942190	hsa-miR-3139	CLIP-seq
MIRT942191	hsa-miR-3199	CLIP-seq
MIRT942192	hsa-miR-3616-5p	CLIP-seq
MIRT942193	hsa-miR-3647-5p	CLIP-seq
MIRT942194	hsa-miR-3652	CLIP-seq
MIRT942195	hsa-miR-3663-5p	CLIP-seq
MIRT942196	hsa-miR-371-3p	CLIP-seq
MIRT942197	hsa-miR-3929	CLIP-seq
MIRT942198	hsa-miR-4276	CLIP-seq
MIRT942199	hsa-miR-4292	CLIP-seq
MIRT942200	hsa-miR-4308	CLIP-seq
MIRT942201	hsa-miR-4419b	CLIP-seq
MIRT942202	hsa-miR-4430	CLIP-seq
MIRT942203	hsa-miR-4438	CLIP-seq
MIRT942204	hsa-miR-4478	CLIP-seq
MIRT942205	hsa-miR-4505	CLIP-seq
MIRT942206	hsa-miR-4633-3p	CLIP-seq
MIRT942207	hsa-miR-4694-5p	CLIP-seq
MIRT942208	hsa-miR-4778-5p	CLIP-seq
MIRT942209	hsa-miR-4794	CLIP-seq
MIRT942210	hsa-miR-4795-5p	CLIP-seq
MIRT942211	hsa-miR-5095	CLIP-seq
MIRT942212	hsa-miR-573	CLIP-seq
MIRT942213	hsa-miR-708	CLIP-seq
MIRT942183	hsa-miR-1245	CLIP-seq
MIRT1978926	hsa-miR-106a	CLIP-seq
MIRT1978927	hsa-miR-106b	CLIP-seq
MIRT1978928	hsa-miR-1200	CLIP-seq
MIRT1978929	hsa-miR-1208	CLIP-seq
MIRT1978930	hsa-miR-1225-3p	CLIP-seq
MIRT1978931	hsa-miR-1233	CLIP-seq
MIRT942183	hsa-miR-1245	CLIP-seq
MIRT1978932	hsa-miR-1247	CLIP-seq
MIRT1978933	hsa-miR-1254	CLIP-seq
MIRT1978934	hsa-miR-129-3p	CLIP-seq
MIRT1978935	hsa-miR-1470	CLIP-seq
MIRT1978936	hsa-miR-17	CLIP-seq
MIRT1978937	hsa-miR-20a	CLIP-seq
MIRT1978938	hsa-miR-20b	CLIP-seq
MIRT1978939	hsa-miR-3116	CLIP-seq
MIRT1978940	hsa-miR-3130-3p	CLIP-seq
MIRT1978941	hsa-miR-3189-3p	CLIP-seq
MIRT1978942	hsa-miR-325	CLIP-seq
MIRT942192	hsa-miR-3616-5p	CLIP-seq
MIRT942193	hsa-miR-3647-5p	CLIP-seq
MIRT942195	hsa-miR-3663-5p	CLIP-seq
MIRT1978943	hsa-miR-3668	CLIP-seq
MIRT942196	hsa-miR-371-3p	CLIP-seq
MIRT942197	hsa-miR-3929	CLIP-seq
MIRT1978944	hsa-miR-411	CLIP-seq
MIRT1978945	hsa-miR-4324	CLIP-seq
MIRT942201	hsa-miR-4419b	CLIP-seq
MIRT1978946	hsa-miR-4420	CLIP-seq
MIRT1978947	hsa-miR-4469	CLIP-seq
MIRT942204	hsa-miR-4478	CLIP-seq
MIRT1978948	hsa-miR-4667-3p	CLIP-seq
MIRT942207	hsa-miR-4694-5p	CLIP-seq
MIRT1978949	hsa-miR-4760-5p	CLIP-seq
MIRT942209	hsa-miR-4794	CLIP-seq
MIRT942210	hsa-miR-4795-5p	CLIP-seq
MIRT1978950	hsa-miR-519d	CLIP-seq
MIRT1978951	hsa-miR-520g	CLIP-seq
MIRT1978952	hsa-miR-520h	CLIP-seq
MIRT1978953	hsa-miR-544b	CLIP-seq
MIRT1978954	hsa-miR-549	CLIP-seq
MIRT1978955	hsa-miR-550a	CLIP-seq
MIRT942212	hsa-miR-573	CLIP-seq
MIRT1978956	hsa-miR-576-3p	CLIP-seq
MIRT1978957	hsa-miR-582-3p	CLIP-seq
MIRT1978958	hsa-miR-661	CLIP-seq
MIRT1978959	hsa-miR-93	CLIP-seq
MIRT1978960	hsa-miR-938	CLIP-seq
