DMPK (DM1 protein kinase)

Gene

• Entrez ID: 1760
• Gene name: DM1 protein kinase
• Gene symbol: DMPK
• Synonyms (NCBI Gene): DM, DM1, DM1PK, DMK, MDPK, MT-PK
• Chromosome: 19
• Chromosome location: 19q13.32
• Summary: The protein encoded by this gene is a serine-threonine kinase that is closely related to other kinases that interact with members of the Rho family of small GTPases. Substrates for this enzyme include myogenin, the beta-subunit of the L-type calcium chann

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs762280354	G>A,C	Pathogenic	Missense variant, coding sequence variant, stop gained

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT017260	hsa-miR-335-5p	Microarray	18185580
MIRT509368	hsa-miR-15a-5p	HITS-CLIP	22927820
MIRT509367	hsa-miR-15b-5p	HITS-CLIP	22927820
MIRT509366	hsa-miR-16-5p	HITS-CLIP	22927820
MIRT509365	hsa-miR-195-5p	HITS-CLIP	22927820
MIRT509364	hsa-miR-424-5p	HITS-CLIP	22927820
MIRT509363	hsa-miR-497-5p	HITS-CLIP	22927820
MIRT509362	hsa-miR-6838-5p	HITS-CLIP	22927820
MIRT551016	hsa-miR-1179	HITS-CLIP	22927820
MIRT551015	hsa-miR-4310	HITS-CLIP	22927820
MIRT551014	hsa-miR-7157-5p	HITS-CLIP	22927820
MIRT551013	hsa-miR-4530	HITS-CLIP	22927820
MIRT551012	hsa-miR-361-3p	HITS-CLIP	22927820
MIRT551011	hsa-miR-103a-3p	HITS-CLIP	22927820
MIRT551010	hsa-miR-107	HITS-CLIP	22927820
MIRT509368	hsa-miR-15a-5p	HITS-CLIP	23824327
MIRT509367	hsa-miR-15b-5p	HITS-CLIP	23824327
MIRT509366	hsa-miR-16-5p	HITS-CLIP	23824327
MIRT509365	hsa-miR-195-5p	HITS-CLIP	23824327
MIRT509364	hsa-miR-424-5p	HITS-CLIP	23824327
MIRT509363	hsa-miR-497-5p	HITS-CLIP	23824327
MIRT509362	hsa-miR-6838-5p	HITS-CLIP	23824327
MIRT551016	hsa-miR-1179	HITS-CLIP	23824327
MIRT551015	hsa-miR-4310	HITS-CLIP	23824327
MIRT551014	hsa-miR-7157-5p	HITS-CLIP	23824327
MIRT551011	hsa-miR-103a-3p	HITS-CLIP	23824327
MIRT551010	hsa-miR-107	HITS-CLIP	23824327
MIRT509368	hsa-miR-15a-5p	HITS-CLIP	23824327
MIRT509367	hsa-miR-15b-5p	HITS-CLIP	23824327
MIRT509366	hsa-miR-16-5p	HITS-CLIP	23824327
MIRT509365	hsa-miR-195-5p	HITS-CLIP	23824327
MIRT509364	hsa-miR-424-5p	HITS-CLIP	23824327
MIRT509363	hsa-miR-497-5p	HITS-CLIP	23824327
MIRT509362	hsa-miR-6838-5p	HITS-CLIP	23824327
MIRT551016	hsa-miR-1179	HITS-CLIP	23824327
MIRT551015	hsa-miR-4310	HITS-CLIP	23824327
MIRT551014	hsa-miR-7157-5p	HITS-CLIP	23824327
MIRT551013	hsa-miR-4530	HITS-CLIP	23824327
MIRT551012	hsa-miR-361-3p	HITS-CLIP	23824327
MIRT551011	hsa-miR-103a-3p	HITS-CLIP	23824327
MIRT551010	hsa-miR-107	HITS-CLIP	23824327
MIRT509368	hsa-miR-15a-5p	HITS-CLIP	24906430
MIRT509367	hsa-miR-15b-5p	HITS-CLIP	24906430
MIRT509366	hsa-miR-16-5p	HITS-CLIP	24906430
MIRT509365	hsa-miR-195-5p	HITS-CLIP	24906430
MIRT509364	hsa-miR-424-5p	HITS-CLIP	24906430
MIRT509363	hsa-miR-497-5p	HITS-CLIP	24906430
MIRT509362	hsa-miR-6838-5p	HITS-CLIP	24906430
MIRT551016	hsa-miR-1179	HITS-CLIP	24906430
MIRT551015	hsa-miR-4310	HITS-CLIP	24906430
MIRT551014	hsa-miR-7157-5p	HITS-CLIP	24906430
MIRT551013	hsa-miR-4530	HITS-CLIP	24906430
MIRT551012	hsa-miR-361-3p	HITS-CLIP	24906430
MIRT551011	hsa-miR-103a-3p	HITS-CLIP	24906430
MIRT551010	hsa-miR-107	HITS-CLIP	24906430
MIRT509368	hsa-miR-15a-5p	HITS-CLIP	24906430
MIRT509367	hsa-miR-15b-5p	HITS-CLIP	24906430
MIRT509366	hsa-miR-16-5p	HITS-CLIP	24906430
MIRT509365	hsa-miR-195-5p	HITS-CLIP	24906430
MIRT509364	hsa-miR-424-5p	HITS-CLIP	24906430
MIRT509363	hsa-miR-497-5p	HITS-CLIP	24906430
MIRT509362	hsa-miR-6838-5p	HITS-CLIP	24906430
MIRT551016	hsa-miR-1179	HITS-CLIP	24906430
MIRT551015	hsa-miR-4310	HITS-CLIP	24906430
MIRT551014	hsa-miR-7157-5p	HITS-CLIP	24906430
MIRT551013	hsa-miR-4530	HITS-CLIP	24906430
