Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	1719
Gene name	Dihydrofolate reductase
Gene symbol	DHFR
Synonyms (NCBI Gene)	DHFR1DHFRP1DYR
Chromosome	5
Chromosome location	5q14.1
Summary	Dihydrofolate reductase converts dihydrofolate into tetrahydrofolate, a methyl group shuttle required for the de novo synthesis of purines, thymidylic acid, and certain amino acids. While the functional dihydrofolate reductase gene has been mapped to chro

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SNP ID	Visualize variation	Clinical significance	Consequence
rs121913223	T>A	Pathogenic	Missense variant, coding sequence variant, intron variant, non coding transcript variant
rs387906619	G>A	Pathogenic	Non coding transcript variant, coding sequence variant, missense variant

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miRTarBase ID	miRNA	Experiments	Reference
MIRT002018	hsa-miR-24-3p	real time qRT-PCRWestern blot	17686970
MIRT002018	hsa-miR-24-3p	real time qRT-PCRWestern blot	17686970
MIRT002018	hsa-miR-24-3p	Western blot	17686970
MIRT002018	hsa-miR-24-3p	Luciferase reporter assay	17686970
MIRT002018	hsa-miR-24-3p	Microarray	19748357
MIRT046435	hsa-miR-15b-5p	CLASH	23622248
MIRT044182	hsa-miR-99b-5p	CLASH	23622248
MIRT041132	hsa-miR-503-5p	CLASH	23622248
MIRT038796	hsa-miR-93-3p	CLASH	23622248
MIRT036640	hsa-miR-935	CLASH	23622248
MIRT026630	hsa-miR-192-5p	Luciferase reporter assayWestern blot	26506238
MIRT735249	hsa-miR-196a-3p	Luciferase reporter assayWestern blottingqRT-PCR	32509188
MIRT934710	hsa-miR-105	CLIP-seq
MIRT934711	hsa-miR-1185	CLIP-seq
MIRT934712	hsa-miR-1200	CLIP-seq
MIRT934713	hsa-miR-1207-3p	CLIP-seq
MIRT934714	hsa-miR-122	CLIP-seq
MIRT934715	hsa-miR-1228	CLIP-seq
MIRT934716	hsa-miR-1236	CLIP-seq
MIRT934717	hsa-miR-1238	CLIP-seq
MIRT934718	hsa-miR-1245	CLIP-seq
MIRT934719	hsa-miR-1245b-3p	CLIP-seq
MIRT934720	hsa-miR-1262	CLIP-seq
MIRT934721	hsa-miR-1270	CLIP-seq
MIRT934722	hsa-miR-1273e	CLIP-seq
MIRT934723	hsa-miR-1287	CLIP-seq
MIRT934724	hsa-miR-1298	CLIP-seq
MIRT934725	hsa-miR-1299	CLIP-seq
MIRT934726	hsa-miR-132	CLIP-seq
MIRT934727	hsa-miR-1468	CLIP-seq
MIRT934728	hsa-miR-1470	CLIP-seq
MIRT934729	hsa-miR-1913	CLIP-seq
MIRT934730	hsa-miR-193a-5p	CLIP-seq
MIRT934731	hsa-miR-205	CLIP-seq
MIRT934732	hsa-miR-212	CLIP-seq
MIRT934733	hsa-miR-2278	CLIP-seq
MIRT934734	hsa-miR-24	CLIP-seq
MIRT934735	hsa-miR-3074-5p	CLIP-seq
MIRT934736	hsa-miR-3122	CLIP-seq
MIRT934737	hsa-miR-3124-3p	CLIP-seq
MIRT934738	hsa-miR-3126-3p	CLIP-seq
MIRT934739	hsa-miR-3128	CLIP-seq
MIRT934740	hsa-miR-3135b	CLIP-seq
MIRT934741	hsa-miR-3170	CLIP-seq
MIRT934742	hsa-miR-3182	CLIP-seq
MIRT934743	hsa-miR-3189-5p	CLIP-seq
MIRT934744	hsa-miR-3201	CLIP-seq
MIRT934745	hsa-miR-324-3p	CLIP-seq
MIRT934746	hsa-miR-331-3p	CLIP-seq
MIRT934747	hsa-miR-3605-5p	CLIP-seq
MIRT934748	hsa-miR-365	CLIP-seq
MIRT934749	hsa-miR-3652	CLIP-seq
MIRT934750	hsa-miR-3667-3p	CLIP-seq
MIRT934751	hsa-miR-3679-5p	CLIP-seq
MIRT934752	hsa-miR-3689a-3p	CLIP-seq
MIRT934753	hsa-miR-3689c	CLIP-seq
MIRT934754	hsa-miR-370	CLIP-seq
MIRT934755	hsa-miR-374a	CLIP-seq
MIRT934756	hsa-miR-374b	CLIP-seq
MIRT934757	hsa-miR-378	CLIP-seq
MIRT934758	hsa-miR-378b	CLIP-seq
MIRT934759	hsa-miR-378c	CLIP-seq
MIRT934760	hsa-miR-378d	CLIP-seq
