Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	1769
Gene name	Dynein axonemal heavy chain 8
Gene symbol	DNAH8
Synonyms (NCBI Gene)	ATPaseSPGF46hdhc9
Chromosome	6
Chromosome location	6p21.2
Summary	The protein encoded by this gene is a heavy chain of an axonemal dynein involved in sperm and respiratory cilia motility. Axonemal dyneins generate force through hydrolysis of ATP and binding to microtubules. [provided by RefSeq, Jan 2012]

Show/Hide all (16)

SNP ID	Visualize variation	Clinical significance	Consequence
rs144711161	G>A	Likely-pathogenic	Genic downstream transcript variant, splice donor variant
rs145974361	G>A	Likely-pathogenic	Splice donor variant
rs149070832	C>T	Pathogenic	Genic downstream transcript variant, coding sequence variant, stop gained, non coding transcript variant
rs200115379	A>C,G	Likely-pathogenic	Splice acceptor variant
rs376576474	G>A	Likely-pathogenic	Splice donor variant
rs567050969	C>T	Pathogenic, uncertain-significance	Non coding transcript variant, stop gained, coding sequence variant
rs749731714	T>-	Pathogenic	Intron variant, non coding transcript variant, coding sequence variant, frameshift variant
rs753496815	->GA	Pathogenic	Non coding transcript variant, coding sequence variant, frameshift variant
rs756616538	G>A	Likely-pathogenic	Splice donor variant
rs766256391	G>A	Pathogenic	Coding sequence variant, stop gained, non coding transcript variant
rs766707325	GACCCAT>-	Pathogenic	Coding sequence variant, non coding transcript variant, frameshift variant
rs770372463	->T	Pathogenic	Coding sequence variant, non coding transcript variant, frameshift variant
rs776176679	C>T	Pathogenic	Non coding transcript variant, 5 prime UTR variant, stop gained, intron variant, coding sequence variant
rs1561836628	A>-	Pathogenic	Genic downstream transcript variant, coding sequence variant, non coding transcript variant, frameshift variant
rs1562782355	AG>-	Pathogenic	Coding sequence variant, non coding transcript variant, frameshift variant
rs1582865345	G>A	Likely-pathogenic	Splice acceptor variant

Show/Hide all (16)

miRTarBase ID	miRNA	Experiments	Reference
MIRT038978	hsa-miR-19b-1-5p	CLASH	23622248
MIRT646439	hsa-miR-8485	HITS-CLIP	23824327
MIRT646438	hsa-miR-499a-3p	HITS-CLIP	23824327
MIRT646437	hsa-miR-499b-3p	HITS-CLIP	23824327
MIRT646436	hsa-miR-181b-2-3p	HITS-CLIP	23824327
MIRT646435	hsa-miR-181b-3p	HITS-CLIP	23824327
MIRT646434	hsa-miR-4420	HITS-CLIP	23824327
MIRT646439	hsa-miR-8485	HITS-CLIP	23824327
MIRT646438	hsa-miR-499a-3p	HITS-CLIP	23824327
MIRT646437	hsa-miR-499b-3p	HITS-CLIP	23824327
MIRT646436	hsa-miR-181b-2-3p	HITS-CLIP	23824327
MIRT646435	hsa-miR-181b-3p	HITS-CLIP	23824327
MIRT646434	hsa-miR-4420	HITS-CLIP	23824327
MIRT2213319	hsa-miR-1265	CLIP-seq
MIRT2213320	hsa-miR-2392	CLIP-seq
MIRT2213321	hsa-miR-651	CLIP-seq

