DIO2 (iodothyronine deiodinase 2)

Gene

• Entrez ID: 1734
• Gene name: Iodothyronine deiodinase 2
• Gene symbol: DIO2
• Synonyms (NCBI Gene): 5DII, D2, DIOII, SELENOY, SelY, TXDI2
• Chromosome: 14
• Chromosome location: 14q31.1
• Summary: The protein encoded by this gene belongs to the iodothyronine deiodinase family. It catalyzes the conversion of prohormone thyroxine (3,5,3`,5`-tetraiodothyronine, T4) to the bioactive thyroid hormone (3,5,3`-triiodothyronine, T3) by outer ring 5`-deiodin

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT668748	hsa-miR-4453	HITS-CLIP	23824327
MIRT668747	hsa-miR-4538	HITS-CLIP	23824327
MIRT668746	hsa-miR-5193	HITS-CLIP	23824327
MIRT668745	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT668744	hsa-miR-3124-3p	HITS-CLIP	23824327
MIRT668743	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT668742	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT668741	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT668740	hsa-miR-1257	HITS-CLIP	23824327
MIRT668739	hsa-miR-5571-3p	HITS-CLIP	23824327
MIRT668738	hsa-miR-7975	HITS-CLIP	23824327
MIRT668737	hsa-miR-4727-5p	HITS-CLIP	23824327
MIRT668736	hsa-miR-5001-3p	HITS-CLIP	23824327
MIRT668735	hsa-miR-6836-3p	HITS-CLIP	23824327
MIRT668734	hsa-miR-3685	HITS-CLIP	23824327
MIRT668733	hsa-miR-384	HITS-CLIP	23824327
MIRT668732	hsa-miR-544a	HITS-CLIP	23824327
MIRT668731	hsa-miR-6738-3p	HITS-CLIP	23824327
MIRT628266	hsa-miR-548e-5p	HITS-CLIP	23824327
MIRT628265	hsa-miR-4282	HITS-CLIP	23824327
MIRT628264	hsa-miR-5009-3p	HITS-CLIP	23824327
MIRT668748	hsa-miR-4453	HITS-CLIP	23824327
MIRT668747	hsa-miR-4538	HITS-CLIP	23824327
MIRT668746	hsa-miR-5193	HITS-CLIP	23824327
MIRT668745	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT668744	hsa-miR-3124-3p	HITS-CLIP	23824327
MIRT668743	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT668742	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT668741	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT668740	hsa-miR-1257	HITS-CLIP	23824327
MIRT668739	hsa-miR-5571-3p	HITS-CLIP	23824327
MIRT668738	hsa-miR-7975	HITS-CLIP	23824327
MIRT668737	hsa-miR-4727-5p	HITS-CLIP	23824327
MIRT668736	hsa-miR-5001-3p	HITS-CLIP	23824327
MIRT668735	hsa-miR-6836-3p	HITS-CLIP	23824327
MIRT668734	hsa-miR-3685	HITS-CLIP	23824327
MIRT668733	hsa-miR-384	HITS-CLIP	23824327
MIRT668732	hsa-miR-544a	HITS-CLIP	23824327
MIRT668731	hsa-miR-6738-3p	HITS-CLIP	23824327
MIRT628266	hsa-miR-548e-5p	HITS-CLIP	23824327
MIRT628265	hsa-miR-4282	HITS-CLIP	23824327
MIRT628264	hsa-miR-5009-3p	HITS-CLIP	23824327
MIRT936584	hsa-miR-297	CLIP-seq
MIRT936585	hsa-miR-3176	CLIP-seq
MIRT936586	hsa-miR-3922-3p	CLIP-seq
MIRT936587	hsa-miR-4307	CLIP-seq
MIRT936588	hsa-miR-4312	CLIP-seq
MIRT936589	hsa-miR-567	CLIP-seq
MIRT936590	hsa-miR-581	CLIP-seq
MIRT936591	hsa-miR-4269	CLIP-seq
MIRT936592	hsa-miR-450b-5p	CLIP-seq
MIRT936593	hsa-miR-4514	CLIP-seq
MIRT936594	hsa-miR-4641	CLIP-seq
MIRT936595	hsa-miR-4692	CLIP-seq
MIRT936596	hsa-miR-4698	CLIP-seq
MIRT936597	hsa-miR-4742-5p	CLIP-seq
MIRT936598	hsa-miR-507	CLIP-seq
MIRT936599	hsa-miR-510	CLIP-seq
MIRT936600	hsa-miR-557	CLIP-seq
MIRT936601	hsa-miR-1179	CLIP-seq
MIRT936602	hsa-miR-125a-5p	CLIP-seq
MIRT936603	hsa-miR-125b	CLIP-seq
MIRT936604	hsa-miR-3150a-3p	CLIP-seq
MIRT936605	hsa-miR-3175	CLIP-seq
MIRT936606	hsa-miR-3618	CLIP-seq