MIRT934761	hsa-miR-378e	CLIP-seq
MIRT934762	hsa-miR-378f	CLIP-seq
MIRT934763	hsa-miR-378h	CLIP-seq
MIRT934764	hsa-miR-378i	CLIP-seq
MIRT934765	hsa-miR-3908	CLIP-seq
MIRT934766	hsa-miR-3913-5p	CLIP-seq
MIRT934767	hsa-miR-3929	CLIP-seq
MIRT934768	hsa-miR-3942-5p	CLIP-seq
MIRT934769	hsa-miR-3976	CLIP-seq
MIRT934770	hsa-miR-422a	CLIP-seq
MIRT934771	hsa-miR-425	CLIP-seq
MIRT934772	hsa-miR-4259	CLIP-seq
MIRT934773	hsa-miR-4284	CLIP-seq
MIRT934774	hsa-miR-432	CLIP-seq
MIRT934775	hsa-miR-4324	CLIP-seq
MIRT934776	hsa-miR-4419b	CLIP-seq
MIRT934777	hsa-miR-4430	CLIP-seq
MIRT934778	hsa-miR-4434	CLIP-seq
MIRT934779	hsa-miR-4455	CLIP-seq
MIRT934780	hsa-miR-4478	CLIP-seq
MIRT934781	hsa-miR-4516	CLIP-seq
MIRT934782	hsa-miR-451b	CLIP-seq
MIRT934783	hsa-miR-4528	CLIP-seq
MIRT934784	hsa-miR-4531	CLIP-seq
MIRT934785	hsa-miR-4652-3p	CLIP-seq
MIRT934786	hsa-miR-4663	CLIP-seq
MIRT934787	hsa-miR-4667-3p	CLIP-seq
MIRT934788	hsa-miR-4701-3p	CLIP-seq
MIRT934789	hsa-miR-4703-5p	CLIP-seq
MIRT934790	hsa-miR-4707-5p	CLIP-seq
MIRT934791	hsa-miR-4720-5p	CLIP-seq
MIRT934792	hsa-miR-4724-3p	CLIP-seq
MIRT934793	hsa-miR-4728-5p	CLIP-seq
MIRT934794	hsa-miR-4753-3p	CLIP-seq
MIRT934795	hsa-miR-4758-3p	CLIP-seq
MIRT934796	hsa-miR-4762-5p	CLIP-seq
MIRT934797	hsa-miR-4766-3p	CLIP-seq
MIRT934798	hsa-miR-4782-5p	CLIP-seq
MIRT934799	hsa-miR-4791	CLIP-seq
MIRT934800	hsa-miR-4795-3p	CLIP-seq
MIRT934801	hsa-miR-4799-3p	CLIP-seq
MIRT934802	hsa-miR-485-5p	CLIP-seq
MIRT934803	hsa-miR-496	CLIP-seq
MIRT934804	hsa-miR-516b	CLIP-seq
MIRT934805	hsa-miR-544b	CLIP-seq
MIRT934806	hsa-miR-548c-3p	CLIP-seq
MIRT934807	hsa-miR-579	CLIP-seq
MIRT934808	hsa-miR-615-5p	CLIP-seq
MIRT934809	hsa-miR-620	CLIP-seq
MIRT934810	hsa-miR-629	CLIP-seq
MIRT934811	hsa-miR-646	CLIP-seq
MIRT934812	hsa-miR-656	CLIP-seq
MIRT934813	hsa-miR-658	CLIP-seq
MIRT934814	hsa-miR-944	CLIP-seq
MIRT934722	hsa-miR-1273e	CLIP-seq
MIRT934806	hsa-miR-548c-3p	CLIP-seq
MIRT1976721	hsa-miR-1183	CLIP-seq
MIRT934712	hsa-miR-1200	CLIP-seq
MIRT934713	hsa-miR-1207-3p	CLIP-seq
MIRT1976722	hsa-miR-1208	CLIP-seq
MIRT934714	hsa-miR-122	CLIP-seq
MIRT934718	hsa-miR-1245	CLIP-seq
MIRT1976723	hsa-miR-1268	CLIP-seq
MIRT1976724	hsa-miR-1268b	CLIP-seq
MIRT934721	hsa-miR-1270	CLIP-seq
MIRT1976725	hsa-miR-1273f	CLIP-seq
MIRT1976726	hsa-miR-150	CLIP-seq
MIRT1976727	hsa-miR-1827	CLIP-seq
MIRT934730	hsa-miR-193a-5p	CLIP-seq
MIRT1976728	hsa-miR-2116	CLIP-seq
MIRT934733	hsa-miR-2278	CLIP-seq
MIRT1976729	hsa-miR-2909	CLIP-seq
MIRT934736	hsa-miR-3122	CLIP-seq
MIRT934740	hsa-miR-3135b	CLIP-seq
MIRT1976730	hsa-miR-3137	CLIP-seq
MIRT1976731	hsa-miR-3140-3p	CLIP-seq
MIRT1976732	hsa-miR-3144-5p	CLIP-seq
MIRT934741	hsa-miR-3170	CLIP-seq
MIRT1976733	hsa-miR-3177-5p	CLIP-seq
MIRT1976734	hsa-miR-3179	CLIP-seq
MIRT934742	hsa-miR-3182	CLIP-seq
MIRT1976735	hsa-miR-3191	CLIP-seq
MIRT934749	hsa-miR-3652	CLIP-seq
MIRT1976736	hsa-miR-3665	CLIP-seq
MIRT934752	hsa-miR-3689a-3p	CLIP-seq
MIRT934753	hsa-miR-3689c	CLIP-seq
MIRT934754	hsa-miR-370	CLIP-seq
MIRT934757	hsa-miR-378	CLIP-seq
MIRT934758	hsa-miR-378b	CLIP-seq
MIRT934759	hsa-miR-378c	CLIP-seq
MIRT934760	hsa-miR-378d	CLIP-seq
MIRT934761	hsa-miR-378e	CLIP-seq
MIRT934762	hsa-miR-378f	CLIP-seq
MIRT934763	hsa-miR-378h	CLIP-seq
MIRT934764	hsa-miR-378i	CLIP-seq