MIRT1978926	hsa-miR-106a	CLIP-seq
MIRT1978927	hsa-miR-106b	CLIP-seq
MIRT1978929	hsa-miR-1208	CLIP-seq
MIRT2214081	hsa-miR-1231	CLIP-seq
MIRT942183	hsa-miR-1245	CLIP-seq
MIRT942184	hsa-miR-149	CLIP-seq
MIRT942185	hsa-miR-151-5p	CLIP-seq
MIRT942186	hsa-miR-151b	CLIP-seq
MIRT1978936	hsa-miR-17	CLIP-seq
MIRT1978937	hsa-miR-20a	CLIP-seq
MIRT1978938	hsa-miR-20b	CLIP-seq
MIRT2214082	hsa-miR-302a	CLIP-seq
MIRT2214083	hsa-miR-302b	CLIP-seq
MIRT2214084	hsa-miR-302c	CLIP-seq
MIRT2214085	hsa-miR-302d	CLIP-seq
MIRT2214086	hsa-miR-302e	CLIP-seq
MIRT942189	hsa-miR-3064-5p	CLIP-seq
MIRT2214087	hsa-miR-3168	CLIP-seq
MIRT2214088	hsa-miR-3179	CLIP-seq
MIRT2214089	hsa-miR-3202	CLIP-seq
MIRT1978942	hsa-miR-325	CLIP-seq
MIRT942192	hsa-miR-3616-5p	CLIP-seq
MIRT942193	hsa-miR-3647-5p	CLIP-seq
MIRT942196	hsa-miR-371-3p	CLIP-seq
MIRT2214090	hsa-miR-372	CLIP-seq
MIRT2214091	hsa-miR-373	CLIP-seq
MIRT942197	hsa-miR-3929	CLIP-seq
MIRT2214092	hsa-miR-3974	CLIP-seq
MIRT1978944	hsa-miR-411	CLIP-seq
MIRT942201	hsa-miR-4419b	CLIP-seq
MIRT1978946	hsa-miR-4420	CLIP-seq
MIRT1978947	hsa-miR-4469	CLIP-seq
MIRT2214093	hsa-miR-4476	CLIP-seq
MIRT942204	hsa-miR-4478	CLIP-seq
MIRT942207	hsa-miR-4694-5p	CLIP-seq
MIRT2214094	hsa-miR-4695-3p	CLIP-seq
MIRT2214095	hsa-miR-4715-3p	CLIP-seq
MIRT2214096	hsa-miR-4731-5p	CLIP-seq
MIRT2214097	hsa-miR-4735-5p	CLIP-seq
MIRT2214098	hsa-miR-4761-5p	CLIP-seq
MIRT2214099	hsa-miR-4775	CLIP-seq
MIRT942209	hsa-miR-4794	CLIP-seq
MIRT942210	hsa-miR-4795-5p	CLIP-seq
MIRT2214100	hsa-miR-485-3p	CLIP-seq
MIRT2214101	hsa-miR-512-3p	CLIP-seq
MIRT1978950	hsa-miR-519d	CLIP-seq
MIRT2214102	hsa-miR-520a-3p	CLIP-seq
MIRT2214103	hsa-miR-520b	CLIP-seq
MIRT2214104	hsa-miR-520c-3p	CLIP-seq
MIRT2214105	hsa-miR-520d-3p	CLIP-seq
MIRT2214106	hsa-miR-520e	CLIP-seq
MIRT1978951	hsa-miR-520g	CLIP-seq
MIRT1978952	hsa-miR-520h	CLIP-seq
MIRT1978954	hsa-miR-549	CLIP-seq
MIRT942212	hsa-miR-573	CLIP-seq
MIRT1978956	hsa-miR-576-3p	CLIP-seq
MIRT2214107	hsa-miR-590-3p	CLIP-seq
MIRT2214108	hsa-miR-591	CLIP-seq
MIRT2214109	hsa-miR-628-3p	CLIP-seq
MIRT2214110	hsa-miR-654-3p	CLIP-seq
MIRT1978959	hsa-miR-93	CLIP-seq
MIRT2387033	hsa-miR-1324	CLIP-seq
MIRT2387034	hsa-miR-3166	CLIP-seq
MIRT2387035	hsa-miR-3678-3p	CLIP-seq
MIRT2387036	hsa-miR-4307	CLIP-seq
MIRT2387037	hsa-miR-450b-5p	CLIP-seq
MIRT2387038	hsa-miR-4771	CLIP-seq
MIRT2387039	hsa-miR-507	CLIP-seq
MIRT2387040	hsa-miR-557	CLIP-seq
MIRT1978928	hsa-miR-1200	CLIP-seq
MIRT2518421	hsa-miR-1227	CLIP-seq
