DNASE1L2 (deoxyribonuclease 1 like 2)

Gene
Gene Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
1775
Gene name Gene Name - the full gene name approved by the HGNC.
Deoxyribonuclease 1 like 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
DNASE1L2
Synonyms (NCBI Gene) Gene synonyms aliases
DNAS1L2
Chromosome Chromosome number
16
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
16p13.3
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene Gene ontology Other IDs Protein Associated diseases
Show/Hide all(12)
GO ID Ontology Definition Evidence Reference
GO:0000737 Process DNA catabolic process, endonucleolytic IBA 21873635
GO:0001942 Process Hair follicle development IEA
GO:0003335 Process Corneocyte development IEA
GO:0003677 Function DNA binding IBA 21873635
GO:0004530 Function Deoxyribonuclease I activity IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene Gene ontology Other IDs Protein Associated diseases
MIM HGNC e!Ensembl
602622 2958 ENSG00000167968
Protein
Gene Gene ontology Other IDs Protein Associated diseases
UniProt ID Q92874
Protein name Deoxyribonuclease-1-like 2 (EC 3.1.21.-) (DNase I homolog protein DHP1) (Deoxyribonuclease I-like 2) (DNase I-like 2)
Protein function Divalent cation-dependent acid DNA endonuclease involved in the breakdown of the nucleus during corneocyte formation of epidermal keratinocytes. May play an immune role by eliminating harmful DNA released into the extracellular environment by da
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF03372 Exo_endo_phos 25 → 288 Endonuclease/Exonuclease/phosphatase family Domain
Tissue specificity TISSUE SPECIFICITY: Preferentially expressed in the skin and up-regulated during keratinocytes differentiation. Highly abundant (at protein level) in the stratum granulosum. {ECO:0000269|PubMed:16902420}.
Sequence
Sequence length 299
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene Gene ontology Other IDs Protein Associated diseases
Show/Hide Causal Diseases (1)
Causal
Disease term Disease name dbSNP ID References
Prostate cancer Malignant neoplasm of prostate rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582 17013881
Show/Hide Text Mining Associations (2)
Associations from Text Mining
Disease Name Relationship Type References
Arthritis Psoriatic Inhibit 16902420
Cystic Disease Of Lung Associate 33802146