MIRT936607	hsa-miR-3651	CLIP-seq
MIRT936608	hsa-miR-374a	CLIP-seq
MIRT936609	hsa-miR-374b	CLIP-seq
MIRT936610	hsa-miR-4319	CLIP-seq
MIRT936611	hsa-miR-4426	CLIP-seq
MIRT936612	hsa-miR-4470	CLIP-seq
MIRT936613	hsa-miR-4528	CLIP-seq
MIRT936594	hsa-miR-4641	CLIP-seq
MIRT936614	hsa-miR-4647	CLIP-seq
MIRT936615	hsa-miR-4662b	CLIP-seq
MIRT936616	hsa-miR-4691-5p	CLIP-seq
MIRT936617	hsa-miR-4732-3p	CLIP-seq
MIRT936618	hsa-miR-670	CLIP-seq
MIRT936619	hsa-miR-759	CLIP-seq
MIRT936620	hsa-miR-939	CLIP-seq
MIRT1556223	hsa-miR-134	CLIP-seq
MIRT1556224	hsa-miR-3118	CLIP-seq
MIRT1556225	hsa-miR-668	CLIP-seq
MIRT1556226	hsa-miR-943	CLIP-seq
MIRT936602	hsa-miR-125a-5p	CLIP-seq
MIRT936603	hsa-miR-125b	CLIP-seq
MIRT936607	hsa-miR-3651	CLIP-seq
MIRT936610	hsa-miR-4319	CLIP-seq
MIRT936616	hsa-miR-4691-5p	CLIP-seq
MIRT936617	hsa-miR-4732-3p	CLIP-seq
MIRT936618	hsa-miR-670	CLIP-seq
MIRT936602	hsa-miR-125a-5p	CLIP-seq
MIRT936603	hsa-miR-125b	CLIP-seq
MIRT936607	hsa-miR-3651	CLIP-seq
MIRT936610	hsa-miR-4319	CLIP-seq
MIRT936616	hsa-miR-4691-5p	CLIP-seq
MIRT936617	hsa-miR-4732-3p	CLIP-seq
MIRT936618	hsa-miR-670	CLIP-seq
MIRT936602	hsa-miR-125a-5p	CLIP-seq
MIRT936603	hsa-miR-125b	CLIP-seq
MIRT936607	hsa-miR-3651	CLIP-seq
MIRT936610	hsa-miR-4319	CLIP-seq
MIRT936616	hsa-miR-4691-5p	CLIP-seq
MIRT936617	hsa-miR-4732-3p	CLIP-seq
MIRT936618	hsa-miR-670	CLIP-seq
MIRT1977136	hsa-miR-4802-3p	CLIP-seq
MIRT1977137	hsa-miR-548a-5p	CLIP-seq
MIRT1977138	hsa-miR-548ab	CLIP-seq
MIRT1977139	hsa-miR-548ak	CLIP-seq
MIRT1977140	hsa-miR-548b-5p	CLIP-seq
MIRT1977141	hsa-miR-548c-5p	CLIP-seq
MIRT1977142	hsa-miR-548d-5p	CLIP-seq
MIRT1977143	hsa-miR-548h	CLIP-seq
MIRT1977144	hsa-miR-548i	CLIP-seq
MIRT1977145	hsa-miR-548j	CLIP-seq
MIRT1977146	hsa-miR-548n	CLIP-seq
MIRT1977147	hsa-miR-548w	CLIP-seq
MIRT1977148	hsa-miR-548y	CLIP-seq
MIRT1977149	hsa-miR-559	CLIP-seq
MIRT1977150	hsa-miR-944	CLIP-seq
MIRT2212514	hsa-miR-4666-3p	CLIP-seq
MIRT2212515	hsa-miR-3123	CLIP-seq
MIRT2212516	hsa-miR-3973	CLIP-seq
MIRT2212517	hsa-miR-4477a	CLIP-seq
MIRT2212518	hsa-miR-4729	CLIP-seq
MIRT2212519	hsa-miR-579	CLIP-seq
MIRT2212520	hsa-miR-629	CLIP-seq
MIRT2212521	hsa-miR-935	CLIP-seq
MIRT2516249	hsa-miR-1323	CLIP-seq
MIRT2516250	hsa-miR-216a	CLIP-seq
MIRT2516251	hsa-miR-3164	CLIP-seq
MIRT2516252	hsa-miR-4434	CLIP-seq
MIRT2516253	hsa-miR-4516	CLIP-seq
MIRT2516254	hsa-miR-4677-5p	CLIP-seq
MIRT2212518	hsa-miR-4729	CLIP-seq
MIRT2516255	hsa-miR-502-5p	CLIP-seq
MIRT2516256	hsa-miR-544	CLIP-seq
MIRT2516257	hsa-miR-548o	CLIP-seq
MIRT2516258	hsa-miR-659	CLIP-seq
MIRT2212521	hsa-miR-935	CLIP-seq
MIRT2516259	hsa-miR-103a	CLIP-seq
MIRT2516260	hsa-miR-107	CLIP-seq
MIRT2516261	hsa-miR-1178	CLIP-seq
MIRT2516262	hsa-miR-1202	CLIP-seq
MIRT2516263	hsa-miR-1229	CLIP-seq
MIRT2516264	hsa-miR-1237	CLIP-seq
MIRT2516265	hsa-miR-1243	CLIP-seq
MIRT2516266	hsa-miR-1244	CLIP-seq
MIRT2516267	hsa-miR-1245b-3p	CLIP-seq
MIRT2516268	hsa-miR-1253	CLIP-seq
MIRT2516269	hsa-miR-1254	CLIP-seq
MIRT2516270	hsa-miR-1261	CLIP-seq
MIRT2516271	hsa-miR-1264	CLIP-seq
MIRT2516272	hsa-miR-1266	CLIP-seq
MIRT2516273	hsa-miR-1278	CLIP-seq
MIRT2516274	hsa-miR-1280	CLIP-seq
MIRT2516275	hsa-miR-1284	CLIP-seq
MIRT2516276	hsa-miR-1301	CLIP-seq
MIRT2516277	hsa-miR-1304	CLIP-seq
MIRT2516278	hsa-miR-1305	CLIP-seq
MIRT2516249	hsa-miR-1323	CLIP-seq
