Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
1728
Gene name Gene Name - the full gene name approved by the HGNC.
NAD(P)H quinone dehydrogenase 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
NQO1
Synonyms (NCBI Gene) Gene synonyms aliases
DHQU, DIA4, DTD, NMOR1, NMORI, QR1
Chromosome Chromosome number
16
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
16q22.1
Summary Summary of gene provided in NCBI Entrez Gene.
This gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This protein`s enzymatic activity prevents the one electro
SNPs SNP information provided by dbSNP.
SNP ID Visualize variation Clinical significance Consequence
rs1800566 G>A Drug-response, risk-factor, not-provided, pathogenic Missense variant, coding sequence variant
rs1555537451 G>A Likely-pathogenic Stop gained, coding sequence variant
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT1191823 hsa-let-7a CLIP-seq
MIRT1191824 hsa-let-7b CLIP-seq
MIRT1191825 hsa-let-7c CLIP-seq
MIRT1191826 hsa-let-7d CLIP-seq
MIRT1191827 hsa-let-7e CLIP-seq
Transcription factors
Transcription factor Regulation Reference
ESR1 Repression 20623181
FOS Unknown 8004128
JUN Unknown 11035254;8004128
JUNB Unknown 11035254
JUND Unknown 11035254
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000209 Process Protein polyubiquitination IEA
GO:0003723 Function RNA binding HDA 22658674
GO:0003955 Function NAD(P)H dehydrogenase (quinone) activity IBA
GO:0003955 Function NAD(P)H dehydrogenase (quinone) activity IEA
GO:0003955 Function NAD(P)H dehydrogenase (quinone) activity TAS 10393963
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
125860 2874 ENSG00000181019
Protein
UniProt ID P15559
Protein name NAD(P)H dehydrogenase [quinone] 1 (EC 1.6.5.2) (Azoreductase) (DT-diaphorase) (DTD) (Menadione reductase) (NAD(P)H:quinone oxidoreductase 1) (Phylloquinone reductase) (Quinone reductase 1) (QR1)
Protein function Flavin-containing quinone reductase that catalyzes two-electron reduction of quinones to hydroquinones using either NADH or NADPH as electron donors. In a ping-pong kinetic mechanism, the electrons are sequentially transferred from NAD(P)H to fl
PDB 1D4A , 1DXO , 1GG5 , 1H66 , 1H69 , 1KBO , 1KBQ , 1QBG , 2F1O , 3JSX , 4CET , 4CF6 , 5A4K , 5EA2 , 5EAI , 5FUQ , 6FY4 , 6LLC , 8C9J , 8OK0 , 8PQN , 8RFM , 8RFN
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02525 Flavodoxin_2 4 212 Flavodoxin-like fold Domain
Sequence
Sequence length 274
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Ubiquinone and other terpenoid-quinone biosynthesis
Metabolic pathways
Biosynthesis of cofactors
Pathways in cancer
Chemical carcinogenesis - reactive oxygen species
Hepatocellular carcinoma
Fluid shear stress and atherosclerosis
  Regulation of ornithine decarboxylase (ODC)
<
Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Diabetes Type 2 diabetes N/A N/A GWAS
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Acute erythroleukemia Associate 17339179
Acute Lung Injury Associate 19017358, 36555290
Adenocarcinoma Associate 25880877, 26625776, 26683690, 7669561
Adenoma Associate 23840148
Adenoma Pleomorphic Associate 25928388
Agranulocytosis Associate 40311769
Alzheimer Disease Associate 21220432
Anophthalmia with pulmonary hypoplasia Associate 32633891
Asthma Associate 16385446, 20049212, 20526719, 23066387, 31539146
Atrial Fibrillation Associate 29776386