Show/Hide all (30)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0003777	Function	Microtubule motor activity	IMP	32619401
GO:0003777	Function	Microtubule motor activity	NAS	9373155
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005856	Component	Cytoskeleton	IEA
GO:0005858	Component	Axonemal dynein complex	NAS	9373155
GO:0005874	Component	Microtubule	IEA
GO:0005929	Component	Cilium	IEA
GO:0005930	Component	Axoneme	IDA	31178125
GO:0005930	Component	Axoneme	IEA
GO:0005930	Component	Axoneme	IMP	32619401
GO:0007018	Process	Microtubule-based movement	IEA
GO:0008569	Function	Minus-end-directed microtubule motor activity	IBA
GO:0008569	Function	Minus-end-directed microtubule motor activity	IEA
GO:0030286	Component	Dynein complex	IEA
GO:0031514	Component	Motile cilium	IEA
GO:0036126	Component	Sperm flagellum	IBA
GO:0036126	Component	Sperm flagellum	IDA	31178125
GO:0036126	Component	Sperm flagellum	IMP	32619401
GO:0036157	Component	Outer dynein arm	IBA
GO:0036158	Process	Outer dynein arm assembly	IBA
GO:0042995	Component	Cell projection	IEA
GO:0045505	Function	Dynein intermediate chain binding	IBA
GO:0045505	Function	Dynein intermediate chain binding	IEA
GO:0051959	Function	Dynein light intermediate chain binding	IBA
GO:0051959	Function	Dynein light intermediate chain binding	IEA
GO:0060285	Process	Cilium-dependent cell motility	NAS	9373155
GO:0060294	Process	Cilium movement involved in cell motility	IBA
GO:0097729	Component	9+2 motile cilium	IEA

MIM	HGNC	e!Ensembl
603337	2952	ENSG00000124721

Q96JB1

Protein name

Dynein axonemal heavy chain 8 (Axonemal beta dynein heavy chain 8) (Ciliary dynein heavy chain 8)

Protein function

Force generating protein component of the outer dynein arms (ODAs) in the sperm flagellum. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF08385	DHC_N1	139 → 693	Dynein heavy chain, N-terminal region 1	Family
PF08393	DHC_N2	1268 → 1673	Dynein heavy chain, N-terminal region 2	Family
PF12774	AAA_6	1808 → 2135	Hydrolytic ATP binding site of dynein motor region	Domain
PF17852	Dynein_AAA_lid	2290 → 2410	Dynein heavy chain AAA lid domain	Domain
PF12775	AAA_7	2417 → 2598		Domain
PF17857	AAA_lid_1	2632 → 2727	AAA+ lid domain	Domain
PF12780	AAA_8	2790 → 3052	P-loop containing dynein motor region D4	Domain
PF12777	MT	3065 → 3415	Microtubule-binding stalk of dynein motor	Domain
PF12781	AAA_9	3439 → 3660	ATP-binding dynein motor region	Domain
PF03028	Dynein_heavy	3905 → 4015	Dynein heavy chain region D6 P-loop domain	Domain
PF18198	AAA_lid_11	4029 → 4185	Dynein heavy chain AAA lid domain	Domain
PF18199	Dynein_C	4191 → 4487	Dynein heavy chain C-terminal domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in spermatozoa (at protein level). Not detected in airway epithelial cells (at protein level). {ECO:0000269|PubMed:31178125}.

