DHODH (dihydroorotate dehydrogenase (quinone))
| Gene | |
|
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
1723 |
|
Gene name
Gene Name - the full gene name approved by the HGNC.
|
Dihydroorotate dehydrogenase (quinone) |
|
Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
|
DHODH |
|
Synonyms (NCBI Gene)
Gene synonyms aliases
|
DHOdehase, POADS, URA1 |
|
Chromosome
Chromosome number
|
16 |
|
Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
16q22.2 |
|
Summary
Summary of gene provided in NCBI Entrez Gene.
|
The protein encoded by this gene catalyzes the fourth enzymatic step, the ubiquinone-mediated oxidation of dihydroorotate to orotate, in de novo pyrimidine biosynthesis. This protein is a mitochondrial protein located on the outer surface of the inner mit |
|
SNPs
SNP information provided by dbSNP.
|
|||||||||||||||||||||||||
|
|||||||||||||||||||||||||
|
miRNA
miRNA information provided by mirtarbase database.
|
|||||||||||||||||||||||||
|
|||||||||||||||||||||||||
|
Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
|
|||||||||||||||||||||||||||||||
|
|||||||||||||||||||||||||||||||
|
Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
|
|||||||
|
|||||||
| Protein | |||||||||||
| UniProt ID | Q02127 | ||||||||||
| Protein name | Dihydroorotate dehydrogenase (quinone), mitochondrial (DHOdehase) (EC 1.3.5.2) (Dihydroorotate oxidase) | ||||||||||
| Protein function | Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. Required for UMP biosynthesis via de novo pathway. | ||||||||||
| PDB | 1D3G , 1D3H , 2B0M , 2BXV , 2FPT , 2FPV , 2FPY , 2FQI , 2PRH , 2PRL , 2PRM , 2WV8 , 3F1Q , 3FJ6 , 3FJL , 3G0U , 3G0X , 3KVJ , 3KVK , 3KVL , 3KVM , 3U2O , 3W7R , 3ZWS , 3ZWT , 4IGH , 4JGD , 4JS3 , 4JTS , 4JTT , 4JTU , 4LS0 , 4LS1 , 4LS2 , 4OQV , 4RK8 , 4RKA , 4RLI , 4RR4 , 4YLW , 4ZL1 , 4ZMG , 5H2Z , 5H73 , 5HIN , 5HQE , 5K9C , 5K9D , 5MUT , 5MVC , 5MVD | ||||||||||
| Family and domains |
Pfam
|
||||||||||
| Sequence |
|
||||||||||
| Sequence length | 395 | ||||||||||
| Interactions | View interactions | ||||||||||
|
Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
|
|||||||||
|
|||||||||
|
Associated diseases
Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
|
|||||||||||||||||||||||||||||||||||||
|
|||||||||||||||||||||||||||||||||||||
|
|||||||||||||||||||||||||||||||||||||