MIRT551012	hsa-miR-361-3p	HITS-CLIP	24906430
MIRT551011	hsa-miR-103a-3p	HITS-CLIP	24906430
MIRT551010	hsa-miR-107	HITS-CLIP	24906430
MIRT509368	hsa-miR-15a-5p	PAR-CLIP	21572407
MIRT509367	hsa-miR-15b-5p	PAR-CLIP	21572407
MIRT509366	hsa-miR-16-5p	PAR-CLIP	21572407
MIRT509365	hsa-miR-195-5p	PAR-CLIP	21572407
MIRT509364	hsa-miR-424-5p	PAR-CLIP	21572407
MIRT509363	hsa-miR-497-5p	PAR-CLIP	21572407
MIRT509362	hsa-miR-6838-5p	PAR-CLIP	21572407
MIRT551016	hsa-miR-1179	PAR-CLIP	21572407
MIRT551015	hsa-miR-4310	PAR-CLIP	21572407
MIRT551014	hsa-miR-7157-5p	PAR-CLIP	21572407
MIRT551013	hsa-miR-4530	PAR-CLIP	21572407
MIRT551012	hsa-miR-361-3p	PAR-CLIP	21572407
MIRT551011	hsa-miR-103a-3p	PAR-CLIP	21572407
MIRT551010	hsa-miR-107	PAR-CLIP	21572407
MIRT509368	hsa-miR-15a-5p	PAR-CLIP	23446348
MIRT509367	hsa-miR-15b-5p	PAR-CLIP	23446348
MIRT509366	hsa-miR-16-5p	PAR-CLIP	23446348
MIRT509365	hsa-miR-195-5p	PAR-CLIP	23446348
MIRT509364	hsa-miR-424-5p	PAR-CLIP	23446348
MIRT509363	hsa-miR-497-5p	PAR-CLIP	23446348
MIRT509362	hsa-miR-6838-5p	PAR-CLIP	23446348
MIRT551011	hsa-miR-103a-3p	PAR-CLIP	27292025
MIRT551011	hsa-miR-103a-3p	PAR-CLIP	27292025
MIRT551010	hsa-miR-107	PAR-CLIP	27292025
MIRT551010	hsa-miR-107	PAR-CLIP	27292025
MIRT551016	hsa-miR-1179	PAR-CLIP	27292025
MIRT551016	hsa-miR-1179	PAR-CLIP	27292025
MIRT509368	hsa-miR-15a-5p	PAR-CLIP	27292025
MIRT509368	hsa-miR-15a-5p	PAR-CLIP	27292025
MIRT509367	hsa-miR-15b-5p	PAR-CLIP	27292025
MIRT509367	hsa-miR-15b-5p	PAR-CLIP	27292025
MIRT509366	hsa-miR-16-5p	PAR-CLIP	27292025
MIRT509366	hsa-miR-16-5p	PAR-CLIP	27292025
MIRT575914	hsa-miR-187-5p	PAR-CLIP	27292025
MIRT575914	hsa-miR-187-5p	PAR-CLIP	27292025
MIRT509365	hsa-miR-195-5p	PAR-CLIP	27292025
MIRT509365	hsa-miR-195-5p	PAR-CLIP	27292025
MIRT509364	hsa-miR-424-5p	PAR-CLIP	27292025
MIRT509364	hsa-miR-424-5p	PAR-CLIP	27292025
MIRT551015	hsa-miR-4310	PAR-CLIP	27292025
MIRT551015	hsa-miR-4310	PAR-CLIP	27292025
MIRT509363	hsa-miR-497-5p	PAR-CLIP	27292025
MIRT509363	hsa-miR-497-5p	PAR-CLIP	27292025
MIRT575929	hsa-miR-624-3p	PAR-CLIP	27292025
MIRT575929	hsa-miR-624-3p	PAR-CLIP	27292025
MIRT509362	hsa-miR-6838-5p	PAR-CLIP	27292025
MIRT509362	hsa-miR-6838-5p	PAR-CLIP	27292025
MIRT551014	hsa-miR-7157-5p	PAR-CLIP	27292025
MIRT551014	hsa-miR-7157-5p	PAR-CLIP	27292025
MIRT551011	hsa-miR-103a-3p	HITS-CLIP	27418678
MIRT551011	hsa-miR-103a-3p	HITS-CLIP	27418678
MIRT551011	hsa-miR-103a-3p	HITS-CLIP	27418678
MIRT551011	hsa-miR-103a-3p	HITS-CLIP	27418678
MIRT551010	hsa-miR-107	HITS-CLIP	27418678
MIRT551010	hsa-miR-107	HITS-CLIP	27418678
MIRT551010	hsa-miR-107	HITS-CLIP	27418678
MIRT551010	hsa-miR-107	HITS-CLIP	27418678
MIRT551016	hsa-miR-1179	HITS-CLIP	27418678
MIRT551016	hsa-miR-1179	HITS-CLIP	27418678
MIRT551016	hsa-miR-1179	HITS-CLIP	27418678
MIRT551016	hsa-miR-1179	HITS-CLIP	27418678
MIRT509368	hsa-miR-15a-5p	HITS-CLIP	27418678
MIRT509368	hsa-miR-15a-5p	HITS-CLIP	27418678
MIRT509368	hsa-miR-15a-5p	HITS-CLIP	27418678
MIRT509367	hsa-miR-15b-5p	HITS-CLIP	27418678
MIRT509367	hsa-miR-15b-5p	HITS-CLIP	27418678
MIRT509367	hsa-miR-15b-5p	HITS-CLIP	27418678
MIRT509366	hsa-miR-16-5p	HITS-CLIP	27418678
MIRT509366	hsa-miR-16-5p	HITS-CLIP	27418678
MIRT509366	hsa-miR-16-5p	HITS-CLIP	27418678
MIRT575914	hsa-miR-187-5p	HITS-CLIP	27418678
MIRT575914	hsa-miR-187-5p	HITS-CLIP	27418678
MIRT575914	hsa-miR-187-5p	HITS-CLIP	27418678
MIRT575914	hsa-miR-187-5p	HITS-CLIP	27418678
MIRT509365	hsa-miR-195-5p	HITS-CLIP	27418678
MIRT509365	hsa-miR-195-5p	HITS-CLIP	27418678
MIRT509365	hsa-miR-195-5p	HITS-CLIP	27418678
MIRT509364	hsa-miR-424-5p	HITS-CLIP	27418678