MIRT934766	hsa-miR-3913-5p	CLIP-seq
MIRT934767	hsa-miR-3929	CLIP-seq
MIRT934769	hsa-miR-3976	CLIP-seq
MIRT934770	hsa-miR-422a	CLIP-seq
MIRT1976737	hsa-miR-4252	CLIP-seq
MIRT934772	hsa-miR-4259	CLIP-seq
MIRT1976738	hsa-miR-4273	CLIP-seq
MIRT1976739	hsa-miR-4274	CLIP-seq
MIRT1976740	hsa-miR-4278	CLIP-seq
MIRT1976741	hsa-miR-4300	CLIP-seq
MIRT934774	hsa-miR-432	CLIP-seq
MIRT934776	hsa-miR-4419b	CLIP-seq
MIRT934777	hsa-miR-4430	CLIP-seq
MIRT934778	hsa-miR-4434	CLIP-seq
MIRT1976742	hsa-miR-4436a	CLIP-seq
MIRT1976743	hsa-miR-4437	CLIP-seq
MIRT934780	hsa-miR-4478	CLIP-seq
MIRT1976744	hsa-miR-4489	CLIP-seq
MIRT934781	hsa-miR-4516	CLIP-seq
MIRT934782	hsa-miR-451b	CLIP-seq
MIRT934783	hsa-miR-4528	CLIP-seq
MIRT934784	hsa-miR-4531	CLIP-seq
MIRT1976745	hsa-miR-4634	CLIP-seq
MIRT1976746	hsa-miR-4649-3p	CLIP-seq
MIRT1976747	hsa-miR-4652-5p	CLIP-seq
MIRT1976748	hsa-miR-4660	CLIP-seq
MIRT934786	hsa-miR-4663	CLIP-seq
MIRT1976749	hsa-miR-4667-5p	CLIP-seq
MIRT1976750	hsa-miR-4674	CLIP-seq
MIRT1976751	hsa-miR-4677-5p	CLIP-seq
MIRT1976752	hsa-miR-4680-5p	CLIP-seq
MIRT1976753	hsa-miR-4688	CLIP-seq
MIRT1976754	hsa-miR-4690-5p	CLIP-seq
MIRT1976755	hsa-miR-4700-3p	CLIP-seq
MIRT1976756	hsa-miR-4700-5p	CLIP-seq
MIRT1976757	hsa-miR-4704-3p	CLIP-seq
MIRT1976758	hsa-miR-4705	CLIP-seq
MIRT934790	hsa-miR-4707-5p	CLIP-seq
MIRT1976759	hsa-miR-4722-5p	CLIP-seq
MIRT934793	hsa-miR-4728-5p	CLIP-seq
MIRT1976760	hsa-miR-4731-5p	CLIP-seq
MIRT1976761	hsa-miR-4738-3p	CLIP-seq
MIRT1976762	hsa-miR-4747-5p	CLIP-seq
MIRT1976763	hsa-miR-4763-5p	CLIP-seq
MIRT1976764	hsa-miR-4768-3p	CLIP-seq
MIRT934800	hsa-miR-4795-3p	CLIP-seq
MIRT934802	hsa-miR-485-5p	CLIP-seq
MIRT1976765	hsa-miR-513c	CLIP-seq
MIRT1976766	hsa-miR-514b-5p	CLIP-seq
MIRT1976767	hsa-miR-518a-3p	CLIP-seq
MIRT1976768	hsa-miR-518b	CLIP-seq
MIRT1976769	hsa-miR-518c	CLIP-seq
MIRT1976770	hsa-miR-518d-3p	CLIP-seq
MIRT1976771	hsa-miR-518e	CLIP-seq
MIRT1976772	hsa-miR-518f	CLIP-seq
MIRT934805	hsa-miR-544b	CLIP-seq
MIRT934806	hsa-miR-548c-3p	CLIP-seq
MIRT934808	hsa-miR-615-5p	CLIP-seq
MIRT934809	hsa-miR-620	CLIP-seq
MIRT1976773	hsa-miR-622	CLIP-seq
MIRT934811	hsa-miR-646	CLIP-seq
MIRT934812	hsa-miR-656	CLIP-seq
MIRT1976774	hsa-miR-718	CLIP-seq
MIRT1976775	hsa-miR-764	CLIP-seq
MIRT1976776	hsa-miR-767-3p	CLIP-seq
MIRT1976777	hsa-miR-885-3p	CLIP-seq
MIRT1976778	hsa-miR-892a	CLIP-seq
MIRT1976779	hsa-miR-920	CLIP-seq
MIRT1976780	hsa-miR-940	CLIP-seq
MIRT1976781	hsa-miR-943	CLIP-seq
MIRT2212043	hsa-miR-1184	CLIP-seq
MIRT934712	hsa-miR-1200	CLIP-seq
MIRT934714	hsa-miR-122	CLIP-seq
MIRT934715	hsa-miR-1228	CLIP-seq
MIRT934720	hsa-miR-1262	CLIP-seq
MIRT934721	hsa-miR-1270	CLIP-seq
MIRT2212044	hsa-miR-1279	CLIP-seq
MIRT934724	hsa-miR-1298	CLIP-seq
MIRT934726	hsa-miR-132	CLIP-seq
MIRT934728	hsa-miR-1470	CLIP-seq
MIRT934729	hsa-miR-1913	CLIP-seq
MIRT934730	hsa-miR-193a-5p	CLIP-seq
MIRT934731	hsa-miR-205	CLIP-seq
MIRT934732	hsa-miR-212	CLIP-seq
MIRT2212045	hsa-miR-2355-5p	CLIP-seq
MIRT2212046	hsa-miR-302f	CLIP-seq
MIRT934736	hsa-miR-3122	CLIP-seq
MIRT934740	hsa-miR-3135b	CLIP-seq
MIRT1976732	hsa-miR-3144-5p	CLIP-seq
MIRT2212047	hsa-miR-3146	CLIP-seq
MIRT934741	hsa-miR-3170	CLIP-seq
MIRT934742	hsa-miR-3182	CLIP-seq
MIRT934743	hsa-miR-3189-5p	CLIP-seq