MIRT1556223	hsa-miR-134	CLIP-seq
MIRT2516279	hsa-miR-142-5p	CLIP-seq
MIRT2516280	hsa-miR-147b	CLIP-seq
MIRT2516281	hsa-miR-150	CLIP-seq
MIRT2516282	hsa-miR-1587	CLIP-seq
MIRT2516283	hsa-miR-190	CLIP-seq
MIRT2516284	hsa-miR-190b	CLIP-seq
MIRT2516285	hsa-miR-1912	CLIP-seq
MIRT2516286	hsa-miR-193a-3p	CLIP-seq
MIRT2516287	hsa-miR-193a-5p	CLIP-seq
MIRT2516288	hsa-miR-193b	CLIP-seq
MIRT2516289	hsa-miR-197	CLIP-seq
MIRT2516290	hsa-miR-199a-3p	CLIP-seq
MIRT2516291	hsa-miR-199b-3p	CLIP-seq
MIRT2516292	hsa-miR-205	CLIP-seq
MIRT2516293	hsa-miR-2052	CLIP-seq
MIRT2516294	hsa-miR-208a	CLIP-seq
MIRT2516295	hsa-miR-208b	CLIP-seq
MIRT2516296	hsa-miR-2116	CLIP-seq
MIRT2516250	hsa-miR-216a	CLIP-seq
MIRT2516297	hsa-miR-216b	CLIP-seq
MIRT2516298	hsa-miR-223	CLIP-seq
MIRT2516299	hsa-miR-224	CLIP-seq
MIRT2516300	hsa-miR-2276	CLIP-seq
MIRT2516301	hsa-miR-23a	CLIP-seq
MIRT2516302	hsa-miR-23b	CLIP-seq
MIRT2516303	hsa-miR-23c	CLIP-seq
MIRT2516304	hsa-miR-2861	CLIP-seq
MIRT2516305	hsa-miR-300	CLIP-seq
MIRT2516306	hsa-miR-302f	CLIP-seq
MIRT2516307	hsa-miR-3116	CLIP-seq
MIRT1556224	hsa-miR-3118	CLIP-seq
MIRT2516308	hsa-miR-3119	CLIP-seq
MIRT2516309	hsa-miR-3120-5p	CLIP-seq
MIRT2516310	hsa-miR-3122	CLIP-seq
MIRT2212515	hsa-miR-3123	CLIP-seq
MIRT2516311	hsa-miR-3127-3p	CLIP-seq
MIRT2516312	hsa-miR-3127-5p	CLIP-seq
MIRT2516313	hsa-miR-3129-3p	CLIP-seq
MIRT2516314	hsa-miR-3129-5p	CLIP-seq
MIRT2516315	hsa-miR-3130-3p	CLIP-seq
MIRT2516316	hsa-miR-3130-5p	CLIP-seq
MIRT2516317	hsa-miR-3135	CLIP-seq
MIRT2516318	hsa-miR-3136-3p	CLIP-seq
MIRT936604	hsa-miR-3150a-3p	CLIP-seq
MIRT2516319	hsa-miR-3150a-5p	CLIP-seq
MIRT2516320	hsa-miR-3150b-5p	CLIP-seq
MIRT2516321	hsa-miR-3157-5p	CLIP-seq
MIRT2516322	hsa-miR-3160-5p	CLIP-seq
MIRT2516323	hsa-miR-3162-3p	CLIP-seq
MIRT2516251	hsa-miR-3164	CLIP-seq
MIRT2516324	hsa-miR-3173-3p	CLIP-seq
MIRT2516325	hsa-miR-3174	CLIP-seq
MIRT936605	hsa-miR-3175	CLIP-seq
MIRT2516326	hsa-miR-3181	CLIP-seq
MIRT2516327	hsa-miR-3182	CLIP-seq
MIRT2516328	hsa-miR-3184	CLIP-seq
MIRT2516329	hsa-miR-3194-3p	CLIP-seq
MIRT2516330	hsa-miR-3194-5p	CLIP-seq
MIRT2516331	hsa-miR-3200-3p	CLIP-seq
MIRT2516332	hsa-miR-3200-5p	CLIP-seq
MIRT2516333	hsa-miR-3201	CLIP-seq
MIRT2516334	hsa-miR-320e	CLIP-seq
MIRT2516335	hsa-miR-323-3p	CLIP-seq
MIRT2516336	hsa-miR-330-3p	CLIP-seq
MIRT2516337	hsa-miR-340	CLIP-seq
MIRT2516338	hsa-miR-3529	CLIP-seq
MIRT2516339	hsa-miR-361-3p	CLIP-seq
MIRT2516340	hsa-miR-3614-3p	CLIP-seq
MIRT2516341	hsa-miR-3654	CLIP-seq
MIRT2516342	hsa-miR-3660	CLIP-seq
MIRT2516343	hsa-miR-3664-5p	CLIP-seq
MIRT2516344	hsa-miR-3667-3p	CLIP-seq
MIRT2516345	hsa-miR-3671	CLIP-seq
MIRT2516346	hsa-miR-3677-5p	CLIP-seq
MIRT2516347	hsa-miR-374c	CLIP-seq
MIRT2516348	hsa-miR-376c	CLIP-seq
MIRT2516349	hsa-miR-379	CLIP-seq
MIRT2516350	hsa-miR-381	CLIP-seq
MIRT2516351	hsa-miR-3913-5p	CLIP-seq
MIRT2516352	hsa-miR-3914	CLIP-seq
MIRT2516353	hsa-miR-3918	CLIP-seq
MIRT2516354	hsa-miR-3925-5p	CLIP-seq
MIRT2516355	hsa-miR-3926	CLIP-seq
MIRT2516356	hsa-miR-3938	CLIP-seq
MIRT2516357	hsa-miR-3944-3p	CLIP-seq
MIRT2516358	hsa-miR-3972	CLIP-seq
MIRT2212516	hsa-miR-3973	CLIP-seq
MIRT2516359	hsa-miR-3976	CLIP-seq
MIRT2516360	hsa-miR-3977	CLIP-seq
MIRT2516361	hsa-miR-412	CLIP-seq
MIRT2516362	hsa-miR-423-5p	CLIP-seq
MIRT2516363	hsa-miR-4251	CLIP-seq
MIRT2516364	hsa-miR-4254	CLIP-seq
MIRT2516365	hsa-miR-4270	CLIP-seq