Sequence

MMKLYIDNAAPDKLKGLCIFFVRCRNDVAINVKTIQEEALFTVLDASKGLLNGIRDMLAN
IFLPAVLATNNWGALNQSKQGESEKHIFTETINRYLSFLDGARISIEGTVKLKTIDNVNF
SKLHTFEEVTAAASNSETVHQLEEVLMVWYKQIEQVLIESEQMRKEAGDSGPLTELEHWK
RMSAKFNYIIEQIKGPSCKAVINVLNVAHSKLLKNWRDLDARITDTANESKDNVRYLYTL
EKVCQPLYNHDLVSMAHGIQNLINAIRMIHGVSRYYNTSERMTSLFIKVTNQMVTACKAY
ITDGGLNHVWDQETPVVLKKIQDCIFLFKEYQASFHKTRKLISESSGEKSFEVSEMYIFG
KFEAFCKRLEKITEMITVVQTYSTLSNSTIEGIDIMAIKFRNIYQGVKKKQYDILDPRRT
EFDTDFLDFMTKINGLEVQIQAFMNSSFGKILSSQQALQLLQRFQKLNIPCLGLEINHTI
ERILQYYVAELDATKKLYHSQKDDPPLARNMPPIAGKILWVRQLYRRISEPINYFFKNSD
ILSSPDGKAVIRQYNKISYVLVEFEVVYHTAWIREISQLHYALQATLFVRHPETGKLLVN
FDPKILEVVRETKCMIKMKLDVPEQAKRLLKLESKLKADKLYLQGLLQYYDELCQEVPSV
FVNLMTPKMKKVESVLRQGLTVLTWSSLTLESFFQEVELVLDMFNQLLKKISDLCEMHID
TVLKEIAKTVLISLPESGATKVEDMLTLNETYTKEWADILNHKSKHVEEAVRELISIFEQ
IYEVKYTGKVGKQSEQRKHVVFGSETGEGENNDYEANIVNEFDTHDKEDEFKKECKEVFA
FFSHQLLDSLQKATRLSLDTMKRRIFVASLYGRKQSEDIISFIKSEVHLAIPNVVMIPSL
DDIQQAINRMIQLTLEVSRGVAHWGQQQIRPIKSVIPSPTTTDVTHQNTGKLLKKEERSF
EEAIPARKLKNFYPGVAEHKDISKLVLLLSSSVNSLRKAAHEALQDFQKYKTLWTEDRDV
KVKEFLANNPSLTEIRSEILHYATFEQEIDELKPIIVVGALELHTEPMKLALSIEAKAWK
MLLCRYLNEEYKKKMSYMIAFINEYLKKLSRPIRDLDDVRFAMEALSCIRDNEIQMDMTL
GPIEEAYAILNRFEVEVTKEESEAVDTLRYSFNKLQSKAVSVQEDLVQVQPKFKSNLLES
VEVFREDVINFAEAYELEGPMVPNIPPQEASNRLQIFQASFDDLWRKFVTYSSGEQLFGL
PVTDYEVLHKTRKELNLLQKLYGLYDTVMSSISGYYEILWGDVDIEKINAELLEFQNRCR
KLPKGLKDWQAFLDLKKRIDDFSESCPLLEMMTNKAMKQRHWDRISELTGTPFDVESDSF
CLRNIMEAPLLKHKDDIEDICISAIKEKDIEAKLTQVIENWTNQNLSFAAFKGKGELLLK
GTESGEIITLMEDSLMVLGSLLSNRYNAPFKKNIQNWVYKLSTSSDIIEEWLVVQNLWVY
LEAVFVGGDIAKQLPQEAKRFQNIDKSWIKIMQRAHENPNVINCCVGDETMGQLLPHLHE
QLEVCQKSLTGYLEKKRLLFPRFFFVSDPVLLEILGQASDSHTIQPHLPAVSDNINEVTF
HAKDYDRIMAVISREGEKIVLDNSVMAKGPVEIWLLDLLKMQMSSLHNIIRSAFYQISDS
GFQLLPFLSHFPAQVGLLGIQMLWTHDSEEALRNAKDDRKIMQVTNQKFLDILNTLISQT
THDLSKFDRVKFETLITIHVHQRDIFDDLVKMHIKSPTDFEWLKQSRFYFKEDLDQTVVS
ITDVDFIYQNEFLGCTDRLVITPLTDRCYITLAQALGMNMGGAPAGPAGTGKTETTKDMG
RCLGKYVVVFNCSDQMDFRGLGRIFKGLAQSGSWGCFDEFNRIELPVLSVAAQQIYIVLT
ARKERKKQFIFSDGDCVDLNPEFGIFLTMNPGYAGRQELPENLKIQFRTVAMMVPDRQII
MRVKLASCGFLENVILAQKFYVLYKLCEEQLTKQVHYDFGLRNILSVLRTLGSQKRARPE
DSELSIVMRGLRDMNLSKLVDEDEPLFLSLINDLFPGLQLDSNTYAELQNAVAHQVQIEG
LINHPPWNLKLVQLYETSLVRHGLMTLGPSGSGKTTVITILMKAQTECGRPHREMRMNPK
AITAPQMFGRLDTATNDWTDGIFSTLWRKTLKAKKGENIFLILDGPVDAIWIENLNSVLD