MIRT1976735	hsa-miR-3191	CLIP-seq
MIRT2212048	hsa-miR-3192	CLIP-seq
MIRT2212049	hsa-miR-3199	CLIP-seq
MIRT934745	hsa-miR-324-3p	CLIP-seq
MIRT2212050	hsa-miR-324-5p	CLIP-seq
MIRT934746	hsa-miR-331-3p	CLIP-seq
MIRT2212051	hsa-miR-3545-3p	CLIP-seq
MIRT2212052	hsa-miR-3617	CLIP-seq
MIRT2212053	hsa-miR-3622b-5p	CLIP-seq
MIRT934749	hsa-miR-3652	CLIP-seq
MIRT934750	hsa-miR-3667-3p	CLIP-seq
MIRT2212054	hsa-miR-3677-3p	CLIP-seq
MIRT2212055	hsa-miR-3680	CLIP-seq
MIRT934752	hsa-miR-3689a-3p	CLIP-seq
MIRT934753	hsa-miR-3689c	CLIP-seq
MIRT934754	hsa-miR-370	CLIP-seq
MIRT934755	hsa-miR-374a	CLIP-seq
MIRT934756	hsa-miR-374b	CLIP-seq
MIRT934765	hsa-miR-3908	CLIP-seq
MIRT934766	hsa-miR-3913-5p	CLIP-seq
MIRT934767	hsa-miR-3929	CLIP-seq
MIRT2212056	hsa-miR-3934	CLIP-seq
MIRT2212057	hsa-miR-3940-5p	CLIP-seq
MIRT934768	hsa-miR-3942-5p	CLIP-seq
MIRT934769	hsa-miR-3976	CLIP-seq
MIRT1976737	hsa-miR-4252	CLIP-seq
MIRT934772	hsa-miR-4259	CLIP-seq
MIRT2212058	hsa-miR-4275	CLIP-seq
MIRT2212059	hsa-miR-4293	CLIP-seq
MIRT2212060	hsa-miR-431	CLIP-seq
MIRT2212061	hsa-miR-4314	CLIP-seq
MIRT934774	hsa-miR-432	CLIP-seq
MIRT934775	hsa-miR-4324	CLIP-seq
MIRT2212062	hsa-miR-4328	CLIP-seq
MIRT2212063	hsa-miR-4417	CLIP-seq
MIRT2212064	hsa-miR-4418	CLIP-seq
MIRT934776	hsa-miR-4419b	CLIP-seq
MIRT934777	hsa-miR-4430	CLIP-seq
MIRT934778	hsa-miR-4434	CLIP-seq
MIRT1976743	hsa-miR-4437	CLIP-seq
MIRT2212065	hsa-miR-4438	CLIP-seq
MIRT934780	hsa-miR-4478	CLIP-seq
MIRT2212066	hsa-miR-4507	CLIP-seq
MIRT934781	hsa-miR-4516	CLIP-seq
MIRT934784	hsa-miR-4531	CLIP-seq
MIRT2212067	hsa-miR-4636	CLIP-seq
MIRT2212068	hsa-miR-4640-5p	CLIP-seq
MIRT2212069	hsa-miR-4646-5p	CLIP-seq
MIRT934785	hsa-miR-4652-3p	CLIP-seq
MIRT1976747	hsa-miR-4652-5p	CLIP-seq
MIRT934786	hsa-miR-4663	CLIP-seq
MIRT934787	hsa-miR-4667-3p	CLIP-seq
MIRT1976750	hsa-miR-4674	CLIP-seq
MIRT1976752	hsa-miR-4680-5p	CLIP-seq
MIRT2212070	hsa-miR-4686	CLIP-seq
MIRT934788	hsa-miR-4701-3p	CLIP-seq
MIRT934789	hsa-miR-4703-5p	CLIP-seq
MIRT1976758	hsa-miR-4705	CLIP-seq
MIRT934790	hsa-miR-4707-5p	CLIP-seq
MIRT934792	hsa-miR-4724-3p	CLIP-seq
MIRT2212071	hsa-miR-4726-5p	CLIP-seq
MIRT934793	hsa-miR-4728-5p	CLIP-seq
MIRT1976762	hsa-miR-4747-5p	CLIP-seq
MIRT934795	hsa-miR-4758-3p	CLIP-seq
MIRT2212072	hsa-miR-4764-3p	CLIP-seq
MIRT934797	hsa-miR-4766-3p	CLIP-seq
MIRT934802	hsa-miR-485-5p	CLIP-seq
MIRT2212073	hsa-miR-509-3-5p	CLIP-seq
MIRT2212074	hsa-miR-5095	CLIP-seq
MIRT2212075	hsa-miR-509-5p	CLIP-seq
MIRT1976767	hsa-miR-518a-3p	CLIP-seq
MIRT1976768	hsa-miR-518b	CLIP-seq
MIRT1976769	hsa-miR-518c	CLIP-seq
MIRT1976770	hsa-miR-518d-3p	CLIP-seq
MIRT1976771	hsa-miR-518e	CLIP-seq
MIRT1976772	hsa-miR-518f	CLIP-seq
MIRT934805	hsa-miR-544b	CLIP-seq
MIRT2212076	hsa-miR-550a	CLIP-seq
MIRT2212077	hsa-miR-552	CLIP-seq
MIRT2212078	hsa-miR-596	CLIP-seq
MIRT934808	hsa-miR-615-5p	CLIP-seq
MIRT934809	hsa-miR-620	CLIP-seq
MIRT1976773	hsa-miR-622	CLIP-seq
MIRT934810	hsa-miR-629	CLIP-seq
MIRT2212079	hsa-miR-641	CLIP-seq
MIRT934813	hsa-miR-658	CLIP-seq
MIRT2212080	hsa-miR-661	CLIP-seq
MIRT934727	hsa-miR-1468	CLIP-seq
MIRT934731	hsa-miR-205	CLIP-seq
MIRT934736	hsa-miR-3122	CLIP-seq
MIRT2386879	hsa-miR-3620	CLIP-seq
MIRT934750	hsa-miR-3667-3p	CLIP-seq
MIRT934752	hsa-miR-3689a-3p	CLIP-seq