MIRT2516366	hsa-miR-4273	CLIP-seq
MIRT2516367	hsa-miR-4274	CLIP-seq
MIRT2516368	hsa-miR-4279	CLIP-seq
MIRT2516369	hsa-miR-4287	CLIP-seq
MIRT2516370	hsa-miR-4292	CLIP-seq
MIRT2516371	hsa-miR-4297	CLIP-seq
MIRT2516372	hsa-miR-4299	CLIP-seq
MIRT2516373	hsa-miR-4302	CLIP-seq
MIRT936587	hsa-miR-4307	CLIP-seq
MIRT2516374	hsa-miR-4308	CLIP-seq
MIRT936588	hsa-miR-4312	CLIP-seq
MIRT2516375	hsa-miR-4318	CLIP-seq
MIRT2516376	hsa-miR-4329	CLIP-seq
MIRT2516377	hsa-miR-4330	CLIP-seq
MIRT936611	hsa-miR-4426	CLIP-seq
MIRT2516378	hsa-miR-4428	CLIP-seq
MIRT2516252	hsa-miR-4434	CLIP-seq
MIRT2516379	hsa-miR-4436b-3p	CLIP-seq
MIRT2516380	hsa-miR-4441	CLIP-seq
MIRT2516381	hsa-miR-4449	CLIP-seq
MIRT2516382	hsa-miR-4451	CLIP-seq
MIRT2516383	hsa-miR-4456	CLIP-seq
MIRT2516384	hsa-miR-4462	CLIP-seq
MIRT2516385	hsa-miR-4468	CLIP-seq
MIRT2516386	hsa-miR-4469	CLIP-seq
MIRT936612	hsa-miR-4470	CLIP-seq
MIRT2516387	hsa-miR-4476	CLIP-seq
MIRT2516388	hsa-miR-4477b	CLIP-seq
MIRT2516389	hsa-miR-4482	CLIP-seq
MIRT2516390	hsa-miR-4487	CLIP-seq
MIRT2516391	hsa-miR-4490	CLIP-seq
MIRT2516392	hsa-miR-4494	CLIP-seq
MIRT2516393	hsa-miR-4499	CLIP-seq
MIRT2516394	hsa-miR-4501	CLIP-seq
MIRT2516395	hsa-miR-4504	CLIP-seq
MIRT2516396	hsa-miR-4512	CLIP-seq
MIRT2516253	hsa-miR-4516	CLIP-seq
MIRT2516397	hsa-miR-4518	CLIP-seq
MIRT2516398	hsa-miR-452	CLIP-seq
MIRT2516399	hsa-miR-4521	CLIP-seq
MIRT2516400	hsa-miR-4522	CLIP-seq
MIRT2516401	hsa-miR-4526	CLIP-seq
MIRT2516402	hsa-miR-4531	CLIP-seq
MIRT2516403	hsa-miR-4633-3p	CLIP-seq
MIRT2516404	hsa-miR-4637	CLIP-seq
MIRT2516405	hsa-miR-4639-3p	CLIP-seq
MIRT2516406	hsa-miR-4643	CLIP-seq
MIRT936614	hsa-miR-4647	CLIP-seq
MIRT2516407	hsa-miR-4650-3p	CLIP-seq
MIRT2516408	hsa-miR-4659a-3p	CLIP-seq
MIRT2516409	hsa-miR-4659b-3p	CLIP-seq
MIRT2516410	hsa-miR-466	CLIP-seq
MIRT936615	hsa-miR-4662b	CLIP-seq
MIRT2212514	hsa-miR-4666-3p	CLIP-seq
MIRT2516411	hsa-miR-4674	CLIP-seq
MIRT2516412	hsa-miR-4676-3p	CLIP-seq
MIRT2516413	hsa-miR-4676-5p	CLIP-seq
MIRT2516414	hsa-miR-4677-3p	CLIP-seq
MIRT2516254	hsa-miR-4677-5p	CLIP-seq
MIRT2516415	hsa-miR-4679	CLIP-seq
MIRT2516416	hsa-miR-4685-3p	CLIP-seq
MIRT2516417	hsa-miR-4686	CLIP-seq
MIRT2516418	hsa-miR-4687-5p	CLIP-seq
MIRT2516419	hsa-miR-4693-5p	CLIP-seq
MIRT2516420	hsa-miR-4709-5p	CLIP-seq
MIRT2516421	hsa-miR-4713-5p	CLIP-seq
MIRT2516422	hsa-miR-4716-3p	CLIP-seq
MIRT2516423	hsa-miR-4723-5p	CLIP-seq
MIRT2516424	hsa-miR-4728-5p	CLIP-seq
MIRT2212518	hsa-miR-4729	CLIP-seq
MIRT2516425	hsa-miR-4737	CLIP-seq
MIRT2516426	hsa-miR-4738-3p	CLIP-seq
MIRT2516427	hsa-miR-4750	CLIP-seq
MIRT2516428	hsa-miR-4755-3p	CLIP-seq
MIRT2516429	hsa-miR-4761-3p	CLIP-seq
MIRT2516430	hsa-miR-4762-5p	CLIP-seq
MIRT2516431	hsa-miR-4767	CLIP-seq
MIRT2516432	hsa-miR-4772-3p	CLIP-seq
MIRT2516433	hsa-miR-4774-5p	CLIP-seq
MIRT2516434	hsa-miR-4781-3p	CLIP-seq
MIRT2516435	hsa-miR-4785	CLIP-seq
MIRT2516436	hsa-miR-4786-5p	CLIP-seq
MIRT2516437	hsa-miR-4789-3p	CLIP-seq
MIRT2516438	hsa-miR-4789-5p	CLIP-seq
MIRT2516439	hsa-miR-4791	CLIP-seq
MIRT2516440	hsa-miR-4793-3p	CLIP-seq
MIRT2516441	hsa-miR-4793-5p	CLIP-seq
MIRT2516442	hsa-miR-4795-5p	CLIP-seq
MIRT1977136	hsa-miR-4802-3p	CLIP-seq
MIRT2516443	hsa-miR-483-5p	CLIP-seq
MIRT2516444	hsa-miR-487b	CLIP-seq
MIRT2516445	hsa-miR-494	CLIP-seq
MIRT2516446	hsa-miR-499a-5p	CLIP-seq
MIRT2516447	hsa-miR-501-3p	CLIP-seq