MIRT509364	hsa-miR-424-5p	HITS-CLIP	27418678
MIRT509364	hsa-miR-424-5p	HITS-CLIP	27418678
MIRT551015	hsa-miR-4310	HITS-CLIP	27418678
MIRT551015	hsa-miR-4310	HITS-CLIP	27418678
MIRT551015	hsa-miR-4310	HITS-CLIP	27418678
MIRT551015	hsa-miR-4310	HITS-CLIP	27418678
MIRT509363	hsa-miR-497-5p	HITS-CLIP	27418678
MIRT509363	hsa-miR-497-5p	HITS-CLIP	27418678
MIRT509363	hsa-miR-497-5p	HITS-CLIP	27418678
MIRT575929	hsa-miR-624-3p	HITS-CLIP	27418678
MIRT575929	hsa-miR-624-3p	HITS-CLIP	27418678
MIRT575929	hsa-miR-624-3p	HITS-CLIP	27418678
MIRT575929	hsa-miR-624-3p	HITS-CLIP	27418678
MIRT509362	hsa-miR-6838-5p	HITS-CLIP	27418678
MIRT509362	hsa-miR-6838-5p	HITS-CLIP	27418678
MIRT509362	hsa-miR-6838-5p	HITS-CLIP	27418678
MIRT551014	hsa-miR-7157-5p	HITS-CLIP	27418678
MIRT551014	hsa-miR-7157-5p	HITS-CLIP	27418678
MIRT551014	hsa-miR-7157-5p	HITS-CLIP	27418678
MIRT551014	hsa-miR-7157-5p	HITS-CLIP	27418678
MIRT551011	hsa-miR-103a-3p	HITS-CLIP	28735896
MIRT551011	hsa-miR-103a-3p	HITS-CLIP	28735896
MIRT551011	hsa-miR-103a-3p	HITS-CLIP	28735896
MIRT551011	hsa-miR-103a-3p	HITS-CLIP	28735896
MIRT551011	hsa-miR-103a-3p	HITS-CLIP	28735896
MIRT551011	hsa-miR-103a-3p	HITS-CLIP	28735896
MIRT551010	hsa-miR-107	HITS-CLIP	28735896
MIRT551010	hsa-miR-107	HITS-CLIP	28735896
MIRT551010	hsa-miR-107	HITS-CLIP	28735896
MIRT551010	hsa-miR-107	HITS-CLIP	28735896
MIRT551010	hsa-miR-107	HITS-CLIP	28735896
MIRT551010	hsa-miR-107	HITS-CLIP	28735896
MIRT551016	hsa-miR-1179	HITS-CLIP	28735896
MIRT551016	hsa-miR-1179	HITS-CLIP	28735896
MIRT551016	hsa-miR-1179	HITS-CLIP	28735896
MIRT551016	hsa-miR-1179	HITS-CLIP	28735896
MIRT551016	hsa-miR-1179	HITS-CLIP	28735896
MIRT551016	hsa-miR-1179	HITS-CLIP	28735896
MIRT509368	hsa-miR-15a-5p	HITS-CLIP	28735896
MIRT509368	hsa-miR-15a-5p	HITS-CLIP	28735896
MIRT509368	hsa-miR-15a-5p	HITS-CLIP	28735896
MIRT509368	hsa-miR-15a-5p	HITS-CLIP	28735896
MIRT509368	hsa-miR-15a-5p	HITS-CLIP	28735896
MIRT509368	hsa-miR-15a-5p	HITS-CLIP	28735896
MIRT509367	hsa-miR-15b-5p	HITS-CLIP	28735896
MIRT509367	hsa-miR-15b-5p	HITS-CLIP	28735896
MIRT509367	hsa-miR-15b-5p	HITS-CLIP	28735896
MIRT509367	hsa-miR-15b-5p	HITS-CLIP	28735896
MIRT509367	hsa-miR-15b-5p	HITS-CLIP	28735896
MIRT509367	hsa-miR-15b-5p	HITS-CLIP	28735896
MIRT509366	hsa-miR-16-5p	HITS-CLIP	28735896
MIRT509366	hsa-miR-16-5p	HITS-CLIP	28735896
MIRT509366	hsa-miR-16-5p	HITS-CLIP	28735896
MIRT509366	hsa-miR-16-5p	HITS-CLIP	28735896
MIRT509366	hsa-miR-16-5p	HITS-CLIP	28735896
MIRT509366	hsa-miR-16-5p	HITS-CLIP	28735896
MIRT575914	hsa-miR-187-5p	HITS-CLIP	28735896
MIRT575914	hsa-miR-187-5p	HITS-CLIP	28735896
MIRT575914	hsa-miR-187-5p	HITS-CLIP	28735896
MIRT575914	hsa-miR-187-5p	HITS-CLIP	28735896
MIRT575914	hsa-miR-187-5p	HITS-CLIP	28735896
MIRT575914	hsa-miR-187-5p	HITS-CLIP	28735896
MIRT509365	hsa-miR-195-5p	HITS-CLIP	28735896
MIRT509365	hsa-miR-195-5p	HITS-CLIP	28735896
MIRT509365	hsa-miR-195-5p	HITS-CLIP	28735896
MIRT509365	hsa-miR-195-5p	HITS-CLIP	28735896
MIRT509365	hsa-miR-195-5p	HITS-CLIP	28735896
MIRT509365	hsa-miR-195-5p	HITS-CLIP	28735896
MIRT509364	hsa-miR-424-5p	HITS-CLIP	28735896
MIRT509364	hsa-miR-424-5p	HITS-CLIP	28735896
MIRT509364	hsa-miR-424-5p	HITS-CLIP	28735896
MIRT509364	hsa-miR-424-5p	HITS-CLIP	28735896
MIRT509364	hsa-miR-424-5p	HITS-CLIP	28735896
MIRT509364	hsa-miR-424-5p	HITS-CLIP	28735896
MIRT551015	hsa-miR-4310	HITS-CLIP	28735896
MIRT551015	hsa-miR-4310	HITS-CLIP	28735896
MIRT551015	hsa-miR-4310	HITS-CLIP	28735896
MIRT551015	hsa-miR-4310	HITS-CLIP	28735896
MIRT551015	hsa-miR-4310	HITS-CLIP	28735896
MIRT551015	hsa-miR-4310	HITS-CLIP	28735896
MIRT509363	hsa-miR-497-5p	HITS-CLIP	28735896