MIRT2214081	hsa-miR-1231	CLIP-seq
MIRT942183	hsa-miR-1245	CLIP-seq
MIRT1978933	hsa-miR-1254	CLIP-seq
MIRT2518422	hsa-miR-1297	CLIP-seq
MIRT2518423	hsa-miR-140-3p	CLIP-seq
MIRT1978935	hsa-miR-1470	CLIP-seq
MIRT942184	hsa-miR-149	CLIP-seq
MIRT942185	hsa-miR-151-5p	CLIP-seq
MIRT942186	hsa-miR-151b	CLIP-seq
MIRT942187	hsa-miR-197	CLIP-seq
MIRT2518424	hsa-miR-26a	CLIP-seq
MIRT2518425	hsa-miR-26b	CLIP-seq
MIRT942188	hsa-miR-28-5p	CLIP-seq
MIRT942189	hsa-miR-3064-5p	CLIP-seq
MIRT1978939	hsa-miR-3116	CLIP-seq
MIRT942190	hsa-miR-3139	CLIP-seq
MIRT2518426	hsa-miR-3152-3p	CLIP-seq
MIRT2214087	hsa-miR-3168	CLIP-seq
MIRT1978941	hsa-miR-3189-3p	CLIP-seq
MIRT942191	hsa-miR-3199	CLIP-seq
MIRT1978942	hsa-miR-325	CLIP-seq
MIRT942192	hsa-miR-3616-5p	CLIP-seq
MIRT942193	hsa-miR-3647-5p	CLIP-seq
MIRT942195	hsa-miR-3663-5p	CLIP-seq
MIRT1978943	hsa-miR-3668	CLIP-seq
MIRT942196	hsa-miR-371-3p	CLIP-seq
MIRT942197	hsa-miR-3929	CLIP-seq
MIRT1978944	hsa-miR-411	CLIP-seq
MIRT1978945	hsa-miR-4324	CLIP-seq
MIRT942201	hsa-miR-4419b	CLIP-seq
MIRT942203	hsa-miR-4438	CLIP-seq
MIRT2518427	hsa-miR-4465	CLIP-seq
MIRT1978947	hsa-miR-4469	CLIP-seq
MIRT942204	hsa-miR-4478	CLIP-seq
MIRT942206	hsa-miR-4633-3p	CLIP-seq
MIRT1978948	hsa-miR-4667-3p	CLIP-seq
MIRT2518428	hsa-miR-4682	CLIP-seq
MIRT942207	hsa-miR-4694-5p	CLIP-seq
MIRT2214095	hsa-miR-4715-3p	CLIP-seq
MIRT2518429	hsa-miR-4729	CLIP-seq
MIRT2214097	hsa-miR-4735-5p	CLIP-seq
MIRT2214099	hsa-miR-4775	CLIP-seq
MIRT942208	hsa-miR-4778-5p	CLIP-seq
MIRT942209	hsa-miR-4794	CLIP-seq
MIRT942210	hsa-miR-4795-5p	CLIP-seq
MIRT2518430	hsa-miR-4797-5p	CLIP-seq
MIRT942211	hsa-miR-5095	CLIP-seq
MIRT1978953	hsa-miR-544b	CLIP-seq
MIRT1978954	hsa-miR-549	CLIP-seq
MIRT1978955	hsa-miR-550a	CLIP-seq
MIRT942212	hsa-miR-573	CLIP-seq
MIRT1978956	hsa-miR-576-3p	CLIP-seq
MIRT2214107	hsa-miR-590-3p	CLIP-seq
MIRT2214109	hsa-miR-628-3p	CLIP-seq
MIRT2518431	hsa-miR-642b	CLIP-seq
MIRT2214110	hsa-miR-654-3p	CLIP-seq
MIRT1978958	hsa-miR-661	CLIP-seq
MIRT942213	hsa-miR-708	CLIP-seq
MIRT1978926	hsa-miR-106a	CLIP-seq
MIRT1978927	hsa-miR-106b	CLIP-seq
MIRT1978928	hsa-miR-1200	CLIP-seq
MIRT2518421	hsa-miR-1227	CLIP-seq
MIRT2214081	hsa-miR-1231	CLIP-seq
MIRT942183	hsa-miR-1245	CLIP-seq
MIRT1978933	hsa-miR-1254	CLIP-seq
MIRT2518422	hsa-miR-1297	CLIP-seq
MIRT2518423	hsa-miR-140-3p	CLIP-seq
MIRT1978935	hsa-miR-1470	CLIP-seq
MIRT942184	hsa-miR-149	CLIP-seq
MIRT2679352	hsa-miR-150	CLIP-seq
MIRT942185	hsa-miR-151-5p	CLIP-seq