MIRT2516448	hsa-miR-502-3p	CLIP-seq
MIRT2516255	hsa-miR-502-5p	CLIP-seq
MIRT2516449	hsa-miR-5047	CLIP-seq
MIRT2516450	hsa-miR-509-3p	CLIP-seq
MIRT2516451	hsa-miR-517b	CLIP-seq
MIRT2516452	hsa-miR-520d-5p	CLIP-seq
MIRT2516453	hsa-miR-524-5p	CLIP-seq
MIRT2516454	hsa-miR-526b	CLIP-seq
MIRT2516455	hsa-miR-532-3p	CLIP-seq
MIRT2516456	hsa-miR-543	CLIP-seq
MIRT2516256	hsa-miR-544	CLIP-seq
MIRT2516457	hsa-miR-548a-3p	CLIP-seq
MIRT1977137	hsa-miR-548a-5p	CLIP-seq
MIRT2516458	hsa-miR-548aa	CLIP-seq
MIRT1977138	hsa-miR-548ab	CLIP-seq
MIRT2516459	hsa-miR-548ac	CLIP-seq
MIRT2516460	hsa-miR-548ae	CLIP-seq
MIRT2516461	hsa-miR-548aj	CLIP-seq
MIRT1977139	hsa-miR-548ak	CLIP-seq
MIRT2516462	hsa-miR-548am	CLIP-seq
MIRT1977140	hsa-miR-548b-5p	CLIP-seq
MIRT1977141	hsa-miR-548c-5p	CLIP-seq
MIRT2516463	hsa-miR-548d-3p	CLIP-seq
MIRT1977142	hsa-miR-548d-5p	CLIP-seq
MIRT2516464	hsa-miR-548e	CLIP-seq
MIRT2516465	hsa-miR-548f	CLIP-seq
MIRT1977143	hsa-miR-548h	CLIP-seq
MIRT1977144	hsa-miR-548i	CLIP-seq
MIRT1977145	hsa-miR-548j	CLIP-seq
MIRT2516466	hsa-miR-548k	CLIP-seq
MIRT2516467	hsa-miR-548l	CLIP-seq
MIRT2516257	hsa-miR-548o	CLIP-seq
MIRT2516468	hsa-miR-548q	CLIP-seq
MIRT2516469	hsa-miR-548s	CLIP-seq
MIRT1977147	hsa-miR-548w	CLIP-seq
MIRT2516470	hsa-miR-548x	CLIP-seq
MIRT1977148	hsa-miR-548y	CLIP-seq
MIRT2516471	hsa-miR-548z	CLIP-seq
MIRT1977149	hsa-miR-559	CLIP-seq
MIRT2516472	hsa-miR-575	CLIP-seq
MIRT2212519	hsa-miR-579	CLIP-seq
MIRT2516473	hsa-miR-590-3p	CLIP-seq
MIRT2516474	hsa-miR-607	CLIP-seq
MIRT2516475	hsa-miR-617	CLIP-seq
MIRT2516476	hsa-miR-627	CLIP-seq
MIRT2212520	hsa-miR-629	CLIP-seq
MIRT2516477	hsa-miR-633	CLIP-seq
MIRT2516478	hsa-miR-635	CLIP-seq
MIRT2516479	hsa-miR-642a	CLIP-seq
MIRT2516480	hsa-miR-655	CLIP-seq
MIRT2516258	hsa-miR-659	CLIP-seq
MIRT2516481	hsa-miR-663b	CLIP-seq
MIRT1556225	hsa-miR-668	CLIP-seq
MIRT2516482	hsa-miR-769-5p	CLIP-seq
MIRT2516483	hsa-miR-890	CLIP-seq
MIRT2516484	hsa-miR-891b	CLIP-seq
MIRT2516485	hsa-miR-892a	CLIP-seq
MIRT2516486	hsa-miR-9	CLIP-seq
MIRT2516487	hsa-miR-921	CLIP-seq
MIRT2516488	hsa-miR-924	CLIP-seq
MIRT2212521	hsa-miR-935	CLIP-seq
MIRT2516489	hsa-miR-936	CLIP-seq
MIRT936620	hsa-miR-939	CLIP-seq
MIRT2516249	hsa-miR-1323	CLIP-seq
MIRT2516250	hsa-miR-216a	CLIP-seq
MIRT2516252	hsa-miR-4434	CLIP-seq
MIRT2516253	hsa-miR-4516	CLIP-seq
MIRT2212518	hsa-miR-4729	CLIP-seq
MIRT2516256	hsa-miR-544	CLIP-seq
MIRT2516257	hsa-miR-548o	CLIP-seq
MIRT2516259	hsa-miR-103a	CLIP-seq
MIRT2516260	hsa-miR-107	CLIP-seq
MIRT2516261	hsa-miR-1178	CLIP-seq
MIRT2516262	hsa-miR-1202	CLIP-seq
MIRT2516263	hsa-miR-1229	CLIP-seq
MIRT2516264	hsa-miR-1237	CLIP-seq
MIRT2516265	hsa-miR-1243	CLIP-seq
MIRT2516266	hsa-miR-1244	CLIP-seq
MIRT2516268	hsa-miR-1253	CLIP-seq
MIRT2516269	hsa-miR-1254	CLIP-seq
MIRT2516271	hsa-miR-1264	CLIP-seq
MIRT2516273	hsa-miR-1278	CLIP-seq
MIRT2516275	hsa-miR-1284	CLIP-seq
MIRT2516276	hsa-miR-1301	CLIP-seq
MIRT2516277	hsa-miR-1304	CLIP-seq
MIRT2516278	hsa-miR-1305	CLIP-seq
MIRT2516249	hsa-miR-1323	CLIP-seq
MIRT1556223	hsa-miR-134	CLIP-seq
MIRT2516279	hsa-miR-142-5p	CLIP-seq
MIRT2516282	hsa-miR-1587	CLIP-seq
MIRT2516285	hsa-miR-1912	CLIP-seq
MIRT2516286	hsa-miR-193a-3p	CLIP-seq
MIRT2516288	hsa-miR-193b	CLIP-seq
MIRT2516289	hsa-miR-197	CLIP-seq
MIRT2516290	hsa-miR-199a-3p	CLIP-seq
MIRT2516291	hsa-miR-199b-3p	CLIP-seq