MIRT509363	hsa-miR-497-5p	HITS-CLIP	28735896
MIRT509363	hsa-miR-497-5p	HITS-CLIP	28735896
MIRT509363	hsa-miR-497-5p	HITS-CLIP	28735896
MIRT509363	hsa-miR-497-5p	HITS-CLIP	28735896
MIRT509363	hsa-miR-497-5p	HITS-CLIP	28735896
MIRT575929	hsa-miR-624-3p	HITS-CLIP	28735896
MIRT575929	hsa-miR-624-3p	HITS-CLIP	28735896
MIRT575929	hsa-miR-624-3p	HITS-CLIP	28735896
MIRT575929	hsa-miR-624-3p	HITS-CLIP	28735896
MIRT575929	hsa-miR-624-3p	HITS-CLIP	28735896
MIRT575929	hsa-miR-624-3p	HITS-CLIP	28735896
MIRT509362	hsa-miR-6838-5p	HITS-CLIP	28735896
MIRT509362	hsa-miR-6838-5p	HITS-CLIP	28735896
MIRT509362	hsa-miR-6838-5p	HITS-CLIP	28735896
MIRT509362	hsa-miR-6838-5p	HITS-CLIP	28735896
MIRT509362	hsa-miR-6838-5p	HITS-CLIP	28735896
MIRT509362	hsa-miR-6838-5p	HITS-CLIP	28735896
MIRT551014	hsa-miR-7157-5p	HITS-CLIP	28735896
MIRT551014	hsa-miR-7157-5p	HITS-CLIP	28735896
MIRT551014	hsa-miR-7157-5p	HITS-CLIP	28735896
MIRT551014	hsa-miR-7157-5p	HITS-CLIP	28735896
MIRT551014	hsa-miR-7157-5p	HITS-CLIP	28735896
MIRT551014	hsa-miR-7157-5p	HITS-CLIP	28735896
MIRT735733	hsa-miR-7-5p	Western blotting, Immunofluorescence, qRT-PCR	31855836
MIRT509368	hsa-miR-15a-5p	HITS-CLIP	22927820
MIRT509367	hsa-miR-15b-5p	HITS-CLIP	22927820
MIRT509366	hsa-miR-16-5p	HITS-CLIP	22927820
MIRT509365	hsa-miR-195-5p	HITS-CLIP	22927820
MIRT509364	hsa-miR-424-5p	HITS-CLIP	22927820
MIRT509363	hsa-miR-497-5p	HITS-CLIP	22927820
MIRT509362	hsa-miR-6838-5p	HITS-CLIP	22927820
MIRT551016	hsa-miR-1179	HITS-CLIP	22927820
MIRT551015	hsa-miR-4310	HITS-CLIP	22927820
MIRT551014	hsa-miR-7157-5p	HITS-CLIP	22927820
MIRT551013	hsa-miR-4530	HITS-CLIP	22927820
MIRT551012	hsa-miR-361-3p	HITS-CLIP	22927820
MIRT551011	hsa-miR-103a-3p	HITS-CLIP	22927820
MIRT551010	hsa-miR-107	HITS-CLIP	22927820
MIRT509368	hsa-miR-15a-5p	HITS-CLIP	23824327
MIRT509367	hsa-miR-15b-5p	HITS-CLIP	23824327
MIRT509366	hsa-miR-16-5p	HITS-CLIP	23824327
MIRT509365	hsa-miR-195-5p	HITS-CLIP	23824327
MIRT509364	hsa-miR-424-5p	HITS-CLIP	23824327
MIRT509363	hsa-miR-497-5p	HITS-CLIP	23824327
MIRT509362	hsa-miR-6838-5p	HITS-CLIP	23824327
MIRT551016	hsa-miR-1179	HITS-CLIP	23824327
MIRT551015	hsa-miR-4310	HITS-CLIP	23824327
MIRT551014	hsa-miR-7157-5p	HITS-CLIP	23824327
MIRT551011	hsa-miR-103a-3p	HITS-CLIP	23824327
MIRT551010	hsa-miR-107	HITS-CLIP	23824327
MIRT509368	hsa-miR-15a-5p	HITS-CLIP	23824327
MIRT509367	hsa-miR-15b-5p	HITS-CLIP	23824327
MIRT509366	hsa-miR-16-5p	HITS-CLIP	23824327
MIRT509365	hsa-miR-195-5p	HITS-CLIP	23824327
MIRT509364	hsa-miR-424-5p	HITS-CLIP	23824327
MIRT509363	hsa-miR-497-5p	HITS-CLIP	23824327
MIRT509362	hsa-miR-6838-5p	HITS-CLIP	23824327
MIRT551016	hsa-miR-1179	HITS-CLIP	23824327
MIRT551015	hsa-miR-4310	HITS-CLIP	23824327
MIRT551014	hsa-miR-7157-5p	HITS-CLIP	23824327
MIRT551013	hsa-miR-4530	HITS-CLIP	23824327
MIRT551012	hsa-miR-361-3p	HITS-CLIP	23824327
MIRT551011	hsa-miR-103a-3p	HITS-CLIP	23824327
MIRT551010	hsa-miR-107	HITS-CLIP	23824327
MIRT509368	hsa-miR-15a-5p	PAR-CLIP	21572407
MIRT509367	hsa-miR-15b-5p	PAR-CLIP	21572407
MIRT509366	hsa-miR-16-5p	PAR-CLIP	21572407
MIRT509365	hsa-miR-195-5p	PAR-CLIP	21572407
MIRT509364	hsa-miR-424-5p	PAR-CLIP	21572407
MIRT509363	hsa-miR-497-5p	PAR-CLIP	21572407
MIRT509362	hsa-miR-6838-5p	PAR-CLIP	21572407
MIRT551016	hsa-miR-1179	PAR-CLIP	21572407
MIRT551015	hsa-miR-4310	PAR-CLIP	21572407
MIRT551014	hsa-miR-7157-5p	PAR-CLIP	21572407
MIRT551013	hsa-miR-4530	PAR-CLIP	21572407
MIRT551012	hsa-miR-361-3p	PAR-CLIP	21572407
MIRT551011	hsa-miR-103a-3p	PAR-CLIP	21572407
MIRT551010	hsa-miR-107	PAR-CLIP	21572407
MIRT509368	hsa-miR-15a-5p	PAR-CLIP	23446348
MIRT509367	hsa-miR-15b-5p	PAR-CLIP	23446348