MIRT934753	hsa-miR-3689c	CLIP-seq
MIRT934766	hsa-miR-3913-5p	CLIP-seq
MIRT2386880	hsa-miR-412	CLIP-seq
MIRT934792	hsa-miR-4724-3p	CLIP-seq
MIRT934793	hsa-miR-4728-5p	CLIP-seq
MIRT2386881	hsa-miR-4780	CLIP-seq
MIRT934802	hsa-miR-485-5p	CLIP-seq
MIRT934810	hsa-miR-629	CLIP-seq
MIRT934716	hsa-miR-1236	CLIP-seq
MIRT934717	hsa-miR-1238	CLIP-seq
MIRT2515809	hsa-miR-1244	CLIP-seq
MIRT2515810	hsa-miR-1254	CLIP-seq
MIRT2212044	hsa-miR-1279	CLIP-seq
MIRT2515811	hsa-miR-129-5p	CLIP-seq
MIRT2515812	hsa-miR-2113	CLIP-seq
MIRT1976729	hsa-miR-2909	CLIP-seq
MIRT2515813	hsa-miR-3064-5p	CLIP-seq
MIRT2515814	hsa-miR-3116	CLIP-seq
MIRT934736	hsa-miR-3122	CLIP-seq
MIRT1976733	hsa-miR-3177-5p	CLIP-seq
MIRT2515815	hsa-miR-337-3p	CLIP-seq
MIRT934748	hsa-miR-365	CLIP-seq
MIRT934749	hsa-miR-3652	CLIP-seq
MIRT934752	hsa-miR-3689a-3p	CLIP-seq
MIRT934753	hsa-miR-3689c	CLIP-seq
MIRT934766	hsa-miR-3913-5p	CLIP-seq
MIRT934767	hsa-miR-3929	CLIP-seq
MIRT2386880	hsa-miR-412	CLIP-seq
MIRT1976737	hsa-miR-4252	CLIP-seq
MIRT1976739	hsa-miR-4274	CLIP-seq
MIRT1976740	hsa-miR-4278	CLIP-seq
MIRT934776	hsa-miR-4419b	CLIP-seq
MIRT934777	hsa-miR-4430	CLIP-seq
MIRT934780	hsa-miR-4478	CLIP-seq
MIRT1976744	hsa-miR-4489	CLIP-seq
MIRT2515816	hsa-miR-4505	CLIP-seq
MIRT934783	hsa-miR-4528	CLIP-seq
MIRT2515817	hsa-miR-4646-3p	CLIP-seq
MIRT1976753	hsa-miR-4688	CLIP-seq
MIRT2515818	hsa-miR-4691-5p	CLIP-seq
MIRT1976757	hsa-miR-4704-3p	CLIP-seq
MIRT934793	hsa-miR-4728-5p	CLIP-seq
MIRT2515819	hsa-miR-4735-5p	CLIP-seq
MIRT2515820	hsa-miR-4775	CLIP-seq
MIRT934802	hsa-miR-485-5p	CLIP-seq
MIRT2212076	hsa-miR-550a	CLIP-seq
MIRT2515821	hsa-miR-590-3p	CLIP-seq
MIRT2515822	hsa-miR-599	CLIP-seq
MIRT2212080	hsa-miR-661	CLIP-seq
MIRT1976778	hsa-miR-892a	CLIP-seq
MIRT1976781	hsa-miR-943	CLIP-seq
MIRT2679254	hsa-miR-1	CLIP-seq
MIRT934717	hsa-miR-1238	CLIP-seq
MIRT2515809	hsa-miR-1244	CLIP-seq
MIRT2212044	hsa-miR-1279	CLIP-seq
MIRT2679255	hsa-miR-206	CLIP-seq
MIRT2515812	hsa-miR-2113	CLIP-seq
MIRT1976729	hsa-miR-2909	CLIP-seq
MIRT934736	hsa-miR-3122	CLIP-seq
MIRT1976733	hsa-miR-3177-5p	CLIP-seq
MIRT2679256	hsa-miR-3190	CLIP-seq
MIRT2679257	hsa-miR-3607-5p	CLIP-seq
MIRT934748	hsa-miR-365	CLIP-seq
MIRT2679258	hsa-miR-3673	CLIP-seq
MIRT934752	hsa-miR-3689a-3p	CLIP-seq
MIRT934753	hsa-miR-3689c	CLIP-seq
MIRT2679259	hsa-miR-3911	CLIP-seq
MIRT934766	hsa-miR-3913-5p	CLIP-seq
MIRT934767	hsa-miR-3929	CLIP-seq
MIRT2386880	hsa-miR-412	CLIP-seq
MIRT2679260	hsa-miR-4268	CLIP-seq
MIRT1976739	hsa-miR-4274	CLIP-seq
MIRT1976740	hsa-miR-4278	CLIP-seq
MIRT934776	hsa-miR-4419b	CLIP-seq
MIRT2679261	hsa-miR-4448	CLIP-seq
MIRT934779	hsa-miR-4455	CLIP-seq
MIRT934780	hsa-miR-4478	CLIP-seq
MIRT1976744	hsa-miR-4489	CLIP-seq
MIRT934783	hsa-miR-4528	CLIP-seq
MIRT2515817	hsa-miR-4646-3p	CLIP-seq
MIRT1976753	hsa-miR-4688	CLIP-seq
MIRT2515818	hsa-miR-4691-5p	CLIP-seq
MIRT1976757	hsa-miR-4704-3p	CLIP-seq
MIRT934793	hsa-miR-4728-5p	CLIP-seq
MIRT2515819	hsa-miR-4735-5p	CLIP-seq
MIRT2515820	hsa-miR-4775	CLIP-seq
MIRT934802	hsa-miR-485-5p	CLIP-seq
MIRT2679262	hsa-miR-556-3p	CLIP-seq
MIRT2515821	hsa-miR-590-3p	CLIP-seq
MIRT2515822	hsa-miR-599	CLIP-seq
MIRT2679263	hsa-miR-609	CLIP-seq
MIRT2679264	hsa-miR-613	CLIP-seq
MIRT1976778	hsa-miR-892a	CLIP-seq
MIRT1976781	hsa-miR-943	CLIP-seq