DNKTLTLANGDRIPMAPSCKLLFEVHNIENASPATVSRMGMVYISSSALSWRPILQAWLK
KRTAQEAAVFLTLYEKVFEDTYTYMKLNLNPKMQLLECNYIVQSLNLLEGLIPSKEEGGV
SCVEHLHKLFVFGLMWSLGALLELESREKLEAFLRQHESKLDLPEIPKGSNQTMYEFYVT
DYGDWEHWNKKLQPYYYPTDSIPEYSSILVPNVDNIRTNFLIDTIAKQHKAVLLTGEQGT
AKTVMVKAYLKKYDPEVQLSKSLNFSSATEPMMFQRTIESYVDKRIGSTYGPPGGRKMTV
FIDDINMPVINEWGDQITNEIVRQMMEMEGMYSLDKPGDFTTIVDVQLIAAMIHPGGGRN
DIPQRLKRQFTVFNCTLPSNASIDKIFGIIGCGYFDPCRSFKPQICEMIVNLVSVGRVLW
QWTKVKMLPTPSKFHYIFNLRDLSRIWQGMLTIKAEECASIPTLLSLFKHECSRVIADRF
ITPEDEQWFNAHLTRAVEENIGSDAASCILPEPYFVDFLREMPEPTGDEPEDSVFEVPKI
YELMPSFDFLAEKLQFYQRQFNEIIRGTSLDLVFFKDAMTHLIKISRIIRTSCGNALLVG
VGGSGKQSLSRLASFIAGYQIFQITLTRSYNVTNLTDDLKALYKVAGADGKGITFIFTDS
EIKDEAFLEYLNNLLSSGEISNLFARDEMDEITQGLISVMKRELPRHPPTFDNLYEYFIS
RSRKNLHVVLCFSPVGEKFRARSLKFPGLISGCTMDWFSRWPREALIAVASYFLSDYNIV
CSSEIKRQVVETMGLFHDMVSESCESYFQRYRRRAHVTPKSYLSFINGYKNIYAEKVKFI
NEQAERMNIGLDKLMEASESVAKLSQDLAVKEKELAVASIKADEVLAEVTVSAQASAKIK
NEVQEVKDKAQKIVDEIDSEKVKAESKLEAAKPALEEAEAALNTIKPNDIATVRKLAKPP
HLIMRIMDCVLLLFQKKIDPVTMDPEKSCCKPSWGESLKLMSATGFLWSLQQFPKDTINE
ETVELLQPYFNMDDYTFESAKKVCGNVAGLLSWTLAMAIFYGINREVLPLKANLAKQEGR
LAVANAELGKAQALLDEKQAELDKVQAKFDAAMNEKMDLLNDADTCRKKMQAASTLIDGL
SGEKIRWTQQSKEFKAQINRLVGDILLCTGFLSYLGPFNQIFRNYLLKDQWEMELRARKI
PFTENLNLISMLVDPPTIGEWGLQGLPGDDLSIQNGIIVTKATRYPLLIDPQTQGKTWIK
SKEKENDLQVTSLNHKYFRTHLEDSLSLGRPLLIEDIHEELDPALDNVLEKNFIKSGTTF
KVKVGDKECDIMDTFKLYITTKLPNPAFTPEINAKTSVIDFTVTMKGLENQLLRRVILTE
KQELEAERVKLLEDVTFNKRKMKELEDNLLYKLSATKGSLVDDESLIGVLRTTKQTAAEV
SEKLHVAAETEIKINAAQEEFRPAATRGSILYFLITEMSMVNIMYQTSLAQFLKLFDQSM
ARSEKSPLPQKRITNIIEYLTYEVFTYSVRGLYENHKFLFVLLMTLKIDLQRGTVKHREF
QALIKGGAALDLKACPPKPYRWILDMTWLNLVELSKLPQFAEIMNQISRNEKGWKSWFDK
DAPEEEIIPDGYNDSLDTCHKLLLIRSWCPDRTVFQARKYIADSLEEKYTEPVILNLEKT
WEESDTRTPLICFLSMGSDPTNQIDALAKKLKLECRTISMGQGQEVHARKLIQMSMQQGG
WVLLQNCHLGLEFMEELLETLITTEASDDSFRVWITTEPHDRFPITLLQTSLKFTNEPPQ
GVRAGLKRTFAGINQDLLDISNLPMWKPMLYTVAFLHSTVQERRKFGPLGWNIPYEFNSA
DFSASVQFIQNHLDECDIKKGVSWNTVRYMIGEVQYGGRVTDDFDKRLLNCFARVWFSEK
MFEPSFCFYTGYKIPLCKTLDQYFEYIQSLPSLDNPEVFGLHPNADITYQSNTASAVLET
ITNIQPKESGGGVGETREAIVYRLSEDMLSKLPPDYIPHEVKSRLIKMGHLNSMNIFLRQ
EIDRMQRVISILRSSLSDLKLAIEGTIIMSENLRDALDNMYDARIPQLWKRVSWDSSTLG
FWFTELLERNAQFSTWIFEGRPNVFWMTGFFNPQGFLTAMRQEVTRAHKGWALDTVTIHN
EVLRQTKEEITSPPGEGVYIYGLYMDGAAWDRRNGKLMESTPKVLFTQLPVLHIFAINST
APKDPKLYVCPIYKKPRRTDLTFITVVYLRTVLSPDHWILRGVALLCDIK