MIRT509366	hsa-miR-16-5p	PAR-CLIP	23446348
MIRT509365	hsa-miR-195-5p	PAR-CLIP	23446348
MIRT509364	hsa-miR-424-5p	PAR-CLIP	23446348
MIRT509363	hsa-miR-497-5p	PAR-CLIP	23446348
MIRT509362	hsa-miR-6838-5p	PAR-CLIP	23446348
MIRT939160	hsa-miR-1	CLIP-seq
MIRT939161	hsa-miR-103a	CLIP-seq
MIRT939162	hsa-miR-1275	CLIP-seq
MIRT939163	hsa-miR-148a	CLIP-seq
MIRT939164	hsa-miR-148b	CLIP-seq
MIRT939165	hsa-miR-152	CLIP-seq
MIRT939166	hsa-miR-15a	CLIP-seq
MIRT939167	hsa-miR-15b	CLIP-seq
MIRT939168	hsa-miR-16	CLIP-seq
MIRT939169	hsa-miR-195	CLIP-seq
MIRT939170	hsa-miR-206	CLIP-seq
MIRT939171	hsa-miR-3137	CLIP-seq
MIRT939172	hsa-miR-3147	CLIP-seq
MIRT939173	hsa-miR-3170	CLIP-seq
MIRT939174	hsa-miR-324-5p	CLIP-seq
MIRT939175	hsa-miR-424	CLIP-seq
MIRT939176	hsa-miR-4264	CLIP-seq
MIRT939177	hsa-miR-4293	CLIP-seq
MIRT939178	hsa-miR-4425	CLIP-seq
MIRT939179	hsa-miR-4486	CLIP-seq
MIRT939180	hsa-miR-4512	CLIP-seq
MIRT939181	hsa-miR-4523	CLIP-seq
MIRT939182	hsa-miR-4527	CLIP-seq
MIRT939183	hsa-miR-4534	CLIP-seq
MIRT939184	hsa-miR-4665-5p	CLIP-seq
MIRT939185	hsa-miR-4677-3p	CLIP-seq
MIRT939186	hsa-miR-4679	CLIP-seq
MIRT939187	hsa-miR-4797-3p	CLIP-seq
MIRT939188	hsa-miR-4802-5p	CLIP-seq
MIRT939189	hsa-miR-486-5p	CLIP-seq
MIRT939190	hsa-miR-497	CLIP-seq
MIRT939191	hsa-miR-522	CLIP-seq
MIRT939192	hsa-miR-596	CLIP-seq
MIRT939193	hsa-miR-613	CLIP-seq
MIRT939194	hsa-miR-615-5p	CLIP-seq
MIRT939195	hsa-miR-624	CLIP-seq
MIRT939161	hsa-miR-103a	CLIP-seq
MIRT939166	hsa-miR-15a	CLIP-seq
MIRT939167	hsa-miR-15b	CLIP-seq
MIRT939168	hsa-miR-16	CLIP-seq
MIRT939169	hsa-miR-195	CLIP-seq
MIRT939175	hsa-miR-424	CLIP-seq
MIRT939190	hsa-miR-497	CLIP-seq
MIRT939161	hsa-miR-103a	CLIP-seq
MIRT939166	hsa-miR-15a	CLIP-seq
MIRT939167	hsa-miR-15b	CLIP-seq
MIRT939168	hsa-miR-16	CLIP-seq
MIRT939169	hsa-miR-195	CLIP-seq
MIRT1977840	hsa-miR-2392	CLIP-seq
MIRT1977841	hsa-miR-342-5p	CLIP-seq
MIRT1977842	hsa-miR-3605-5p	CLIP-seq
MIRT939175	hsa-miR-424	CLIP-seq
MIRT1977843	hsa-miR-4664-5p	CLIP-seq
MIRT939190	hsa-miR-497	CLIP-seq
MIRT1977844	hsa-miR-765	CLIP-seq
MIRT939160	hsa-miR-1	CLIP-seq
MIRT939161	hsa-miR-103a	CLIP-seq
MIRT939163	hsa-miR-148a	CLIP-seq
MIRT939164	hsa-miR-148b	CLIP-seq
MIRT939165	hsa-miR-152	CLIP-seq
MIRT939166	hsa-miR-15a	CLIP-seq
MIRT939167	hsa-miR-15b	CLIP-seq
MIRT939168	hsa-miR-16	CLIP-seq
MIRT939169	hsa-miR-195	CLIP-seq
MIRT939170	hsa-miR-206	CLIP-seq
MIRT2213175	hsa-miR-3144-5p	CLIP-seq
MIRT2213176	hsa-miR-3191	CLIP-seq
MIRT939174	hsa-miR-324-5p	CLIP-seq
MIRT939175	hsa-miR-424	CLIP-seq
MIRT939176	hsa-miR-4264	CLIP-seq
MIRT2213177	hsa-miR-4447	CLIP-seq
MIRT2213178	hsa-miR-4472	CLIP-seq
MIRT939181	hsa-miR-4523	CLIP-seq
MIRT2213179	hsa-miR-4652-5p	CLIP-seq
MIRT2213180	hsa-miR-4785	CLIP-seq
MIRT939187	hsa-miR-4797-3p	CLIP-seq
MIRT2213181	hsa-miR-491-5p	CLIP-seq
MIRT939190	hsa-miR-497	CLIP-seq
MIRT939193	hsa-miR-613	CLIP-seq
MIRT939194	hsa-miR-615-5p	CLIP-seq
MIRT939161	hsa-miR-103a	CLIP-seq
MIRT939166	hsa-miR-15a	CLIP-seq
MIRT939167	hsa-miR-15b	CLIP-seq
MIRT939168	hsa-miR-16	CLIP-seq
MIRT939169	hsa-miR-195	CLIP-seq
MIRT939175	hsa-miR-424	CLIP-seq
MIRT939190	hsa-miR-497	CLIP-seq
MIRT939166	hsa-miR-15a	CLIP-seq
MIRT939167	hsa-miR-15b	CLIP-seq
MIRT939168	hsa-miR-16	CLIP-seq
MIRT939169	hsa-miR-195	CLIP-seq
MIRT939175	hsa-miR-424	CLIP-seq
MIRT939190	hsa-miR-497	CLIP-seq
MIRT939166	hsa-miR-15a	CLIP-seq
MIRT939167	hsa-miR-15b	CLIP-seq
MIRT939168	hsa-miR-16	CLIP-seq
MIRT939169	hsa-miR-195	CLIP-seq
MIRT939175	hsa-miR-424	CLIP-seq
MIRT939190	hsa-miR-497	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
CTCF	Unknown	11479593
SPEN	Activation	21637295