Show/Hide all (3)

Transcription factor	Regulation	Reference
E2F1	Activation	14618416
RB1	Repression	9671466
TFDP1	Activation	14618416

Show/Hide all (37)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000900	Function	MRNA regulatory element binding translation repressor activity	IDA	8490020
GO:0003723	Function	RNA binding	IEA
GO:0003729	Function	MRNA binding	IDA	21876184
GO:0004146	Function	Dihydrofolate reductase activity	IBA
GO:0004146	Function	Dihydrofolate reductase activity	IDA	2303423, 12096917, 21876184, 23707606
GO:0004146	Function	Dihydrofolate reductase activity	IEA
GO:0004146	Function	Dihydrofolate reductase activity	ISS
GO:0004146	Function	Dihydrofolate reductase activity	NAS	6687716
GO:0005515	Function	Protein binding	IPI	33961781
GO:0005542	Function	Folic acid binding	IDA	2303423
GO:0005737	Component	Cytoplasm	IEA
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IBA
GO:0005739	Component	Mitochondrion	IDA
GO:0005739	Component	Mitochondrion	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006729	Process	Tetrahydrobiopterin biosynthetic process	IMP	23707606
GO:0006729	Process	Tetrahydrobiopterin biosynthetic process	ISS
GO:0006730	Process	One-carbon metabolic process	IEA
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0017148	Process	Negative regulation of translation	IDA	8490020
GO:0031103	Process	Axon regeneration	ISS
GO:0031427	Process	Response to methotrexate	IEA
GO:0046452	Process	Dihydrofolate metabolic process	IBA
GO:0046452	Process	Dihydrofolate metabolic process	IDA	2303423, 23707606
GO:0046653	Process	Tetrahydrofolate metabolic process	IDA	12096917, 21876184
GO:0046653	Process	Tetrahydrofolate metabolic process	IEA
GO:0046654	Process	Tetrahydrofolate biosynthetic process	IBA
GO:0046654	Process	Tetrahydrofolate biosynthetic process	IDA	2303423
GO:0046654	Process	Tetrahydrofolate biosynthetic process	IEA
GO:0046655	Process	Folic acid metabolic process	IBA
GO:0046655	Process	Folic acid metabolic process	ISS
GO:0050661	Function	NADP binding	IBA
GO:0050661	Function	NADP binding	IEA
GO:0070402	Function	NADPH binding	IDA	2303423
GO:1990825	Function	Sequence-specific mRNA binding	IDA	8490020
GO:2000121	Process	Regulation of removal of superoxide radicals	ISS