MIRT942186	hsa-miR-151b	CLIP-seq
MIRT1978936	hsa-miR-17	CLIP-seq
MIRT942187	hsa-miR-197	CLIP-seq
MIRT1978937	hsa-miR-20a	CLIP-seq
MIRT1978938	hsa-miR-20b	CLIP-seq
MIRT2518424	hsa-miR-26a	CLIP-seq
MIRT2518425	hsa-miR-26b	CLIP-seq
MIRT942188	hsa-miR-28-5p	CLIP-seq
MIRT2214082	hsa-miR-302a	CLIP-seq
MIRT2214083	hsa-miR-302b	CLIP-seq
MIRT2214084	hsa-miR-302c	CLIP-seq
MIRT2214085	hsa-miR-302d	CLIP-seq
MIRT2214086	hsa-miR-302e	CLIP-seq
MIRT942189	hsa-miR-3064-5p	CLIP-seq
MIRT1978939	hsa-miR-3116	CLIP-seq
MIRT942190	hsa-miR-3139	CLIP-seq
MIRT2518426	hsa-miR-3152-3p	CLIP-seq
MIRT2214087	hsa-miR-3168	CLIP-seq
MIRT1978941	hsa-miR-3189-3p	CLIP-seq
MIRT942191	hsa-miR-3199	CLIP-seq
MIRT1978942	hsa-miR-325	CLIP-seq
MIRT942192	hsa-miR-3616-5p	CLIP-seq
MIRT942193	hsa-miR-3647-5p	CLIP-seq
MIRT942195	hsa-miR-3663-5p	CLIP-seq
MIRT1978943	hsa-miR-3668	CLIP-seq
MIRT942196	hsa-miR-371-3p	CLIP-seq
MIRT2214090	hsa-miR-372	CLIP-seq
MIRT2214091	hsa-miR-373	CLIP-seq
MIRT942197	hsa-miR-3929	CLIP-seq
MIRT1978944	hsa-miR-411	CLIP-seq
MIRT1978945	hsa-miR-4324	CLIP-seq
MIRT942201	hsa-miR-4419b	CLIP-seq
MIRT942203	hsa-miR-4438	CLIP-seq
MIRT2518427	hsa-miR-4465	CLIP-seq
MIRT1978947	hsa-miR-4469	CLIP-seq
MIRT942204	hsa-miR-4478	CLIP-seq
MIRT942206	hsa-miR-4633-3p	CLIP-seq
MIRT1978948	hsa-miR-4667-3p	CLIP-seq
MIRT2518428	hsa-miR-4682	CLIP-seq
MIRT942207	hsa-miR-4694-5p	CLIP-seq
MIRT2214095	hsa-miR-4715-3p	CLIP-seq
MIRT2518429	hsa-miR-4729	CLIP-seq
MIRT2214096	hsa-miR-4731-5p	CLIP-seq
MIRT2214097	hsa-miR-4735-5p	CLIP-seq
MIRT2214099	hsa-miR-4775	CLIP-seq
MIRT942208	hsa-miR-4778-5p	CLIP-seq
MIRT942209	hsa-miR-4794	CLIP-seq
MIRT942210	hsa-miR-4795-5p	CLIP-seq
MIRT2518430	hsa-miR-4797-5p	CLIP-seq
MIRT942211	hsa-miR-5095	CLIP-seq
MIRT2214101	hsa-miR-512-3p	CLIP-seq
MIRT1978950	hsa-miR-519d	CLIP-seq
MIRT2214102	hsa-miR-520a-3p	CLIP-seq
MIRT2214103	hsa-miR-520b	CLIP-seq
MIRT2214104	hsa-miR-520c-3p	CLIP-seq
MIRT2214105	hsa-miR-520d-3p	CLIP-seq
MIRT2214106	hsa-miR-520e	CLIP-seq
MIRT1978951	hsa-miR-520g	CLIP-seq
MIRT1978952	hsa-miR-520h	CLIP-seq
MIRT1978953	hsa-miR-544b	CLIP-seq
MIRT1978954	hsa-miR-549	CLIP-seq
MIRT1978955	hsa-miR-550a	CLIP-seq
MIRT942212	hsa-miR-573	CLIP-seq
MIRT1978956	hsa-miR-576-3p	CLIP-seq
MIRT2214107	hsa-miR-590-3p	CLIP-seq
MIRT2214109	hsa-miR-628-3p	CLIP-seq
MIRT2518431	hsa-miR-642b	CLIP-seq
MIRT2214110	hsa-miR-654-3p	CLIP-seq
MIRT1978958	hsa-miR-661	CLIP-seq
MIRT942213	hsa-miR-708	CLIP-seq
MIRT1978959	hsa-miR-93	CLIP-seq