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0002028	Process	Regulation of sodium ion transport	IEA
GO:0004672	Function	Protein kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	IBA
GO:0004674	Function	Protein serine/threonine kinase activity	IDA	10913253, 11287000
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0005515	Function	Protein binding	IPI	15598648, 21949239, 32814053
GO:0005524	Function	ATP binding	IDA	10913253
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IEA
GO:0005640	Component	Nuclear outer membrane	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005739	Component	Mitochondrion	IEA
GO:0005741	Component	Mitochondrial outer membrane	IDA	15684391
GO:0005741	Component	Mitochondrial outer membrane	IEA
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	ISS
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	ISS
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	ISS
GO:0006468	Process	Protein phosphorylation	IDA	10913253, 11287000
GO:0006874	Process	Intracellular calcium ion homeostasis	IBA
GO:0006874	Process	Intracellular calcium ion homeostasis	IEA
GO:0006874	Process	Intracellular calcium ion homeostasis	ISS
GO:0006998	Process	Nuclear envelope organization	IBA
GO:0006998	Process	Nuclear envelope organization	IEA
GO:0006998	Process	Nuclear envelope organization	IMP	21949239
GO:0008016	Process	Regulation of heart contraction	IBA
GO:0008016	Process	Regulation of heart contraction	IDA	15598648
GO:0008016	Process	Regulation of heart contraction	IEA
GO:0010657	Process	Muscle cell apoptotic process	IDA	18729234
GO:0010830	Process	Regulation of myotube differentiation	IEA
GO:0010830	Process	Regulation of myotube differentiation	ISS
GO:0014722	Process	Regulation of skeletal muscle contraction by calcium ion signaling	IBA
GO:0014722	Process	Regulation of skeletal muscle contraction by calcium ion signaling	IEA
GO:0014853	Process	Regulation of excitatory postsynaptic membrane potential involved in skeletal muscle contraction	IEA
GO:0016020	Component	Membrane	IEA
GO:0016301	Function	Kinase activity	IEA
GO:0016529	Component	Sarcoplasmic reticulum	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0017020	Function	Myosin phosphatase regulator activity	IDA	11287000
GO:0031965	Component	Nuclear membrane	ISS
GO:0031966	Component	Mitochondrial membrane	IEA
GO:0033017	Component	Sarcoplasmic reticulum membrane	IEA
GO:0033017	Component	Sarcoplasmic reticulum membrane	ISS
GO:0033017	Component	Sarcoplasmic reticulum membrane	TAS
GO:0046872	Function	Metal ion binding	IEA
GO:0051823	Process	Regulation of synapse structural plasticity	IEA
GO:0106310	Function	Protein serine kinase activity	IEA