MIM	HGNC	e!Ensembl
126060	2861	ENSG00000228716

P00374

Protein name

Dihydrofolate reductase (EC 1.5.1.3)

Protein function

Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of

PDB

1BOZ , 1DHF , 1DLR , 1DLS , 1DRF , 1HFP , 1HFQ , 1HFR , 1KMS , 1KMV , 1MVS , 1MVT , 1OHJ , 1OHK , 1PD8 , 1PD9 , 1PDB , 1S3U , 1S3V , 1S3W , 1U71 , 1U72 , 1YHO , 2C2S , 2C2T , 2DHF , 2W3A , 2W3B , 2W3M , 3EIG , 3F8Y , 3F8Z , 3F91 , 3FS6 , 3GHC , 3GHV , 3GHW , 3GI2 , 3GYF , 3L3R , 3N0H , 3NTZ , 3NU0 , 3NXO , 3NXR , 3NXT , 3NXV , 3NXX , 3NXY , 3NZD , 3OAF

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00186	DHFR_1	4 → 185	Dihydrofolate reductase	Domain

Tissue specificity

TISSUE SPECIFICITY: Widely expressed in fetal and adult tissues, including throughout the fetal and adult brains and whole blood. Expression is higher in the adult brain than in the fetal brain. {ECO:0000269|PubMed:21310276}.