MIRT2516292	hsa-miR-205	CLIP-seq
MIRT2516293	hsa-miR-2052	CLIP-seq
MIRT2516298	hsa-miR-223	CLIP-seq
MIRT2516299	hsa-miR-224	CLIP-seq
MIRT2516301	hsa-miR-23a	CLIP-seq
MIRT2516302	hsa-miR-23b	CLIP-seq
MIRT2516303	hsa-miR-23c	CLIP-seq
MIRT2516304	hsa-miR-2861	CLIP-seq
MIRT2516305	hsa-miR-300	CLIP-seq
MIRT2516306	hsa-miR-302f	CLIP-seq
MIRT2516307	hsa-miR-3116	CLIP-seq
MIRT1556224	hsa-miR-3118	CLIP-seq
MIRT2516308	hsa-miR-3119	CLIP-seq
MIRT2516309	hsa-miR-3120-5p	CLIP-seq
MIRT2212515	hsa-miR-3123	CLIP-seq
MIRT2516311	hsa-miR-3127-3p	CLIP-seq
MIRT2516313	hsa-miR-3129-3p	CLIP-seq
MIRT2516314	hsa-miR-3129-5p	CLIP-seq
MIRT2516315	hsa-miR-3130-3p	CLIP-seq
MIRT2516316	hsa-miR-3130-5p	CLIP-seq
MIRT2516318	hsa-miR-3136-3p	CLIP-seq
MIRT936604	hsa-miR-3150a-3p	CLIP-seq
MIRT2516321	hsa-miR-3157-5p	CLIP-seq
MIRT2516323	hsa-miR-3162-3p	CLIP-seq
MIRT2516251	hsa-miR-3164	CLIP-seq
MIRT2516324	hsa-miR-3173-3p	CLIP-seq
MIRT2516325	hsa-miR-3174	CLIP-seq
MIRT936605	hsa-miR-3175	CLIP-seq
MIRT2516326	hsa-miR-3181	CLIP-seq
MIRT2516327	hsa-miR-3182	CLIP-seq
MIRT2516328	hsa-miR-3184	CLIP-seq
MIRT2516331	hsa-miR-3200-3p	CLIP-seq
MIRT2516337	hsa-miR-340	CLIP-seq
MIRT2516339	hsa-miR-361-3p	CLIP-seq
MIRT2516340	hsa-miR-3614-3p	CLIP-seq
MIRT2516341	hsa-miR-3654	CLIP-seq
MIRT2516344	hsa-miR-3667-3p	CLIP-seq
MIRT2516345	hsa-miR-3671	CLIP-seq
MIRT2516346	hsa-miR-3677-5p	CLIP-seq
MIRT2516347	hsa-miR-374c	CLIP-seq
MIRT2516350	hsa-miR-381	CLIP-seq
MIRT2516352	hsa-miR-3914	CLIP-seq
MIRT2516355	hsa-miR-3926	CLIP-seq
MIRT2516356	hsa-miR-3938	CLIP-seq
MIRT2516357	hsa-miR-3944-3p	CLIP-seq
MIRT2516358	hsa-miR-3972	CLIP-seq
MIRT2212516	hsa-miR-3973	CLIP-seq
MIRT2516360	hsa-miR-3977	CLIP-seq
MIRT2516361	hsa-miR-412	CLIP-seq
MIRT2516362	hsa-miR-423-5p	CLIP-seq
MIRT2516364	hsa-miR-4254	CLIP-seq
MIRT2516365	hsa-miR-4270	CLIP-seq
MIRT2516368	hsa-miR-4279	CLIP-seq
MIRT2516369	hsa-miR-4287	CLIP-seq
MIRT2516371	hsa-miR-4297	CLIP-seq
MIRT2516372	hsa-miR-4299	CLIP-seq
MIRT936587	hsa-miR-4307	CLIP-seq
MIRT936611	hsa-miR-4426	CLIP-seq
MIRT2516378	hsa-miR-4428	CLIP-seq
MIRT2516252	hsa-miR-4434	CLIP-seq
MIRT2516379	hsa-miR-4436b-3p	CLIP-seq
MIRT2516380	hsa-miR-4441	CLIP-seq
MIRT2516381	hsa-miR-4449	CLIP-seq
MIRT2516383	hsa-miR-4456	CLIP-seq
MIRT2516386	hsa-miR-4469	CLIP-seq
MIRT936612	hsa-miR-4470	CLIP-seq
MIRT2516387	hsa-miR-4476	CLIP-seq
MIRT2516389	hsa-miR-4482	CLIP-seq
MIRT2516391	hsa-miR-4490	CLIP-seq
MIRT2516394	hsa-miR-4501	CLIP-seq
MIRT2516395	hsa-miR-4504	CLIP-seq
MIRT2516253	hsa-miR-4516	CLIP-seq
MIRT2516399	hsa-miR-4521	CLIP-seq
MIRT2516400	hsa-miR-4522	CLIP-seq
MIRT2516402	hsa-miR-4531	CLIP-seq
MIRT2516404	hsa-miR-4637	CLIP-seq
MIRT2516406	hsa-miR-4643	CLIP-seq
MIRT936614	hsa-miR-4647	CLIP-seq
MIRT2516408	hsa-miR-4659a-3p	CLIP-seq
MIRT2516409	hsa-miR-4659b-3p	CLIP-seq
MIRT2516410	hsa-miR-466	CLIP-seq
MIRT936615	hsa-miR-4662b	CLIP-seq
MIRT2212514	hsa-miR-4666-3p	CLIP-seq
MIRT2516411	hsa-miR-4674	CLIP-seq
MIRT2516416	hsa-miR-4685-3p	CLIP-seq
MIRT2516422	hsa-miR-4716-3p	CLIP-seq
MIRT2516423	hsa-miR-4723-5p	CLIP-seq
MIRT2516424	hsa-miR-4728-5p	CLIP-seq
MIRT2212518	hsa-miR-4729	CLIP-seq
MIRT2516425	hsa-miR-4737	CLIP-seq
MIRT2516427	hsa-miR-4750	CLIP-seq
MIRT2516428	hsa-miR-4755-3p	CLIP-seq
MIRT2516429	hsa-miR-4761-3p	CLIP-seq
MIRT2516430	hsa-miR-4762-5p	CLIP-seq
MIRT2516433	hsa-miR-4774-5p	CLIP-seq