Other IDs

• MIM: 605377
• HGNC: 2933
• e!Ensembl: ENSG00000104936

Protein

• UniProt ID: Q09013
• Protein name: Myotonin-protein kinase (MT-PK) (EC 2.7.11.1) (DM-kinase) (DMK) (DM1 protein kinase) (DMPK) (Myotonic dystrophy protein kinase)
• Protein function: Non-receptor serine/threonine protein kinase which is necessary for the maintenance of skeletal muscle structure and function. May play a role in myocyte differentiation and survival by regulating the integrity of the nuclear envelope and the ex
• PDB: 1WT6, 2VD5
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00069	Pkinase	71 → 339	Protein kinase domain	Domain
  PF08826	DMPK_coil	470 → 530	DMPK coiled coil domain like	Coiled-coil

• Tissue specificity: TISSUE SPECIFICITY: Most isoforms are expressed in many tissues including heart, skeletal muscle, liver and brain, except for isoform 2 which is only found in the heart and skeletal muscle, and isoform 14 which is only found in the brain, with high levels
• Sequence:

  MSAEVRLRRLQQLVLDPGFLGLEPLLDLLLGVHQELGASELAQDKYVADFLQWAEPIVVR
  LKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREER
  DVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIV
  MAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSP
  EILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLP
  LVDEGVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPPFTPDFEG
  ATDTCNFDLVEDGLTAMVSGGGETLSDIREGAPLGVHLPFVGYSYSCMALRDSEVPGPTP
  MELEAEQLLEPHVQAPSLEPSVSPQDETAEVAVPAAVPAAEAEAEVTLRELQEALEEEVL
  TRQSLSREMEAIRTDNQNFASQLREAEARNRDLEAHVRQLQERMELLQAEGATAVTGVPS
  PRATDPPSHLDGPPAVAVGQCPLVGPGPMHRRHLLLPARVPRPGLSEALSLLLFAVVLSR
  AAALGCIGLVAHAGQLTAVWRRPGAARAP