Sequence length

4490

Interactions

View interactions

	KEGG
	Motor proteins Amyotrophic lateral sclerosis Huntington disease Pathways of neurodegeneration - multiple diseases

1776

Show/Hide Causal Diseases (4)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
DNAH8-related disorder	Likely pathogenic; Pathogenic	rs144711161, rs2532361573, rs2533985932, rs758035061	RCV003417812 RCV003419156 RCV003392957 RCV003394395
Inherited obesity	Pathogenic	rs149070832	RCV005414539
Primary ciliary dyskinesia	Pathogenic; Likely pathogenic	rs2127637299, rs767180208, rs1297488496, rs2150536009, rs765386646, rs150428096, rs1299196993, rs201568629, rs777610268, rs777613343, rs2150520528, rs2150400998, rs1250753880, rs781634544, rs781128315 View all (77 more)	RCV001387978 RCV001389130 RCV001383007 RCV001389347 RCV001386198 RCV001386442 RCV001382267 RCV001924917 RCV001950767 RCV001946690 RCV001916141 RCV002002540 RCV001958677 RCV002040921 RCV003058658 RCV003086020 RCV003076050 RCV002579020 RCV002662549 RCV002653693 RCV002819923 RCV002837619 RCV002866859 RCV002872214 RCV002886195 RCV002882237 RCV002957927 RCV003047773 RCV000228661 RCV005099991 RCV003536113 RCV003536427 RCV003537554 RCV003537647 RCV003538933 RCV003539123 RCV003539061 RCV003536904 RCV003537014 RCV003536743 RCV003538241 RCV003648024 RCV003647514 RCV003647292 RCV003647293 RCV003651099 RCV003651096 RCV003651152 RCV003651190 RCV003651191 RCV003652359 RCV003652659 RCV003652777 RCV003649861 RCV003650057 RCV003650178 RCV003650275 RCV003651667 RCV003651357 RCV003651704 RCV003838907 RCV003872247 RCV000461675 RCV000535093 RCV000545575 RCV000524761 RCV000629379 RCV000629371 RCV000629354 RCV000629385 RCV000704988 RCV000686591 RCV000704751 RCV000685592 RCV000700010 RCV000700884 RCV000689710 RCV000703864 RCV000690985 RCV000809648 RCV000822721 RCV000813448 RCV000794179 RCV000803454 RCV001046662 RCV001048431 RCV001213978 RCV001225896 RCV001230655 RCV001226235 RCV001247703 RCV001243071 RCV003652117
Spermatogenic failure 46	Likely pathogenic; Pathogenic	rs199969537, rs2533558063, rs2533098735, rs766707325, rs376903331, rs776176679, rs753831132, rs1563044711, rs752692263, rs1762922751	RCV005356284 RCV003989172 RCV003990632 RCV005367463 RCV004760742 RCV005633645 RCV005400485 RCV001265116 RCV001265119 RCV001265120