Sequence

MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND

Sequence length

187

Interactions

View interactions

	KEGG		Reactome
	One carbon pool by folate Folate biosynthesis Metabolic pathways Biosynthesis of cofactors Antifolate resistance Folate transport and metabolism		Metabolism of folate and pterines G1/S-Specific Transcription

Show/Hide Causal Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Constitutional megaloblastic anemia with severe neurologic disease	Pathogenic	rs387906619, rs121913223	RCV000022524 RCV000022525

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Cervical cancer	Likely benign	rs773136060	RCV005924010
DHFR-related disorder	Benign; Likely benign	rs530740538, rs141831067	RCV003958584 RCV003958122

Show/Hide Text Mining Associations (81)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Acquired Immunodeficiency Syndrome	Associate	31284044
Adenocarcinoma of Lung	Associate	36769342
Adenomatous Polyps	Associate	26875486
Adrenoleukodystrophy	Associate	19353223
Alzheimer Disease	Associate	21310276, 37519165
Anemia	Associate	21310276
Anemia Megaloblastic	Associate	21310276, 21310277
Aortic Aneurysm Abdominal	Associate	34176283
Arthritis Rheumatoid	Associate	22450926, 23897011, 30758239
Autoimmune Diseases	Associate	23197646
Bone Diseases	Associate	18005268
Brain Neoplasms	Associate	33545223
Breast Neoplasms	Associate	17413111, 1834700, 22954684, 28188287, 7174686
Carcinoma Non Small Cell Lung	Associate	20737570, 23709418
Cardiovascular Diseases	Associate	31964986
Cerebellar Diseases	Associate	32157568
Cerebral Infarction	Associate	32319147
Cleft Lip	Inhibit	26221921
Cleft Palate	Inhibit	26221921
Cockayne Syndrome	Associate	21214942, 23733932
Cognition Disorders	Associate	34788822
Cognitive Dysfunction	Associate	34788822
Colonic Neoplasms	Associate	2914962, 8449831
Colorectal Neoplasms	Associate	20020129, 20615890, 25537274, 26108676, 26633373, 26676887, 26875486, 29925788, 34521988
Colorectal Neoplasms	Inhibit	20615890
Communicable Diseases	Associate	23197646
Demyelinating Autoimmune Diseases CNS	Associate	19353223
Depressive Disorder	Associate	21310276
Diabetes Mellitus Type 1	Associate	34682638
Diabetes Mellitus Type 2	Associate	34682638
Disease Resistance	Associate	7812005
DNA Repair Deficiency Disorders	Associate	21214942
Down Syndrome	Associate	23421317
Drug Related Side Effects and Adverse Reactions	Associate	36382444
Drug Resistant Epilepsy	Associate	2765667
Fatigue	Associate	23709418
Folate Malabsorption Hereditary	Associate	34502300
Glioma	Associate	33545223
Graft vs Host Disease	Inhibit	25425682
Head and Neck Neoplasms	Associate	22954684, 23276522, 33369477
Hematologic Diseases	Associate	21310277
Hematologic Neoplasms	Associate	20059476
Hereditary Breast and Ovarian Cancer Syndrome	Associate	7529065
Heredodegenerative Disorders Nervous System	Associate	21310277
HIV Infections	Associate	20573194, 25122865
Hypertension	Associate	32319147, 33382484
Inflammation	Associate	25564249
Laryngeal Neoplasms	Associate	23838799
Leukemia	Associate	6572370, 8449831
Leukemia Biphenotypic Acute	Associate	11380466
Leukemia Promyelocytic Acute	Associate	3856428
Leukemia T Cell	Associate	22954684, 36769342
Leukopenia	Associate	22994778
Liver Neoplasms	Associate	21128869
Lymphoma Non Hodgkin	Associate	22954684
Megaloblastic Anemia due to Dihydrofolate Reductase Deficiency	Associate	21310277
Melanoma	Associate	17611626
Mesothelioma Malignant	Associate	20485525
Metabolism Inborn Errors	Inhibit	21310276
Microphthalmia Syndromic 10	Associate	34788822
Neoplasms	Associate	14679136, 20485525, 23197646, 28188287, 32752079, 33545223, 34502300, 36769342
Neurodegeneration Due To Cerebral Folate Transport Deficiency	Associate	21310276, 21310277
Nystagmus Pathologic	Associate	32157568
Orofacial Cleft 1	Associate	26221921
Osteosarcoma	Associate	14679136, 18385200, 19159907, 25739012
Pancytopenia	Associate	21310276
Parkinson Disease	Associate	21310276
Phenylketonurias	Associate	21310276
Pneumonia Pneumocystis	Associate	15504856, 30718779, 31284044, 34562541
Precursor B Cell Lymphoblastic Leukemia Lymphoma	Associate	11380466
Precursor Cell Lymphoblastic Leukemia Lymphoma	Associate	22954684, 31443485, 34521988, 7605998, 7812005, 9226157
Precursor T Cell Lymphoblastic Leukemia Lymphoma	Associate	11380466, 36769342, 9226157
Premature Birth	Associate	20834190
Rectal Neoplasms	Associate	25041994
Retinoblastoma	Inhibit	17510060
Retinoblastoma	Associate	22648968
Skin Diseases	Associate	25759212
Spinal Dysraphism	Associate	19683694, 20834190
Stroke	Inhibit	33382484
Thrombocytopenia	Associate	22994778
Xeroderma Pigmentosum Complementation Group C	Associate	1649389

DHFR (dihydrofolate reductase)