• Sequence length: 629

Pathways

Reactome:

Ion homeostasis

Associated diseases

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Catecholaminergic polymorphic ventricular tachycardia 1	Uncertain significance	rs766818029	RCV000208175
DMPK-related disorder	Benign; Likely benign	rs527221, rs147014815, rs182565629, rs143006643, rs771536499, rs147815859, rs1349414063, rs1969449509, rs113426968, rs140685882, rs140030942, rs766547162, rs201332435, rs142936719, rs78771765	RCV003975018 RCV003929788 RCV003904047 RCV003914109 RCV003944135 RCV003961805 RCV003963917 RCV003949678 RCV003947141 RCV003949434 RCV003936871 RCV003946851 RCV003934649 RCV003971804 RCV003915686
Familial cancer of breast	Benign	rs1799894	RCV005888053
Gastric cancer	Likely benign; Uncertain significance	rs143006643, rs199731275	RCV005936906 RCV005937444
Hepatocellular carcinoma	Benign	rs1799894	RCV005888054
Myotonic dystrophy	Likely benign; Uncertain significance	rs78771765, rs747348407, rs536277584	RCV000590940 RCV000590931 RCV000662180
Noonan syndrome	Uncertain significance	rs752437441	RCV000208532
Steinert myotonic dystrophy syndrome	Benign; Uncertain significance; Likely benign	rs1799894, rs1403210034, rs192671827, rs200491028, rs530588467, rs149990515, rs750614096, rs200760629, rs780659624, rs1003871860, rs762280354, rs1310210930, rs1600444823	RCV000610817 RCV003146180 RCV003146181 RCV003146182 RCV003146183 RCV003146184 RCV003146185 RCV003146186 RCV000415714 RCV000626249 RCV000714720 RCV000785076 RCV000791205

Associations from Text Mining
Disease Name	Relationship Type	References
Adrenal Insufficiency	Associate	16376058
Arrhythmias Cardiac	Associate	27182706
Autistic Disorder	Associate	32717741
CANVAS syndrome	Associate	40113266
Cardiomyopathies	Associate	27182706
Cardiomyopathy Dilated	Associate	23349452
Cataract	Associate	10434869
Disease	Associate	34372915
Dystonia	Associate	21868014
Fasciculation	Associate	12598332
Hearing Loss	Associate	19321466
Heart Diseases	Associate	25958258
Heart Septal Defects Atrial	Associate	17652903
Insulinoma	Associate	10411358
Muscle Hypotonia	Associate	27353517
Muscular Atrophy	Associate	21949239
Muscular Dystrophies	Associate	21949239
Muscular Dystrophies Limb Girdle	Associate	39232665
Myalgia	Associate	21868014
Myocardial Infarction	Associate	19321466
Myotonia	Associate	33682722
Myotonic Dystrophy	Associate	10434869, 11433021, 12150906, 12718910, 12970845, 14627806, 14730559, 15114529, 15185171, 15489504, 15546872, 15576360, 15722335, 15750273, 16027111, 16376058, 16487687, 17825047, 19321466, 19546810, 20171614, 20228473, 21868014, 21949239, 22218462, 22643181, 23025897, 23159592, 23166594, 23680132, 23853500, 24440524, 24781112, 24824895, 25684273, 25702800, 26036855, 26190529, 26708183, 26756355, 26919350, 27222292, 27253733, 27346000, 27346009, 27733504, 27854230, 27876818, 28257691, 28363916, 28435090, 28886202, 29114849, 29274549, 29334465, 29651162, 29947794, 29955039, 29967337, 30216892, 30274788, 30700578, 30760283, 31010208, 31027145, 31048891, 31116797, 31164682, 31220271, 31227653, 31395669, 31608518, 31759551, 31766224, 31965181, 32074227, 32155193, 32203199, 32287265, 32407311, 32607474, 32645888, 32823742, 33472919, 33530452, 33624941, 33682722, 34114984, 34776509, 34915310, 35741732, 35767654, 36011377, 36099027, 36222125, 36352383, 36767649, 36883684, 37373276, 37638448, 37871474, 38050269, 38270551, 39326259, 39373365, 39383229, 39710066, 40004498, 40113266, 40296143, 7726160, 7896884, 8659513, 8948631, 9094985, 9207101, 9207102, 9463318, 9950368
Myotonic Dystrophy	Inhibit	12598332
Neoplastic Syndromes Hereditary	Associate	39232665
Neuromuscular Diseases	Associate	24269018, 32717741, 9207101
Oncogene Addiction	Associate	33077317
Pulmonary Disease Chronic Obstructive	Associate	29547942
Sensorimotor neuropathy with ataxia autosomal dominant	Associate	19321466
Sick Sinus Syndrome	Associate	27182706