Show/Hide Unknown Diseases (14)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Acute myeloid leukemia	Benign	rs56315820, rs73420237, rs77769111	RCV005924660 RCV005920400 RCV005899535
Cervical cancer	Benign	rs77769111	RCV005899536
Cholangiocarcinoma	Benign	rs4714199	RCV005915378
EBV-positive nodal T- and NK-cell lymphoma	Likely benign	rs1361266974	RCV004560234
Familial cancer of breast	Benign	rs77031115, rs35696175	RCV005914519 RCV005923189
Gastric cancer	Benign	rs13209006	RCV005918500
Lung cancer	Benign	rs13209006, rs73420237, rs77769111	RCV005918501 RCV005920402 RCV005899537
Malignant lymphoma, large B-cell, diffuse	Benign	rs3823430, rs9357279	RCV005909541 RCV005920033
Prostate cancer	Uncertain significance	rs193921092	RCV000149108
Recurrent infections	Uncertain significance	rs1783196286	RCV001262397
Recurrent infections of the middle ear	Uncertain significance	rs1783196286	RCV001706724
Recurrent respiratory infections	Uncertain significance	rs1783196286	RCV001706724
Sarcoma	Benign	rs73420237	RCV005920401
Uterine corpus endometrial carcinoma	Benign	rs77769111	RCV005899538

