DHODH (dihydroorotate dehydrogenase (quinone))
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 1723 |
| Gene name | Dihydroorotate dehydrogenase (quinone) |
| Gene symbol | DHODH |
| Synonyms (NCBI Gene) |
DHOdehasePOADSURA1
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| Chromosome | 16 |
| Chromosome location | 16q22.2 |
| Summary | The protein encoded by this gene catalyzes the fourth enzymatic step, the ubiquinone-mediated oxidation of dihydroorotate to orotate, in de novo pyrimidine biosynthesis. This protein is a mitochondrial protein located on the outer surface of the inner mit |
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SNPs
SNP information provided by dbSNP.
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miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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Q02127 | ||||||||||
| Protein name | Dihydroorotate dehydrogenase (quinone), mitochondrial (DHOdehase) (EC 1.3.5.2) (Dihydroorotate oxidase) | ||||||||||
| Protein function | Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. Required for UMP biosynthesis via de novo pathway. | ||||||||||
| PDB | 1D3G , 1D3H , 2B0M , 2BXV , 2FPT , 2FPV , 2FPY , 2FQI , 2PRH , 2PRL , 2PRM , 2WV8 , 3F1Q , 3FJ6 , 3FJL , 3G0U , 3G0X , 3KVJ , 3KVK , 3KVL , 3KVM , 3U2O , 3W7R , 3ZWS , 3ZWT , 4IGH , 4JGD , 4JS3 , 4JTS , 4JTT , 4JTU , 4LS0 , 4LS1 , 4LS2 , 4OQV , 4RK8 , 4RKA , 4RLI , 4RR4 , 4YLW , 4ZL1 , 4ZMG , 5H2Z , 5H73 , 5HIN , 5HQE , 5K9C , 5K9D , 5MUT , 5MVC , 5MVD | ||||||||||
| Family and domains |
Pfam
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| Sequence |
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| Sequence length | 395 | ||||||||||
| Interactions | View interactions | ||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
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