MIRT2516435	hsa-miR-4785	CLIP-seq
MIRT2516436	hsa-miR-4786-5p	CLIP-seq
MIRT2516437	hsa-miR-4789-3p	CLIP-seq
MIRT2516438	hsa-miR-4789-5p	CLIP-seq
MIRT2516440	hsa-miR-4793-3p	CLIP-seq
MIRT2516441	hsa-miR-4793-5p	CLIP-seq
MIRT2516442	hsa-miR-4795-5p	CLIP-seq
MIRT2516447	hsa-miR-501-3p	CLIP-seq
MIRT2516448	hsa-miR-502-3p	CLIP-seq
MIRT2516255	hsa-miR-502-5p	CLIP-seq
MIRT2516449	hsa-miR-5047	CLIP-seq
MIRT2516451	hsa-miR-517b	CLIP-seq
MIRT2516452	hsa-miR-520d-5p	CLIP-seq
MIRT2516453	hsa-miR-524-5p	CLIP-seq
MIRT2516454	hsa-miR-526b	CLIP-seq
MIRT2516456	hsa-miR-543	CLIP-seq
MIRT2516457	hsa-miR-548a-3p	CLIP-seq
MIRT1977137	hsa-miR-548a-5p	CLIP-seq
MIRT1977138	hsa-miR-548ab	CLIP-seq
MIRT1977139	hsa-miR-548ak	CLIP-seq
MIRT1977140	hsa-miR-548b-5p	CLIP-seq
MIRT1977141	hsa-miR-548c-5p	CLIP-seq
MIRT1977142	hsa-miR-548d-5p	CLIP-seq
MIRT2516464	hsa-miR-548e	CLIP-seq
MIRT2516465	hsa-miR-548f	CLIP-seq
MIRT1977143	hsa-miR-548h	CLIP-seq
MIRT1977144	hsa-miR-548i	CLIP-seq
MIRT1977145	hsa-miR-548j	CLIP-seq
MIRT2516466	hsa-miR-548k	CLIP-seq
MIRT2516467	hsa-miR-548l	CLIP-seq
MIRT2516257	hsa-miR-548o	CLIP-seq
MIRT2516468	hsa-miR-548q	CLIP-seq
MIRT2516469	hsa-miR-548s	CLIP-seq
MIRT1977147	hsa-miR-548w	CLIP-seq
MIRT1977148	hsa-miR-548y	CLIP-seq
MIRT1977149	hsa-miR-559	CLIP-seq
MIRT2212519	hsa-miR-579	CLIP-seq
MIRT2516474	hsa-miR-607	CLIP-seq
MIRT2516476	hsa-miR-627	CLIP-seq
MIRT2212520	hsa-miR-629	CLIP-seq
MIRT2516478	hsa-miR-635	CLIP-seq
MIRT2516479	hsa-miR-642a	CLIP-seq
MIRT2516480	hsa-miR-655	CLIP-seq
MIRT2516258	hsa-miR-659	CLIP-seq
MIRT2516481	hsa-miR-663b	CLIP-seq
MIRT1556225	hsa-miR-668	CLIP-seq
MIRT2516482	hsa-miR-769-5p	CLIP-seq
MIRT2516483	hsa-miR-890	CLIP-seq
MIRT2516486	hsa-miR-9	CLIP-seq
MIRT2516487	hsa-miR-921	CLIP-seq
MIRT2516488	hsa-miR-924	CLIP-seq
MIRT2212521	hsa-miR-935	CLIP-seq
MIRT2516489	hsa-miR-936	CLIP-seq
MIRT936620	hsa-miR-939	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001514	Process	Selenocysteine incorporation	NAS	9837913
GO:0004800	Function	Thyroxine 5'-deiodinase activity	IBA
GO:0004800	Function	Thyroxine 5'-deiodinase activity	IDA	10403186, 11108274, 12586771, 19651899
GO:0004800	Function	Thyroxine 5'-deiodinase activity	IEA
GO:0004800	Function	Thyroxine 5'-deiodinase activity	TAS	9837913
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IDA	11089566
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0006590	Process	Thyroid hormone generation	IEA
GO:0006590	Process	Thyroid hormone generation	TAS	8755651, 9837913
GO:0008430	Function	Selenium binding	IC	9837913
GO:0008430	Function	Selenium binding	TAS	8755651
GO:0016020	Component	Membrane	IC	9837913
GO:0016020	Component	Membrane	IEA
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0031625	Function	Ubiquitin protein ligase binding	IPI	19651899
GO:0032496	Process	Response to lipopolysaccharide	IEA
GO:0033798	Function	Thyroxine 5-deiodinase activity	IDA	18566113
GO:0042403	Process	Thyroid hormone metabolic process	IBA
GO:0042403	Process	Thyroid hormone metabolic process	IDA	19651899
GO:0042403	Process	Thyroid hormone metabolic process	IEA
GO:0042404	Process	Thyroid hormone catabolic process	IDA	10403186, 11108274, 12586771
GO:0042446	Process	Hormone biosynthetic process	IEA
GO:0120162	Process	Positive regulation of cold-induced thermogenesis	ISS	11696583