Show/Hide Text Mining Associations (89)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Abnormalities Multiple	Associate	33704367, 36308074
Acidosis Renal Tubular	Associate	18632794
Amyotrophic Lateral Sclerosis	Associate	26475856
Asthenozoospermia	Associate	33611675, 37417617
Ataxia	Associate	28807751
Bipolar Disorder	Associate	20872768
Bloom Syndrome	Associate	17878217, 19671661
Breast Neoplasms	Associate	19889640, 23639630, 34329194, 9774623
Carcinoma Hepatocellular	Associate	23233483, 30981109
Carcinoma Pancreatic Ductal	Associate	36319832
Carcinoma Renal Cell	Associate	34870494
Carcinoma Small Cell	Associate	32649682, 6147348
Cardiomyopathy Dilated	Associate	31578282
Cardiomyopathy Hypertrophic Familial	Associate	8981935
Cerebellar Ataxia	Associate	28807751, 35110381
Cerebellar Diseases	Associate	22892528
Ciliary Motility Disorders	Associate	24307375, 37998386
Colorectal Neoplasms	Associate	15063740, 33476933
Colorectal Neoplasms	Stimulate	35754345
Congenital disorder of glycosylation type 1A	Associate	28807751
Congenital Disorders of Glycosylation	Associate	28807751
Deafness Cataract Retinitis Pigmentosa And Sperm Abnormalities	Associate	33704367
Developmental Disabilities	Associate	32693025
Diabetes Mellitus Transient Neonatal 1	Associate	18025464, 23665564
Diabetes Mellitus Type 2	Associate	23665564
Distal myopathy Nonaka type	Associate	19506019, 22270372, 26475856
Drug Related Side Effects and Adverse Reactions	Associate	35220010
Dystonia	Associate	28871039, 35110381
Endometriosis	Associate	25276049
Epilepsy	Stimulate	32748370
Facioscapulohumeral Muscular Dystrophy 1B	Associate	31312724
Familial Primary Pulmonary Hypertension	Associate	22792409
Frontotemporal Dementia	Associate	22270372, 26475856
Gastritis Atrophic	Associate	34944008
Genetic Diseases Inborn	Associate	34360842
Glioblastoma	Associate	35220010
Growth Disorders	Associate	32693025
Heart Diseases	Associate	12151382, 23515276
Heart Failure	Associate	36834924
Hepatolenticular Degeneration	Associate	11415452, 12968035, 14514926, 15205462, 17634212, 18974300, 19364131
Heredodegenerative Disorders Nervous System	Associate	31701538
Hyperaldosteronism	Associate	33796077
Inclusion Body Myopathy With Early Onset Paget Disease And Frontotemporal Dementia	Associate	34360842
Infertility Male	Associate	33611675, 33704367
Influenza Human	Associate	22393008
Kufor Rakeb syndrome	Associate	37080960
Leigh Disease	Associate	15146020, 15228605, 9221962
Leukemia Lymphocytic Chronic B Cell	Associate	17480228
Leukemia Myeloid Acute	Associate	31178587
Liver Failure Acute	Associate	24630891
Liver Neoplasms	Associate	34360842
Lung Neoplasms	Associate	31883965, 40311306
Melanoma	Associate	19784067
MELAS Syndrome	Associate	9221962
Migraine with Aura	Associate	35110381
Mitochondrial Diseases	Associate	9221962
Mitochondrial Encephalomyopathies	Associate	19735676
Moyamoya Disease	Associate	24658080
Muscle Hypotonia	Associate	28807751
Myocardial Infarction	Associate	28728608
Myopathy Myosin Storage	Associate	8981935
Neoplasms	Associate	23233483, 24439526, 24878061, 26139243, 27363033, 30647132, 31883965, 34520757, 35607442, 37197441
Nervous System Diseases	Associate	34059105, 35132656
Neurodegenerative Diseases	Associate	24878061, 26475856, 36316435
Nystagmus Pathologic	Associate	28807751
Osteitis Deformans	Associate	26475856
Ovarian Cysts	Associate	33235102
Ovarian Neoplasms	Associate	25686833, 29559470
Pancreatitis Acute Necrotizing	Associate	9221962
Parkinson Disease	Associate	19097176
Parkinson Disease Secondary	Associate	31132336
Peripheral Nervous System Diseases	Associate	34059105
Plagiocephaly and X linked mental retardation	Associate	32693025
Polyomavirus Infections	Associate	19200446
Positive Pressure Respiration Intrinsic	Associate	21310790
Prostatic Neoplasms	Associate	27363033, 37301535
Pulmonary Disease Chronic Obstructive	Associate	26736064
Respiratory Distress Syndrome	Associate	27374344, 36480289
Respiratory Insufficiency	Associate	22532554
Retinitis Pigmentosa	Associate	27072132
Sarcoidosis	Associate	21310790
Schimke immunoosseous dysplasia	Associate	18974355, 26195148
Sitosterolemia	Associate	33228147
Spastic Paraplegia Hereditary	Associate	36316435
Stroke	Associate	24344137
Thyroid Cancer Papillary	Associate	26079849
Trichohepatoenteric Syndrome	Associate	20176027
Triosephosphate Isomerase Deficiency	Stimulate	9294216
Tuberculosis Multidrug Resistant	Associate	26902225

DNAH8 (dynein axonemal heavy chain 8)