Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
1728
Gene name Gene Name - the full gene name approved by the HGNC.
NAD(P)H quinone dehydrogenase 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
NQO1
Synonyms (NCBI Gene) Gene synonyms aliases
DHQU, DIA4, DTD, NMOR1, NMORI, QR1
Disease Acronyms (UniProt) Disease acronyms from UniProt database
DTD
Chromosome Chromosome number
16
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
16q22.1
Summary Summary of gene provided in NCBI Entrez Gene.
This gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This protein`s enzymatic activity prevents the one electro
SNPs SNP information provided by dbSNP.
SNP ID Visualize variation Clinical significance Consequence
rs1800566 G>A Drug-response, risk-factor, not-provided, pathogenic Missense variant, coding sequence variant
rs1555537451 G>A Likely-pathogenic Stop gained, coding sequence variant
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT1191823 hsa-let-7a CLIP-seq
MIRT1191824 hsa-let-7b CLIP-seq
MIRT1191825 hsa-let-7c CLIP-seq
MIRT1191826 hsa-let-7d CLIP-seq
MIRT1191827 hsa-let-7e CLIP-seq
Transcription factors
Transcription factor Regulation Reference
ESR1 Repression 20623181
FOS Unknown 8004128
JUN Unknown 11035254;8004128
JUNB Unknown 11035254
JUND Unknown 11035254
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0002931 Process Response to ischemia IEA
GO:0003723 Function RNA binding HDA 22658674
GO:0003955 Function NAD(P)H dehydrogenase (quinone) activity IBA 21873635
GO:0004128 Function Cytochrome-b5 reductase activity, acting on NAD(P)H TAS 9579781
GO:0004784 Function Superoxide dismutase activity IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
125860 2874 ENSG00000181019
Protein
UniProt ID P15559
Protein name NAD(P)H dehydrogenase [quinone] 1 (EC 1.6.5.2) (Azoreductase) (DT-diaphorase) (DTD) (Menadione reductase) (NAD(P)H:quinone oxidoreductase 1) (Phylloquinone reductase) (Quinone reductase 1) (QR1)
Protein function Flavin-containing quinone reductase that catalyzes two-electron reduction of quinones to hydroquinones using either NADH or NADPH as electron donors. In a ping-pong kinetic mechanism, the electrons are sequentially transferred from NAD(P)H to fl
PDB 1D4A , 1DXO , 1GG5 , 1H66 , 1H69 , 1KBO , 1KBQ , 1QBG , 2F1O , 3JSX , 4CET , 4CF6 , 5A4K , 5EA2 , 5EAI , 5FUQ , 6FY4 , 6LLC , 8C9J , 8OK0 , 8PQN , 8RFM , 8RFN
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02525 Flavodoxin_2 4 212 Flavodoxin-like fold Domain
Sequence
Sequence length 274
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Ubiquinone and other terpenoid-quinone biosynthesis
Metabolic pathways
Biosynthesis of cofactors
Pathways in cancer
Chemical carcinogenesis - reactive oxygen species
Hepatocellular carcinoma
Fluid shear stress and atherosclerosis
  Regulation of ornithine decarboxylase (ODC)
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Breast cancer Malignant neoplasm of breast rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158
View all (309 more)
18511948
Breast carcinoma Breast Carcinoma rs80359671, rs11540652, rs28934575, rs28897672, rs137886232, rs193922376, rs80357783, rs80359306, rs80359405, rs80359507, rs80359598, rs80358429, rs397507683, rs397515636, rs80359451
View all (71 more)
18511948
Cholestasis Cholestasis rs121909103, rs751511532, rs376368459, rs762702807, rs1578490102, rs1578499691, rs1578504946, rs1317656688, rs199791850, rs1452792080, rs1578491039 22461449
Colorectal cancer Colorectal Carcinoma rs137854568, rs137854573, rs137854575, rs387906234, rs121908380, rs121908702, rs267606674, rs794729661, rs121909055, rs281865417, rs267606884, rs28934575, rs587776769, rs104893815, rs587776800
View all (467 more)
20593958
Unknown
Disease term Disease name Evidence References Source
Asthma Asthma 20049212 ClinVar
Diabetes Diabetes GWAS
Associations from Text Mining
Disease Name Relationship Type References
Acute erythroleukemia Associate 17339179
Acute Lung Injury Associate 19017358, 36555290
Adenocarcinoma Associate 25880877, 26625776, 26683690, 7669561
Adenoma Associate 23840148
Adenoma Pleomorphic Associate 25928388
Agranulocytosis Associate 40311769
Alzheimer Disease Associate 21220432
Anophthalmia with pulmonary hypoplasia Associate 32633891
Asthma Associate 16385446, 20049212, 20526719, 23066387, 31539146
Atrial Fibrillation Associate 29776386