Transcription factors

Show/Hide all(2)

Transcription factor	Regulation	Reference
SP1	Activation	12694199
SP3	Activation	12694199

Show/Hide all(19)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003677	Function	DNA binding	TAS	9714827
GO:0004518	Function	Nuclease activity	IEA
GO:0004519	Function	Endonuclease activity	IEA
GO:0004520	Function	DNA endonuclease activity	IEA
GO:0004531	Function	Deoxyribonuclease II activity	IBA
GO:0004531	Function	Deoxyribonuclease II activity	IEA
GO:0004531	Function	Deoxyribonuclease II activity	TAS	9714827
GO:0005515	Function	Protein binding	IPI	28514442, 33961781
GO:0005764	Component	Lysosome	IEA
GO:0005764	Component	Lysosome	TAS	9714827
GO:0006259	Process	DNA metabolic process	IEA
GO:0006259	Process	DNA metabolic process	TAS	9714827
GO:0006308	Process	DNA catabolic process	IEA
GO:0006309	Process	Apoptotic DNA fragmentation	IBA
GO:0006915	Process	Apoptotic process	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0043353	Process	Enucleate erythrocyte differentiation	IEA
GO:0050776	Process	Regulation of immune response	IEA
GO:0070062	Component	Extracellular exosome	HDA	23533145

MIM	HGNC	e!Ensembl
126350	2960	ENSG00000105612

Protein

UniProt ID

O00115

Protein name

Deoxyribonuclease-2-alpha (EC 3.1.22.1) (Acid DNase) (Deoxyribonuclease II alpha) (DNase II alpha) (Lysosomal DNase II) (R31240_2)

Protein function

Hydrolyzes DNA under acidic conditions with a preference for double-stranded DNA. Plays a major role in the clearance of nucleic acids generated through apoptosis, hence preventing autoinflammation (PubMed:29259162, PubMed:31775019). Necessary f

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03265	DNase_II	18 → 347	Deoxyribonuclease II	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed in monocytes/macrophages (at protein level). {ECO:0000269|PubMed:29259162}.

Sequence

MIPLLLAALLCVPAGALTCYGDSGQPVDWFVVYKLPALRGSGEAAQRGLQYKYLDESSGG
WRDGRALINSPEGAVGRSLQPLYRSNTSQLAFLLYNDQPPQPSKAQDSSMRGHTKGVLLL
DHDGGFWLVHSVPNFPPPASSAAYSWPHSACTYGQTLLCVSFPFAQFSKMGKQLTYTYPW
VYNYQLEGIFAQEFPDLENVVKGHHVSQEPWNSSITLTSQAGAVFQSFAKFSKFGDDLYS
GWLAAALGTNLQVQFWHKTVGILPSNCSDIWQVLNVNQIAFPGPAGPSFNSTEDHSKWCV
SPKGPWTCVGDMNRNQGEEQRGGGTLCAQLPALWKAFQPLVKNYQPCNGMARKPSRAYKI

Sequence length

360

Interactions

View interactions

	KEGG		Reactome
	Lysosome Cytosolic DNA-sensing pathway		Lysosome Vesicle Biogenesis

Show/Hide Unknown Diseases (2)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Pancytopenia	autoinflammatory-pancytopenia syndrome due to DNASE2 deficiency	N/A	N/A	GenCC
Systemic lupus erythematosus	systemic lupus erythematosus	N/A	N/A	ClinVar

Show/Hide Text Mining Associations (10)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Anemia	Associate	34807970
Arthritis Rheumatoid	Associate	19538721
general anxiety disorder	Associate	36344488
Glomerulonephritis	Associate	29259162
Hematologic Diseases	Associate	29259162
Hereditary Autoinflammatory Diseases	Associate	29259162
Joint Diseases	Associate	29259162
Obsessive Compulsive Disorder	Associate	36344488
Overweight	Associate	25527748
Uremia	Associate	34807970

DNASE2 (deoxyribonuclease 2, lysosomal)