Other IDs

• MIM: 601413
• HGNC: 2884
• e!Ensembl: ENSG00000211448

Protein

• UniProt ID: Q92813
• Protein name: Type II iodothyronine deiodinase (EC 1.21.99.4) (5DII) (DIOII) (Type 2 DI) (Type-II 5'-deiodinase)
• Protein function: Plays a crucial role in the metabolism of thyroid hormones (TH) and has specific roles in TH activation and inactivation by deiodination (PubMed:12586771, PubMed:11108274, PubMed:10403186, PubMed:18821722). Catalyzes the deiodination of L-thyrox
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00837	T4_deiodinase	4 → 262	Iodothyronine deiodinase	Family

• Tissue specificity: TISSUE SPECIFICITY: Isoform 1 is expressed in the lung, trachea, kidney, heart, skeletal muscle, placenta, fetal brain and several regions of the adult brain (PubMed:11165050, PubMed:8755651). Isoform 2 is expressed in the brain, heart, kidney and trachea
• Sequence:

  MGILSVDLLITLQILPVFFSNCLFLALYDSVILLKHVVLLLSRSKSTRGEWRRMLTSEGL
  RCVWKSFLLDAYKQVKLGEDAPNSSVVHVSSTEGGDNSGNGTQEKIAEGATCHLLDFASP
  ERPLVVNFGSATUPPFTSQLPAFRKLVEEFSSVADFLLVYIDEAHPSDGWAIPGDSSLSF
  EVKKHQNQEDRCAAAQQLLERFSLPPQCRVVADRMDNNANIAYGVAFERVCIVQRQKIAY
  LGGKGPFSYNLQEVRHWLEKNFSKRUKKTRLAG

• Sequence length: 273

Pathways

KEGG:

Hormone signaling
Thyroid hormone signaling pathway

Reactome:

Regulation of thyroid hormone activity

Associated diseases

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Levothyroxine response	other	rs225014, rs225015	RCV003317018 RCV003317019

Associations from Text Mining
Disease Name	Relationship Type	References
Abortion Spontaneous	Inhibit	37968664
Acute Lung Injury	Associate	35137147
AIDS Associated Nephropathy	Associate	22259052
Autism Spectrum Disorder	Associate	33449341
Bone Diseases	Associate	35412619
Breast Neoplasms	Associate	36077333
Carcinoma Hepatocellular	Associate	26199857, 37059745
Cartilage Diseases	Associate	35412619
Chemical and Drug Induced Liver Injury	Associate	37059745
Cognition Disorders	Associate	33449341
Congenital Hypothyroidism	Associate	15286152
COVID 19	Associate	35137147
Death	Associate	35137147
Diabetes Gestational	Associate	33232364
Diabetes Mellitus Type 2	Associate	20930717, 22142372, 25105294, 35739305
Disease	Associate	35205233
Drug Related Side Effects and Adverse Reactions	Associate	29321381
Embolism Fat	Associate	22259052
Endometrial Neoplasms	Associate	35205233
Fibrosis	Associate	37059745
Gaucher Disease	Associate	33049131
Glucose Intolerance	Associate	22142372
Goiter	Associate	17940114
Graves Disease	Associate	23193417, 33049131
Hepatitis Chronic	Associate	37059745
HIV Associated Lipodystrophy Syndrome	Associate	22259052
HIV Infections	Associate	26756119
Hypertension	Associate	35739305, 36646987
Hypothyroidism	Associate	29321381, 29973617, 36646987
Idiopathic Pulmonary Fibrosis	Associate	36681777
Inflammation	Stimulate	30978267
Insulin Resistance	Associate	18198294, 20930717, 25105294, 35739305
Intellectual Disability	Associate	15286152
Intestinal Pseudo Obstruction	Associate	22259052
Kashin Beck Disease	Associate	25072641, 33455417
Lipodystrophy Familial Partial	Associate	20373986
Liver Cirrhosis	Associate	37059745
Liver Diseases	Associate	37059745
Metabolic Syndrome	Associate	18198294, 20930717
Neoplasms	Associate	16012517
Neoplasms Adipose Tissue	Associate	22259052
Neurodegenerative Diseases	Associate	33449341
Neurologic Manifestations	Associate	26004626
Obesity	Associate	22142372, 25622596, 30116736
Obesity Morbid	Associate	35739305
Osteoarthritis	Associate	21400473, 24695009, 24825461, 33455417
Osteoarthritis Hip	Associate	21400473
Pendred syndrome	Associate	17940114
Pre Eclampsia	Associate	26388242
Pulmonary Disease Chronic Obstructive	Stimulate	30978267
Pulmonary Fibrosis	Associate	35137147
Thyroid Adenoma Hyperfunctioning	Associate	23193417
Thyroid cancer medullary	Associate	18514391
Thyroid Cancer Papillary	Associate	39408960
Thyroid Hormone Metabolism Abnormal	Associate	29973617
Thyroid Neoplasms	Associate	24910925