Gene Gene information from NCBI Gene database.
Entrez ID 1750
Gene name Distal-less homeobox 6
Gene symbol DLX6
Synonyms (NCBI Gene)
-
Chromosome 7
Chromosome location 7q21.3
Summary This gene encodes a member of a homeobox transcription factor gene family similiar to the Drosophila distal-less gene. This family is comprised of at least 6 different members that encode proteins with roles in forebrain and craniofacial development. This
miRNA miRNA information provided by mirtarbase database.
432
miRTarBase ID miRNA Experiments Reference
MIRT019311 hsa-miR-148b-3p Microarray 17612493
MIRT049253 hsa-miR-92a-3p CLASH 23622248
MIRT452367 hsa-miR-4428 PAR-CLIP 20371350
MIRT452365 hsa-miR-6758-5p PAR-CLIP 20371350
MIRT452364 hsa-miR-6856-5p PAR-CLIP 20371350
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
23
GO ID Ontology Definition Evidence Reference
GO:0000785 Component Chromatin ISA
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
GO:0000981 Function DNA-binding transcription factor activity, RNA polymerase II-specific IBA
GO:0000981 Function DNA-binding transcription factor activity, RNA polymerase II-specific IEA
GO:0000981 Function DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
600030 2919 ENSG00000006377
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P56179
Protein name Homeobox protein DLX-6
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00046 Homeodomain 50 106 Homeodomain Domain
Sequence
MSHSQHSPYLQSYHNSSAAAQTRGDDTDQQKTTVIENGEIRFNGKGKKIRKPRTIYSSLQ
LQALNHRFQQTQYLALPERAELAASLGLTQTQVKIWFQNKRSKFKK
LLKQGSNPHESDPL
QGSAALSPRSPALPPVWDVSASAKGVSMPPNSYMPGYSHWYSSPHQDTMQRPQMM
Sequence length 175
Interactions View interactions
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
14
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
DLX6-related disorder Uncertain significance; Benign; Likely benign rs530625473, rs559903070, rs191859647, rs747232821, rs753286015, rs553310103, rs761942448, rs549707573, rs1408021135, rs749816102 RCV003923398
RCV003984210
RCV003903377
RCV003973513
RCV003898571
RCV003973547
RCV003906379
RCV003929241
RCV003929330
RCV003893361
RCV003931845
RCV003904602
RCV003944759
RCV003925992
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 35668376
Astrocytoma Associate 32108034
Auriculo condylar syndrome Associate 22560091
Autism Spectrum Disorder Associate 28321286
Breast Neoplasms Associate 35668376
Carcinogenesis Associate 28881158
Carcinoma Adenoid Cystic Associate 26953815
Carcinoma Hepatocellular Associate 30805988, 36204642
Carcinoma Ovarian Epithelial Associate 31081076
Carcinoma Renal Cell Associate 28881158